Hub : Traits : Parametrial fat weight : ← →

chr6:25,869,940-29,090,273

Trait: Parametrial fat weight

Best TWAS P=1.531064e-10 · Best GWAS P=5.237343e-09 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Ncoa1	alternative polyA	ENSRNOT00000105343	0.04	0.00	blup	576	0.01	3.6e-02	5.5	-5.7	1.0e-08	-0.93	0.28	0.35	TRUE
2	Adipose	Ncoa1	alternative polyA	ENSRNOT00000110405	0.04	0.01	enet	6	0.01	1.5e-02	5.5	6.1	8.6e-10	0.91	0.30	0.38	FALSE
3	Adipose	Dnajc27	gene expression	ENSRNOG00000003988	0.59	0.32	enet	90	0.35	1.1e-39	5.5	5.3	1.5e-07	0.88	0.68	0.32	FALSE
4	Adipose	Adcy3	gene expression	ENSRNOG00000003999	0.39	0.12	top1	1	0.12	1.2e-13	5.6	-5.6	2.0e-08	-0.92	0.19	0.81	FALSE
5	Adipose	Klhl29	gene expression	ENSRNOG00000005371	0.13	0.04	enet	21	0.04	1.1e-05	5.2	-5.1	2.8e-07	-0.80	0.19	0.81	FALSE
6	Adipose	NA	isoform ratio	ENSRNOT00000114599	0.09	0.05	top1	1	0.05	3.2e-06	5.6	-5.6	2.4e-08	-0.97	0.22	0.73	FALSE
7	BLA	Efr3b	gene expression	ENSRNOG00000012950	0.17	0.11	lasso	8	0.13	1.2e-07	5.2	-5.2	1.8e-07	-0.87	0.59	0.41	FALSE
8	BLA	Ubxn2a	intron excision ratio	chr6:27893322:27894997	0.04	0.02	enet	11	0.03	1.2e-02	5.5	5.5	2.9e-08	0.62	0.18	0.44	FALSE
9	BLA	Efr3b	mRNA stability	ENSRNOG00000012950	0.15	0.10	blup	1188	0.13	1.2e-07	5.2	-5.1	3.3e-07	-0.90	0.66	0.34	FALSE
10	Brain	Dnajc27	gene expression	ENSRNOG00000003988	0.03	0.03	blup	1155	0.03	1.0e-03	5.1	5.3	1.1e-07	0.93	0.49	0.45	FALSE
11	Brain	Ncoa1	gene expression	ENSRNOG00000004068	0.19	0.14	lasso	4	0.14	5.5e-13	5.2	5.3	9.8e-08	0.98	0.22	0.78	FALSE
12	Brain	Efr3b	gene expression	ENSRNOG00000012950	0.19	0.14	top1	1	0.14	1.0e-12	5.6	-5.6	2.5e-08	-0.91	0.19	0.81	FALSE
13	Brain	NA	isoform ratio	ENSRNOT00000099733	0.05	0.02	enet	32	0.03	2.1e-03	5.8	-6.4	1.5e-10	-0.90	0.20	0.66	TRUE
14	Brain	NA	intron excision ratio	chr6:27482426:27483205	0.02	0.03	top1	1	0.03	2.0e-03	5.2	-5.2	2.1e-07	-0.97	0.02	0.03	FALSE
15	Brain	Efr3b	mRNA stability	ENSRNOG00000012950	0.20	0.14	enet	27	0.15	4.7e-14	5.2	-5.3	9.3e-08	-0.92	0.47	0.53	FALSE
16	Eye	Efr3b	alternative TSS	ENSRNOT00000068214	0.32	0.09	top1	1	0.09	1.8e-02	5.2	-5.2	2.3e-07	-0.91	0.07	0.06	FALSE
17	IL	Efr3b	gene expression	ENSRNOG00000012950	0.47	0.33	top1	1	0.33	1.1e-08	5.2	-5.2	1.8e-07	-0.90	0.48	0.31	FALSE
18	IL	Efr3b	mRNA stability	ENSRNOG00000012950	0.21	0.20	enet	8	0.22	6.2e-06	4.4	-5.3	1.2e-07	-0.86	0.53	0.45	TRUE
19	LHb	Dtnb	isoform ratio	ENSRNOT00000060810	0.19	0.13	top1	1	0.13	6.0e-04	5.2	-5.2	1.8e-07	-0.85	0.06	0.07	FALSE
20	LHb	Dtnb	isoform ratio	ENSRNOT00000094568	0.47	0.08	top1	1	0.08	5.0e-03	5.2	5.2	1.8e-07	0.85	0.06	0.06	FALSE
21	LHb	NA	isoform ratio	ENSRNOT00000099733	0.13	0.11	top1	1	0.11	1.8e-03	5.5	-5.5	3.4e-08	-0.97	0.03	0.06	FALSE
