Hub : Traits

Retroperitoneal fat weight

Tags: Physiology · Weight

Project: dissection

1570 significantly associated models · 229 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 133358665 134882883 2 1 9.6e-08 6.2e-07 4.6e-01 98 Idh2
2 1 149857704 156065975 46 5 9.2e-11 1.5e-09 1.0e+00 100 Alg8 Aamdc Fam168a NA Coa4
3 1 251351727 260518987 46 5 7.0e-51 1.9e-51 1.0e+00 100 Rab11fip2 Cacul1 Afap1l2 Hspa12a NA
4 3 45415084 46813656 1 1 1.8e-07 1.2e-06 3.0e-01 95 Tank
5 3 88764368 94152740 37 7 6.4e-15 6.7e-14 1.0e+00 100 AABR07053185.1 Arl14ep Cd44 Pdhx Apip Caprin1 Tcp11l1
6 3 126323673 128707024 6 1 1.8e-10 4.4e-12 6.6e-04 76 AABR07054000.1
7 3 129554891 132898674 17 6 1.3e-20 2.3e-20 1.0e+00 100 Kif16b Pcsk2 Rrbp1 Sec23b Scp2d1 NA
8 6 19271415 20658264 1 1 3.0e-07 1.3e-08 1.7e-03 69 Rasgrp3
9 6 20965724 29090273 70 7 2.4e-32 1.0e-32 1.0e+00 100 Dnajc27 Ncoa1 Pcare Dtnb Drc1 Rab10 Cenpo
10 7 110658552 112052634 1 1 2.9e-07 4.3e-08 8.2e-03 77 Nptxr
11 10 92666462 94065985 1 1 2.2e-07 1.3e-07 3.1e-25 -286 Cep112
12 10 103916742 105312647 1 1 3.1e-07 3.4e-07 1.0e+00 100 Slc26a11

