chr1:253,445,764-260,518,987

Trait: BMI with tail

Best TWAS P=5.50e-34 · Best GWAS P=1.80e-35 conditioned to 1.00e+00

Associated models

Tissue Gene RNA modality RNA phenotype h2 # weights Model R2 Model R2 P TWAS Z TWAS P Coloc P Joint
Adipose Nhlrc2 alternative polyA ENSRNOT00000022788 0.03 1 0 1.8e-01 6.62 3.57e-11 0.03 FALSE
Adipose Nhlrc2 alternative polyA ENSRNOT00000105890 0.03 1 0.01 3.7e-02 -6.66 2.82e-11 0.04 FALSE
Adipose Atrnl1 alternative polyA ENSRNOT00000105444 0.08 1 0.07 4.0e-08 6 1.98e-09 0.9 FALSE
Adipose Atrnl1 alternative polyA ENSRNOT00000115590 0.02 1 0.02 6.5e-03 6.52 6.92e-11 0.37 FALSE
Adipose Atrnl1 alternative polyA ENSRNOT00000118477 0.63 1 0.22 1.4e-23 -6.52 6.92e-11 1 FALSE
Adipose Atrnl1 alternative polyA ENSRNOT00000105444 0.08 1 0.07 7.2e-08 6 1.98e-09 0.9 FALSE
Adipose Atrnl1 alternative polyA ENSRNOT00000115590 0.02 1 0.02 6.5e-03 6.52 6.92e-11 0.37 FALSE
Adipose Atrnl1 alternative polyA ENSRNOT00000118477 0.24 4 0.19 5.0e-21 -6.52 7.02e-11 0.97 FALSE
Adipose Zdhhc6 alternative polyA ENSRNOT00000054681 0.08 1 0.06 1.1e-07 6.13 8.52e-10 0.43 FALSE
Adipose Zdhhc6 alternative polyA ENSRNOT00000103424 0.08 1 0.07 1.7e-08 -6.13 8.52e-10 0.43 FALSE
Adipose Dennd10 gene expression ENSRNOG00000010230 0.03 1 0.03 2.5e-04 -9.62 6.32e-22 0.02 FALSE
Adipose Prdx3 gene expression ENSRNOG00000010958 0.19 34 0.22 1.6e-23 -8.52 1.54e-17 0 TRUE
Adipose Grk5 gene expression ENSRNOG00000011439 0.17 24 0.22 8.6e-24 10.66 1.49e-26 0 FALSE
Adipose Nrap gene expression ENSRNOG00000016714 0.05 2070 0.05 2.5e-06 5.5 3.78e-08 0.12 FALSE
Adipose Ces2c gene expression ENSRNOG00000036571 0.11 596 0.07 2.3e-08 6.28 3.34e-10 0.01 FALSE
Adipose AABR07007032.1 gene expression ENSRNOG00000046333 0.54 19 0.31 3.7e-35 -5.95 2.69e-09 0.48 FALSE
Adipose ENSRNOG00000065957 gene expression ENSRNOG00000065957 0.02 2197 0.01 1.2e-02 -6.99 2.70e-12 0.03 FALSE
Adipose Acsl5 isoform ratio ENSRNOT00000103067 0.03 1 0.02 9.2e-04 -6.25 4.04e-10 0.05 TRUE
Adipose Nhlrc2 isoform ratio ENSRNOT00000022788 0.04 1 0.02 2.9e-03 6.7 2.07e-11 0.2 FALSE
Adipose Nhlrc2 isoform ratio ENSRNOT00000105890 0.04 1 0.02 4.0e-03 -6.7 2.07e-11 0.15 FALSE
Adipose Atrnl1 isoform ratio ENSRNOT00000105444 0.08 1 0.07 4.2e-08 6 1.98e-09 0.9 FALSE
Adipose Atrnl1 isoform ratio ENSRNOT00000115590 0.02 1 0.02 4.6e-03 6.52 6.92e-11 0.54 FALSE
