Hub : Traits : light_reinforcement_lr_active : ← →

chr19:17,307,470-20,307,530

Best TWAS P=8.349821e-09 · Best GWAS P=3.088948e-09 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Nod2	gene expression	ENSRNOG00000014124	0.03	0.00	top1	1	0.00	9.9e-02	-5.14	-5.1	2.8e-07	0.94	0.06	0.03	FALSE
2	Adipose	Snx20	gene expression	ENSRNOG00000014202	0.06	0.05	top1	1	0.05	1.1e-06	-5.30	5.3	1.2e-07	-0.95	0.61	0.22	FALSE
3	Adipose	Adcy7	gene expression	ENSRNOG00000014776	0.02	0.01	top1	1	0.01	1.6e-02	-5.52	5.5	3.5e-08	-0.97	0.05	0.03	FALSE
4	Adipose	Snx20	mRNA stability	ENSRNOG00000014202	0.16	0.15	enet	442	0.16	2.3e-17	-5.40	5.2	2.2e-07	-0.91	0.55	0.45	FALSE
5	BLA	Cyld	alternative TSS	ENSRNOT00000018888	0.11	0.12	top1	1	0.12	6.6e-07	-5.51	-5.5	3.6e-08	0.94	0.40	0.42	FALSE
6	BLA	Cyld	alternative TSS	ENSRNOT00000091626	0.11	0.11	blup	1788	0.11	1.4e-06	-5.25	5.4	5.1e-08	-0.94	0.56	0.44	FALSE
7	BLA	Cyld	gene expression	ENSRNOG00000014048	0.40	0.39	lasso	60	0.40	1.2e-22	-5.37	-5.4	7.3e-08	0.93	0.54	0.46	FALSE
8	BLA	Cyld	intron excision ratio	chr19:18338598:18344904	0.13	0.09	top1	1	0.09	1.5e-05	-5.19	5.2	2.2e-07	-0.94	0.22	0.06	FALSE
9	BLA	Cyld	intron excision ratio	chr19:18365476:18373011	0.28	0.17	lasso	19	0.18	6.3e-10	-5.24	-5.2	2.3e-07	0.92	0.56	0.44	FALSE
10	BLA	Sall1	mRNA stability	ENSRNOG00000013907	0.19	0.12	blup	2035	0.14	6.0e-08	-5.37	-5.1	2.9e-07	0.92	0.50	0.50	FALSE
11	BLA	Snx20	mRNA stability	ENSRNOG00000014202	0.06	0.03	top1	1	0.03	1.2e-02	-5.29	5.3	1.2e-07	-0.94	0.07	0.04	FALSE
12	BLA	Nkd1	mRNA stability	ENSRNOG00000014293	0.08	0.06	top1	1	0.06	2.5e-04	-5.27	-5.3	1.4e-07	0.94	0.09	0.04	FALSE
13	Brain	Cyld	alternative TSS	ENSRNOT00000018888	0.19	0.30	lasso	48	0.31	3.4e-29	-5.41	-5.5	3.7e-08	0.94	0.59	0.41	FALSE
14	Brain	Cyld	alternative TSS	ENSRNOT00000091626	0.19	0.30	lasso	26	0.31	3.8e-29	-5.41	5.6	2.8e-08	-0.95	0.59	0.41	FALSE
15	Brain	Cyld	gene expression	ENSRNOG00000014048	0.53	0.66	lasso	58	0.67	2.9e-82	-5.64	-5.5	3.4e-08	0.94	0.57	0.43	FALSE
16	Brain	Nod2	gene expression	ENSRNOG00000014124	0.25	0.31	enet	128	0.32	1.1e-30	-5.49	-5.4	8.8e-08	0.94	0.41	0.59	FALSE
17	Brain	Snx20	gene expression	ENSRNOG00000014202	0.17	0.24	lasso	25	0.24	7.1e-22	-5.30	5.4	8.0e-08	-0.94	0.58	0.42	FALSE
18	Brain	Nkd1	gene expression	ENSRNOG00000014293	0.05	0.04	blup	1834	0.05	3.2e-05	-5.52	5.5	3.8e-08	-0.93	0.53	0.47	FALSE
19	Brain	Brd7	gene expression	ENSRNOG00000014419	0.06	0.09	top1	1	0.09	8.5e-09	-5.41	-5.4	6.2e-08	0.96	0.60	0.39	FALSE
