Hub : Traits

retroperitoneal_fat_g

Project: dissection

1734 significantly associated models · 237 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 133358665 134912264 4 1 9.6e-08 6.2e-07 0.45515 98 Idh2
2 1 149857704 156065975 48 7 9.2e-11 1.5e-09 1.00000 100 Alg8 Aamdc B3gnt6 P4ha3 Fam168a Mogat2 NA
3 1 251351727 260518987 47 5 7.0e-51 1.9e-51 1.00000 100 Cacul1 Tectb AABR07007032.1 NA NA
4 3 45415084 46813656 1 1 1.8e-07 1.2e-06 0.30060 95 Tank
5 3 88764368 94152740 38 6 6.4e-15 6.7e-14 1.00000 100 Pax6 AABR07053185.1 Mpped2 Pdhx Hipk3 Ccdc73
6 3 126323673 128707024 6 1 1.8e-10 4.4e-12 0.00066 76 AABR07054000.1
7 3 129554891 132898674 17 5 2.1e-20 2.3e-20 NaN NaN Snrpb2 Pcsk2 Sec23b Scp2d1 NA
8 6 19271415 20658264 1 1 3.0e-07 1.3e-08 0.00169 69 Rasgrp3
9 6 20965724 29090273 71 9 2.0e-32 1.0e-32 1.00000 100 Zfp513 Klhl29 Ehd3 Mapre3 Slc35f6 Dtnb Efr3b Dnmt3a NA
10 7 110658552 112133640 2 2 2.2e-07 4.3e-08 0.60411 99 Nptxr Apobec3
11 10 92666462 94065985 1 1 1.7e-07 1.3e-07 0.00032 54 Cep112
12 10 103916742 105312647 1 1 3.1e-07 3.4e-07 1.00000 100 Slc26a11

