Best TWAS P=1.97e-09 · Best GWAS P=1.08e-08 conditioned to 2.99e-01
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Ccdc85b | gene expression | Ccdc85b | 0.04 | 1 | 0.02 | 1.0e-03 | 5.31 | 1.09e-07 | 0.34 | FALSE |
| Adipose | Ehbp1l1 | gene expression | Ehbp1l1 | 0.31 | 1415 | 0.21 | 1.7e-22 | -5.57 | 2.61e-08 | 0.57 | FALSE |
| Adipose | Fosl1 | gene expression | Fosl1 | 0.08 | 43 | 0.05 | 5.7e-06 | 5.35 | 8.94e-08 | 0.86 | FALSE |
| Adipose | Naaladl1 | gene expression | Naaladl1 | 0.22 | 1 | 0.15 | 1.8e-16 | -5.37 | 8.04e-08 | 0.76 | FALSE |
| Adipose | Ovol1 | gene expression | Ovol1 | 0.12 | 1327 | 0.04 | 4.3e-05 | -5.29 | 1.25e-07 | 0.38 | FALSE |
| Adipose | Pcnx3 | gene expression | Pcnx3 | 0.13 | 1 | 0.09 | 5.9e-10 | -5.31 | 1.09e-07 | 0.71 | FALSE |
| Adipose | Cox8a | mRNA stability | Cox8a | 0.04 | 1339 | 0.02 | 5.4e-03 | 5.27 | 1.35e-07 | 0.58 | FALSE |
| Adipose | Rpl37-ps2 | mRNA stability | Rpl37-ps2 | 0.09 | 22 | 0.05 | 5.0e-06 | -5.53 | 3.22e-08 | 0.82 | FALSE |
| Adipose | Scyl1 | mRNA stability | Scyl1 | 0.15 | 1 | 0.1 | 1.9e-11 | 5.42 | 6.09e-08 | 0.8 | FALSE |
| BLA | Fermt3 | alternative polyA | XM_006230811.4 | 0.1 | 1 | 0 | 2.1e-01 | -5.24 | 1.57e-07 | 0.05 | FALSE |
| BLA | Fermt3 | alternative polyA | XM_039079706.1 | 0.11 | 1 | 0 | 1.8e-01 | 5.24 | 1.57e-07 | 0.05 | FALSE |
| BLA | Snx32 | alternative polyA | XM_039094858.1 | 0.08 | 1306 | 0.07 | 8.7e-05 | 5.41 | 6.17e-08 | 0.66 | FALSE |
| BLA | Kcnk4 | alternative TSS | XM_008760056.3 | 0.13 | 1364 | 0.08 | 3.9e-05 | -5.36 | 8.41e-08 | 0.84 | FALSE |
| BLA | Capn1 | gene expression | Capn1 | 0.24 | 4 | 0.13 | 1.2e-07 | -5.43 | 5.67e-08 | 0.67 | FALSE |
| BLA | Kcnk4 | gene expression | Kcnk4 | 0.36 | 1364 | 0.26 | 4.2e-14 | 5.37 | 7.72e-08 | 0.86 | FALSE |
| BLA | Naaladl1 | gene expression | Naaladl1 | 0.71 | 1 | 0.52 | 6.3e-32 | -5.42 | 6.09e-08 | 0.81 | FALSE |
| BLA | Ovol1 | gene expression | Ovol1 | 0.25 | 1327 | 0.13 | 1.1e-07 | -5.37 | 7.99e-08 | 0.88 | FALSE |
| BLA | Rps6ka4 | gene expression | Rps6ka4 | 0.43 | 224 | 0.25 | 7.5e-14 | -5.35 | 9.02e-08 | 0.87 | FALSE |
| BLA | Snx15 | gene expression | Snx15 | 0.12 | 117 | 0.07 | 1.7e-04 | 5.51 | 3.68e-08 | 0.73 | FALSE |
| BLA | Kcnk4 | isoform ratio | XM_008760056.3 | 0.12 | 1 | 0.1 | 8.3e-06 | 5.44 | 5.31e-08 | 0.55 | FALSE |
| BLA | Rtn3 | isoform ratio | NM_001009953.3 | 0.16 | 39 | 0.11 | 1.0e-06 | -5.22 | 1.76e-07 | 0.82 | FALSE |
| Brain | Snx32 | alternative polyA | XM_039094858.1 | 0.08 | 1 | 0.07 | 2.0e-07 | -5.46 | 4.67e-08 | 0.88 | FALSE |
| Brain | Snx32 | alternative polyA | XM_039094864.1 | 0.12 | 1 | 0.11 | 1.9e-10 | 5.61 | 2.03e-08 | 0.95 | FALSE |
