Best TWAS P = 1.15e-08 · Best GWAS P= 2.27e-08 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Zfp347 | gene expression | Zfp347 | 0.09 | 407 | 0.08 | 2.0e-09 | -5.57 | 2.60e-08 | 0.4 | FALSE |
| Adipose | Zfp77 | isoform ratio | XM_006240826.5 | 0.05 | 64 | 0.03 | 3.7e-04 | -5.71 | 1.15e-08 | 0.44 | TRUE |
| Adipose | Zfp77 | intron excision ratio | chr7_7940407_7942321 | 0.02 | 1 | 0.02 | 4.2e-03 | 5.4 | 6.57e-08 | 0.04 | FALSE |
| Adipose | Zfp77 | intron excision ratio | chr7_7940407_7960069 | 0.02 | 1 | 0.02 | 4.1e-03 | -5.4 | 6.57e-08 | 0.03 | FALSE |
| BLA | Zfp77 | alternative polyA | XM_003750272.6 | 0.18 | 1993 | 0.2 | 8.1e-11 | 5.24 | 1.65e-07 | 0.19 | FALSE |
| BLA | Zfp77 | alternative polyA | XM_003750272.6 | 0.21 | 1993 | 0.22 | 8.7e-12 | 5.25 | 1.51e-07 | 0.18 | FALSE |
| BLA | Neurod4 | mRNA stability | Neurod4 | 0.1 | 1938 | 0.09 | 1.6e-05 | -5.22 | 1.79e-07 | 0.16 | FALSE |
| Brain | Zfp77 | isoform ratio | XM_039080018.2 | 0.06 | 1993 | 0.06 | 1.8e-06 | -5.29 | 1.24e-07 | 0.24 | FALSE |
| IL | Zfp347 | alternative TSS | XM_039078337.2 | 0.18 | 1 | 0.06 | 1.3e-02 | 5.4 | 6.57e-08 | 0.06 | FALSE |
| IL | Zfp347 | alternative TSS | XM_063262943.1 | 0.17 | 13 | 0.03 | 6.5e-02 | 5.4 | 6.56e-08 | 0.27 | FALSE |
| Liver | Zfp77 | alternative polyA | XM_003750272.6 | 0.14 | 1993 | 0.12 | 4.0e-13 | 5.23 | 1.68e-07 | 0.4 | FALSE |
| Liver | Zfp77 | alternative polyA | XM_063264477.1 | 0.37 | 356 | 0.3 | 3.8e-34 | 5.34 | 9.13e-08 | 0.42 | FALSE |
| Liver | Zfp77 | alternative polyA | XM_003750272.6 | 0.19 | 1993 | 0.15 | 1.5e-16 | 5.23 | 1.71e-07 | 0.41 | FALSE |
| Liver | Zfp77 | alternative polyA | XM_063264477.1 | 0.36 | 357 | 0.3 | 7.4e-34 | 5.29 | 1.23e-07 | 0.41 | FALSE |
| Liver | Znf431l4 | alternative polyA | NM_001409172.1 | 0.04 | 1973 | 0.02 | 4.7e-03 | 5.29 | 1.22e-07 | 0.37 | FALSE |
| Liver | Znf431l4 | alternative polyA | XM_006240824.5 | 0.02 | 1973 | 0.01 | 2.8e-02 | -5.29 | 1.20e-07 | 0.31 | FALSE |
| Liver | Zfp347 | gene expression | Zfp347 | 0.09 | 1 | 0.08 | 7.4e-09 | -5.49 | 3.99e-08 | 0.91 | FALSE |
| Liver | Zfp77 | gene expression | Zfp77 | 0.52 | 26 | 0.43 | 6.7e-52 | 5.52 | 3.41e-08 | 0.53 | FALSE |
| Liver | Znf431l4 | isoform ratio | XM_006240824.5 | 0.04 | 1 | 0.02 | 1.8e-03 | 5.49 | 3.99e-08 | 0.08 | FALSE |
| NAcc | Zfp77 | alternative polyA | XM_039080019.2 | 0.03 | 1993 | 0.03 | 5.3e-06 | -5.23 | 1.65e-07 | 0.19 | FALSE |
| NAcc | Znf431l4 | alternative TSS | NM_001409173.1 | 0.02 | 1973 | 0.02 | 1.3e-04 | -5.25 | 1.50e-07 | 0.19 | FALSE |
| NAcc | Zfp77 | isoform ratio | XM_003750272.6 | 0.04 | 1993 | 0.04 | 4.7e-06 | 5.26 | 1.45e-07 | 0.23 | FALSE |
| NAcc | Znf431l4 | isoform ratio | NM_001409173.1 | 0.01 | 1973 | 0.01 | 1.8e-03 | -5.21 | 1.90e-07 | 0.18 | FALSE |
| NAcc | Zfp77 | intron excision ratio | chr7_7935224_7964901 | 0.02 | 1993 | 0.01 | 3.6e-03 | 5.26 | 1.45e-07 | 0.26 | FALSE |
| OFC | Zfp77 | isoform ratio | XM_006240826.5 | 0.26 | 1993 | 0.2 | 1.7e-05 | 5.27 | 1.40e-07 | 0.28 | FALSE |
| OFC | Zfp77 | isoform ratio | XR_010053548.1 | 0.34 | 1993 | 0.29 | 1.0e-07 | -5.31 | 1.07e-07 | 0.3 | FALSE |
| PL | Zfp347 | isoform ratio | XM_039078333.2 | 0.06 | 17 | 0.04 | 7.3e-05 | -5.36 | 8.13e-08 | 0.39 | FALSE |
| PL | Neurod4 | mRNA stability | Neurod4 | 0.03 | 23 | 0.02 | 2.6e-03 | 5.63 | 1.84e-08 | 0.56 | FALSE |