20	Brain	Zfp423	gene expression	ENSRNOG00000014658	0.20	0.26	lasso	51	0.27	9.8e-25	-5.64	-5.5	4.7e-08	-0.71	0.36	0.64	TRUE
21	Brain	NA	gene expression	ENSRNOG00000062389	0.02	0.03	top1	1	0.03	4.3e-04	-5.52	5.5	3.5e-08	-0.97	0.06	0.04	FALSE
22	Brain	Cyld	intron excision ratio	chr19:18338598:18344904	0.03	0.02	top1	1	0.02	4.8e-03	-5.50	5.5	3.8e-08	-0.94	0.07	0.05	FALSE
23	Brain	Cyld	intron excision ratio	chr19:18345020:18348718	0.09	0.09	enet	37	0.10	1.2e-09	-5.49	5.4	7.1e-08	-0.92	0.61	0.39	FALSE
24	Brain	Cyld	intron excision ratio	chr19:18365476:18373011	0.09	0.11	blup	1788	0.13	6.2e-12	-5.51	-5.4	5.6e-08	0.92	0.61	0.39	FALSE
25	Brain	Cyld	intron excision ratio	chr19:18365476:18373513	0.08	0.02	top1	1	0.02	2.5e-03	-5.12	5.1	3.0e-07	-0.90	0.07	0.03	FALSE
26	Brain	NA	intron excision ratio	chr19:18008033:18008164	0.06	0.07	top1	1	0.07	2.1e-07	-5.31	5.3	1.1e-07	-0.93	0.67	0.28	FALSE
27	Brain	Sall1	mRNA stability	ENSRNOG00000013907	0.21	0.29	top1	1	0.29	6.4e-27	-5.61	-5.6	2.0e-08	0.93	0.31	0.69	FALSE
28	Brain	Snx20	mRNA stability	ENSRNOG00000014202	0.12	0.17	enet	319	0.18	1.2e-16	-5.52	5.4	5.3e-08	-0.94	0.59	0.41	FALSE
29	Brain	Nkd1	mRNA stability	ENSRNOG00000014293	0.08	0.11	lasso	25	0.11	2.8e-10	-5.53	-5.6	2.4e-08	0.92	0.50	0.50	FALSE
30	Eye	Nkd1	gene expression	ENSRNOG00000014293	0.26	0.13	enet	14	0.13	5.2e-03	-5.36	5.5	3.7e-08	-0.90	0.32	0.25	FALSE
31	Eye	Cyld	intron excision ratio	chr19:18365476:18373513	0.30	0.12	top1	1	0.12	6.3e-03	-5.43	-5.4	5.8e-08	0.94	0.09	0.06	FALSE
32	IL	Nod2	gene expression	ENSRNOG00000014124	0.18	0.20	top1	1	0.20	1.3e-05	-5.30	-5.3	1.1e-07	0.94	0.15	0.07	FALSE
33	IL	Sall1	mRNA stability	ENSRNOG00000013907	0.24	0.23	top1	1	0.23	3.0e-06	-5.45	-5.5	5.0e-08	0.93	0.14	0.09	FALSE
34	LHb	Zfp423	alternative TSS	ENSRNOT00000101491	0.18	0.07	lasso	2	0.07	9.5e-03	-5.25	5.3	1.4e-07	-0.77	0.33	0.34	FALSE
35	LHb	Zfp423	alternative TSS	ENSRNOT00000101895	0.19	0.07	enet	3	0.10	2.5e-03	-5.25	-5.1	2.7e-07	0.73	0.36	0.35	FALSE
36	LHb	Cyld	gene expression	ENSRNOG00000014048	0.30	0.16	top1	1	0.16	1.0e-04	-5.52	-5.5	3.4e-08	0.93	0.11	0.07	FALSE
37	LHb	Nod2	gene expression	ENSRNOG00000014124	0.39	0.25	top1	1	0.25	1.1e-06	-5.37	-5.4	8.0e-08	0.94	0.18	0.10	FALSE
38	LHb	Snx20	gene expression	ENSRNOG00000014202	0.29	0.13	top1	1	0.13	6.2e-04	-5.31	5.3	1.1e-07	-0.94	0.11	0.06	FALSE
39	LHb	Cbln1	mRNA stability	ENSRNOG00000000010	0.32	0.08	enet	5	0.09	4.0e-03	-5.48	5.5	3.3e-08	-1.00	0.28	0.49	FALSE
40	Liver	Snx20	gene expression	ENSRNOG00000014202	0.08	0.07	enet	229	0.07	3.7e-08	-5.14	5.4	8.2e-08	-0.92	0.55	0.45	FALSE
