Best TWAS P = 5.73e-17 · Best GWAS P= 2.01e-17 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Ctsc | alternative polyA | NM_017097.2 | 0.18 | 2571 | 0.19 | 1.5e-20 | 6.46 | 1.05e-10 | 0 | FALSE |
| Adipose | Ctsc | alternative polyA | XM_008759637.4 | 0.19 | 2571 | 0.2 | 1.0e-21 | -6.39 | 1.66e-10 | 0 | FALSE |
| Adipose | LOC102554680 | gene expression | LOC102554680 | 0.11 | 1 | 0.1 | 9.1e-11 | 5.46 | 4.76e-08 | 0 | FALSE |
| Adipose | Ctsc | isoform ratio | NM_017097.2 | 0.17 | 2571 | 0.16 | 1.9e-17 | 6.73 | 1.75e-11 | 0 | FALSE |
| Adipose | Ctsc | isoform ratio | XM_008759637.4 | 0.17 | 2571 | 0.17 | 3.0e-18 | -6.7 | 2.11e-11 | 0 | FALSE |
| Adipose | Ctsc | intron excision ratio | chr1_151443766_151448822 | 0.05 | 2571 | 0.03 | 7.1e-04 | -7.36 | 1.86e-13 | 0.63 | FALSE |
| Adipose | Ctsc | intron excision ratio | chr1_151443766_151458158 | 0.04 | 2571 | 0.03 | 4.0e-04 | 7.12 | 1.05e-12 | 0.58 | FALSE |
| BLA | Ctsc | gene expression | Ctsc | 0.15 | 281 | 0.12 | 7.5e-07 | 5.71 | 1.16e-08 | 0.69 | FALSE |
| BLA | Tyr | gene expression | Tyr | 0.1 | 1 | 0.06 | 3.3e-04 | -5.8 | 6.76e-09 | 0.04 | FALSE |
| BLA | Ctsc | isoform ratio | NM_017097.2 | 0.06 | 1 | 0.03 | 1.8e-02 | -7.13 | 9.91e-13 | 0.04 | FALSE |
| BLA | Ctsc | isoform ratio | XM_008759637.4 | 0.06 | 1 | 0.02 | 1.8e-02 | 7.13 | 9.91e-13 | 0.04 | FALSE |
| Brain | Ctsc | alternative polyA | NM_017097.2 | 0.06 | 24 | 0.07 | 6.8e-07 | -7.67 | 1.78e-14 | 0.62 | FALSE |
| Brain | Ctsc | alternative polyA | XM_008759637.4 | 0.06 | 24 | 0.07 | 7.0e-07 | 7.67 | 1.65e-14 | 0.61 | FALSE |
| Brain | Ctsc | gene expression | Ctsc | 0.28 | 2571 | 0.37 | 1.3e-36 | -6.34 | 2.27e-10 | 0 | FALSE |
| Brain | Grm5 | gene expression | Grm5 | 0.46 | 13 | 0.3 | 2.7e-28 | 7.52 | 5.29e-14 | 0.59 | FALSE |
| Brain | Ctsc | isoform ratio | NM_017097.2 | 0.06 | 1 | 0.05 | 2.1e-05 | -7.69 | 1.51e-14 | 0.09 | FALSE |
| Brain | Ctsc | isoform ratio | XM_008759637.4 | 0.06 | 1 | 0.05 | 2.6e-05 | 7.69 | 1.51e-14 | 0.09 | FALSE |
| Brain | Grm5 | mRNA stability | Grm5 | 0.1 | 1 | 0.09 | 4.9e-09 | -7.73 | 1.10e-14 | 0.03 | FALSE |
| Eye | Ctsc | gene expression | Ctsc | 0.34 | 13 | 0.16 | 1.8e-03 | -6.51 | 7.69e-11 | 0.14 | FALSE |
| IC | Ctsc | alternative polyA | NM_017097.2 | 0.09 | 1 | 0.06 | 1.6e-03 | -6.63 | 3.41e-11 | 0.04 | FALSE |
| IC | Ctsc | alternative polyA | XM_008759637.4 | 0.08 | 1 | 0.05 | 2.6e-03 | 6.63 | 3.41e-11 | 0.04 | FALSE |
| IC | Ctsc | gene expression | Ctsc | 0.16 | 2571 | 0.13 | 4.2e-06 | -6.32 | 2.57e-10 | 0.05 | TRUE |
| IC | Grm5 | gene expression | Grm5 | 0.3 | 44 | 0.24 | 1.4e-10 | 6.69 | 2.29e-11 | 0.23 | FALSE |
| IC | Tyr | gene expression | Tyr | 0.14 | 1 | 0.03 | 1.5e-02 | -5.81 | 6.20e-09 | 0.04 | TRUE |
| IC | Grm5 | isoform ratio | XM_006229659.5 | 0.06 | 52 | 0.03 | 2.4e-02 | 6.83 | 8.72e-12 | 0.27 | FALSE |
