chr8:81,565,760-84,417,859

Trait: BMI with tail

Best TWAS P = 1.41e-09 · Best GWAS P= 7.77e-09 conditioned to NaN

Associated models

Tissue Gene RNA modality RNA phenotype h2 # weights Model R2 Model R2 P TWAS Z TWAS P Coloc P Joint
Adipose Ccpg1 alternative polyA NM_001401186.1 0.04 1390 0.03 2.0e-04 -5.94 2.89e-09 0.64 FALSE
Adipose Ccpg1 alternative polyA NM_001401186.1 0.02 1390 0.01 1.4e-02 -6 1.96e-09 0.52 FALSE
Adipose Ccpg1 alternative polyA XM_006243332.5 0.02 1390 0.01 1.7e-02 5.98 2.30e-09 0.51 FALSE
Adipose Prtg alternative TSS XM_039081519.2 0.05 1399 0.02 1.4e-03 5.91 3.46e-09 0.44 FALSE
Adipose Prtg alternative TSS XM_039081517.2 0.03 1399 0.02 3.4e-03 -5.73 9.96e-09 0.35 FALSE
Adipose Prtg alternative TSS XM_039081519.2 0.04 1399 0.02 5.7e-03 5.93 2.97e-09 0.47 FALSE
Adipose Pygo1 gene expression Pygo1 0.02 1336 0.02 2.5e-03 -6.05 1.41e-09 0.52 TRUE
Adipose Pigb isoform ratio NM_001108166.3 0.04 1541 0.03 1.6e-04 -6.02 1.72e-09 0.61 FALSE
Adipose Pigb isoform ratio XM_063265549.1 0.04 1541 0.03 2.1e-04 6.01 1.83e-09 0.62 FALSE
Adipose Prtg isoform ratio XM_039081519.2 0.02 1399 0.02 6.0e-03 5.93 3.04e-09 0.41 FALSE
BLA Khdc3 gene expression Khdc3 0.12 1815 0.09 2.4e-05 5.6 2.09e-08 0.68 FALSE
BLA Rab27a gene expression Rab27a 0.4 27 0.42 5.7e-24 5.49 3.96e-08 0.85 FALSE
BLA Dnaaf4 isoform ratio NM_001007010.1 0.1 27 0.06 4.6e-04 -5.48 4.30e-08 0.7 FALSE
Brain Nedd4 gene expression Nedd4 0.1 1313 0.09 1.0e-08 5.3 1.13e-07 0.06 FALSE
Brain Rab27a gene expression Rab27a 0.15 1 0.17 2.1e-15 5.63 1.80e-08 0.88 FALSE
Brain Dnaaf4 intron excision ratio chr8_82581359_82583858 0.03 1383 0.01 3.4e-02 -5.62 1.90e-08 0.34 FALSE
Brain Pygo1 intron excision ratio chr8_82581359_82583858 0.03 1377 0.01 3.5e-02 -5.63 1.85e-08 0.34 FALSE
Eye Pigb isoform ratio NM_001108166.3 0.52 1 0.06 4.3e-02 -5.52 3.35e-08 0.06 FALSE
IC Khdc3 gene expression Khdc3 0.07 1815 0.07 5.3e-04 5.71 1.12e-08 0.47 FALSE
IC Pigb gene expression Pigb 0.21 43 0.22 1.9e-09 5.77 7.89e-09 0.74 FALSE
IC Rab27a gene expression Rab27a 0.2 1 0.22 8.7e-10 5.56 2.74e-08 0.82 FALSE
IC Wdr72 gene expression Wdr72 0.07 2522 0.01 9.4e-02 5.34 9.20e-08 0.3 TRUE
IC Ccpg1 isoform ratio NM_001401188.1 0.14 6 0.08 2.4e-04 -5.6 2.12e-08 0.69 TRUE