Adipose Atrnl1 isoform ratio ENSRNOT00000118477 0.73 1 0.22 1.2e-23 -6.52 6.92e-11 1 FALSE
Adipose AABR07007068.1 isoform ratio ENSRNOT00000104357 0.13 1 0.09 8.3e-10 5.12 3.10e-07 0.82 FALSE
Adipose AABR07007032.1 isoform ratio ENSRNOT00000108182 0.32 1 0.12 4.9e-13 -5.26 1.46e-07 0.04 FALSE
Adipose AABR07007032.1 intron excision ratio chr1:256098045:256100373 0.05 2742 0.04 8.7e-05 5.58 2.38e-08 0.28 FALSE
Adipose AABR07007032.1 intron excision ratio chr1:256098051:256100373 0.23 260 0.1 6.0e-11 -6.09 1.14e-09 0.94 FALSE
Adipose AABR07007032.1 intron excision ratio chr1:256100420:256102022 0.1 22 0.05 1.4e-06 5.8 6.71e-09 0.57 FALSE
Adipose AABR07007032.1 intron excision ratio chr1:256230416:256255914 0.03 1 0.02 1.1e-03 6 1.98e-09 0.06 FALSE
Adipose AABR07007032.1 intron excision ratio chr1:256230416:256298551 0.03 1 0.02 8.8e-04 -6 1.98e-09 0.06 FALSE
Adipose Pdzd8 mRNA stability ENSRNOG00000009460 0.04 1998 0.01 7.6e-02 6.99 2.66e-12 0.06 FALSE
Adipose Cacul1 mRNA stability ENSRNOG00000009954 0.09 62 0.04 5.6e-05 7.52 5.38e-14 0.03 FALSE
Adipose Afap1l2 mRNA stability ENSRNOG00000017164 0.03 3 0.03 6.3e-04 5.69 1.26e-08 0.33 FALSE
Adipose Atrnl1 mRNA stability ENSRNOG00000017406 0.11 83 0.06 1.0e-06 5.71 1.13e-08 0.51 FALSE
BLA Rab11fip2 gene expression ENSRNOG00000009523 0.11 1 0.05 1.1e-03 -9.39 6.01e-21 0.04 FALSE
BLA Cacul1 gene expression ENSRNOG00000009954 0.23 1 0.16 9.5e-09 5.43 5.51e-08 0 FALSE
BLA Ces2c gene expression ENSRNOG00000036571 0.26 16 0.2 1.1e-10 9.85 6.72e-23 0.06 FALSE
BLA Sfxn4 gene expression ENSRNOG00000036572 0.07 1 0.02 2.1e-02 11.9 1.21e-32 0.04 FALSE
BLA ENSRNOG00000065260 gene expression ENSRNOG00000065260 0.36 1 0.23 1.9e-12 -5.43 5.51e-08 0 FALSE
BLA Cacul1 isoform ratio ENSRNOT00000084760 0.07 1 0 2.4e-01 -10.08 6.45e-24 0.04 FALSE
BLA AABR07007068.1 isoform ratio ENSRNOT00000104357 0.17 1 0.04 3.5e-03 5.18 2.25e-07 0.1 FALSE
BLA AABR07007068.1 isoform ratio ENSRNOT00000119102 0.2 1 0.04 3.4e-03 -5.18 2.25e-07 0.1 FALSE
BLA Nhlrc2 mRNA stability ENSRNOG00000016948 0.05 2147 0.03 1.1e-02 -5.11 3.19e-07 0.14 FALSE
Brain Rab11fip2 gene expression ENSRNOG00000009523 0.09 2 0.06 3.6e-06 -9.62 6.84e-22 0.04 TRUE
Brain Prlhr gene expression ENSRNOG00000009922 0.03 1906 0.01 1.4e-02 7.78 7.14e-15 0.22 FALSE
