Best TWAS P=2.181737e-07 · Best GWAS P=2.102828e-07 conditioned to 0.05925192
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brain | Blm | gene expression | ENSRNOG00000011213 | 0.14 | 0.10 | lasso | 9 | 0.11 | 1.1e-10 | -4.7 | -5.2 | 2.3e-07 | 0.86 | 0.27 | 0.73 | FALSE |
| 2 | Brain | Cpeb1 | gene expression | ENSRNOG00000019161 | 0.07 | 0.02 | enet | 47 | 0.03 | 4.9e-04 | -5.1 | 5.2 | 2.2e-07 | -0.77 | 0.18 | 0.79 | TRUE |
| 3 | PL | Homer2 | mRNA stability | ENSRNOG00000061450 | 0.12 | 0.07 | top1 | 1 | 0.07 | 8.8e-06 | -5.1 | 5.1 | 2.7e-07 | -0.79 | 0.09 | 0.56 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.