| Brain | Kcnk4 | alternative TSS | XM_008760056.3 | 0.18 | 5 | 0.13 | 1.1e-11 | -5.76 | 8.34e-09 | 0.86 | FALSE |
| Brain | Kcnk4 | gene expression | Kcnk4 | 0.33 | 11 | 0.26 | 3.6e-24 | -5.77 | 7.73e-09 | 0.86 | FALSE |
| Brain | Naaladl1 | gene expression | Naaladl1 | 0.73 | 26 | 0.56 | 4.1e-62 | 5.64 | 1.69e-08 | 0.76 | FALSE |
| Brain | Rps6ka4 | gene expression | Rps6ka4 | 0.08 | 1 | 0.04 | 9.7e-05 | -5.44 | 5.31e-08 | 0.3 | FALSE |
| Brain | Sac3d1 | gene expression | Sac3d1 | 0.15 | 1636 | 0.06 | 3.2e-06 | 5.25 | 1.56e-07 | 0.84 | FALSE |
| Brain | Snx15 | gene expression | Snx15 | 0.21 | 71 | 0.17 | 1.2e-15 | 5.59 | 2.31e-08 | 0.74 | FALSE |
| Brain | Snx32 | gene expression | Snx32 | 0.14 | 147 | 0.11 | 1.8e-10 | 5.41 | 6.13e-08 | 0.72 | FALSE |
| Brain | Kcnk4 | isoform ratio | XM_008760056.3 | 0.17 | 5 | 0.12 | 3.6e-11 | -5.81 | 6.39e-09 | 0.85 | FALSE |
| Brain | Snx32 | isoform ratio | XM_341993.9 | 0.07 | 1306 | 0.07 | 6.8e-07 | -5.44 | 5.33e-08 | 0.67 | FALSE |
| Brain | Rpl37-ps2 | intron excision ratio | chr1_202839369_202840008 | 0.13 | 10 | 0.08 | 3.4e-08 | -5.5 | 3.85e-08 | 0.72 | FALSE |
| Brain | Rpl37-ps2 | intron excision ratio | chr1_202839369_202855817 | 0.12 | 2 | 0.11 | 2.9e-10 | -5.2 | 1.97e-07 | 0.72 | FALSE |
| Brain | Cox8a | mRNA stability | Cox8a | 0.12 | 10 | 0.1 | 9.2e-10 | -5.79 | 7.10e-09 | 0.89 | FALSE |
| Brain | Kcnk4 | mRNA stability | Kcnk4 | 0.12 | 6 | 0.07 | 1.7e-07 | -5.71 | 1.12e-08 | 0.82 | FALSE |
| Brain | Rpl37-ps2 | mRNA stability | Rpl37-ps2 | 0.33 | 142 | 0.22 | 1.5e-20 | 5.56 | 2.63e-08 | 0.72 | FALSE |
| Brain | Snx32 | mRNA stability | Snx32 | 0.06 | 1 | 0.04 | 6.2e-05 | 5.39 | 7.04e-08 | 0.49 | FALSE |
| Eye | Kcnk4 | gene expression | Kcnk4 | 0.53 | 10 | 0.09 | 1.8e-02 | 5.73 | 1.03e-08 | 0.13 | FALSE |
| IL | Naaladl1 | gene expression | Naaladl1 | 0.67 | 1 | 0.21 | 9.4e-06 | -5.22 | 1.78e-07 | 0.18 | FALSE |
| IL | Ovol1 | gene expression | Ovol1 | 0.33 | 1 | 0.14 | 3.6e-04 | 5.39 | 6.87e-08 | 0.09 | FALSE |
| IL | Rps6ka4 | gene expression | Rps6ka4 | 0.19 | 304 | 0.08 | 5.0e-03 | -5.5 | 3.76e-08 | 0.32 | FALSE |
| LHb | Fermt3 | alternative TSS | NM_001127543.1 | 0.2 | 75 | 0.12 | 9.0e-04 | -5.21 | 1.90e-07 | 0.02 | FALSE |
| LHb | Flrt1 | gene expression | Flrt1 | 0.4 | 1 | 0.19 | 3.2e-05 | 5.36 | 8.38e-08 | 0.08 | FALSE |
| LHb | Naaladl1 | gene expression | Naaladl1 | 0.2 | 54 | 0.11 | 1.3e-03 | -5.39 | 7.13e-08 | 0.56 | FALSE |
| LHb | Snx15 | gene expression | Snx15 | 0.72 | 5 | 0.12 | 7.2e-04 | -5.32 | 1.06e-07 | 0.6 | FALSE |
| Liver | Otub1 | gene expression | Otub1 | 0.33 | 22 | 0.23 | 2.1e-25 | -5.54 | 3.00e-08 | 0.88 | FALSE |