Brain Cacul1 gene expression ENSRNOG00000009954 0.16 1783 0.15 4.8e-14 6.79 1.09e-11 0 FALSE
Brain Afap1l2 gene expression ENSRNOG00000017164 0.21 21 0.22 2.2e-20 -6.03 1.63e-09 0.92 FALSE
Brain Fhip2a gene expression ENSRNOG00000017225 0.05 3 0.06 2.5e-06 -5.34 9.51e-08 0.26 FALSE
Brain Nanos1 gene expression ENSRNOG00000025060 0.03 58 0.01 2.2e-02 -10.92 8.99e-28 0.29 FALSE
Brain Ces2c gene expression ENSRNOG00000036571 0.2 597 0.29 3.4e-27 9.79 1.20e-22 0 FALSE
Brain Sfxn4 gene expression ENSRNOG00000036572 0.09 36 0.09 2.2e-08 6.94 3.93e-12 0 FALSE
Brain Casp7 gene expression ENSRNOG00000056216 0.13 2102 0.17 1.9e-15 5.63 1.81e-08 0.03 FALSE
Brain ENSRNOG00000065260 gene expression ENSRNOG00000065260 0.37 1 0.39 3.9e-38 -5.53 3.22e-08 0 TRUE
Brain ENSRNOG00000071003 gene expression ENSRNOG00000071003 0.11 5 0.06 4.5e-06 -6.35 2.18e-10 0.01 FALSE
Brain Cacul1 isoform ratio ENSRNOT00000050617 0.14 1 0.11 3.3e-10 12.07 1.53e-33 0.32 FALSE
Brain Cacul1 isoform ratio ENSRNOT00000084760 0.12 5 0.11 5.6e-10 -9.66 4.59e-22 0.89 FALSE
Brain Zfp950 isoform ratio ENSRNOT00000047883 0.04 954 0.05 9.3e-06 9.31 1.30e-20 0.02 FALSE
Brain Cacul1 intron excision ratio chr1:259677583:259686255 0.12 36 0.1 1.6e-09 10.52 7.23e-26 0.86 FALSE
Brain Gpam intron excision ratio chr1:254140727:254142324 0.03 2121 0.02 2.8e-03 5.2 1.96e-07 0.28 FALSE
Brain ENSRNOG00000065957 intron excision ratio chr1:258565051:258626309 0.03 1 0.05 1.1e-05 -6.29 3.19e-10 0.03 FALSE
Brain Cacul1 mRNA stability ENSRNOG00000009954 0.03 1 0.01 2.3e-02 5.4 6.65e-08 0.03 FALSE
Brain Nrap mRNA stability ENSRNOG00000016714 0.04 1 0.04 1.5e-04 -5.12 3.09e-07 0.03 FALSE
Brain Afap1l2 mRNA stability ENSRNOG00000017164 0.56 2422 0.44 2.6e-44 -5.57 2.56e-08 0.16 FALSE
Brain Atrnl1 mRNA stability ENSRNOG00000017406 0.24 2591 0.27 1.4e-24 -5.17 2.33e-07 0.06 FALSE
Brain Casp7 mRNA stability ENSRNOG00000056216 0.12 2102 0.04 5.0e-05 5.11 3.22e-07 0.33 FALSE
Eye Tectb gene expression ENSRNOG00000015671 0.33 24 0.2 5.8e-04 5.74 9.21e-09 0.34 FALSE
Eye Casp7 gene expression ENSRNOG00000056216 0.51 2102 0.12 7.2e-03 5.8 6.47e-09 0.31 FALSE
Eye ENSRNOG00000065260 gene expression ENSRNOG00000065260 0.45 1 0.18 9.5e-04 -11.38 5.38e-30 0.06 FALSE
IL Ces2c gene expression ENSRNOG00000036571 0.35 1 0.35 2.3e-09 9.93 2.98e-23 0.03 FALSE