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI with tail 11.5 64 46 124.3 1.00 0.0e+00 Tasp1 Ndufaf5 Flrt3 Kif16b Snrpb2 Pcsk2 Dstn Rrbp1 Kat14 Dzank1 Polr3f Rbbp9 Sec23b Dtd1 Pdzd8 Scp2d1 Rab11fip2 Fam204a Prlhr Cacul1 Dennd10 Prdx3 Grk5 Gpam Tectb Gucy2g Acsl5 Habp2 Nrap Nhlrc2 Adrb1 Tdrd1 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Pnlip Hspa12a Eno4 Shtn1 Cep112 Nanos1 Dclre1a Zfp133 Mgme1 Otor Zfp950 Ces2c Sfxn4 Zdhhc6 Smim26 AABR07007032.1 Bbip1 Tcf7l2 AABR07054000.1 Ccdc186 Casp7 Ism1 NA NA NA NA NA
BMI without tail 13.7 32 15 40.5 0.99 7.2e-115 Kif16b Snrpb2 Pcsk2 Dstn Rrbp1 Pdzd8 Rab11fip2 Prlhr Cacul1 Dennd10 Prdx3 Tenm4 Grk5 Gab2 Alg8 Ndufc2 Ints4 Aamdc Clns1a Aqp11 Rsf1 Kctd21 Usp35 Nanos1 Otor Pak1 Zfp950 Ces2c Sfxn4 NA NA NA
Body weight 11.6 82 62 167.6 0.99 0.0e+00 Adcy3 Ncoa1 Tasp1 Esf1 Ndufaf5 Flrt3 Kif16b Snrpb2 Pcsk2 Dstn Rrbp1 Kat14 Dzank1 Polr3f Rbbp9 Sec23b Dtd1 Pdzd8 Scp2d1 Rab11fip2 Fam204a Prlhr Cacul1 Dennd10 Prdx3 Tenm4 Grk5 Gab2 Xpnpep1 Alg8 Aamdc Add3 Efr3b Rbm20 Gpam Shoc2 Tectb Gucy2g Acsl5 Habp2 Nrap Nhlrc2 Adrb1 Tdrd1 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Pnlip Hspa12a Eno4 Shtn1 Cep112 Kctd21 Usp35 Nanos1 Dclre1a Zfp133 Mgme1 Otor Pak1 Slc26a11 Zfp950 Mxi1 Ces2c Sfxn4 Zdhhc6 Smim26 AABR07007032.1 Bbip1 Tcf7l2 AABR07054000.1 Ccdc186 Casp7 Ism1 NA NA NA NA NA NA
Epididymis fat weight 16.0 124 102 275.7 0.99 0.0e+00 Dnajc27 Adcy3 Ncoa1 Babam2 Tasp1 Spdya Ppp1cb Rbks Ndufaf5 Flrt3 Slc4a1ap Gpn1 Kif16b Snrpb2 Zfp513 Klhl29 Pcsk2 Dstn Rrbp1 Trim54 Slc30a3 Preb Rbbp9 Sec23b Alk Clip4 Pcare Mapre3 Dpysl5 Slc35f6 Pdzd8 Rab11fip2 Kcnk3 Fam204a Fam166c Prlhr Cacul1 Otof Dennd10 Hadhb Prdx3 Kif3c Grk5 Asxl2 Dtnb Efr3b Gpam Tectb Gucy2g Acsl5 Habp2 Nrap Nhlrc2 Adrb1 Tdrd1 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Pnlip Hspa12a Eno4 Shtn1 Cep112 Hadha Drc1 Nanos1 NA Abhd1 Plb1 Dclre1a Togaram2 Cad Dnmt3a Ypel5 Snx17 Ppm1g Zfp133 Otor Zfp950 Mxi1 Ces2c Sfxn4 Zdhhc6 Zfp512 AABR07007032.1 Itsn2 Bbip1 Rab10 Fkbp1b Krtcap3 Garem2 Gckr Tcf7l2 Mpv17 Fam228b Cenpo Nrbp1 AABR07054000.1 AABR07063279.1 Ccdc186 Casp7 Gtf3c2 Slc5a6 AABR07063281.1 Ism1 NA NA NA NA NA NA NA NA NA NA NA Fosl2 NA Ubxn2a NA NA NA
Heart weight 12.9 3 0 0.0 0.00 1.0e+00 Rbks Cacul1 Sfxn4
Left kidney weight 10.8 21 13 35.1 0.98 4.0e-39 Rab11fip2 Prlhr Cacul1 Dennd10 Prdx3 Grk5 Gpam Gucy2g Nptxr Acsl5 Nhlrc2 Nanos1 Zfp950 Ces2c Sfxn4 Tcf7l2 Casp7 NA NA NA NA
Right kidney weight 9.4 31 15 40.5 0.97 1.3e-59 Rab11fip2 Prlhr Cacul1 Dennd10 Prdx3 Grk5 Gpam Gucy2g Nptxr Acsl5 Habp2 Nrap Nhlrc2 Adrb1 Tdrd1 Afap1l2 Fhip2a Atrnl1 Nanos1 Dclre1a Zfp950 Ces2c Sfxn4 AABR07007032.1 Tcf7l2 Ccdc186 Casp7 NA NA NA NA
Tail length 6.5 6 0 0.0 1.00 1.1e-06 Aamdc Fam168a Kctd21 Pak1 Slc26a11 NA
Length with tail 5.4 6 0 0.0 0.94 5.4e-05 Kif16b Cacul1 Fam168a Otor Sfxn4 Arhgef17
Length without tail 8.2 5 0 0.0 0.94 4.6e-04 Cacul1 Acsl5 Habp2 Sfxn4 Casp7
Liver weight, left 10.8 1 0 0.0 0.00 1.0e+00 Cacul1
Liver weight, right 13.0 22 4 10.8 0.98 4.9e-33 Spdya Pcare Dpysl5 Rab11fip2 Prlhr Cacul1 Grk5 Gpam Tectb Acsl5 Habp2 Nhlrc2 Nanos1 Dclre1a Togaram2 Zfp950 Sfxn4 Zdhhc6 Bbip1 Tcf7l2 Casp7 NA