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
dissection: UMAP 1 of all traits 11.0 172 134 335 -0.96 0.0e+00 Dnajc27 Adcy3 Ncoa1 Babam2 Pax6 Tasp1 Spdya Ppp1cb Rbks Esf1 Ndufaf5 AABR07053185.1 Dnajc24 Mpped2 Flrt3 Arl14ep Slc4a1ap Gpn1 Kif16b Snrpb2 Zfp513 Klhl29 Pcsk2 Dstn Rrbp1 Trim54 Slc30a3 Preb Kat14 Dzank1 Polr3f Rbbp9 Sec23b Alk Dtd1 Clip4 Pcare Mapre3 Dpysl5 Slc35f6 Pdzd8 Scp2d1 Rab11fip2 Kcnk3 Fam204a Prlhr Cacul1 Otof Dennd10 Hadhb Prdx3 Tenm4 Kif3c Grk5 Nars2 Gab2 Asxl2 Dtnb Xpnpep1 Cstf3 Alg8 Ndufc2 Ints4 Aamdc Clns1a Add3 Efr3b Aqp11 NA Rcn1 B3gnt6 Rbm20 Gpam Shoc2 Emsy Tectb Gucy2g Nptxr Acsl5 Habp2 Nrap Apobec3 Nhlrc2 Adrb1 Tdrd1 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Pnlip Dnajb13 Hspa12a Mrpl48 Eno4 Shtn1 Dcdc5 Prrg4 Rsf1 Cep112 Hadha Kctd21 Drc1 Usp35 Nanos1 NA Vwa2 Abhd1 Plb1 Dclre1a Togaram2 Cad Dnmt3a Snx17 Ppm1g Tsku Zfp133 Mgme1 Otor Pak1 Arrb1 Slc26a11 Zfp950 Rasgrp3 Mxi1 Ces2c Sfxn4 Zdhhc6 Smim26 Zfp512 Sf3b6 AABR07007032.1 Itsn2 Rab10 Fkbp1b Krtcap3 Garem2 Gckr Tcf7l2 Mpv17 Fam228b Cenpo Nrbp1 AABR07054000.1 AABR07063279.1 Ccdc186 Thap12 Casp7 Gtf3c2 Slc5a6 AABR07063281.1 NA Ism1 NA NA NA NA NA NA NA NA NA NA NA NA Fosl2 Ubxn2a NA NA NA NA NA
body_g 11.2 80 64 160 0.99 0.0e+00 Adcy3 Tasp1 Esf1 Ndufaf5 Flrt3 Kif16b Snrpb2 Pcsk2 Dstn Rrbp1 Kat14 Dzank1 Polr3f Rbbp9 Sec23b Dtd1 Pdzd8 Scp2d1 Rab11fip2 Fam204a Prlhr Cacul1 Dennd10 Prdx3 Tenm4 Grk5 Gab2 Alg8 Aamdc Add3 Efr3b Rbm20 Gpam Shoc2 Tectb Gucy2g Acsl5 Habp2 Nrap Nhlrc2 Adrb1 Tdrd1 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Pnlip Hspa12a Eno4 Shtn1 Cep112 Kctd21 Nanos1 Vwa2 Dclre1a Zfp133 Mgme1 Otor Slc26a11 Zfp950 Mxi1 Ces2c Sfxn4 Zdhhc6 Smim26 AABR07007032.1 Itsn2 Tcf7l2 AABR07054000.1 Ccdc186 Casp7 Ism1 NA NA NA NA NA NA NA
kidney_right_g 9.2 35 18 45 0.97 3.0e-60 Rab11fip2 Fam204a Prlhr Cacul1 Dennd10 Prdx3 Grk5 Gpam Gucy2g Nptxr Acsl5 Habp2 Nrap Apobec3 Nhlrc2 Adrb1 Tdrd1 Afap1l2 Fhip2a Atrnl1 Nanos1 Vwa2 Dclre1a Zfp950 Ces2c Sfxn4 AABR07007032.1 Tcf7l2 Ccdc186 Casp7 NA NA NA NA NA
dissection: PC 3 of all traits 8.6 12 2 5 1.00 4.6e-63 Dnajc27 Adcy3 Ncoa1 Rab11fip2 Prlhr Cacul1 Dtnb Efr3b Dnmt3a Itsn2 NA NA
dissection: PC 2 of all traits 10.3 19 10 25 -1.00 3.4e-65 Ncoa1 Kif16b Snrpb2 Pcsk2 Pdzd8 Rab11fip2 Prlhr Cacul1 Dennd10 Grk5 Dtnb Efr3b Nanos1 Otor Zfp950 Ces2c Sfxn4 Cenpo NA
heart_g 12.9 3 0 0 0.00 1.0e+00 Rbks Cacul1 Sfxn4
EDL weight in grams 4.6 40 0 0 -1.00 0.0e+00 Babam2 Spdya Ppp1cb Rbks Slc4a1ap Gpn1 Zfp513 Trim54 Slc30a3 Preb Alk Clip4 Pcare Mapre3 Dpysl5 Slc35f6 Drc1 NA Abhd1 Plb1 Togaram2 Cad Ypel5 Snx17 Ppm1g Zfp512 Lbh Krtcap3 Gckr Mpv17 Nrbp1 AABR07063279.1 Gtf3c2 Slc5a6 AABR07063281.1 NA NA NA NA NA
Tibia length in mm 7.2 10 0 0 0.99 9.4e-47 Tasp1 Esf1 Ndufaf5 Flrt3 Kif16b Snrpb2 Otor Slc26a11 AABR07054000.1 Ism1
sol weight in grams 6.8 17 0 0 0.66 1.4e-04 Spdya Alk Gpam Gucy2g Acsl5 Habp2 Afap1l2 Fhip2a Trub1 Atrnl1 Eno4 Plb1 AABR07007032.1 Ccdc186 NA NA NA
TA weight in grams 5.8 1 0 0 0.00 1.0e+00 Rasgrp3
pavca_ny_levercs_d4d5 15.2 16 2 5 -1.00 2.9e-26 Aamdc Clns1a Myo7a Capn5 B3gnt6 Lrrc32 Emsy Ucp2 Dnajb13 Mrpl48 Mogat2 Tsku Acer3 Thap12 NA Coa4
Total sessions with >9 infusions 19.8 1 0 0 0.00 1.0e+00 Casp7
Total cortical area 11.2 2 0 0 0.00 1.0e+00 Esf1 AABR07054000.1
tb_th_sd 15.3 5 0 0 1.00 1.1e-07 Prlhr Cacul1 Grk5 Nanos1 Sfxn4
tautz: manual_spc20 13.4 10 0 0 1.00 9.6e-29 Lmo2 Fbxo3 NA Hipk3 Cstf3 Depdc7 Ccdc73 Tcp11l1 Cd59 NA
punishment 15.9 12 0 0 -1.00 4.8e-154 Adcy3 Hadhb Kif3c Asxl2 Dtnb Efr3b Hadha Drc1 Dnmt3a Rab10 Garem2 NA

