Hub : Traits : BMI with tail : ← →

chr3:129,554,891-132,693,612

Trait: BMI with tail

Best TWAS P=3.809616e-12 · Best GWAS P=1.299045e-12 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Kif16b	alternative polyA	ENSRNOT00000118037	0.08	0.05	top1	1	0.05	5.3e-06	5.2	5.2	2.4e-07	0.73	0.45	0.02	FALSE
2	Adipose	Dstn	gene expression	ENSRNOG00000005924	0.59	0.44	blup	1575	0.48	3.4e-60	-5.4	5.6	2.5e-08	0.89	0.89	0.11	TRUE
3	Adipose	Dtd1	gene expression	ENSRNOG00000008746	0.28	0.14	lasso	19	0.15	5.0e-16	-5.0	5.2	1.6e-07	0.87	0.47	0.53	FALSE
4	Adipose	Snrpb2	mRNA stability	ENSRNOG00000004967	0.04	0.01	enet	20	0.01	1.5e-02	6.2	-6.3	2.4e-10	-0.78	0.51	0.42	FALSE
5	Adipose	Dstn	mRNA stability	ENSRNOG00000005924	0.83	0.57	enet	184	0.60	1.1e-83	-5.4	5.2	2.6e-07	0.82	0.90	0.10	FALSE
6	BLA	Kif16b	gene expression	ENSRNOG00000004951	0.04	0.04	top1	1	0.04	4.1e-03	6.7	6.7	2.2e-11	0.98	0.09	0.04	FALSE
7	BLA	Snrpb2	gene expression	ENSRNOG00000004967	0.05	0.02	top1	1	0.02	4.4e-02	6.9	6.9	3.8e-12	0.98	0.08	0.05	TRUE
8	BLA	Pcsk2	gene expression	ENSRNOG00000005438	0.11	0.07	top1	1	0.07	1.9e-04	6.4	6.4	2.0e-10	0.96	0.11	0.05	FALSE
9	BLA	Dstn	gene expression	ENSRNOG00000005924	0.84	0.63	enet	268	0.64	9.8e-44	-5.8	5.8	8.2e-09	0.87	0.71	0.29	FALSE
10	BLA	Otor	gene expression	ENSRNOG00000028721	0.07	0.04	blup	1960	0.04	2.7e-03	4.3	-6.2	4.7e-10	-0.83	0.49	0.26	TRUE
11	BLA	NA	gene expression	ENSRNOG00000067833	0.09	0.02	top1	1	0.02	3.9e-02	-5.3	5.3	1.2e-07	0.60	0.08	0.06	FALSE
12	BLA	Rbbp9	intron excision ratio	chr3:131927367:131929585	0.14	0.07	top1	1	0.07	8.2e-05	-5.6	5.6	2.8e-08	0.74	0.11	0.42	FALSE
13	BLA	Rbbp9	intron excision ratio	chr3:131929308:131929585	0.13	0.08	top1	1	0.07	7.7e-05	-5.6	-5.6	2.8e-08	-0.73	0.10	0.34	FALSE
14	BLA	Rbbp9	intron excision ratio	chr3:131929690:131931999	0.17	0.14	top1	1	0.14	6.7e-08	5.4	-5.4	8.4e-08	-0.84	0.35	0.63	FALSE
15	BLA	Pcsk2	mRNA stability	ENSRNOG00000005438	0.23	0.15	top1	1	0.15	3.1e-08	-6.0	-6.0	2.2e-09	-0.94	0.87	0.02	FALSE
16	BLA	Dstn	mRNA stability	ENSRNOG00000005924	0.45	0.38	enet	182	0.39	2.2e-22	-6.1	6.2	6.3e-10	0.93	0.39	0.61	FALSE
17	BLA	Kat14	mRNA stability	ENSRNOG00000007160	0.05	0.03	enet	4	0.03	9.8e-03	5.4	-5.2	2.4e-07	-0.83	0.38	0.23	FALSE
18	Brain	Rrbp1	alternative TSS	ENSRNOT00000055602	0.03	0.02	blup	1597	0.03	2.1e-03	-5.1	-5.1	3.1e-07	-0.74	0.48	0.40	FALSE