| IL | Ctsc | gene expression | Ctsc | 0.44 | 18 | 0.11 | 1.6e-03 | -8.37 | 5.73e-17 | 0.65 | TRUE |
| LHb | Ctsc | gene expression | Ctsc | 0.2 | 15 | 0.14 | 3.9e-04 | -6.63 | 3.45e-11 | 0.14 | TRUE |
| Liver | Ctsc | alternative TSS | NM_017097.2 | 0.04 | 1 | 0.04 | 8.4e-05 | 5.48 | 4.22e-08 | 0.03 | FALSE |
| Liver | Ctsc | alternative TSS | XM_008759637.4 | 0.05 | 1 | 0.04 | 9.7e-06 | -5.48 | 4.22e-08 | 0.02 | FALSE |
| Liver | LOC102554680 | gene expression | LOC102554680 | 0.05 | 13 | 0.04 | 7.2e-05 | 7.65 | 2.01e-14 | 0.64 | FALSE |
| NAcc | Ctsc | alternative polyA | NM_017097.2 | 0.04 | 1 | 0.04 | 2.0e-06 | -6.34 | 2.28e-10 | 0 | FALSE |
| NAcc | Ctsc | alternative polyA | XM_008759637.4 | 0.04 | 27 | 0.04 | 1.0e-06 | 7.27 | 3.68e-13 | 0.22 | FALSE |
| NAcc | Ctsc | gene expression | Ctsc | 0.13 | 2571 | 0.19 | 2.3e-28 | -7.29 | 3.20e-13 | 0.44 | FALSE |
| NAcc | Grm5 | gene expression | Grm5 | 0.08 | 1 | 0.08 | 7.3e-12 | -7.96 | 1.68e-15 | 0.17 | FALSE |
| NAcc | Tyr | gene expression | Tyr | 0.02 | 2904 | 0.01 | 1.3e-02 | 7.35 | 1.95e-13 | 0.43 | TRUE |
| NAcc | Ctsc | isoform ratio | NM_017097.2 | 0.05 | 1 | 0.05 | 2.9e-08 | -6.34 | 2.28e-10 | 0 | TRUE |
| NAcc | Ctsc | isoform ratio | XM_008759637.4 | 0.05 | 1 | 0.05 | 1.5e-07 | 6.34 | 2.28e-10 | 0 | FALSE |
| NAcc | Ctsc | intron excision ratio | chr1_151443766_151448822 | 0.02 | 1 | 0.01 | 1.7e-03 | 6.34 | 2.28e-10 | 0.02 | FALSE |
| NAcc | Ctsc | intron excision ratio | chr1_151443766_151458158 | 0.02 | 4 | 0.01 | 8.6e-03 | -6.96 | 3.43e-12 | 0.51 | FALSE |
| NAcc | Grm5 | mRNA stability | Grm5 | 0.03 | 1 | 0.03 | 3.3e-05 | -7.96 | 1.68e-15 | 0.07 | FALSE |
| OFC | Grm5 | gene expression | Grm5 | 0.23 | 11 | 0.16 | 1.0e-04 | -7.22 | 5.10e-13 | 0.44 | TRUE |
| PL | Ctsc | alternative polyA | NM_017097.2 | 0.03 | 2571 | 0.02 | 1.7e-03 | 6.55 | 5.62e-11 | 0.23 | FALSE |
| PL | Ctsc | alternative polyA | XM_008759637.4 | 0.03 | 1 | 0.02 | 1.3e-03 | 5.91 | 3.46e-09 | 0.03 | FALSE |
| PL | Ctsc | gene expression | Ctsc | 0.21 | 2571 | 0.21 | 1.0e-22 | -6.83 | 8.45e-12 | 0.07 | FALSE |
| PL | Grm5 | gene expression | Grm5 | 0.03 | 2746 | 0.02 | 2.8e-03 | 6.45 | 1.10e-10 | 0.33 | FALSE |
| PL | Ctsc | isoform ratio | NM_017097.2 | 0.02 | 2571 | 0.02 | 2.0e-03 | 6.54 | 6.07e-11 | 0.2 | FALSE |
| PL | Ctsc | isoform ratio | XM_008759637.4 | 0.02 | 2571 | 0.02 | 2.0e-03 | -6.54 | 6.35e-11 | 0.19 | FALSE |
| PL | Grm5 | intron excision ratio | chr1_150723078_150733678 | 0.03 | 2746 | 0.02 | 1.7e-03 | 5.77 | 7.71e-09 | 0.14 | FALSE |
| pVTA | Ctsc | gene expression | Ctsc | 0.25 | 1 | 0.25 | 2.0e-20 | 5.63 | 1.79e-08 | 0 | FALSE |
| pVTA | Grm5 | mRNA stability | Grm5 | 0.06 | 2746 | 0.03 | 3.6e-03 | 5.55 | 2.87e-08 | 0.49 | FALSE |