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 31 1.46 3.4
Adipose alternative TSS 7 0.43 2.7
Adipose gene expression 91 1.10 3.2
Adipose isoform ratio 34 1.20 3.1
Adipose intron excision ratio 21 0.72 3.0
Adipose mRNA stability 37 1.07 3.3
BLA alternative polyA 11 0.92 3.2
BLA alternative TSS 11 1.31 3.7
BLA gene expression 64 1.06 3.4
BLA isoform ratio 19 1.08 3.0
BLA intron excision ratio 36 1.21 3.3
BLA mRNA stability 21 1.04 3.3
Brain alternative polyA 18 0.90 3.3
Brain alternative TSS 16 0.93 3.3
Brain gene expression 96 1.06 3.3
Brain isoform ratio 25 0.79 3.2
Brain intron excision ratio 51 0.94 3.2
Brain mRNA stability 50 1.15 3.4
Eye alternative polyA 2 1.12 3.3
Eye alternative TSS 4 1.67 3.9
Eye gene expression 13 1.16 3.4
Eye isoform ratio 5 1.41 2.9
Eye intron excision ratio 4 0.65 2.7
Eye mRNA stability 3 1.29 3.6
IL alternative polyA 3 0.49 2.9
IL alternative TSS 1 0.35 3.0
IL gene expression 34 0.93 3.3
IL isoform ratio 8 1.01 3.3
IL intron excision ratio 17 1.76 3.6
IL mRNA stability 18 1.62 3.5
LHb alternative polyA 5 0.87 3.3
LHb alternative TSS 3 0.86 3.1
LHb gene expression 41 1.28 3.5
LHb isoform ratio 10 1.33 3.4
LHb intron excision ratio 22 2.14 3.6
LHb mRNA stability 20 1.93 3.8
Liver alternative polyA 17 1.13 3.2
Liver alternative TSS 22 1.45 3.4
Liver gene expression 73 1.02 3.3
Liver isoform ratio 33 1.38 3.4
Liver intron excision ratio 49 1.12 3.2
Liver mRNA stability 29 1.18 3.4
NAcc alternative polyA 5 0.96 3.1
NAcc alternative TSS 7 2.04 3.6
NAcc gene expression 46 1.40 3.6
NAcc isoform ratio 6 0.81 3.1
NAcc intron excision ratio 12 1.26 3.3
NAcc mRNA stability 23 2.13 3.7
NAcc2 alternative polyA 12 1.08 3.4
NAcc2 alternative TSS 5 0.68 3.3
NAcc2 gene expression 65 1.22 3.4
NAcc2 isoform ratio 18 1.17 3.3
NAcc2 intron excision ratio 31 1.17 3.1
NAcc2 mRNA stability 24 1.34 3.6
OFC alternative polyA 13 2.23 4.2
OFC alternative TSS 0 0.00 3.5
OFC gene expression 52 1.40 3.4
OFC isoform ratio 11 1.35 3.3
OFC intron excision ratio 17 1.69 3.4
OFC mRNA stability 23 2.13 4.0
PL alternative polyA 9 1.50 3.6
PL alternative TSS 8 2.59 4.3
PL gene expression 41 1.10 3.3
PL isoform ratio 7 0.80 3.3
PL intron excision ratio 19 1.82 3.8
PL mRNA stability 23 2.00 4.0
PL2 alternative polyA 14 1.11 3.3
PL2 alternative TSS 7 0.75 3.3
PL2 gene expression 71 1.11 3.4
PL2 isoform ratio 21 1.14 3.2
PL2 intron excision ratio 39 1.24 3.2
PL2 mRNA stability 30 1.23 3.5

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.