19	Brain	Rrbp1	alternative TSS	ENSRNOT00000101060	0.03	0.02	blup	1597	0.02	2.7e-03	-5.1	5.2	2.0e-07	0.75	0.47	0.39	FALSE
20	Brain	Snrpb2	gene expression	ENSRNOG00000004967	0.06	0.03	blup	1963	0.05	1.0e-05	6.8	5.7	1.6e-08	0.89	0.52	0.48	FALSE
21	Brain	Pcsk2	gene expression	ENSRNOG00000005438	0.38	0.44	top1	1	0.44	3.9e-44	6.1	6.1	1.4e-09	0.96	0.97	0.03	FALSE
22	Brain	Dstn	gene expression	ENSRNOG00000005924	0.72	0.80	enet	189	0.80	3.2e-120	-5.6	5.6	1.8e-08	0.86	0.90	0.10	FALSE
23	Brain	Rrbp1	gene expression	ENSRNOG00000005958	0.14	0.15	blup	1597	0.16	4.1e-15	-5.7	-5.8	6.8e-09	-0.91	0.65	0.35	FALSE
24	Brain	Sec23b	gene expression	ENSRNOG00000008411	0.78	0.78	enet	128	0.80	7.8e-119	4.9	5.1	3.0e-07	0.88	0.88	0.12	FALSE
25	Brain	Otor	gene expression	ENSRNOG00000028721	0.10	0.09	enet	25	0.11	5.1e-10	-6.5	-6.0	2.2e-09	-0.61	0.56	0.44	FALSE
26	Brain	Snrpb2	intron excision ratio	chr3:130399307:130400989	0.03	0.03	top1	1	0.03	5.7e-04	6.4	6.4	1.2e-10	0.98	0.07	0.03	FALSE
27	Brain	Sec23b	intron excision ratio	chr3:131955920:131958981	0.30	0.22	enet	118	0.22	3.0e-20	5.0	5.1	3.3e-07	0.88	0.78	0.22	FALSE
28	Brain	Snrpb2	mRNA stability	ENSRNOG00000004967	0.03	0.01	blup	1963	0.01	1.3e-02	6.7	5.6	2.4e-08	0.88	0.49	0.36	FALSE
29	Brain	Dstn	mRNA stability	ENSRNOG00000005924	0.71	0.52	enet	239	0.52	1.2e-56	-5.7	5.8	6.7e-09	0.88	0.90	0.10	FALSE
30	Eye	Dstn	gene expression	ENSRNOG00000005924	0.77	0.20	blup	1048	0.25	1.1e-04	-5.7	5.7	1.4e-08	0.85	0.47	0.38	FALSE
31	Eye	Sec23b	gene expression	ENSRNOG00000008411	0.81	0.22	lasso	19	0.29	2.1e-05	-5.6	5.4	6.5e-08	0.77	0.30	0.59	FALSE
32	Eye	Zfp133	intron excision ratio	chr3:131829590:131840865	0.30	0.03	top1	1	0.04	9.9e-02	-5.6	-5.6	2.0e-08	-0.87	0.06	0.06	FALSE
33	IL	Pcsk2	gene expression	ENSRNOG00000005438	0.49	0.21	top1	1	0.21	7.5e-06	6.8	6.8	1.1e-11	0.97	0.10	0.17	FALSE
34	IL	Dstn	gene expression	ENSRNOG00000005924	0.79	0.38	blup	1574	0.39	2.0e-10	-5.9	5.9	3.4e-09	0.89	0.48	0.52	FALSE
35	IL	Dzank1	intron excision ratio	chr3:131906549:131908083	0.18	0.10	top1	1	0.10	2.0e-03	-5.2	5.2	1.6e-07	0.74	0.09	0.05	FALSE
36	IL	Dstn	mRNA stability	ENSRNOG00000005924	0.54	0.27	blup	1574	0.34	4.2e-09	-6.1	5.2	1.8e-07	0.74	0.50	0.50	FALSE
37	LHb	Snrpb2	gene expression	ENSRNOG00000004967	0.24	0.15	top1	1	0.15	2.3e-04	6.7	6.7	2.0e-11	0.98	0.10	0.05	FALSE
38	LHb	Dstn	gene expression	ENSRNOG00000005924	0.80	0.49	enet	8	0.50	1.3e-13	-5.6	5.9	4.3e-09	0.90	0.59	0.41	FALSE