Parametrial fat weight 13.7 80 42 113.5 0.98 0.0e+00 Dnajc27 Adcy3 Ncoa1 Kif16b Snrpb2 Klhl29 Pcsk2 Dstn Rrbp1 Kat14 Dzank1 Polr3f Rbbp9 Sec23b Dtd1 Dpysl5 Slc35f6 Pdzd8 Scp2d1 Rab11fip2 Kcnk3 Fam204a Fam166c Prlhr Cacul1 Otof Dennd10 Hadhb Prdx3 Kif3c Grk5 Asxl2 Dtnb Efr3b Gpam Tectb Acsl5 Habp2 Nrap Nhlrc2 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Pnlip Hspa12a Shtn1 Hadha Drc1 Nanos1 Dclre1a Dnmt3a Zfp133 Mgme1 Otor Zfp950 Ces2c Sfxn4 Zdhhc6 Smim26 Sf3b6 AABR07007032.1 Itsn2 Rab10 Fkbp1b Garem2 Tcf7l2 Fam228b Cenpo Casp7 NA NA NA NA NA NA NA NA Ubxn2a
Extensor digitorum longus weight 4.6 36 0 0.0 -1.00 0.0e+00 Babam2 Spdya Ppp1cb Rbks Slc4a1ap Gpn1 Zfp513 Trim54 Slc30a3 Preb Alk Clip4 Pcare Dpysl5 Drc1 NA Abhd1 Plb1 Togaram2 Cad Ypel5 Snx17 Ppm1g Krtcap3 Gckr Mpv17 Nrbp1 AABR07063279.1 Gtf3c2 Slc5a6 AABR07063281.1 NA NA NA NA NA
Soleus weight 6.5 18 0 0.0 0.35 3.7e-02 Spdya Alk Gpam Acsl5 Habp2 Afap1l2 Fhip2a Trub1 Atrnl1 Eno4 Plb1 Togaram2 Zdhhc6 AABR07007032.1 Ccdc186 Casp7 NA NA
Tibialis anterior weight 5.7 1 0 0.0 0.00 1.0e+00 Rasgrp3
Tibia length 7.2 9 0 0.0 0.99 2.7e-49 Tasp1 Esf1 Ndufaf5 Flrt3 Kif16b Otor Slc26a11 AABR07054000.1 Ism1
Delay discounting water rate 18 sec 13.6 2 0 0.0 -1.00 1.8e-04 Dtd1 Scp2d1
Condit. Reinf. lever presses 14.5 9 0 0.0 -1.00 1.9e-14 Myo7a Capn5 B3gnt6 Lrrc32 Emsy Ucp2 Tsku Acer3 Thap12
Pavlov. Cond. lever latency 14.8 13 0 0.0 1.00 5.2e-22 Aamdc Clns1a Myo7a Capn5 B3gnt6 Lrrc32 Emsy Ucp2 Tsku Acer3 Thap12 NA Coa4
Pavlov. Cond. change in total contacts 14.5 1 0 0.0 0.00 1.0e+00 Ucp2
Pavlov. Cond. index score 13.7 5 0 0.0 -1.00 7.8e-06 Aamdc Capn5 B3gnt6 Lrrc32 Ucp2
Pavlov. Cond. latency score 13.9 1 0 0.0 0.00 1.0e+00 B3gnt6
Pavlov. Cond. lever contacts 14.9 14 0 0.0 -1.00 8.3e-24 Aamdc Clns1a Myo7a Capn5 B3gnt6 Lrrc32 Emsy Ucp2 Mrpl48 Tsku Acer3 Thap12 NA Coa4
Pavlov. Cond. response bias 14.4 20 0 0.0 -1.00 2.1e-38 Aamdc Clns1a Myo7a Capn5 B3gnt6 Lrrc32 Emsy P4ha3 Ucp2 Dnajb13 Slco2b1 Mrpl48 Fam168a AC110837.1 Tsku Acer3 Thap12 NA Coa4 NA
Conditioned reinforcement - inactives 16.4 10 1 2.7 1.00 3.9e-33 Hipk3 Cstf3 Eif3m Wt1 NA Rcn1 Ccdc73 Prrg4 Tcp11l1 NA
Intermitt. access day 15 inactive lever presses 19.7 5 1 2.7 -0.98 4.8e-04 NA Mpv17 AABR07063279.1 Gtf3c2 AABR07063281.1
Progressive ratio test 1 inactive lever presses 18.6 1 0 0.0 0.00 1.0e+00 AABR07063281.1
Bone volume 10.6 1 0 0.0 0.00 1.0e+00 Sfxn4
Bone: cortical area 13.6 20 0 0.0 0.97 2.0e-39 Rab11fip2 Prlhr Cacul1 Dennd10 Grk5 Acsl5 Habp2 Nhlrc2 Afap1l2 Nanos1 Dclre1a Zfp950 Ces2c Sfxn4 AABR07007032.1 Tcf7l2 Casp7 NA NA NA
Bone: cortical thickness 14.5 8 3 8.1 0.93 5.1e-09 Tasp1 Esf1 Ndufaf5 Rab11fip2 AABR07054000.1 Ism1 NA NA
Bone: final force 11.1 4 0 0.0 1.00 1.8e-03 Rab11fip2 Cacul1 Grk5 Sfxn4
Bone: final moment 11.4 7 0 0.0 1.00 6.5e-14 Rab11fip2 Cacul1 Grk5 Nanos1 Zfp950 Sfxn4 NA
Bone: maximum diameter 11.1 9 0 0.0 0.99 1.1e-19 Cacul1 Acsl5 Habp2 Nhlrc2 Afap1l2 Dclre1a AABR07007032.1 Tcf7l2 Casp7
Bone: maximum force 10.4 3 0 0.0 1.00 3.4e-05 Rab11fip2 Cacul1 Sfxn4
Bone: maximum moment 10.9 4 0 0.0 1.00 2.1e-07 Rab11fip2 Cacul1 Sfxn4 NA
Bone: periosteal estimation 9.6 15 0 0.0 0.97 2.8e-21 Rab11fip2 Prlhr Cacul1 Grk5 Acsl5 Habp2 Nhlrc2 Nanos1 Dclre1a Zfp950 Ces2c Sfxn4 Tcf7l2 Casp7 NA
Bone: periosteal perimeter 13.0 24 2 5.4 0.95 3.2e-58 Rab11fip2 Cacul1 Dennd10 Grk5 Acsl5 Habp2 Nrap Nhlrc2 Adrb1 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Nanos1 Dclre1a Zfp950 Ces2c Sfxn4 AABR07007032.1 Tcf7l2 Ccdc186 Casp7 NA
Bone: trabecular thickness 14.9 4 0 0.0 1.00 1.1e-09 Rab11fip2 Cacul1 Grk5 Sfxn4
Food seeking constrained by brief footshock 15.9 12 0 0.0 -1.00 1.9e-148 Adcy3 Hadhb Kif3c Asxl2 Dtnb Efr3b Hadha Drc1 Dnmt3a Rab10 Garem2 NA