41	Liver	Nkd1	gene expression	ENSRNOG00000014293	0.03	0.02	top1	1	0.02	2.0e-03	-5.47	5.5	4.5e-08	-0.95	0.06	0.04	FALSE
42	Liver	NA	gene expression	ENSRNOG00000069560	0.17	0.19	enet	175	0.19	3.4e-21	-5.51	-5.2	1.8e-07	0.93	0.54	0.46	FALSE
43	Liver	Sall1	mRNA stability	ENSRNOG00000013907	0.63	0.55	enet	595	0.57	2.5e-77	-5.69	-5.4	7.9e-08	0.93	0.53	0.47	FALSE
44	NAcc	Cyld	gene expression	ENSRNOG00000014048	0.31	0.13	top1	1	0.13	7.7e-04	-5.42	-5.4	6.0e-08	0.94	0.10	0.06	FALSE
45	NAcc	Cyld	intron excision ratio	chr19:18365476:18368246	0.12	0.06	top1	1	0.06	2.2e-02	-5.42	5.4	5.8e-08	-0.94	0.09	0.05	FALSE
46	NAcc	Sall1	mRNA stability	ENSRNOG00000013907	0.34	0.18	lasso	11	0.21	2.2e-05	-5.42	-5.4	5.7e-08	0.93	0.51	0.44	FALSE
47	NAcc2	Cyld	alternative TSS	ENSRNOT00000018888	0.05	0.03	blup	1788	0.03	6.4e-03	-5.52	-5.4	8.5e-08	0.94	0.44	0.34	FALSE
48	NAcc2	Cyld	alternative TSS	ENSRNOT00000091626	0.07	0.04	blup	1788	0.05	1.4e-03	-5.52	5.3	1.1e-07	-0.94	0.50	0.40	FALSE
49	NAcc2	Cyld	gene expression	ENSRNOG00000014048	0.20	0.20	top1	1	0.20	6.0e-11	-5.21	-5.2	1.9e-07	0.94	0.82	0.18	FALSE
50	NAcc2	Snx20	gene expression	ENSRNOG00000014202	0.07	0.06	lasso	3	0.06	3.5e-04	-5.24	5.2	1.6e-07	-0.93	0.52	0.44	FALSE
51	NAcc2	Cyld	intron excision ratio	chr19:18338598:18344904	0.18	0.09	blup	1788	0.11	1.7e-06	-5.28	5.2	1.8e-07	-0.88	0.59	0.41	FALSE
52	NAcc2	Cyld	intron excision ratio	chr19:18345020:18348718	0.06	0.02	top1	1	0.02	1.7e-02	-5.21	5.2	1.9e-07	-0.94	0.07	0.04	FALSE
53	NAcc2	Cyld	intron excision ratio	chr19:18365476:18373011	0.19	0.24	top1	1	0.24	5.1e-13	-5.24	-5.2	1.6e-07	0.94	0.79	0.21	FALSE
54	NAcc2	Cyld	intron excision ratio	chr19:18365476:18373513	0.06	0.04	blup	1788	0.04	2.3e-03	-5.51	5.5	4.4e-08	-0.94	0.52	0.39	FALSE
55	NAcc2	Cyld	intron excision ratio	chr19:18365476:18373606	0.05	0.04	top1	1	0.04	2.6e-03	-5.24	5.2	1.6e-07	-0.94	0.07	0.04	FALSE
56	NAcc2	Nkd1	mRNA stability	ENSRNOG00000014293	0.06	0.00	top1	1	0.00	2.0e-01	-5.27	-5.3	1.4e-07	0.95	0.07	0.04	FALSE
57	OFC	Cyld	alternative TSS	ENSRNOT00000091626	0.15	0.01	enet	4	0.04	4.4e-02	-0.72	5.1	2.9e-07	-0.62	0.32	0.15	FALSE
58	OFC	Cyld	gene expression	ENSRNOG00000014048	0.31	0.31	top1	1	0.31	4.6e-08	-5.37	-5.4	8.0e-08	0.94	0.24	0.13	FALSE
59	OFC	Zfp423	gene expression	ENSRNOG00000014658	0.53	0.36	enet	13	0.40	1.2e-10	-5.48	-5.4	7.9e-08	0.98	0.40	0.60	FALSE
60	PL	Cyld	gene expression	ENSRNOG00000014048	0.52	0.44	top1	1	0.44	7.4e-12	-5.70	-5.7	1.2e-08	0.94	0.24	0.74	FALSE
