Hub : Traits : BMI with tail : ← →

chr18:25,070,927-26,946,372

Trait: BMI with tail

Best TWAS P=3.997775e-10 · Best GWAS P=4.288739e-08 conditioned to 0.7515877

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Cdc23	alternative polyA	ENSRNOT00000037888	0.17	0.12	top1	1	0.12	1.2e-13	5.4	5.4	5.5e-08	0.98	0.21	0.79	FALSE
2	Adipose	Cdc23	gene expression	ENSRNOG00000024241	0.05	0.03	blup	835	0.03	1.1e-04	4.4	5.5	4.6e-08	0.98	0.32	0.68	FALSE
3	Adipose	Cdc23	isoform ratio	ENSRNOT00000037888	0.03	0.01	blup	835	0.02	4.9e-03	5.4	5.3	1.2e-07	1.00	0.26	0.54	FALSE
4	Adipose	Cdc23	isoform ratio	ENSRNOT00000101231	0.14	0.10	blup	835	0.11	2.3e-12	5.2	-5.5	3.7e-08	-0.95	0.32	0.68	FALSE
5	Adipose	Cdc23	mRNA stability	ENSRNOG00000024241	0.06	0.04	blup	835	0.04	1.5e-05	4.2	5.5	3.3e-08	0.93	0.32	0.67	FALSE
6	BLA	Cdc23	alternative polyA	ENSRNOT00000101231	0.13	0.12	lasso	21	0.13	3.3e-07	5.4	-5.4	8.3e-08	-0.99	0.29	0.71	FALSE
7	BLA	Reep5	gene expression	ENSRNOG00000020167	0.15	0.14	top1	1	0.14	3.9e-08	5.4	5.4	8.3e-08	0.98	0.28	0.70	FALSE
8	BLA	Cdc23	isoform ratio	ENSRNOT00000101231	0.10	0.08	blup	835	0.09	1.6e-05	5.4	-5.1	2.9e-07	-1.00	0.30	0.70	FALSE
9	BLA	Reep5	intron excision ratio	chr18:25947663:25949991	0.06	0.05	top1	1	0.04	1.9e-03	5.4	-5.4	7.1e-08	-0.98	0.05	0.05	FALSE
10	BLA	Reep5	intron excision ratio	chr18:25950159:25957916	0.08	0.06	top1	1	0.06	2.3e-04	5.4	5.4	7.1e-08	0.98	0.06	0.09	FALSE
11	BLA	Reep5	mRNA stability	ENSRNOG00000020167	0.05	0.00	blup	1162	0.02	4.6e-02	3.8	5.5	3.9e-08	0.91	0.26	0.40	FALSE
12	Brain	Reep5	alternative polyA	ENSRNOT00000027345	0.07	0.07	top1	1	0.07	7.0e-07	5.4	-5.4	8.2e-08	-0.95	0.27	0.69	FALSE
13	Brain	Reep5	alternative polyA	ENSRNOT00000108864	0.06	0.06	top1	1	0.06	1.5e-06	5.4	5.4	8.2e-08	0.95	0.26	0.67	FALSE
14	Brain	Cdc23	alternative polyA	ENSRNOT00000037888	0.08	0.07	blup	835	0.07	2.0e-07	4.3	5.2	1.9e-07	0.99	0.36	0.64	FALSE
15	Brain	Cdc23	alternative polyA	ENSRNOT00000101231	0.08	0.09	blup	835	0.10	3.6e-09	5.2	-5.3	9.8e-08	-0.99	0.30	0.70	FALSE
16	Brain	Cdc23	alternative polyA	ENSRNOT00000101231	0.03	0.01	blup	835	0.02	8.4e-03	3.9	-5.4	7.2e-08	-0.84	0.31	0.38	FALSE
17	Brain	Cdc23	alternative polyA	ENSRNOT00000114348	0.03	0.01	blup	835	0.02	8.8e-03	3.9	5.4	7.2e-08	0.84	0.30	0.38	FALSE
18	Brain	Cdc23	gene expression	ENSRNOG00000024241	0.03	0.03	top1	1	0.03	5.8e-04	5.5	5.5	4.8e-08	0.95	0.06	0.17	FALSE
19	Brain	Epb41l4a	gene expression	ENSRNOG00000026050	0.58	0.40	enet	382	0.54	6.6e-59	4.3	5.2	2.2e-07	0.72	0.99	0.01	FALSE
20	Brain	Cdc23	isoform ratio	ENSRNOT00000101231	0.08	0.08	blup	835	0.10	3.8e-09	5.4	-5.6	2.2e-08	-0.96	0.29	0.71	FALSE
21	Brain	Reep5	intron excision ratio	chr18:25947663:25949991	0.03	0.02	top1	1	0.02	7.1e-03	5.4	-5.4	8.6e-08	-0.97	0.04	0.04	FALSE
22	Brain	Cdc23	mRNA stability	ENSRNOG00000024241	0.02	0.00	blup	835	0.01	4.2e-02	5.4	5.6	2.8e-08	0.92	0.25	0.50	FALSE
23	Eye	Fam13b	gene expression	ENSRNOG00000020384	0.57	0.11	enet	578	0.24	1.5e-04	4.5	5.6	2.7e-08	0.65	0.21	0.30	FALSE
