Hub : Traits : Locomotion velocity, NPP test : ← : →

chr1:140,510,980-142,727,457

Trait: Locomotion velocity, NPP test

Best TWAS P=4.54e-17 · Best GWAS P=1.19e-17 conditioned to NaN

Associated models

Tissue	Gene	RNA modality	RNA phenotype	h2	# weights	Model R2	Model R2 P	TWAS Z	TWAS P	Coloc P	Joint
Adipose	Ctsc	alternative polyA	NM_017097.2	0.17	1	0.18	7.5e-20	-5.22	1.79e-07	0	TRUE
Adipose	Ctsc	alternative polyA	XM_008759637.3	0.19	1	0.19	5.0e-21	5.22	1.79e-07	0	FALSE
Adipose	LOC102554680	gene expression	LOC102554680	0.07	1	0.06	1.3e-07	5.18	2.23e-07	0	FALSE
Adipose	Ctsc	isoform ratio	NM_017097.2	0.18	2521	0.16	5.6e-17	6.67	2.50e-11	0	FALSE
Adipose	Ctsc	isoform ratio	XM_008759637.3	0.19	2521	0.16	1.2e-17	-6.62	3.71e-11	0	FALSE
Adipose	Ctsc	intron excision ratio	chr1_142031177_142036233	0.05	2521	0.02	1.1e-03	-7.42	1.16e-13	0.64	FALSE
Adipose	Ctsc	intron excision ratio	chr1_142031177_142045569	0.04	2521	0.03	4.0e-04	7.24	4.52e-13	0.61	FALSE
BLA	Ctsc	gene expression	Ctsc	0.1	1	0.08	7.2e-05	8.4	4.54e-17	0.82	TRUE
BLA	Tyr	gene expression	Tyr	0.11	1	0.05	1.4e-03	-5.86	4.63e-09	0.04	TRUE
BLA	Ctsc	isoform ratio	XM_008759637.3	0.05	1	0.03	1.2e-02	7.24	4.65e-13	0.04	FALSE
BLA	Grm5	isoform ratio	XM_017588778.2	0.12	1	0.06	3.4e-04	5.41	6.21e-08	0.04	FALSE
BLA	Grm5	isoform ratio	XM_017588780.2	0.06	2702	0.01	6.6e-02	7.5	6.34e-14	0.57	FALSE
Brain	Ctsc	alternative polyA	NM_017097.2	0.06	1	0.07	5.1e-07	-7.24	4.65e-13	0.01	FALSE
Brain	Ctsc	alternative polyA	XM_008759637.3	0.06	1	0.07	2.3e-07	7.72	1.20e-14	0.17	FALSE
Brain	Ctsc	gene expression	Ctsc	0.3	143	0.38	2.8e-37	6.16	7.08e-10	0	FALSE
Brain	Grm5	gene expression	Grm5	0.55	26	0.32	1.9e-30	-7.09	1.32e-12	0.49	FALSE
Brain	Ctsc	isoform ratio	NM_017097.2	0.06	1	0.06	4.1e-06	-7.74	9.87e-15	0.18	FALSE
Brain	Ctsc	isoform ratio	XM_008759637.3	0.06	1	0.06	1.2e-06	7.74	9.87e-15	0.19	FALSE
Brain	Grm5	isoform ratio	XM_017588780.2	0.05	93	0.04	2.2e-04	-7.72	1.14e-14	0.51	FALSE
Brain	Grm5	mRNA stability	Grm5	0.11	1	0.09	4.7e-09	-7.65	2.00e-14	0.01	FALSE
Eye	Ctsc	gene expression	Ctsc	0.37	2521	0.14	3.3e-03	-7.66	1.84e-14	0.16	FALSE
IL	Ctsc	gene expression	Ctsc	0.48	10	0.14	2.9e-04	-7.98	1.49e-15	0.64	FALSE
LHb	Ctsc	gene expression	Ctsc	0.19	168	0.12	9.8e-04	5.82	5.82e-09	0.17	FALSE
Liver	Ctsc	alternative TSS	NM_017097.2	0.06	1	0.05	3.3e-06	5.38	7.48e-08	0.01	FALSE
Liver	Ctsc	alternative TSS	XM_008759637.3	0.06	1	0.06	6.6e-07	-5.38	7.48e-08	0.01	FALSE
Liver	LOC102554680	gene expression	LOC102554680	0.04	2516	0.03	5.3e-04	-7.78	7.13e-15	0.64	FALSE
NAcc	Ctsc	gene expression	Ctsc	0.14	2521	0.16	1.5e-18	-7.34	2.17e-13	0.5	FALSE
NAcc	Grm5	gene expression	Grm5	0.05	1	0.05	1.4e-06	-7.89	3.00e-15	0.06	FALSE
NAcc	Ctsc	isoform ratio	NM_017097.2	0.03	1	0.04	2.3e-05	-7.24	4.57e-13	0.03	FALSE
NAcc	Ctsc	isoform ratio	XM_008759637.3	0.03	1	0.04	5.3e-05	7.24	4.57e-13	0.03	FALSE
NAcc	Grm5	isoform ratio	XM_017588779.2	0.05	2702	0.05	4.8e-06	-6.81	9.66e-12	0.57	FALSE
NAcc	Grm5	isoform ratio	XM_017588780.2	0.04	2702	0.03	1.1e-04	7.45	9.25e-14	0.72	FALSE
OFC	Grm5	gene expression	Grm5	0.29	2702	0.25	1.4e-06	5.8	6.58e-09	0.19	FALSE
PL	Ctsc	gene expression	Ctsc	0.2	2521	0.2	7.0e-22	-6.91	4.81e-12	0.09	FALSE
PL	Grm5	gene expression	Grm5	0.03	23	0.03	1.2e-04	7.71	1.21e-14	0.2	FALSE
PL	Ctsc	isoform ratio	NM_017097.2	0.02	1	0.01	4.8e-02	-5.81	6.12e-09	0.03	FALSE
PL	Ctsc	isoform ratio	XM_008759637.3	0.02	1	0.01	5.1e-02	5.81	6.12e-09	0.03	FALSE
PL	Grm5	isoform ratio	XM_006229659.4	0.02	2702	0.01	5.9e-02	-6.2	5.78e-10	0.22	FALSE
pVTA	Ctsc	gene expression	Ctsc	0.24	11	0.21	1.1e-09	6.5	8.24e-11	0.02	TRUE
RMTg	Grm5	mRNA stability	Grm5	0.21	2702	0.11	6.1e-04	5.19	2.08e-07	0.09	TRUE