Hub : Traits : light_reinforcement_lr_active : ←

chr19:22,559,764-24,711,172

Best TWAS P=1.835398e-08 · Best GWAS P=2.638565e-08 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Dhps	gene expression	ENSRNOG00000004219	0.08	0.07	top1	1	0.07	1.7e-08	-5.3	5.3	1.1e-07	-0.96	0.14	0.86	FALSE
2	Adipose	Cacna1a	gene expression	ENSRNOG00000052707	0.07	0.05	lasso	14	0.05	1.6e-06	-5.0	-5.2	1.8e-07	0.87	0.24	0.75	FALSE
3	Adipose	Cesl1	intron excision ratio	chr19:22684897:22686745	0.03	0.02	enet	8	0.03	3.0e-04	-5.0	-5.2	1.7e-07	0.91	0.03	0.85	FALSE
4	BLA	Gcdh	gene expression	ENSRNOG00000003307	0.45	0.36	top1	1	0.36	2.7e-20	-5.2	-5.2	2.6e-07	0.92	0.39	0.61	FALSE
5	BLA	Mri1	gene expression	ENSRNOG00000026211	0.31	0.21	top1	1	0.21	1.8e-11	-5.4	5.4	6.2e-08	-0.99	0.17	0.83	FALSE
6	BLA	Brme1	mRNA stability	ENSRNOG00000025796	0.09	0.06	lasso	14	0.06	4.3e-04	-5.5	-5.5	3.9e-08	1.00	0.16	0.80	FALSE
7	Brain	Gcdh	gene expression	ENSRNOG00000003307	0.59	0.53	lasso	14	0.57	5.0e-64	-5.1	-5.3	1.4e-07	0.96	0.13	0.87	FALSE
8	Brain	Nfix	mRNA stability	ENSRNOG00000002983	0.07	0.03	top1	1	0.03	1.4e-03	-5.1	5.1	2.7e-07	-0.86	0.07	0.08	FALSE
9	Brain	Gcdh	mRNA stability	ENSRNOG00000003307	0.13	0.09	enet	56	0.10	4.2e-09	-5.1	5.2	2.4e-07	-0.88	0.37	0.63	FALSE
10	Brain	Brme1	mRNA stability	ENSRNOG00000025796	0.06	0.05	top1	1	0.05	2.1e-05	-5.5	-5.5	4.6e-08	0.97	0.11	0.80	FALSE
11	IL	Gcdh	gene expression	ENSRNOG00000003307	0.58	0.35	lasso	5	0.36	1.3e-09	-5.0	-5.2	2.3e-07	0.81	0.20	0.80	FALSE
12	LHb	Gcdh	mRNA stability	ENSRNOG00000003307	0.24	0.12	top1	1	0.12	1.1e-03	-5.1	5.1	2.7e-07	-0.88	0.04	0.06	FALSE
13	Liver	Gcdh	gene expression	ENSRNOG00000003307	0.33	0.29	enet	174	0.30	4.2e-34	-5.5	-5.5	4.1e-08	0.96	0.11	0.89	FALSE
14	Liver	Trmt1	isoform ratio	ENSRNOT00000003941	0.05	0.04	top1	1	0.04	5.8e-05	-5.4	5.4	7.9e-08	-0.97	0.12	0.37	FALSE
15	Liver	Trmt1	isoform ratio	ENSRNOT00000098952	0.03	0.02	top1	1	0.02	1.2e-03	-5.4	-5.4	7.9e-08	1.00	0.04	0.06	FALSE
16	Liver	Gcdh	isoform ratio	ENSRNOT00000116825	0.03	0.03	top1	1	0.03	1.4e-04	-5.2	5.2	2.6e-07	-1.00	0.06	0.10	FALSE
17	NAcc	Mri1	gene expression	ENSRNOG00000026211	0.20	0.07	top1	1	0.07	9.7e-03	-5.5	5.5	4.7e-08	-0.91	0.08	0.07	FALSE
18	NAcc	Rnaseh2a	gene expression	ENSRNOG00000068063	0.23	0.07	top1	1	0.07	1.2e-02	-5.4	5.4	7.9e-08	-0.84	0.04	0.08	FALSE
19	NAcc2	Cacna1a	alternative TSS	ENSRNOT00000083448	0.07	0.03	blup	1513	0.03	1.1e-02	-5.5	5.6	1.8e-08	-0.95	0.18	0.67	TRUE
20	NAcc2	Cacna1a	alternative TSS	ENSRNOT00000102295	0.09	0.04	top1	1	0.04	2.5e-03	-5.5	-5.5	4.2e-08	0.99	0.07	0.13	FALSE
21	NAcc2	Gcdh	gene expression	ENSRNOG00000003307	0.53	0.45	enet	128	0.46	3.0e-27	-5.6	-5.4	7.5e-08	0.99	0.11	0.89	FALSE
22	NAcc2	Mri1	gene expression	ENSRNOG00000026211	0.24	0.10	enet	283	0.17	1.7e-09	-5.5	5.6	2.8e-08	-0.50	0.18	0.82	FALSE
23	NAcc2	Rad23a	mRNA stability	ENSRNOG00000003026	0.10	0.06	blup	925	0.06	3.0e-04	-5.5	-5.6	1.9e-08	0.92	0.12	0.80	FALSE
24	OFC	Mri1	gene expression	ENSRNOG00000026211	0.31	0.15	top1	1	0.15	2.3e-04	-5.4	5.4	5.8e-08	-0.94	0.08	0.08	FALSE
25	OFC	Gcdh	intron excision ratio	chr19:23264057:23264177	0.23	0.03	blup	773	0.05	2.9e-02	-5.4	5.5	3.9e-08	-0.87	0.10	0.42	FALSE
26	PL2	Gcdh	gene expression	ENSRNOG00000003307	0.54	0.39	lasso	31	0.40	5.5e-23	-5.1	-5.1	3.0e-07	0.96	0.12	0.88	FALSE
27	PL2	Gcdh	intron excision ratio	chr19:23263340:23263398	0.16	0.12	blup	776	0.13	1.6e-07	-5.5	-5.2	2.2e-07	0.96	0.12	0.88	FALSE
28	PL2	Gcdh	intron excision ratio	chr19:23263527:23263608	0.16	0.13	top1	1	0.13	2.0e-07	-5.5	5.5	4.7e-08	-0.95	0.11	0.88	FALSE
29	PL2	Gadd45gip1	mRNA stability	ENSRNOG00000003011	0.15	0.05	blup	955	0.10	3.6e-06	3.4	-5.1	2.8e-07	0.75	0.64	0.34	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.