24	IL	Cdc23	alternative polyA	ENSRNOT00000037888	0.27	0.03	top1	1	0.03	7.0e-02	5.4	5.4	6.7e-08	0.99	0.04	0.06	FALSE
25	IL	Brd8	gene expression	ENSRNOG00000020340	0.20	0.08	top1	1	0.08	7.2e-03	5.4	5.4	6.1e-08	0.97	0.05	0.06	FALSE
26	IL	Cdc23	isoform ratio	ENSRNOT00000101231	0.17	0.01	blup	834	0.03	7.3e-02	5.4	-5.6	2.5e-08	-0.95	0.17	0.31	FALSE
27	LHb	Cdc23	gene expression	ENSRNOG00000024241	0.29	0.15	top1	1	0.15	1.8e-04	5.4	5.4	6.1e-08	0.92	0.05	0.08	FALSE
28	LHb	Cdc23	isoform ratio	ENSRNOT00000101231	0.18	0.06	top1	1	0.06	1.3e-02	5.4	-5.4	7.6e-08	-0.96	0.04	0.06	FALSE
29	LHb	Cdc23	mRNA stability	ENSRNOG00000024241	0.23	0.12	top1	1	0.12	9.7e-04	5.4	5.4	6.1e-08	0.95	0.05	0.06	FALSE
30	Liver	Cdc23	alternative polyA	ENSRNOT00000037888	0.15	0.10	blup	835	0.11	5.0e-12	5.2	5.3	1.3e-07	1.00	0.32	0.68	FALSE
31	Liver	Cdc23	alternative polyA	ENSRNOT00000101231	0.17	0.11	blup	835	0.12	2.2e-13	5.2	-5.2	2.1e-07	-1.00	0.32	0.68	FALSE
32	Liver	Cdc23	gene expression	ENSRNOG00000024241	0.19	0.13	blup	835	0.14	6.0e-15	5.3	5.2	2.5e-07	1.00	0.32	0.68	FALSE
33	Liver	Pkd2l2	gene expression	ENSRNOG00000025489	0.03	0.02	top1	1	0.02	1.3e-03	5.4	5.4	5.5e-08	0.99	0.04	0.06	FALSE
34	Liver	Cdc23	isoform ratio	ENSRNOT00000101231	0.20	0.13	blup	835	0.15	7.8e-16	5.2	-5.3	1.1e-07	-0.99	0.32	0.68	FALSE
35	Liver	Reep5	mRNA stability	ENSRNOG00000020167	0.05	0.04	top1	1	0.04	9.1e-06	5.4	5.4	5.5e-08	0.97	0.19	0.68	FALSE
36	Liver	Cdc23	mRNA stability	ENSRNOG00000024241	0.04	0.02	lasso	16	0.03	5.7e-04	5.3	5.3	1.3e-07	0.98	0.30	0.64	FALSE
37	NAcc	Reep5	alternative polyA	ENSRNOT00000027345	0.07	0.09	lasso	28	0.09	3.4e-07	5.3	-5.3	1.3e-07	-0.95	0.31	0.69	FALSE
38	NAcc	Reep5	alternative polyA	ENSRNOT00000108864	0.07	0.08	lasso	31	0.09	6.5e-07	5.3	5.3	1.3e-07	0.90	0.31	0.69	FALSE
39	NAcc	Cdc23	alternative polyA	ENSRNOT00000101231	0.08	0.07	top1	1	0.07	5.6e-06	5.4	-5.4	5.2e-08	-0.98	0.16	0.63	FALSE
40	NAcc	Epb41l4a	gene expression	ENSRNOG00000026050	0.07	0.00	blup	1032	0.02	1.7e-02	5.4	6.0	2.4e-09	0.76	0.21	0.43	FALSE
41	NAcc	Nme5	mRNA stability	ENSRNOG00000020118	0.04	0.03	blup	908	0.04	4.5e-04	4.6	5.3	1.1e-07	1.00	0.31	0.66	FALSE
42	PL	Reep5	gene expression	ENSRNOG00000020167	0.14	0.11	blup	1160	0.13	2.1e-10	5.4	6.3	4.0e-10	0.90	0.31	0.69	TRUE
43	PL	Apc	isoform ratio	ENSRNOT00000027691	0.03	0.03	top1	1	0.03	3.1e-03	5.2	-5.2	1.6e-07	-0.97	0.05	0.04	FALSE
44	PL	Apc	isoform ratio	ENSRNOT00000102176	0.03	0.03	top1	1	0.03	1.2e-03	5.2	5.2	1.6e-07	0.98	0.05	0.05	FALSE
45	PL	Nme5	intron excision ratio	chr18:26169875:26180166	0.05	0.04	blup	908	0.04	2.6e-04	4.3	5.5	3.6e-08	0.96	0.31	0.65	FALSE
46	PL	Apc	intron excision ratio	chr18:25828942:25871423	0.04	0.01	blup	1184	0.03	3.0e-03	4.2	5.3	1.4e-07	0.96	0.39	0.48	FALSE
47	PL	Cdc23	intron excision ratio	chr18:26240669:26242295	0.05	0.04	top1	1	0.04	3.2e-04	5.3	5.3	1.3e-07	0.96	0.06	0.08	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.