Best TWAS P=2.70e-08 · Best GWAS P=3.33e-08 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Plekhm3 | mRNA stability | Plekhm3 | 0.02 | 11 | 0.02 | 2.1e-03 | -5.29 | 1.26e-07 | 0.39 | FALSE |
| BLA | Cryga | gene expression | Cryga | 0.04 | 1234 | 0.03 | 1.7e-02 | -5.56 | 2.70e-08 | 0.41 | TRUE |
| Brain | Pikfyve | gene expression | Pikfyve | 0.07 | 1 | 0.05 | 8.2e-06 | 5.49 | 4.11e-08 | 0.57 | FALSE |
| Brain | Plekhm3 | gene expression | Plekhm3 | 0.04 | 1338 | 0.04 | 6.5e-05 | 5.39 | 6.90e-08 | 0.5 | FALSE |
| Brain | Cryga | intron excision ratio | chr9_66453498_66490303 | 0.04 | 1 | 0.03 | 5.8e-04 | -5.49 | 4.11e-08 | 0.1 | FALSE |
| Brain | Crygc | intron excision ratio | chr9_66453498_66490303 | 0.04 | 1 | 0.03 | 5.8e-04 | -5.49 | 4.11e-08 | 0.1 | FALSE |
| Brain | Mettl21a | mRNA stability | Mettl21a | 0.04 | 1324 | 0.04 | 1.3e-04 | 5.19 | 2.08e-07 | 0.32 | FALSE |
| Eye | Pikfyve | gene expression | Pikfyve | 0.61 | 1628 | 0.34 | 3.0e-06 | -5.56 | 2.77e-08 | 0.33 | FALSE |
| IL | Fzd5 | gene expression | Fzd5 | 0.19 | 15 | 0.08 | 6.8e-03 | -5.27 | 1.34e-07 | 0.32 | FALSE |
| LHb | Mettl21a | gene expression | Mettl21a | 0.22 | 1324 | 0.15 | 2.2e-04 | 5.23 | 1.71e-07 | 0.31 | FALSE |
| Liver | Ccnyl1 | gene expression | Ccnyl1 | 0.02 | 1306 | 0.01 | 3.3e-02 | 5.3 | 1.15e-07 | 0.29 | FALSE |
| Liver | Mettl21a | intron excision ratio | chr9_65985095_65986197 | 0.04 | 58 | 0.03 | 4.6e-04 | -5.29 | 1.21e-07 | 0.41 | FALSE |
| NAcc | LOC120094695 | gene expression | LOC120094695 | 0.19 | 53 | 0.02 | 1.4e-03 | 5.25 | 1.51e-07 | 0.45 | FALSE |
| NAcc | Plekhm3 | gene expression | Plekhm3 | 0.05 | 1338 | 0.05 | 8.9e-07 | 5.25 | 1.50e-07 | 0.53 | FALSE |
| PL | Fzd5 | gene expression | Fzd5 | 0.06 | 1274 | 0.05 | 2.0e-06 | -5.33 | 9.70e-08 | 0.47 | FALSE |
| PL | Plekhm3 | gene expression | Plekhm3 | 0.02 | 1338 | 0.02 | 3.1e-03 | 5.47 | 4.42e-08 | 0.41 | FALSE |
| PL | Cryga | intron excision ratio | chr9_66453498_66490303 | 0.02 | 1234 | 0.02 | 2.0e-03 | 5.29 | 1.20e-07 | 0.47 | FALSE |
| PL | Cryga | intron excision ratio | chr9_66486750_66490303 | 0.1 | 1234 | 0.12 | 8.0e-13 | -5.47 | 4.42e-08 | 0.55 | FALSE |
| PL | Crygc | intron excision ratio | chr9_66453498_66490303 | 0.02 | 1233 | 0.02 | 2.0e-03 | 5.3 | 1.16e-07 | 0.47 | FALSE |
| PL | Crygc | intron excision ratio | chr9_66486750_66490303 | 0.1 | 1233 | 0.12 | 8.1e-13 | -5.48 | 4.33e-08 | 0.55 | FALSE |
| PL | Idh1 | mRNA stability | Idh1 | 0.02 | 1 | 0.01 | 4.3e-02 | 5.33 | 1.01e-07 | 0.03 | FALSE |
| pVTA | Pikfyve | gene expression | Pikfyve | 0.09 | 1 | 0.1 | 6.0e-05 | 5.25 | 1.54e-07 | 0.06 | FALSE |
| pVTA | Cryga | intron excision ratio | chr9_66453498_66490303 | 0.17 | 30 | 0.21 | 1.8e-09 | 5.42 | 5.82e-08 | 0.56 | FALSE |
| pVTA | Crygc | intron excision ratio | chr9_66453498_66490303 | 0.18 | 25 | 0.21 | 1.7e-09 | 5.42 | 5.87e-08 | 0.56 | FALSE |