IL Sfxn4 gene expression ENSRNOG00000036572 0.19 1 0.13 5.3e-04 9.85 6.89e-23 0.05 FALSE
IL ENSRNOG00000065260 gene expression ENSRNOG00000065260 0.38 1 0.26 4.6e-07 -5.56 2.72e-08 0.04 FALSE
IL Afap1l2 mRNA stability ENSRNOG00000017164 0.39 1 0.23 3.5e-06 -5.26 1.41e-07 0.05 FALSE
IL Atrnl1 mRNA stability ENSRNOG00000017406 0.21 2586 0.15 1.7e-04 -5.26 1.43e-07 0.48 FALSE
IL Dclre1a mRNA stability ENSRNOG00000026204 0.31 3 0.29 1.2e-07 6.02 1.76e-09 0.58 FALSE
LHb Gpam gene expression ENSRNOG00000015124 0.18 2117 0.12 1.1e-03 -5.66 1.54e-08 0.44 FALSE
LHb Gucy2g gene expression ENSRNOG00000015724 0.29 9 0.21 9.6e-06 -5.97 2.43e-09 0.46 FALSE
LHb AABR07007068.1 gene expression ENSRNOG00000017438 0.2 1 0.08 6.4e-03 -5.23 1.66e-07 0.08 FALSE
LHb Ces2c gene expression ENSRNOG00000036571 0.25 594 0.19 2.3e-05 9.59 8.72e-22 0.31 FALSE
LHb Tcf7l2 gene expression ENSRNOG00000049232 0.14 6 0.06 1.2e-02 6.2 5.80e-10 0.28 FALSE
LHb Afap1l2 mRNA stability ENSRNOG00000017164 0.46 1 0.29 1.2e-07 -5.1 3.32e-07 0.04 FALSE
LHb Atrnl1 mRNA stability ENSRNOG00000017406 0.21 1 0.14 3.1e-04 -6.06 1.35e-09 0.22 FALSE
LHb Tcf7l2 mRNA stability ENSRNOG00000049232 0.15 7 0.08 6.4e-03 5.43 5.73e-08 0.23 FALSE
Liver Casp7 alternative TSS ENSRNOT00000080511 0.02 2101 0.01 8.5e-03 -6.1 1.03e-09 0.32 FALSE
Liver Rab11fip2 gene expression ENSRNOG00000009523 0.03 2371 0.01 1.3e-02 -9.25 2.24e-20 0.23 FALSE
Liver Acsl5 gene expression ENSRNOG00000016265 0.05 1 0.03 1.4e-04 6.25 4.04e-10 0.11 FALSE
Liver Habp2 gene expression ENSRNOG00000016659 0.92 1 0.57 1.3e-76 -6.34 2.31e-10 0.21 FALSE
Liver Nhlrc2 gene expression ENSRNOG00000016948 0.11 1 0.11 1.4e-12 -5.16 2.45e-07 0 FALSE
Liver Fhip2a gene expression ENSRNOG00000017225 0.02 1 0.03 8.2e-04 -6.52 6.92e-11 0.51 FALSE
Liver Trub1 gene expression ENSRNOG00000017321 0.42 23 0.44 3.5e-54 -6.09 1.15e-09 0.06 FALSE
Liver Nanos1 gene expression ENSRNOG00000025060 0.03 1 0.02 1.2e-03 -8.26 1.41e-16 0.03 FALSE
Liver Zfp950 gene expression ENSRNOG00000032668 0.03 1 0.01 7.7e-03 -11.3 1.27e-29 0.03 FALSE
Liver Cacul1 isoform ratio ENSRNOT00000050617 0.03 1 0.02 1.3e-03 11.52 1.11e-30 0.03 FALSE
Liver Cacul1 isoform ratio ENSRNOT00000084760 0.03 1780 0.02 4.5e-03 -9.75 1.85e-22 0.42 FALSE
Liver AABR07007068.1 isoform ratio ENSRNOT00000119102 0.51 1 0.39 1.5e-46 -5.16 2.53e-07 0.85 FALSE
