Best TWAS P=9.40e-09 · Best GWAS P=4.96e-09 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Cep112 | intron excision ratio | chr10_93731914_93738578 | 0.05 | 1 | 0.04 | 3.5e-05 | -5.55 | 2.85e-08 | 0.2 | FALSE |
| Adipose | Cep112 | mRNA stability | Cep112 | 0.1 | 5 | 0.06 | 5.1e-07 | 5.2 | 1.96e-07 | 0.67 | FALSE |
| Brain | Arsg | alternative TSS | XM_006247602.4 | 0.03 | 1 | 0.02 | 6.2e-03 | -5.4 | 6.67e-08 | 0.14 | FALSE |
| Brain | Slc16a6 | alternative TSS | XM_039086231.1 | 0.03 | 1 | 0.04 | 5.6e-05 | 5.37 | 7.84e-08 | 0.53 | FALSE |
| Brain | Cep112 | isoform ratio | XR_005489759.1 | 0.03 | 1 | 0.02 | 4.1e-03 | -5.56 | 2.64e-08 | 0.05 | FALSE |
| IL | Axin2 | gene expression | Axin2 | 0.29 | 2034 | 0.16 | 1.1e-04 | -5.29 | 1.25e-07 | 0.46 | FALSE |
| IL | LOC120095201 | gene expression | LOC120095201 | 0.19 | 8 | 0.07 | 1.0e-02 | 5.31 | 1.09e-07 | 0.32 | FALSE |
| LHb | Cep112 | gene expression | Cep112 | 0.41 | 1 | 0.31 | 3.2e-08 | 5.62 | 1.86e-08 | 0.33 | FALSE |
| Liver | Apoh | mRNA stability | Apoh | 0.25 | 26 | 0.26 | 3.5e-28 | 5.74 | 9.40e-09 | 0.68 | TRUE |
| NAcc | LOC102550112 | gene expression | LOC102550112 | 0.04 | 1 | 0.03 | 4.3e-04 | -5.2 | 1.96e-07 | 0.05 | FALSE |
| NAcc | LOC120095197 | gene expression | LOC120095197 | 0.07 | 28 | 0.02 | 3.3e-03 | -5.24 | 1.64e-07 | 0.79 | FALSE |
| OFC | Wipi1 | alternative TSS | XM_039086173.1 | 0.14 | 1 | 0.09 | 3.2e-03 | 5.18 | 2.23e-07 | 0.07 | FALSE |
| PL | Map2k6 | alternative TSS | NM_053703.3 | 0.1 | 1 | 0.17 | 2.0e-18 | -5.23 | 1.67e-07 | 0.99 | FALSE |
| PL | Map2k6 | alternative TSS | XM_039085033.1 | 0.13 | 1 | 0.22 | 6.0e-24 | 5.23 | 1.67e-07 | 0.99 | FALSE |
| PL | Cep112 | gene expression | Cep112 | 0.18 | 141 | 0.2 | 1.3e-21 | 5.29 | 1.22e-07 | 0.67 | FALSE |
| PL | Arsg | intron excision ratio | chr10_94533510_94541749 | 0.06 | 16 | 0.02 | 3.1e-03 | -5.27 | 1.33e-07 | 0.48 | FALSE |
| pVTA | Amz2 | gene expression | Amz2 | 0.12 | 1 | 0.07 | 5.5e-04 | -5.2 | 2.02e-07 | 0.17 | FALSE |
| RMTg | Arsg | alternative polyA | XM_008768369.2 | 0.13 | 1 | 0.07 | 6.2e-03 | -5.2 | 2.01e-07 | 0.07 | FALSE |