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 31 1.46 3.4
Adipose alternative TSS 7 0.43 2.7
Adipose gene expression 91 1.10 3.2
Adipose isoform ratio 34 1.20 3.1
Adipose intron excision ratio 21 0.72 3.0
Adipose mRNA stability 37 1.07 3.3
BLA alternative polyA 11 0.92 3.2
BLA alternative TSS 11 1.31 3.7
BLA gene expression 64 1.06 3.4
BLA isoform ratio 19 1.08 3.0
BLA intron excision ratio 36 1.21 3.3
BLA mRNA stability 21 1.04 3.3
Brain alternative polyA 18 0.90 3.3
Brain alternative TSS 16 0.93 3.3
Brain gene expression 96 1.06 3.3
Brain isoform ratio 25 0.79 3.2
Brain intron excision ratio 52 0.96 3.2
Brain mRNA stability 50 1.15 3.4
Eye alternative polyA 2 1.12 3.3
Eye alternative TSS 4 1.67 3.9
Eye gene expression 13 1.16 3.4
Eye isoform ratio 5 1.41 2.9
Eye intron excision ratio 4 0.65 2.7
Eye mRNA stability 3 1.29 3.6
IL alternative polyA 4 0.66 2.9
IL alternative TSS 1 0.35 3.0
IL gene expression 35 0.96 3.3
IL isoform ratio 8 1.01 3.3
IL intron excision ratio 17 1.76 3.6
IL mRNA stability 18 1.62 3.5
LHb alternative polyA 5 0.87 3.3
LHb alternative TSS 3 0.86 3.1
LHb gene expression 42 1.31 3.5
LHb isoform ratio 10 1.33 3.4
LHb intron excision ratio 22 2.14 3.6
LHb mRNA stability 20 1.93 3.8
Liver alternative polyA 17 1.13 3.2
Liver alternative TSS 22 1.45 3.4
Liver gene expression 73 1.02 3.3
Liver isoform ratio 33 1.38 3.4
Liver intron excision ratio 50 1.14 3.2
Liver mRNA stability 29 1.18 3.4
NAcc alternative polyA 12 0.92 3.2
NAcc alternative TSS 10 1.08 3.4
NAcc gene expression 77 1.22 3.5
NAcc isoform ratio 23 1.22 3.5
NAcc intron excision ratio 31 1.01 3.1
NAcc mRNA stability 33 1.46 3.6
OFC alternative polyA 13 2.23 4.2
OFC alternative TSS 0 0.00 3.5
OFC gene expression 53 1.43 3.4
OFC isoform ratio 11 1.35 3.3
OFC intron excision ratio 17 1.69 3.4
OFC mRNA stability 24 2.22 4.0
PL alternative polyA 8 0.56 3.1
PL alternative TSS 5 0.43 3.3
PL gene expression 78 1.06 3.4
PL isoform ratio 18 0.82 3.2
PL intron excision ratio 41 1.14 3.2
PL mRNA stability 36 1.23 3.5

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.