39	LHb	Rrbp1	gene expression	ENSRNOG00000005958	0.22	0.21	top1	1	0.21	1.0e-05	-6.1	-6.1	9.4e-10	-0.93	0.09	0.08	FALSE
40	LHb	Otor	gene expression	ENSRNOG00000028721	0.26	-0.01	lasso	5	0.01	1.7e-01	6.3	-6.6	5.3e-11	-0.86	0.39	0.28	FALSE
41	LHb	Kif16b	mRNA stability	ENSRNOG00000004951	0.11	0.01	enet	6	0.03	7.3e-02	6.3	-6.4	1.2e-10	-0.76	0.42	0.34	FALSE
42	LHb	Dstn	mRNA stability	ENSRNOG00000005924	0.39	0.37	top1	1	0.37	8.7e-10	-5.6	5.6	2.1e-08	0.88	0.48	0.07	FALSE
43	Liver	Kif16b	alternative polyA	ENSRNOT00000036273	0.18	0.14	top1	1	0.14	6.7e-15	6.8	-6.8	1.5e-11	-0.98	0.56	0.44	FALSE
44	Liver	Kif16b	alternative polyA	ENSRNOT00000118037	0.18	0.14	top1	1	0.14	1.3e-15	6.7	6.7	1.9e-11	0.98	0.62	0.38	FALSE
45	Liver	Kif16b	gene expression	ENSRNOG00000004951	0.21	0.17	lasso	12	0.18	3.7e-19	6.9	-6.7	1.7e-11	-0.99	0.40	0.60	FALSE
46	Liver	Dstn	gene expression	ENSRNOG00000005924	0.67	0.52	blup	1575	0.53	2.6e-69	-5.9	5.6	2.4e-08	0.87	0.75	0.25	FALSE
47	Liver	Kif16b	isoform ratio	ENSRNOT00000083061	0.06	0.04	top1	1	0.04	4.7e-05	6.7	-6.7	2.2e-11	-0.98	0.33	0.17	FALSE
48	Liver	Kif16b	isoform ratio	ENSRNOT00000118037	0.15	0.13	blup	2140	0.13	4.0e-14	6.8	6.7	1.7e-11	0.97	0.52	0.48	FALSE
49	Liver	Mgme1	isoform ratio	ENSRNOT00000038865	0.03	0.02	top1	1	0.02	4.0e-03	5.6	-5.6	2.2e-08	-0.87	0.05	0.03	FALSE
50	Liver	Mgme1	isoform ratio	ENSRNOT00000098696	0.03	0.02	top1	1	0.02	3.2e-03	5.6	5.6	2.2e-08	0.87	0.05	0.04	FALSE
51	Liver	Kif16b	intron excision ratio	chr3:129976371:129996958	0.03	0.01	blup	2140	0.01	2.4e-02	4.6	-5.8	5.3e-09	-0.81	0.36	0.09	FALSE
52	Liver	Snrpb2	intron excision ratio	chr3:130399307:130400989	0.04	0.03	top1	1	0.03	3.5e-04	-6.1	6.1	1.1e-09	0.98	0.25	0.03	FALSE
53	Liver	Snrpb2	intron excision ratio	chr3:130399832:130400989	0.06	0.03	blup	1963	0.03	2.4e-04	-6.1	-6.5	5.8e-11	-0.98	0.57	0.42	FALSE
54	Liver	Dstn	mRNA stability	ENSRNOG00000005924	0.67	0.50	blup	1575	0.50	1.1e-63	-5.6	5.6	2.6e-08	0.89	0.84	0.16	FALSE
55	Liver	Rbbp9	mRNA stability	ENSRNOG00000007972	0.04	0.01	blup	1818	0.01	8.2e-03	-4.3	5.1	2.7e-07	0.82	0.35	0.58	FALSE
56	NAcc	Snrpb2	gene expression	ENSRNOG00000004967	0.04	0.02	top1	1	0.02	1.4e-02	6.0	6.0	1.6e-09	0.98	0.07	0.03	FALSE
57	NAcc	Pcsk2	gene expression	ENSRNOG00000005438	0.25	0.15	lasso	6	0.15	3.4e-11	6.1	6.0	2.6e-09	0.97	0.64	0.36	FALSE