IL Rab27a gene expression Rab27a 0.32 1 0.2 1.8e-05 5.64 1.71e-08 0.23 FALSE
IL Ccpg1 isoform ratio XM_063265779.1 0.15 1 0.09 3.7e-03 5.61 1.99e-08 0.07 FALSE
Liver Ccpg1 gene expression Ccpg1 0.12 18 0.13 1.5e-14 -5.29 1.19e-07 0.56 TRUE
Liver Pierce2 gene expression Pierce2 0.06 18 0.05 7.2e-06 -5.61 1.99e-08 0.64 FALSE
Liver Ccpg1 mRNA stability Ccpg1 0.07 28 0.09 1.1e-09 -5.55 2.93e-08 0.62 FALSE
NAcc Rab27a gene expression Rab27a 0.09 22 0.1 5.5e-15 5.5 3.71e-08 0.84 FALSE
NAcc Rsl24d1 gene expression Rsl24d1 0.02 1810 0.01 1.8e-03 -5.45 4.93e-08 0.62 FALSE
NAcc Ccpg1 isoform ratio NM_001401188.1 0.13 30 0.15 4.4e-22 -5.48 4.27e-08 0.24 FALSE
NAcc Ccpg1 intron excision ratio chr8_82629952_82632051 0.02 2 0.01 2.7e-03 -5.44 5.42e-08 0.68 FALSE
NAcc Dnaaf4 intron excision ratio chr8_82579838_82580225 0.03 1 0.03 1.0e-04 -5.66 1.54e-08 0.54 FALSE
NAcc Dnaaf4 intron excision ratio chr8_82579838_82581134 0.04 14 0.04 2.6e-07 5.5 3.87e-08 0.75 FALSE
NAcc Dnaaf4 intron excision ratio chr8_82580358_82581134 0.02 1383 0.02 1.6e-03 -5.64 1.75e-08 0.53 FALSE
OFC Rab27a gene expression Rab27a 0.37 1 0.15 2.5e-04 5.6 2.17e-08 0.08 FALSE
OFC Ccpg1 isoform ratio NM_001401188.1 0.22 1 0.06 1.4e-02 -5.6 2.17e-08 0.06 FALSE
PL Ccpg1 alternative polyA NM_001401186.1 0.03 1431 0.02 1.9e-03 -5.43 5.49e-08 0.45 FALSE
PL Ccpg1 alternative polyA XM_006243332.5 0.13 1431 0.15 3.6e-16 5.69 1.30e-08 0.44 FALSE
PL Dnaaf4 gene expression Dnaaf4 0.02 1 0.02 6.7e-03 -5.63 1.80e-08 0.08 FALSE
PL Rab27a gene expression Rab27a 0.24 23 0.32 3.4e-35 5.59 2.22e-08 0.85 FALSE
PL Ccpg1 isoform ratio XM_008766317.4 0.02 1431 0.01 9.4e-03 -5.25 1.52e-07 0.19 FALSE
pVTA Ccpg1 alternative polyA XM_006243332.5 0.06 1431 0.06 2.1e-05 5.42 6.00e-08 0.6 FALSE
pVTA Dnaaf4 alternative polyA XM_006243329.5 0.03 1383 0.03 1.5e-03 5.9 3.71e-09 0.42 FALSE
pVTA Rsl24d1 gene expression Rsl24d1 0.07 1 0.08 8.4e-07 -5.67 1.39e-08 0.89 FALSE
pVTA Dnaaf4 isoform ratio NM_001007010.1 0.1 1383 0.09 1.6e-07 -5.97 2.41e-09 0.51 FALSE
pVTA Dnaaf4 isoform ratio XM_006243329.5 0.12 1383 0.1 1.3e-08 6.01 1.85e-09 0.46 FALSE
RMTg Dnaaf4 isoform ratio NM_001007010.1 0.13 1383 0.07 6.9e-03 -5.61 1.97e-08 0.38 FALSE
RMTg Dnaaf4 isoform ratio XM_006243329.5 0.11 36 0.06 1.4e-02 5.35 8.69e-08 0.49 FALSE