Best TWAS P=1.448046e-08 · Best GWAS P=2.285466e-07 conditioned to 0.5683272
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | Pigb | gene expression | ENSRNOG00000059622 | 0.07 | 0.07 | enet | 22 | 0.08 | 2.2e-09 | 4.8 | -5.4 | 6.6e-08 | -0.92 | 0.33 | 0.67 | FALSE |
| 2 | Adipose | Pygo1 | gene expression | ENSRNOG00000066086 | 0.02 | 0.00 | blup | 1308 | 0.01 | 2.5e-02 | 4.8 | -5.7 | 1.4e-08 | -0.86 | 0.24 | 0.36 | TRUE |
| 3 | Brain | Pygo1 | intron excision ratio | chr8:73700709:73703207 | 0.03 | 0.01 | blup | 1348 | 0.01 | 3.0e-02 | -4.1 | -5.3 | 1.5e-07 | -0.77 | 0.43 | 0.30 | FALSE |
| 4 | Liver | Ccpg1 | gene expression | ENSRNOG00000053428 | 0.07 | 0.08 | lasso | 10 | 0.09 | 7.5e-10 | 4.6 | -5.2 | 2.0e-07 | -0.79 | 0.45 | 0.55 | FALSE |
| 5 | PL | Ccpg1 | alternative polyA | ENSRNOT00000090970 | 0.12 | 0.10 | lasso | 9 | 0.10 | 5.9e-08 | 5.1 | 5.1 | 2.9e-07 | 0.99 | 0.21 | 0.79 | FALSE |
| 6 | PL | Ccpg1 | alternative polyA | ENSRNOT00000090970 | 0.11 | 0.12 | top1 | 1 | 0.12 | 4.3e-09 | 5.1 | 5.1 | 3.4e-07 | 0.94 | 0.09 | 0.91 | FALSE |
| 7 | PL | Ccpg1 | isoform ratio | ENSRNOT00000090970 | 0.13 | 0.10 | lasso | 9 | 0.11 | 6.2e-09 | 5.1 | 5.1 | 3.2e-07 | 0.99 | 0.22 | 0.78 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.