22	LHb	Efr3b	mRNA stability	ENSRNOG00000012950	0.12	0.04	blup	1187	0.10	2.6e-03	5.6	-5.3	1.2e-07	-0.93	0.35	0.42	FALSE
23	Liver	Ncoa1	alternative polyA	ENSRNOT00000068531	0.05	0.01	top1	1	0.01	1.2e-02	5.4	5.4	6.9e-08	0.97	0.02	0.03	FALSE
24	Liver	Fam228b	alternative polyA	ENSRNOT00000113530	0.04	0.02	top1	1	0.03	8.2e-04	5.7	5.7	1.4e-08	0.83	0.02	0.07	FALSE
25	Liver	Fam228b	alternative polyA	ENSRNOT00000114842	0.04	0.03	top1	1	0.03	3.0e-04	5.7	-5.7	1.4e-08	-0.75	0.05	0.31	FALSE
26	Liver	Adcy3	gene expression	ENSRNOG00000003999	0.29	0.14	top1	1	0.14	2.3e-15	5.5	-5.5	3.2e-08	-0.92	0.27	0.73	FALSE
27	Liver	Ncoa1	gene expression	ENSRNOG00000004068	0.06	0.01	blup	576	0.02	3.2e-03	5.8	-5.9	3.8e-09	-0.97	0.25	0.64	FALSE
28	Liver	Fam228b	gene expression	ENSRNOG00000049615	0.19	0.11	top1	1	0.11	1.8e-12	5.8	-5.8	6.7e-09	-0.80	0.06	0.94	FALSE
29	Liver	Ncoa1	isoform ratio	ENSRNOT00000068531	0.04	0.03	top1	1	0.04	8.5e-05	5.5	5.5	4.3e-08	0.96	0.10	0.20	FALSE
30	Liver	Ncoa1	isoform ratio	ENSRNOT00000110405	0.02	0.02	top1	1	0.02	4.2e-03	5.5	-5.5	4.3e-08	-0.96	0.02	0.03	FALSE
31	Liver	Cenpo	mRNA stability	ENSRNOG00000050111	0.27	0.02	top1	1	0.02	3.9e-03	5.8	5.8	6.7e-09	0.94	0.03	0.06	FALSE
32	NAcc	Dnajc27	gene expression	ENSRNOG00000003988	0.08	0.08	blup	1154	0.11	2.7e-08	5.2	5.2	1.7e-07	0.92	0.64	0.36	FALSE
33	NAcc	Efr3b	gene expression	ENSRNOG00000012950	0.19	0.19	blup	1187	0.20	5.3e-15	5.2	-5.2	1.5e-07	-0.93	0.55	0.45	FALSE
34	NAcc	NA	isoform ratio	ENSRNOT00000099733	0.06	0.01	blup	482	0.02	1.2e-02	5.1	-5.8	8.6e-09	-0.96	0.30	0.49	FALSE
35	OFC	Ncoa1	alternative polyA	ENSRNOT00000068531	0.13	0.06	blup	576	0.08	5.3e-03	5.4	5.4	6.7e-08	0.95	0.24	0.41	FALSE
36	OFC	Ncoa1	alternative polyA	ENSRNOT00000110405	0.13	0.06	blup	576	0.07	7.8e-03	5.3	-5.7	1.6e-08	-0.95	0.25	0.42	FALSE
37	OFC	Itsn2	intron excision ratio	chr6:27617212:27638176	0.24	0.11	enet	3	0.12	9.0e-04	5.4	5.5	3.5e-08	-0.60	0.16	0.43	TRUE
38	PL	Dnajc27	gene expression	ENSRNOG00000003988	0.18	0.03	blup	1154	0.04	6.1e-04	5.2	5.2	2.4e-07	0.89	0.21	0.64	FALSE
39	PL	Adcy3	gene expression	ENSRNOG00000003999	0.05	0.03	top1	1	0.03	3.4e-03	5.4	-5.4	6.4e-08	-0.92	0.04	0.04	FALSE
40	PL	Efr3b	gene expression	ENSRNOG00000012950	0.47	0.41	lasso	64	0.42	7.2e-34	5.3	-5.3	1.3e-07	-0.92	0.55	0.45	FALSE
41	PL	Itsn2	gene expression	ENSRNOG00000046741	0.02	0.03	top1	1	0.03	4.6e-03	5.5	5.5	3.3e-08	0.98	0.03	0.07	FALSE
42	PL	Ncoa1	intron excision ratio	chr6:27234917:27235003	0.04	0.02	top1	1	0.02	2.2e-02	5.6	-5.6	2.5e-08	-0.96	0.03	0.05	FALSE
43	PL	Efr3b	mRNA stability	ENSRNOG00000012950	0.20	0.25	lasso	8	0.26	1.6e-19	5.2	-5.2	2.4e-07	-0.93	0.47	0.53	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.