61	PL	Zfp423	gene expression	ENSRNOG00000014658	0.44	0.29	top1	1	0.29	1.7e-07	-5.52	-5.5	3.4e-08	0.97	0.20	0.23	FALSE
62	PL	Zfp423	isoform ratio	ENSRNOT00000020028	0.13	0.02	top1	1	0.02	1.4e-01	-5.76	-5.8	8.3e-09	0.97	0.07	0.06	TRUE
63	PL	Sall1	mRNA stability	ENSRNOG00000013907	0.40	0.26	enet	159	0.27	3.7e-07	-5.30	-5.3	1.3e-07	0.92	0.55	0.45	FALSE
64	PL	Brd7	mRNA stability	ENSRNOG00000014419	0.20	0.09	top1	1	0.09	3.6e-03	-5.20	5.2	2.0e-07	-0.80	0.08	0.05	FALSE
65	PL2	Cyld	alternative TSS	ENSRNOT00000018888	0.13	0.03	enet	19	0.06	5.1e-04	-5.06	-5.4	5.5e-08	0.88	0.55	0.43	FALSE
66	PL2	Cyld	alternative TSS	ENSRNOT00000091626	0.11	0.03	enet	18	0.06	5.0e-04	-5.06	5.4	6.2e-08	-0.87	0.55	0.42	FALSE
67	PL2	Zfp423	alternative TSS	ENSRNOT00000101491	0.08	0.07	lasso	29	0.09	1.2e-05	-5.72	5.5	4.2e-08	-0.98	0.36	0.63	FALSE
68	PL2	Zfp423	alternative TSS	ENSRNOT00000101491	0.13	0.09	blup	1325	0.10	2.9e-06	-5.68	5.2	2.3e-07	-0.95	0.33	0.67	FALSE
69	PL2	Zfp423	alternative TSS	ENSRNOT00000101895	0.15	0.12	enet	192	0.12	5.9e-07	-5.72	-5.2	1.9e-07	0.95	0.33	0.67	FALSE
70	PL2	Cyld	gene expression	ENSRNOG00000014048	0.34	0.33	lasso	32	0.35	8.1e-20	-5.37	-5.4	7.7e-08	0.93	0.53	0.47	FALSE
71	PL2	Nod2	gene expression	ENSRNOG00000014124	0.20	0.14	enet	63	0.14	3.8e-08	-5.45	-5.2	2.0e-07	0.90	0.54	0.46	FALSE
72	PL2	Brd7	gene expression	ENSRNOG00000014419	0.06	0.02	top1	1	0.02	2.3e-02	-5.21	-5.2	1.9e-07	0.95	0.06	0.04	FALSE
73	PL2	Tent4b	gene expression	ENSRNOG00000024212	0.05	0.02	blup	1433	0.03	1.2e-02	-5.72	5.4	8.2e-08	-0.95	0.36	0.38	FALSE
74	PL2	Cyld	intron excision ratio	chr19:18338598:18344904	0.10	0.07	top1	1	0.07	1.1e-04	-5.24	5.2	1.6e-07	-0.94	0.25	0.08	FALSE
75	PL2	Cyld	intron excision ratio	chr19:18365476:18368246	0.05	0.04	top1	1	0.04	4.7e-03	-5.41	5.4	6.4e-08	-0.94	0.07	0.04	FALSE
76	PL2	Cyld	intron excision ratio	chr19:18365476:18373011	0.15	0.18	top1	1	0.18	7.3e-10	-5.47	-5.5	4.5e-08	0.94	0.53	0.47	FALSE
77	PL2	Cyld	intron excision ratio	chr19:18365476:18373606	0.06	0.03	blup	1788	0.03	5.7e-03	-5.37	5.4	6.4e-08	-0.94	0.47	0.39	FALSE
78	PL2	Sall1	mRNA stability	ENSRNOG00000013907	0.27	0.24	top1	1	0.24	2.4e-13	-5.50	-5.5	3.8e-08	0.93	0.46	0.54	TRUE
79	PL2	Snx20	mRNA stability	ENSRNOG00000014202	0.07	0.06	top1	1	0.06	2.2e-04	-5.41	5.4	6.4e-08	-0.94	0.09	0.05	FALSE
80	PL2	Nkd1	mRNA stability	ENSRNOG00000014293	0.05	0.03	top1	1	0.03	1.4e-02	-5.52	-5.5	3.5e-08	0.95	0.07	0.04	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.