Liver Gpam intron excision ratio chr1:254140727:254170436 0.02 2121 0.01 1.0e-02 -5.78 7.40e-09 0.43 FALSE
Liver Habp2 intron excision ratio chr1:255327227:255336618 0.7 28 0.4 5.1e-47 6.32 2.64e-10 0.18 FALSE
Liver Habp2 intron excision ratio chr1:255327227:255338715 0.02 468 0.01 8.3e-03 -5.57 2.52e-08 0.19 FALSE
Liver Habp2 intron excision ratio chr1:255336728:255338715 0.61 26 0.38 7.9e-44 -6.3 3.07e-10 0.17 FALSE
Liver Nhlrc2 intron excision ratio chr1:255640509:255642738 0.23 376 0.27 1.7e-29 5.14 2.77e-07 0 FALSE
Liver Tcf7l2 intron excision ratio chr1:254787414:254860496 0.03 14 0 2.1e-01 -6.05 1.44e-09 0.48 FALSE
Liver Cacul1 mRNA stability ENSRNOG00000009954 0.03 1 0.01 1.4e-02 12.15 5.50e-34 0.03 TRUE
Liver Acsl5 mRNA stability ENSRNOG00000016265 0.06 97 0.06 8.6e-07 6.15 7.78e-10 0.44 FALSE
Liver Habp2 mRNA stability ENSRNOG00000016659 0.47 1 0.38 4.8e-44 -5.92 3.28e-09 0.02 FALSE
Liver Afap1l2 mRNA stability ENSRNOG00000017164 0.02 1 0.01 1.2e-02 -5.83 5.44e-09 0.03 FALSE
NAcc Prlhr gene expression ENSRNOG00000009922 0.14 1904 0.11 2.3e-08 10.53 6.23e-26 0.83 FALSE
NAcc Cacul1 gene expression ENSRNOG00000009954 0.11 1 0.05 7.3e-05 5.63 1.81e-08 0.03 FALSE
NAcc Acsl5 gene expression ENSRNOG00000016265 0.09 1 0.07 4.0e-06 5.95 2.67e-09 0.18 FALSE
NAcc Zfp950 gene expression ENSRNOG00000032668 0.05 15 0.02 7.3e-03 10.32 5.66e-25 0.33 FALSE
NAcc Ces2c gene expression ENSRNOG00000036571 0.22 597 0.22 5.3e-16 9.48 2.51e-21 0 FALSE
NAcc Sfxn4 gene expression ENSRNOG00000036572 0.07 1 0.04 3.8e-04 11.47 1.92e-30 0.03 TRUE
NAcc Casp7 gene expression ENSRNOG00000056216 0.21 179 0.12 3.5e-09 6.26 3.75e-10 0.59 FALSE
NAcc Cacul1 isoform ratio ENSRNOT00000050617 0.05 1781 0.05 9.6e-05 11.52 1.01e-30 0.61 FALSE
NAcc Cacul1 isoform ratio ENSRNOT00000084760 0.05 1781 0.05 1.6e-04 -11.56 6.83e-31 0.6 FALSE
NAcc Acsl5 isoform ratio ENSRNOT00000110033 0.03 1 0.02 2.2e-02 5.91 3.46e-09 0.03 FALSE
NAcc Atrnl1 isoform ratio ENSRNOT00000118477 0.04 2586 0.02 1.7e-02 -5.13 2.83e-07 0.34 FALSE
NAcc Afap1l2 mRNA stability ENSRNOG00000017164 0.09 2417 0.06 3.4e-05 -5.36 8.45e-08 0.5 FALSE
OFC Rab11fip2 gene expression ENSRNOG00000009523 0.3 17 0.27 5.1e-07 -11.29 1.50e-29 0.52 FALSE
OFC Cacul1 gene expression ENSRNOG00000009954 0.45 1782 0.41 9.5e-11 8.37 5.87e-17 0.59 FALSE
