Best TWAS P = 4.77e-08 · Best GWAS P= 3.58e-08 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Tmbim6 | alternative polyA | NM_019381.2 | 0.05 | 5 | 0.03 | 9.5e-05 | -5.24 | 1.61e-07 | 0.49 | FALSE |
| Adipose | Atf1 | gene expression | Atf1 | 0.03 | 1 | 0.03 | 2.4e-04 | 5.36 | 8.10e-08 | 0.18 | FALSE |
| Adipose | Bin2 | gene expression | Bin2 | 0.03 | 1 | 0.03 | 6.4e-04 | 5.3 | 1.15e-07 | 0.1 | FALSE |
| Adipose | Ddx23 | gene expression | Ddx23 | 0.06 | 1908 | 0.04 | 6.1e-05 | 5.24 | 1.61e-07 | 0.41 | FALSE |
| Adipose | Dip2b | gene expression | Dip2b | 0.08 | 1 | 0.09 | 3.0e-10 | -5.22 | 1.80e-07 | 0.9 | FALSE |
| Adipose | LOC134479580 | gene expression | LOC134479580 | 0.14 | 1 | 0.19 | 3.3e-20 | -5.35 | 8.76e-08 | 0.87 | FALSE |
| Adipose | Mettl7a | gene expression | Mettl7a | 0.12 | 1 | 0.15 | 3.1e-16 | 5.41 | 6.23e-08 | 0.9 | FALSE |
| Adipose | Prph | gene expression | Prph | 0.09 | 7 | 0.06 | 2.3e-07 | -5.22 | 1.79e-07 | 0.52 | FALSE |
| Adipose | Tmprss12 | gene expression | Tmprss12 | 0.07 | 1 | 0.07 | 1.1e-08 | 5.21 | 1.85e-07 | 0.76 | FALSE |
| Adipose | Atf1 | intron excision ratio | chr7_133264263_133265779 | 0.03 | 56 | 0.03 | 1.4e-04 | -5.21 | 1.86e-07 | 0.44 | TRUE |
| Adipose | Slc11a2 | intron excision ratio | chr7_133406667_133417698 | 0.02 | 1 | 0.02 | 1.4e-03 | -5.21 | 1.89e-07 | 0.05 | FALSE |
| Adipose | Bcdin3d | mRNA stability | Bcdin3d | 0.04 | 1 | 0.03 | 5.2e-04 | -5.21 | 1.84e-07 | 0.26 | FALSE |
| Adipose | Hdac7 | mRNA stability | Hdac7 | 0.19 | 2467 | 0.18 | 3.0e-19 | -5.2 | 1.95e-07 | 0.31 | FALSE |
| BLA | Tmprss12 | alternative TSS | XM_039080380.2 | 0.05 | 1 | 0.04 | 3.5e-03 | 5.27 | 1.38e-07 | 0.05 | FALSE |
| BLA | Ccdc65 | isoform ratio | XM_063263952.1 | 0.17 | 284 | 0.17 | 2.2e-09 | 5.36 | 8.38e-08 | 0.39 | TRUE |
| BLA | Letmd1 | mRNA stability | Letmd1 | 0.1 | 1 | 0.09 | 1.1e-05 | 5.35 | 8.86e-08 | 0.71 | FALSE |
| Brain | Adcy6 | alternative polyA | NM_001270785.1 | 0.08 | 63 | 0.07 | 6.6e-07 | 5.44 | 5.21e-08 | 0.47 | FALSE |
| Brain | Adcy6 | alternative polyA | XM_017594670.3 | 0.08 | 63 | 0.06 | 1.0e-06 | -5.44 | 5.38e-08 | 0.47 | FALSE |
| Brain | Ccdc65 | alternative polyA | NM_001014203.1 | 0.19 | 1869 | 0.26 | 1.4e-24 | 5.22 | 1.83e-07 | 0.5 | FALSE |