| Liver | Macrod1 | mRNA stability | Macrod1 | 0.06 | 1 | 0.04 | 5.2e-05 | 5.45 | 4.96e-08 | 0.28 | FALSE |
| Liver | Pcnx3 | mRNA stability | Pcnx3 | 0.05 | 1404 | 0.02 | 1.2e-03 | -5.68 | 1.36e-08 | 0.82 | FALSE |
| NAcc | Syvn1 | alternative TSS | XM_006230852.4 | 0.02 | 7 | 0.01 | 6.5e-03 | 5.61 | 1.97e-08 | 0.62 | FALSE |
| NAcc | Naaladl1 | gene expression | Naaladl1 | 0.67 | 19 | 0.49 | 1.5e-64 | 5.42 | 6.12e-08 | 0.76 | FALSE |
| NAcc | Sac3d1 | gene expression | Sac3d1 | 0.39 | 1 | 0.25 | 6.2e-29 | -5.43 | 5.64e-08 | 0.82 | FALSE |
| NAcc | Macrod1 | isoform ratio | NM_139337.2 | 0.03 | 1347 | 0.02 | 3.8e-03 | -5.2 | 1.99e-07 | 0.7 | FALSE |
| NAcc | Snx32 | isoform ratio | XM_039094858.1 | 0.12 | 1306 | 0.11 | 1.9e-12 | 5.21 | 1.92e-07 | 0.57 | FALSE |
| NAcc | Rpl37-ps2 | intron excision ratio | chr1_202839369_202840008 | 0.08 | 1 | 0.05 | 4.2e-06 | -5.34 | 9.11e-08 | 0.78 | FALSE |
| NAcc | Rpl37-ps2 | intron excision ratio | chr1_202839369_202855814 | 0.04 | 1313 | 0.02 | 4.3e-03 | -5.37 | 7.74e-08 | 0.77 | FALSE |
| NAcc | Naaladl1 | mRNA stability | Naaladl1 | 0.06 | 33 | 0.06 | 4.5e-07 | -5.95 | 2.73e-09 | 0.79 | FALSE |
| NAcc | Otub1 | mRNA stability | Otub1 | 0.08 | 1 | 0.06 | 1.6e-07 | -5.31 | 1.08e-07 | 0.71 | FALSE |
| NAcc | Rpl37-ps2 | mRNA stability | Rpl37-ps2 | 0.12 | 62 | 0.12 | 1.2e-13 | 5.61 | 2.02e-08 | 0.67 | FALSE |
| OFC | Kcnk4 | gene expression | Kcnk4 | 0.34 | 24 | 0.13 | 4.5e-04 | 5.36 | 8.46e-08 | 0.58 | FALSE |
| OFC | Naaladl1 | gene expression | Naaladl1 | 0.61 | 1 | 0.25 | 1.3e-06 | -5.22 | 1.78e-07 | 0.12 | FALSE |
| OFC | Ovol1 | gene expression | Ovol1 | 0.34 | 1 | 0.17 | 6.3e-05 | 5.21 | 1.84e-07 | 0.07 | FALSE |
| PL | Macrod1 | alternative polyA | XM_039099901.1 | 0.05 | 1 | 0.02 | 1.6e-03 | -5.72 | 1.08e-08 | 0.22 | FALSE |
| PL | Naa40 | alternative polyA | NM_001108518.1 | 0.06 | 1 | 0.05 | 3.6e-06 | -5.4 | 6.72e-08 | 0.68 | FALSE |
| PL | Naa40 | alternative polyA | XM_039084082.1 | 0.06 | 1 | 0.05 | 1.7e-06 | 5.4 | 6.72e-08 | 0.73 | FALSE |
| PL | Naa40 | alternative polyA | NM_001108518.1 | 0.06 | 1 | 0.05 | 2.6e-06 | -5.4 | 6.72e-08 | 0.71 | FALSE |
| PL | Naa40 | alternative polyA | XM_039084072.1 | 0.06 | 1 | 0.05 | 1.5e-06 | 5.4 | 6.72e-08 | 0.74 | FALSE |
| PL | Arl2 | alternative TSS | XM_006230899.3 | 0.03 | 1 | 0.01 | 8.7e-03 | 5.42 | 6.09e-08 | 0.04 | FALSE |
| PL | Kcnk4 | alternative TSS | XM_008760056.3 | 0.12 | 6 | 0.11 | 8.6e-12 | -5.59 | 2.22e-08 | 0.87 | FALSE |
| PL | Kcnk4 | alternative TSS | NM_053804.3 | 0.13 | 1364 | 0.1 | 1.4e-10 | 5.21 | 1.86e-07 | 0.88 | FALSE |
| PL | Kcnk4 | alternative TSS | XM_008760055.3 | 0.12 | 1364 | 0.09 | 2.4e-10 | -5.22 | 1.81e-07 | 0.88 | FALSE |
