Best TWAS P = 1.43e-10 · Best GWAS P= 4.45e-10 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Lrrc78 | alternative polyA | XM_039082567.2 | 0.47 | 50 | 0.18 | 6.4e-20 | 5.24 | 1.60e-07 | 0.03 | FALSE |
| Adipose | LOC102550734 | gene expression | LOC102550734 | 0.12 | 147 | 0.12 | 4.1e-13 | 5.66 | 1.53e-08 | 0.78 | FALSE |
| Adipose | LOC134480217 | gene expression | LOC134480217 | 0.04 | 1 | 0.03 | 5.0e-04 | -5.24 | 1.60e-07 | 0.03 | FALSE |
| Adipose | Lrrc78 | gene expression | Lrrc78 | 0.38 | 10 | 0.16 | 3.5e-17 | -5.43 | 5.74e-08 | 0.03 | FALSE |
| Adipose | Trpc1 | gene expression | Trpc1 | 0.07 | 141 | 0.05 | 4.1e-06 | 6.02 | 1.78e-09 | 0.77 | FALSE |
| Adipose | Tfdp2 | mRNA stability | Tfdp2 | 0.13 | 32 | 0.12 | 3.9e-13 | 5.22 | 1.78e-07 | 0.16 | FALSE |
| BLA | Gk5 | gene expression | Gk5 | 0.51 | 5 | 0.18 | 8.1e-10 | 5.52 | 3.46e-08 | 0.38 | FALSE |
| BLA | Tfdp2 | gene expression | Tfdp2 | 0.16 | 10 | 0.15 | 1.5e-08 | 5.37 | 7.90e-08 | 0.63 | FALSE |
| BLA | Trpc1 | intron excision ratio | chr8_105159708_105161959 | 0.08 | 1 | 0.06 | 4.9e-04 | 5.85 | 4.85e-09 | 0.12 | FALSE |
| BLA | U2surp | intron excision ratio | chr8_104940705_104946936 | 0.14 | 56 | 0.16 | 9.8e-09 | -5.53 | 3.24e-08 | 0.49 | FALSE |
| BLA | Atp1b3 | mRNA stability | Atp1b3 | 0.07 | 25 | 0.07 | 1.1e-04 | 5.79 | 6.99e-09 | 0.7 | FALSE |
| Brain | Atp1b3 | gene expression | Atp1b3 | 0.07 | 27 | 0.05 | 1.4e-05 | 5.7 | 1.22e-08 | 0.66 | FALSE |
| Brain | Rnf7 | gene expression | Rnf7 | 0.05 | 1935 | 0.02 | 4.0e-03 | 6.32 | 2.55e-10 | 0.67 | FALSE |
| Brain | Tfdp2 | gene expression | Tfdp2 | 0.17 | 39 | 0.22 | 7.5e-20 | 5.79 | 7.01e-09 | 0.73 | FALSE |
| Brain | Trpc1 | isoform ratio | NM_001413355.1 | 0.07 | 1 | 0.05 | 1.0e-05 | 5.56 | 2.65e-08 | 0.14 | FALSE |
| Brain | Trpc1 | isoform ratio | XM_063266253.1 | 0.1 | 2086 | 0.06 | 1.1e-06 | -5.58 | 2.47e-08 | 0.71 | FALSE |
| Brain | Atp1b3 | intron excision ratio | chr8_105802082_105820898 | 0.05 | 1766 | 0.05 | 1.8e-05 | -5.78 | 7.53e-09 | 0.66 | FALSE |
| Brain | Trpc1 | intron excision ratio | chr8_105159708_105160520 | 0.14 | 1 | 0.09 | 9.6e-09 | -5.91 | 3.45e-09 | 0.64 | FALSE |
| Brain | Trpc1 | intron excision ratio | chr8_105159708_105161959 | 0.17 | 2086 | 0.16 | 7.8e-15 | 5.96 | 2.46e-09 | 0.82 | FALSE |
| Brain | Trpc1 | intron excision ratio | chr8_105160576_105161959 | 0.12 | 2086 | 0.1 | 3.3e-09 | -6.41 | 1.43e-10 | 0.76 | TRUE |
| Brain | Atp1b3 | mRNA stability | Atp1b3 | 0.46 | 16 | 0.42 | 1.0e-42 | 5.84 | 5.29e-09 | 0.55 | TRUE |