| Brain | Ccdc65 | alternative polyA | XM_063263953.1 | 0.23 | 1869 | 0.31 | 8.3e-30 | -5.22 | 1.78e-07 | 0.54 | FALSE |
| Brain | Ccdc65 | alternative polyA | XM_063263953.1 | 0.15 | 1869 | 0.18 | 7.7e-17 | -5.24 | 1.58e-07 | 0.5 | FALSE |
| Brain | Ccdc65 | alternative polyA | XM_063263954.1 | 0.19 | 1 | 0.12 | 2.3e-11 | 5.25 | 1.48e-07 | 0.74 | FALSE |
| Brain | Cacnb3 | alternative TSS | XM_006257329.4 | 0.08 | 1 | 0.01 | 1.8e-02 | 5.21 | 1.89e-07 | 0.04 | FALSE |
| Brain | Cacnb3 | alternative TSS | XM_006257329.4 | 0.05 | 1 | 0.02 | 8.1e-03 | 5.25 | 1.50e-07 | 0.04 | FALSE |
| Brain | Kansl2 | gene expression | Kansl2 | 0.09 | 1864 | 0.12 | 3.6e-11 | 5.2 | 1.95e-07 | 0.42 | FALSE |
| Brain | Pou6f1 | gene expression | Pou6f1 | 0.69 | 23 | 0.48 | 1.0e-50 | 5.22 | 1.77e-07 | 0.86 | FALSE |
| Brain | Cacnb3 | isoform ratio | XM_006257329.4 | 0.04 | 1 | 0.02 | 3.5e-03 | 5.25 | 1.50e-07 | 0.04 | FALSE |
| Brain | Ccdc65 | isoform ratio | XM_063263953.1 | 0.59 | 107 | 0.43 | 6.4e-44 | -5.26 | 1.44e-07 | 0.65 | FALSE |
| Brain | Ccdc65 | isoform ratio | XM_063263954.1 | 0.17 | 1 | 0.16 | 2.6e-14 | 5.25 | 1.48e-07 | 0.74 | FALSE |
| Brain | Cacnb3 | intron excision ratio | chr7_131666684_131670928 | 0.04 | 1909 | 0.01 | 3.0e-02 | -5.26 | 1.42e-07 | 0.25 | FALSE |
| Brain | Kansl2 | intron excision ratio | chr7_131564177_131564722 | 0.04 | 1 | 0.03 | 5.0e-04 | -5.28 | 1.29e-07 | 0.09 | FALSE |
| Brain | Atf1 | mRNA stability | Atf1 | 0.06 | 1 | 0.06 | 2.1e-06 | 5.36 | 8.10e-08 | 0.85 | FALSE |
| Eye | Slc11a2 | alternative polyA | NM_013173.2 | 0.58 | 1 | 0.27 | 5.1e-05 | 5.36 | 8.20e-08 | 0.09 | FALSE |
| IC | Slc11a2 | alternative polyA | NM_013173.2 | 0.26 | 25 | 0.23 | 6.7e-10 | 5.4 | 6.51e-08 | 0.56 | FALSE |
| IC | Fkbp11 | gene expression | Fkbp11 | 0.09 | 225 | 0.03 | 2.0e-02 | 5.28 | 1.28e-07 | 0.32 | FALSE |
| IC | LOC134479580 | gene expression | LOC134479580 | 0.17 | 1 | 0.08 | 2.3e-04 | -5.42 | 6.01e-08 | 0.61 | FALSE |
| IC | Slc11a2 | intron excision ratio | chr7_133406667_133417698 | 0.06 | 1 | 0.07 | 8.6e-04 | -5.35 | 8.60e-08 | 0.07 | FALSE |
| IC | Mettl7a | mRNA stability | Mettl7a | 0.09 | 1 | 0.07 | 7.0e-04 | 5.33 | 9.65e-08 | 0.08 | FALSE |