| PL | Catsperz | gene expression | Catsperz | 0.05 | 1 | 0.02 | 2.8e-03 | -5.29 | 1.19e-07 | 0.09 | FALSE |
| PL | Efemp2 | gene expression | Efemp2 | 0.05 | 1 | 0.05 | 4.0e-06 | -5.39 | 7.04e-08 | 0.88 | FALSE |
| PL | Kcnk4 | gene expression | Kcnk4 | 0.19 | 1364 | 0.14 | 1.9e-15 | 5.49 | 4.10e-08 | 0.86 | FALSE |
| PL | Naaladl1 | gene expression | Naaladl1 | 0.67 | 46 | 0.51 | 2.1e-65 | 5.45 | 5.07e-08 | 0.76 | FALSE |
| PL | Ovol1 | gene expression | Ovol1 | 0.31 | 14 | 0.28 | 3.0e-31 | -5.46 | 4.77e-08 | 0.7 | FALSE |
| PL | Pcnx3 | gene expression | Pcnx3 | 0.06 | 65 | 0.04 | 5.4e-05 | -6 | 1.97e-09 | 0.83 | TRUE |
| PL | Rps6ka4 | gene expression | Rps6ka4 | 0.18 | 1 | 0.12 | 2.7e-13 | -5.53 | 3.16e-08 | 0.89 | FALSE |
| PL | Yif1a | gene expression | Yif1a | 0.05 | 1 | 0.03 | 1.4e-04 | 5.34 | 9.11e-08 | 0.82 | FALSE |
| PL | Kcnk4 | isoform ratio | XM_008760056.3 | 0.1 | 4 | 0.09 | 2.2e-10 | -5.49 | 4.07e-08 | 0.84 | FALSE |
| PL | Snx32 | isoform ratio | XM_341993.9 | 0.02 | 1306 | 0.02 | 2.6e-03 | -5.3 | 1.19e-07 | 0.53 | FALSE |
| PL | Kcnk4 | intron excision ratio | chr1_204120828_204124788 | 0.04 | 1 | 0.02 | 1.2e-03 | -5.29 | 1.21e-07 | 0.11 | FALSE |
| PL | Nrxn2 | intron excision ratio | chr1_203763525_203780407 | 0.03 | 1 | 0.01 | 2.5e-02 | 5.45 | 4.96e-08 | 0.07 | FALSE |
| PL | Rpl37-ps2 | intron excision ratio | chr1_202839369_202840008 | 0.32 | 28 | 0.22 | 9.2e-24 | 5.26 | 1.45e-07 | 0.73 | FALSE |
| PL | Scyl1 | mRNA stability | Scyl1 | 0.04 | 1 | 0.02 | 1.5e-03 | -5.38 | 7.54e-08 | 0.12 | FALSE |
| pVTA | Snx32 | alternative polyA | XM_039094829.1 | 0.1 | 1306 | 0.05 | 4.1e-03 | 5.38 | 7.41e-08 | 0.65 | FALSE |
| pVTA | Snx32 | alternative polyA | XM_341993.9 | 0.15 | 1 | 0.09 | 9.0e-05 | 5.18 | 2.27e-07 | 0.19 | FALSE |
| pVTA | Fosl1 | gene expression | Fosl1 | 0.41 | 128 | 0.21 | 1.4e-09 | 5.19 | 2.06e-07 | 0.82 | FALSE |
| pVTA | Naaladl1 | gene expression | Naaladl1 | 0.45 | 1 | 0.25 | 3.3e-11 | -5.68 | 1.36e-08 | 0.95 | FALSE |
| pVTA | Snx15 | gene expression | Snx15 | 0.56 | 11 | 0.2 | 6.8e-09 | -5.41 | 6.19e-08 | 0.79 | FALSE |
| pVTA | Snx32 | gene expression | Snx32 | 0.14 | 1 | 0.05 | 2.3e-03 | -5.61 | 2.03e-08 | 0.61 | FALSE |
| pVTA | Rpl37-ps2 | intron excision ratio | chr1_202839369_202840008 | 0.15 | 1313 | 0.07 | 4.6e-04 | 5.24 | 1.65e-07 | 0.82 | FALSE |
| pVTA | Rpl37-ps2 | intron excision ratio | chr1_202839369_202855817 | 0.17 | 1 | 0.16 | 2.2e-07 | 5.18 | 2.18e-07 | 0.48 | FALSE |
| RMTg | Znrd2 | isoform ratio | NM_001109537.2 | 0.25 | 54 | 0.13 | 2.3e-04 | -5.38 | 7.65e-08 | 0.68 | FALSE |
| RMTg | Sipa1 | mRNA stability | Sipa1 | 0.16 | 1376 | 0.1 | 1.7e-03 | -5.29 | 1.25e-07 | 0.52 | FALSE |