| Brain | Gk5 | mRNA stability | Gk5 | 0.06 | 1917 | 0.04 | 1.9e-04 | 5.74 | 9.27e-09 | 0.67 | FALSE |
| Brain | Pls1 | mRNA stability | Pls1 | 0.08 | 1 | 0.06 | 1.2e-06 | -6.03 | 1.68e-09 | 0.74 | FALSE |
| Brain | Trpc1 | mRNA stability | Trpc1 | 0.13 | 2086 | 0.11 | 5.2e-10 | 5.66 | 1.50e-08 | 0.68 | FALSE |
| IC | Atp1b3 | mRNA stability | Atp1b3 | 0.13 | 2 | 0.11 | 1.8e-05 | 5.22 | 1.75e-07 | 0.58 | FALSE |
| IC | Tfdp2 | mRNA stability | Tfdp2 | 0.08 | 16 | -0 | 5.0e-01 | 5.95 | 2.63e-09 | 0.21 | FALSE |
| IL | PCOLCE2 | gene expression | PCOLCE2 | 0.34 | 1 | 0.09 | 3.8e-03 | -5.23 | 1.69e-07 | 0.05 | FALSE |
| IL | Xrn1 | isoform ratio | XM_039081173.1 | 0.17 | 1956 | 0.06 | 1.8e-02 | 5.97 | 2.43e-09 | 0.4 | FALSE |
| IL | Atp1b3 | mRNA stability | Atp1b3 | 0.27 | 1766 | 0.09 | 3.1e-03 | 5.36 | 8.19e-08 | 0.54 | FALSE |
| LHb | PCOLCE2 | gene expression | PCOLCE2 | 0.34 | 1 | 0.17 | 6.2e-05 | 5.47 | 4.53e-08 | 0.05 | FALSE |
| Liver | Lrrc78 | alternative polyA | XM_039082567.2 | 0.09 | 1 | 0.05 | 1.5e-06 | 5.24 | 1.59e-07 | 0.04 | FALSE |
| Liver | Lrrc78 | alternative polyA | XM_039082568.2 | 0.11 | 1 | 0.05 | 4.6e-06 | -5.24 | 1.59e-07 | 0.04 | FALSE |
| Liver | Lrrc78 | alternative polyA | XM_039082567.2 | 0.31 | 1 | 0.08 | 2.1e-09 | 5.24 | 1.59e-07 | 0.04 | FALSE |
| Liver | Tfdp2 | alternative polyA | NM_001106847.2 | 0.03 | 1853 | 0.02 | 5.2e-03 | -5.26 | 1.45e-07 | 0.55 | FALSE |
| Liver | Gk5 | gene expression | Gk5 | 0.06 | 1917 | 0.05 | 5.1e-06 | -5.23 | 1.71e-07 | 0.68 | FALSE |
| Liver | Lrrc78 | gene expression | Lrrc78 | 0.26 | 79 | 0.1 | 3.4e-11 | -5.31 | 1.10e-07 | 0.03 | FALSE |
| Liver | PCOLCE2 | gene expression | PCOLCE2 | 0.1 | 1 | 0.09 | 6.5e-10 | 5.91 | 3.45e-09 | 0.75 | FALSE |
| Liver | Pls1 | gene expression | Pls1 | 0.32 | 226 | 0.38 | 4.7e-44 | -5.36 | 8.47e-08 | 0.01 | FALSE |
| Liver | Trpc1 | gene expression | Trpc1 | 0.11 | 170 | 0.08 | 2.0e-09 | 6.28 | 3.47e-10 | 0.77 | FALSE |
| Liver | Atp1b3 | mRNA stability | Atp1b3 | 0.06 | 1 | 0.05 | 5.0e-06 | 5.22 | 1.75e-07 | 0.03 | FALSE |
| NAcc | Rnf7 | gene expression | Rnf7 | 0.04 | 8 | 0.02 | 2.7e-04 | 5.4 | 6.56e-08 | 0.29 | TRUE |
| NAcc | Tfdp2 | isoform ratio | NM_001106847.2 | 0.06 | 38 | 0.08 | 1.2e-11 | -5.31 | 1.10e-07 | 0.07 | FALSE |
| NAcc | Trpc1 | isoform ratio | XM_039082218.2 | 0.04 | 1 | 0.05 | 3.4e-08 | -5.64 | 1.67e-08 | 0.28 | FALSE |