| LHb | Mettl7a | alternative polyA | XM_039079337.2 | 0.14 | 1 | 0.11 | 1.6e-03 | 5.36 | 8.35e-08 | 0.07 | FALSE |
| LHb | Hdac7 | gene expression | Hdac7 | 0.5 | 250 | 0.16 | 1.0e-04 | 5.22 | 1.74e-07 | 0.28 | FALSE |
| LHb | Olr1877 | gene expression | Olr1877 | 0.12 | 1 | 0.06 | 1.2e-02 | -5.21 | 1.91e-07 | 0.05 | FALSE |
| LHb | Tmem106c | intron excision ratio | chr7_130971041_130971411 | 0.3 | 1 | 0.26 | 5.3e-07 | -5.21 | 1.91e-07 | 0.19 | FALSE |
| LHb | Tmem106c | intron excision ratio | chr7_130971041_130971447 | 0.29 | 1 | 0.25 | 1.3e-06 | 5.21 | 1.91e-07 | 0.15 | FALSE |
| Liver | Atf1 | alternative TSS | XM_039079335.2 | 0.02 | 1 | 0.01 | 3.0e-02 | -5.36 | 8.10e-08 | 0.06 | FALSE |
| Liver | Pou6f1 | alternative TSS | XM_039078245.2 | 0.06 | 1 | 0.05 | 2.8e-06 | 5.36 | 8.52e-08 | 0.86 | FALSE |
| Liver | Pou6f1 | alternative TSS | XM_063262865.1 | 0.04 | 1 | 0.03 | 1.5e-04 | 5.36 | 8.52e-08 | 0.6 | FALSE |
| Liver | Pou6f1 | alternative TSS | XM_039078245.2 | 0.04 | 1 | 0.05 | 6.4e-06 | 5.35 | 8.75e-08 | 0.8 | FALSE |
| Liver | Pou6f1 | alternative TSS | XM_063262865.1 | 0.03 | 1 | 0.03 | 2.0e-04 | 5.35 | 8.75e-08 | 0.26 | FALSE |
| Liver | Pou6f1 | alternative TSS | XM_063262866.1 | 0.02 | 1 | 0.02 | 9.2e-04 | -5.35 | 8.75e-08 | 0.08 | FALSE |
| Liver | Slc11a2 | alternative TSS | NM_001399169.1 | 0.05 | 1 | 0.06 | 1.2e-07 | -5.21 | 1.85e-07 | 0.76 | FALSE |
| Liver | C1ql4 | gene expression | C1ql4 | 0.03 | 24 | 0.01 | 8.2e-03 | -5.46 | 4.77e-08 | 0.39 | TRUE |
| Liver | Dazap2 | gene expression | Dazap2 | 0.04 | 1 | 0.03 | 6.0e-04 | 5.22 | 1.80e-07 | 0.17 | FALSE |
| Liver | Dhh | gene expression | Dhh | 0.52 | 1 | 0.39 | 4.4e-46 | 5.24 | 1.64e-07 | 0.76 | FALSE |
| Liver | Letmd1 | gene expression | Letmd1 | 0.06 | 1 | 0.05 | 5.4e-06 | 5.21 | 1.85e-07 | 0.59 | FALSE |
| Liver | LOC134479580 | gene expression | LOC134479580 | 0.38 | 1638 | 0.27 | 2.4e-29 | -5.25 | 1.49e-07 | 0.8 | FALSE |
| Liver | Slc4a8 | gene expression | Slc4a8 | 0.04 | 1 | 0.03 | 2.2e-04 | -5.35 | 8.61e-08 | 0.36 | FALSE |
| Liver | Pou6f1 | isoform ratio | XM_039078246.2 | 0.03 | 17 | 0.03 | 2.6e-04 | -5.24 | 1.61e-07 | 0.68 | TRUE |
| Liver | Tmbim6 | isoform ratio | NM_019381.2 | 0.13 | 1 | 0.12 | 1.8e-13 | -5.21 | 1.92e-07 | 0.9 | FALSE |
