Best TWAS P=1.010548e-07 · Best GWAS P=8.092231e-08 conditioned to 1
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | Atp11b | mRNA stability | ENSRNOG00000052116 | 0.13 | 0.06 | blup | 1833 | 0.06 | 1.8e-07 | 5.2 | 5.3 | 1.0e-07 | 0.98 | 0.36 | 0.64 | TRUE |
| 2 | Brain | Qrfpr | mRNA stability | ENSRNOG00000014414 | 0.39 | 0.28 | lasso | 32 | 0.32 | 5.6e-30 | 4.8 | 5.3 | 1.5e-07 | 0.85 | 0.41 | 0.59 | FALSE |
| 3 | Liver | Dcun1d1 | alternative polyA | ENSRNOT00000068334 | 0.03 | 0.00 | blup | 2146 | 0.01 | 6.0e-02 | 4.9 | -5.3 | 1.1e-07 | -0.99 | 0.27 | 0.28 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.