58	NAcc	Dstn	gene expression	ENSRNOG00000005924	0.84	0.70	top1	1	0.70	1.4e-71	-5.8	5.8	7.5e-09	0.90	0.78	0.22	FALSE
59	NAcc	Rrbp1	gene expression	ENSRNOG00000005958	0.11	0.11	top1	1	0.11	2.0e-08	-5.6	-5.6	2.8e-08	-0.91	0.91	0.09	FALSE
60	NAcc	Otor	gene expression	ENSRNOG00000028721	0.04	0.01	top1	1	0.01	5.2e-02	6.5	-6.5	6.6e-11	-0.98	0.07	0.04	FALSE
61	NAcc	Rbbp9	intron excision ratio	chr3:131927367:131929585	0.17	0.08	top1	1	0.08	7.7e-07	-5.1	5.1	3.2e-07	0.74	0.57	0.29	FALSE
62	NAcc	Kif16b	mRNA stability	ENSRNOG00000004951	0.04	0.00	lasso	27	0.01	5.8e-02	-6.0	-6.1	1.3e-09	-0.41	0.46	0.46	TRUE
63	NAcc	Dstn	mRNA stability	ENSRNOG00000005924	0.55	0.47	enet	212	0.48	1.3e-39	-5.8	6.0	2.0e-09	0.92	0.82	0.18	FALSE
64	OFC	Pcsk2	gene expression	ENSRNOG00000005438	0.62	0.36	lasso	9	0.38	5.0e-10	5.4	5.4	5.3e-08	-0.72	0.43	0.57	TRUE
65	OFC	Dstn	gene expression	ENSRNOG00000005924	0.82	0.49	enet	41	0.52	1.4e-14	-5.6	5.8	6.7e-09	0.87	0.57	0.43	FALSE
66	OFC	Dstn	mRNA stability	ENSRNOG00000005924	0.29	0.16	blup	1574	0.19	3.1e-05	-5.6	5.7	1.3e-08	0.84	0.50	0.48	FALSE
67	OFC	Sec23b	mRNA stability	ENSRNOG00000008411	0.59	0.42	top1	1	0.42	3.9e-11	5.4	5.4	6.9e-08	0.81	0.30	0.66	FALSE
68	PL	Snrpb2	gene expression	ENSRNOG00000004967	0.12	0.10	enet	9	0.11	1.3e-08	6.3	6.4	1.8e-10	0.97	0.61	0.39	FALSE
69	PL	Pcsk2	gene expression	ENSRNOG00000005438	0.15	0.16	enet	80	0.18	1.0e-13	-6.1	6.4	1.5e-10	0.95	0.81	0.19	FALSE
70	PL	Dstn	gene expression	ENSRNOG00000005924	0.88	0.60	enet	165	0.62	4.1e-59	-5.7	5.7	1.2e-08	0.88	0.88	0.12	FALSE
71	PL	Zfp133	gene expression	ENSRNOG00000027955	0.19	0.12	top1	1	0.12	1.3e-09	-5.1	-5.1	2.7e-07	-0.83	0.69	0.30	FALSE
72	PL	Otor	gene expression	ENSRNOG00000028721	0.06	0.04	blup	1972	0.05	1.0e-04	6.7	-6.4	1.7e-10	-0.96	0.52	0.48	FALSE
73	PL	Snrpb2	intron excision ratio	chr3:130399307:130400989	0.05	0.03	blup	1963	0.03	2.9e-03	-6.4	6.8	1.2e-11	0.98	0.52	0.45	FALSE
74	PL	Dzank1	intron excision ratio	chr3:131906549:131907051	0.09	0.10	top1	1	0.10	2.3e-08	5.4	-5.4	6.2e-08	-0.82	0.30	0.68	FALSE
75	PL	Kif16b	mRNA stability	ENSRNOG00000004951	0.11	0.07	top1	1	0.07	5.8e-06	5.2	-5.2	1.8e-07	-0.95	0.57	0.02	FALSE
76	PL	Pcsk2	mRNA stability	ENSRNOG00000005438	0.04	0.02	top1	1	0.02	5.4e-03	-6.1	-6.1	8.7e-10	-0.95	0.05	0.03	FALSE
77	PL	Dstn	mRNA stability	ENSRNOG00000005924	0.70	0.48	enet	52	0.49	6.1e-42	-5.7	5.7	1.5e-08	0.87	0.90	0.10	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.