| Liver | Tmbim6 | isoform ratio | XM_039078437.2 | 0.14 | 1 | 0.14 | 2.8e-15 | 5.21 | 1.92e-07 | 0.9 | FALSE |
| Liver | Dazap2 | intron excision ratio | chr7_133595215_133595901 | 0.06 | 1 | 0.07 | 4.6e-08 | 5.35 | 8.87e-08 | 0.87 | FALSE |
| Liver | Dazap2 | intron excision ratio | chr7_133596146_133597663 | 0.07 | 1 | 0.07 | 2.4e-08 | -5.35 | 8.87e-08 | 0.87 | FALSE |
| NAcc | Faim2 | gene expression | Faim2 | 0.15 | 54 | 0.2 | 6.8e-29 | -5.24 | 1.59e-07 | 0.53 | FALSE |
| NAcc | Ccdc65 | intron excision ratio | chr7_131736978_131742817 | 0.14 | 180 | 0.16 | 4.3e-24 | -5.26 | 1.45e-07 | 0.46 | FALSE |
| OFC | Ccdc65 | alternative polyA | XM_063263954.1 | 0.24 | 325 | 0.21 | 1.3e-05 | 5.22 | 1.78e-07 | 0.43 | FALSE |
| OFC | Pou6f1 | gene expression | Pou6f1 | 0.44 | 1 | 0.31 | 3.3e-08 | 5.35 | 8.75e-08 | 0.68 | FALSE |
| OFC | Tmem106c | intron excision ratio | chr7_130971041_130971411 | 0.32 | 1 | 0.09 | 4.3e-03 | -5.22 | 1.79e-07 | 0.06 | FALSE |
| OFC | Tmem106c | intron excision ratio | chr7_130971041_130971447 | 0.28 | 1 | 0.08 | 7.3e-03 | 5.22 | 1.79e-07 | 0.05 | FALSE |
| PL | Pou6f1 | alternative polyA | XM_039078246.2 | 0.15 | 33 | 0.03 | 2.2e-04 | 5.35 | 8.81e-08 | 0.64 | FALSE |
| PL | Pou6f1 | alternative polyA | XM_039078247.2 | 0.19 | 39 | 0.05 | 2.2e-06 | -5.29 | 1.21e-07 | 0.65 | FALSE |
| PL | Ccdc65 | isoform ratio | XM_063263953.1 | 0.3 | 1 | 0.45 | 2.3e-54 | -5.21 | 1.89e-07 | 0.69 | FALSE |
| PL | Pou6f1 | isoform ratio | XM_017594569.3 | 0.05 | 8 | 0.02 | 1.6e-03 | 5.26 | 1.42e-07 | 0.51 | FALSE |
| pVTA | Slc11a2 | alternative polyA | NM_013173.2 | 0.25 | 39 | 0.31 | 6.0e-25 | 5.25 | 1.55e-07 | 0.6 | FALSE |
| pVTA | Ddx23 | gene expression | Ddx23 | 0.08 | 1908 | 0.06 | 7.6e-06 | 5.25 | 1.52e-07 | 0.42 | FALSE |
| pVTA | LOC134479580 | gene expression | LOC134479580 | 0.17 | 1 | 0.2 | 5.8e-16 | -5.3 | 1.17e-07 | 0.84 | FALSE |
| pVTA | Fkbp11 | isoform ratio | XM_006257344.5 | 0.06 | 1800 | 0.04 | 2.3e-04 | 5.22 | 1.79e-07 | 0.41 | FALSE |
| pVTA | Slc11a2 | isoform ratio | NM_013173.2 | 0.19 | 19 | 0.24 | 3.6e-19 | 5.3 | 1.16e-07 | 0.58 | FALSE |
| RMTg | Mettl7a | gene expression | Mettl7a | 0.27 | 1 | 0.25 | 3.0e-07 | 5.36 | 8.35e-08 | 0.55 | FALSE |