| NAcc | Trpc1 | intron excision ratio | chr8_105159708_105160520 | 0.05 | 15 | 0.07 | 1.9e-11 | -5.68 | 1.36e-08 | 0.5 | FALSE |
| NAcc | Trpc1 | intron excision ratio | chr8_105159708_105161959 | 0.1 | 13 | 0.12 | 5.2e-18 | 6.08 | 1.23e-09 | 0.73 | FALSE |
| NAcc | Trpc1 | intron excision ratio | chr8_105160576_105161959 | 0.1 | 84 | 0.14 | 9.2e-21 | -6.11 | 1.01e-09 | 0.71 | FALSE |
| NAcc | LOC120094233 | mRNA stability | LOC120094233 | 0.04 | 1 | 0.05 | 1.4e-08 | 5.47 | 4.53e-08 | 0.13 | FALSE |
| NAcc | Trpc1 | mRNA stability | Trpc1 | 0.04 | 2086 | 0.04 | 5.7e-07 | 6.27 | 3.54e-10 | 0.79 | FALSE |
| OFC | Tfdp2 | gene expression | Tfdp2 | 0.39 | 46 | 0.2 | 2.1e-05 | 5.35 | 8.68e-08 | 0.58 | FALSE |
| OFC | Atp1b3 | mRNA stability | Atp1b3 | 0.38 | 22 | 0.28 | 2.5e-07 | 5.65 | 1.63e-08 | 0.6 | FALSE |
| PL | Tfdp2 | alternative polyA | NM_001106847.2 | 0.13 | 1853 | 0.17 | 8.1e-18 | -5.49 | 4.13e-08 | 0.52 | FALSE |
| PL | Tfdp2 | alternative polyA | XM_017595584.3 | 0.13 | 1853 | 0.16 | 1.6e-17 | 5.44 | 5.20e-08 | 0.49 | TRUE |
| PL | Atp1b3 | mRNA stability | Atp1b3 | 0.16 | 1 | 0.2 | 7.0e-22 | 6.01 | 1.90e-09 | 0.76 | FALSE |
| PL | Trpc1 | mRNA stability | Trpc1 | 0.05 | 2086 | 0.06 | 3.8e-07 | 5.71 | 1.14e-08 | 0.61 | FALSE |
| pVTA | Gk5 | gene expression | Gk5 | 0.21 | 1917 | 0.22 | 1.9e-17 | 5.55 | 2.80e-08 | 0.71 | FALSE |
| pVTA | PCOLCE2 | gene expression | PCOLCE2 | 0.2 | 133 | 0.21 | 1.1e-16 | 5.88 | 4.17e-09 | 0.57 | FALSE |
| pVTA | Tfdp2 | gene expression | Tfdp2 | 0.15 | 1 | 0.15 | 2.9e-12 | 5.92 | 3.21e-09 | 0.64 | FALSE |
| pVTA | Atp1b3 | intron excision ratio | chr8_105802082_105820898 | 0.03 | 1 | 0.02 | 4.3e-03 | -6.04 | 1.55e-09 | 0.09 | FALSE |
| pVTA | Trpc1 | intron excision ratio | chr8_105159708_105160520 | 0.08 | 1 | 0.09 | 5.6e-08 | -5.85 | 4.85e-09 | 0.56 | FALSE |
| pVTA | Trpc1 | intron excision ratio | chr8_105159708_105161959 | 0.12 | 2 | 0.15 | 2.6e-12 | 6.33 | 2.51e-10 | 0.46 | TRUE |
| pVTA | Trpc1 | intron excision ratio | chr8_105160576_105161959 | 0.13 | 196 | 0.15 | 4.0e-12 | -5.97 | 2.39e-09 | 0.56 | TRUE |
| pVTA | Atp1b3 | mRNA stability | Atp1b3 | 0.14 | 17 | 0.18 | 8.8e-15 | 5.32 | 1.01e-07 | 0.65 | FALSE |
| RMTg | LOC102550734 | gene expression | LOC102550734 | 0.15 | 1 | 0.04 | 2.6e-02 | 5.46 | 4.64e-08 | 0.05 | FALSE |
| RMTg | PCOLCE2 | gene expression | PCOLCE2 | 0.18 | 1 | 0.12 | 3.8e-04 | 6.06 | 1.39e-09 | 0.14 | FALSE |
| RMTg | Pls1 | gene expression | Pls1 | 0.23 | 2008 | 0.18 | 1.4e-05 | -5.83 | 5.60e-09 | 0.58 | TRUE |