Hub : Traits : Light reinforcement 1 : ←

chr19:22,559,764-24,711,172

Trait: Light reinforcement 1

Best TWAS P=3.338071e-10 · Best GWAS P=2.638565e-08 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Dhps	gene expression	ENSRNOG00000004219	0.08	0.07	top1	1	0.07	1.7e-08	-5.3	5.3	1.1e-07	-0.96	0.14	0.86	FALSE
2	Adipose	Cacna1a	gene expression	ENSRNOG00000052707	0.07	0.05	lasso	14	0.05	1.6e-06	-5.0	-5.2	1.8e-07	0.87	0.24	0.75	FALSE
3	Adipose	Cesl1	intron excision ratio	chr19:22684897:22686745	0.03	0.02	enet	8	0.03	3.0e-04	-5.0	-5.2	1.7e-07	0.91	0.03	0.85	FALSE
4	BLA	Gcdh	gene expression	ENSRNOG00000003307	0.45	0.36	top1	1	0.36	2.7e-20	-5.2	-5.2	2.6e-07	0.92	0.39	0.61	FALSE
5	BLA	Mri1	gene expression	ENSRNOG00000026211	0.31	0.21	top1	1	0.21	1.8e-11	-5.4	5.4	6.2e-08	-0.99	0.17	0.83	FALSE
6	BLA	Brme1	mRNA stability	ENSRNOG00000025796	0.09	0.06	lasso	14	0.06	4.3e-04	-5.5	-5.5	3.9e-08	1.00	0.16	0.80	FALSE
7	Brain	Gcdh	gene expression	ENSRNOG00000003307	0.59	0.53	lasso	14	0.57	5.0e-64	-5.1	-5.3	1.4e-07	0.96	0.13	0.87	FALSE
8	Brain	MAST1	gene expression	ENSRNOG00000003469	0.30	0.22	enet	14	0.24	1.7e-22	-5.0	5.1	3.5e-07	-0.92	0.47	0.53	TRUE
9	Brain	Nfix	mRNA stability	ENSRNOG00000002983	0.07	0.03	top1	1	0.03	1.4e-03	-5.1	5.1	2.7e-07	-0.86	0.07	0.08	FALSE
10	Brain	Gcdh	mRNA stability	ENSRNOG00000003307	0.13	0.09	enet	56	0.10	4.2e-09	-5.1	5.2	2.4e-07	-0.88	0.37	0.63	FALSE
11	Brain	Brme1	mRNA stability	ENSRNOG00000025796	0.06	0.05	top1	1	0.05	2.1e-05	-5.5	-5.5	4.6e-08	0.97	0.11	0.80	FALSE
12	IL	Gcdh	gene expression	ENSRNOG00000003307	0.58	0.35	lasso	5	0.36	1.3e-09	-5.0	-5.2	2.3e-07	0.81	0.20	0.80	FALSE
13	LHb	Gcdh	mRNA stability	ENSRNOG00000003307	0.24	0.12	top1	1	0.12	1.1e-03	-5.1	5.1	2.7e-07	-0.88	0.04	0.06	FALSE
14	Liver	Gcdh	gene expression	ENSRNOG00000003307	0.33	0.29	enet	174	0.30	4.2e-34	-5.5	-5.5	4.1e-08	0.96	0.11	0.89	FALSE
15	Liver	Trmt1	isoform ratio	ENSRNOT00000003941	0.05	0.04	top1	1	0.04	5.8e-05	-5.4	5.4	7.9e-08	-0.97	0.12	0.37	TRUE
16	Liver	Trmt1	isoform ratio	ENSRNOT00000098952	0.03	0.02	top1	1	0.02	1.2e-03	-5.4	-5.4	7.9e-08	1.00	0.04	0.06	FALSE
17	Liver	Gcdh	isoform ratio	ENSRNOT00000116825	0.03	0.03	top1	1	0.03	1.4e-04	-5.2	5.2	2.6e-07	-1.00	0.06	0.10	FALSE
18	NAcc	Mri1	gene expression	ENSRNOG00000026211	0.23	0.16	enet	137	0.17	1.2e-12	-5.5	6.3	3.3e-10	0.37	0.15	0.85	TRUE
19	NAcc	Gadd45gip1	mRNA stability	ENSRNOG00000003011	0.08	0.02	top1	1	0.02	1.4e-02	-5.1	-5.1	2.7e-07	0.92	0.05	0.05	FALSE
20	NAcc	Calr	mRNA stability	ENSRNOG00000003029	0.07	0.03	blup	885	0.03	3.8e-03	-5.5	-5.6	2.4e-08	0.96	0.13	0.83	FALSE
21	OFC	Mri1	gene expression	ENSRNOG00000026211	0.31	0.15	top1	1	0.15	2.3e-04	-5.4	5.4	5.8e-08	-0.94	0.08	0.08	FALSE
22	OFC	Gcdh	intron excision ratio	chr19:23264057:23264177	0.23	0.03	blup	773	0.05	2.9e-02	-5.4	5.5	3.9e-08	-0.87	0.10	0.42	TRUE
23	PL	Mri1	gene expression	ENSRNOG00000026211	0.17	0.09	blup	1522	0.10	5.3e-08	-5.1	5.4	6.0e-08	-0.95	0.20	0.80	FALSE
24	PL	NA	gene expression	ENSRNOG00000049931	0.08	0.04	blup	1537	0.05	8.7e-05	-4.6	5.4	5.6e-08	-0.98	0.20	0.79	FALSE
25	PL	Gcdh	intron excision ratio	chr19:23263340:23263398	0.07	0.05	top1	1	0.05	1.7e-04	-5.5	-5.5	3.9e-08	0.99	0.07	0.56	FALSE
26	PL	Gcdh	intron excision ratio	chr19:23263527:23263608	0.08	0.04	lasso	13	0.04	3.9e-04	-5.5	5.5	3.9e-08	-1.00	0.12	0.88	FALSE
27	PL	Gcdh	mRNA stability	ENSRNOG00000003307	0.08	0.04	top1	1	0.04	5.4e-04	-5.1	5.1	2.7e-07	-0.95	0.06	0.08	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.