OFC Acsl5 gene expression ENSRNOG00000016265 0.32 2066 0.19 2.8e-05 -5.94 2.83e-09 0.43 FALSE
OFC Fhip2a gene expression ENSRNOG00000017225 0.16 1 0.09 4.6e-03 -5.79 6.85e-09 0.05 FALSE
OFC Ces2c gene expression ENSRNOG00000036571 0.38 1 0.42 3.6e-11 9.86 5.94e-23 0 FALSE
OFC Sfxn4 gene expression ENSRNOG00000036572 0.41 17 0.26 7.0e-07 10.35 3.99e-25 0.02 FALSE
OFC Rab11fip2 mRNA stability ENSRNOG00000009523 0.16 1 0.19 2.9e-05 -11.26 2.06e-29 0.05 FALSE
OFC Afap1l2 mRNA stability ENSRNOG00000017164 0.55 14 0.33 1.3e-08 -5.73 1.01e-08 0.28 FALSE
OFC Dclre1a mRNA stability ENSRNOG00000026204 0.34 11 0.29 1.1e-07 5.84 5.20e-09 0.51 FALSE
PL Rab11fip2 gene expression ENSRNOG00000009523 0.06 76 0.05 1.5e-04 -11.69 1.50e-31 0.64 FALSE
PL Cacul1 gene expression ENSRNOG00000009954 0.24 45 0.18 2.4e-13 7.59 3.28e-14 0 FALSE
PL Gucy2g gene expression ENSRNOG00000015724 0.17 25 0.13 4.3e-10 -5.45 5.14e-08 0.16 FALSE
PL Fhip2a gene expression ENSRNOG00000017225 0.08 1 0.04 4.2e-04 -5.55 2.89e-08 0.05 FALSE
PL AABR07007068.1 gene expression ENSRNOG00000017438 0.39 1 0.15 2.0e-11 -5.13 2.87e-07 0.83 FALSE
PL Ces2c gene expression ENSRNOG00000036571 0.39 1 0.38 3.4e-30 9.7 2.99e-22 0 FALSE
PL Sfxn4 gene expression ENSRNOG00000036572 0.17 158 0.1 9.5e-08 8.41 4.01e-17 0.06 FALSE
PL Tcf7l2 gene expression ENSRNOG00000049232 0.04 26 0.03 4.8e-03 -6.31 2.84e-10 0.45 FALSE
PL Casp7 gene expression ENSRNOG00000056216 0.12 37 0.1 2.6e-08 5.9 3.57e-09 0.67 FALSE
PL ENSRNOG00000065957 gene expression ENSRNOG00000065957 0.12 1 0.07 9.6e-06 -7.23 4.69e-13 0.02 TRUE
PL ENSRNOG00000068145 gene expression ENSRNOG00000068145 0.06 13 0.04 6.9e-04 -8.81 1.21e-18 0.41 FALSE
PL Cacul1 isoform ratio ENSRNOT00000050617 0.03 1 0.02 1.8e-02 11.95 6.61e-33 0.03 FALSE
PL AABR07007068.1 isoform ratio ENSRNOT00000104357 0.11 1 0.06 4.5e-05 5.1 3.34e-07 0.44 FALSE
PL Gpam intron excision ratio chr1:254140727:254170436 0.04 2 0.02 1.8e-02 -6.03 1.59e-09 0.51 FALSE
PL Zfp950 intron excision ratio chr1:260237329:260247276 0.03 954 0.02 1.2e-02 10.17 2.68e-24 0.49 FALSE
PL Tcf7l2 intron excision ratio chr1:254787414:254860496 0.04 1837 0.02 1.3e-02 -5.45 4.90e-08 0.16 FALSE
PL Afap1l2 mRNA stability ENSRNOG00000017164 0.2 16 0.1 3.1e-08 -5.23 1.70e-07 0.4 FALSE
PL Atrnl1 mRNA stability ENSRNOG00000017406 0.14 92 0.11 1.7e-08 -5.27 1.37e-07 0.35 FALSE