Best TWAS P=2.52e-14 · Best GWAS P=2.43e-12 conditioned to NaN
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | N4bp2l2 | alternative polyA | ENSRNOT00000001468 | 0.04 | 681 | 0.01 | 6.8e-02 | 5.27 | 1.34e-07 | 0.68 | FALSE |
| Adipose | N4bp2l2 | alternative polyA | ENSRNOT00000111844 | 0.14 | 1 | 0.12 | 7.1e-13 | 5.71 | 1.10e-08 | 0.98 | FALSE |
| Adipose | N4bp2l2 | alternative polyA | ENSRNOT00000118063 | 0.14 | 1 | 0.12 | 3.9e-13 | -5.71 | 1.10e-08 | 0.98 | FALSE |
| Adipose | B3glct | alternative polyA | ENSRNOT00000116254 | 0.06 | 18 | 0.03 | 1.9e-04 | -5.39 | 7.13e-08 | 0.2 | TRUE |
| Adipose | Pet100 | alternative TSS | ENSRNOT00000071928 | 0.22 | 116 | 0.13 | 3.4e-14 | 5.62 | 1.93e-08 | 0.79 | FALSE |
| Adipose | Pet100 | alternative TSS | ENSRNOT00000107172 | 0.22 | 122 | 0.13 | 2.6e-14 | -5.64 | 1.69e-08 | 0.78 | FALSE |
| Adipose | Fry | gene expression | ENSRNOG00000000894 | 0.24 | 14 | 0.24 | 2.4e-26 | -6.69 | 2.28e-11 | 0.24 | FALSE |
| Adipose | Hsph1 | gene expression | ENSRNOG00000000902 | 0.56 | 55 | 0.22 | 1.8e-24 | -6.47 | 9.59e-11 | 0.57 | FALSE |
| Adipose | Trappc5 | gene expression | ENSRNOG00000001003 | 0.09 | 1 | 0.03 | 9.9e-05 | -5.72 | 1.08e-08 | 0.48 | TRUE |
| Adipose | Evi5l | gene expression | ENSRNOG00000001034 | 0.09 | 1 | -0 | 4.2e-01 | 5.3 | 1.15e-07 | 0.07 | FALSE |
| Adipose | N4bp2l1 | gene expression | ENSRNOG00000059322 | 0.32 | 16 | 0.24 | 1.2e-26 | -5.93 | 2.98e-09 | 0.98 | FALSE |
| Adipose | Pet100 | isoform ratio | ENSRNOT00000071928 | 0.23 | 64 | 0.13 | 1.8e-14 | 5.66 | 1.49e-08 | 0.84 | FALSE |
| Adipose | Pet100 | isoform ratio | ENSRNOT00000107172 | 0.23 | 66 | 0.13 | 2.6e-14 | -5.64 | 1.65e-08 | 0.85 | FALSE |
| Adipose | Zfp958 | isoform ratio | ENSRNOT00000102786 | 0.03 | 169 | 0.01 | 6.9e-03 | 5.37 | 8.08e-08 | 0.3 | FALSE |
| Adipose | Zfp958 | intron excision ratio | chr12:3971128:3971331 | 0.03 | 1113 | 0.01 | 2.8e-02 | 5.15 | 2.58e-07 | 0.14 | FALSE |
| Adipose | Fry | mRNA stability | ENSRNOG00000000894 | 0.08 | 2970 | 0.05 | 2.0e-06 | -6.15 | 7.51e-10 | 0.17 | FALSE |
| Adipose | Snapc2 | mRNA stability | ENSRNOG00000001056 | 0.11 | 19 | 0.01 | 5.0e-02 | -5.41 | 6.34e-08 | 0.36 | FALSE |
| Adipose | Elavl1 | mRNA stability | ENSRNOG00000001069 | 0.16 | 2406 | 0.07 | 9.4e-09 | 5.1 | 3.35e-07 | 0.25 | FALSE |
| BLA | N4bp2l1 | gene expression | ENSRNOG00000059322 | 0.13 | 1 | 0.08 | 5.7e-05 | -5.2 | 1.94e-07 | 0.26 | FALSE |
| BLA | ENSRNOG00000065898 | gene expression | ENSRNOG00000065898 | 0.1 | 20 | 0.03 | 8.9e-03 | -6.76 | 1.42e-11 | 0.08 | FALSE |
| BLA | AABR07035218.1 | intron excision ratio | chr12:5973104:5975080 | 0.09 | 2412 | 0.04 | 4.3e-03 | -5.1 | 3.36e-07 | 0.26 | FALSE |
| BLA | Insr | intron excision ratio | chr12:1257822:1307450 | 0.67 | 213 | 0.35 | 9.1e-20 | 5.57 | 2.58e-08 | 0.9 | FALSE |
| BLA | Pet100 | intron excision ratio | chr12:1680794:1680963 | 0.36 | 13 | 0.19 | 1.7e-10 | -5.52 | 3.32e-08 | 0.85 | FALSE |
| BLA | Pet100 | intron excision ratio | chr12:1680995:1681508 | 0.35 | 11 | 0.2 | 9.8e-11 | 5.49 | 4.13e-08 | 0.84 | FALSE |
| BLA | Fry | mRNA stability | ENSRNOG00000000894 | 0.13 | 2972 | 0.11 | 2.1e-06 | -5.17 | 2.28e-07 | 0.04 | FALSE |
| BLA | Insr | mRNA stability | ENSRNOG00000029986 | 0.74 | 153 | 0.48 | 1.6e-28 | 5.56 | 2.64e-08 | 0.9 | FALSE |
| Brain | Zfp958 | alternative polyA | ENSRNOT00000102786 | 0.06 | 10 | 0.06 | 7.8e-06 | 5.12 | 3.07e-07 | 0.81 | FALSE |
| Brain | Fry | alternative TSS | ENSRNOT00000076483 | 0.03 | 6 | 0.02 | 2.9e-03 | 5.11 | 3.30e-07 | 0.25 | FALSE |
| Brain | Fry | alternative TSS | ENSRNOT00000076483 | 0.03 | 6 | 0.02 | 2.6e-03 | 5.11 | 3.18e-07 | 0.25 | FALSE |
| Brain | Zfp958 | alternative TSS | ENSRNOT00000103468 | 0.17 | 1115 | 0.13 | 7.5e-12 | 5.45 | 5.01e-08 | 0.83 | FALSE |
| Brain | Zfp958 | alternative TSS | ENSRNOT00000104360 | 0.17 | 14 | 0.13 | 1.0e-11 | -5.46 | 4.80e-08 | 0.83 | FALSE |
| Brain | Rxfp2 | gene expression | ENSRNOG00000000897 | 0.13 | 3311 | 0.12 | 3.5e-11 | -6.41 | 1.45e-10 | 0.53 | FALSE |
| Brain | Arhgef18 | gene expression | ENSRNOG00000028090 | 0.12 | 11 | 0.08 | 1.2e-07 | -5.47 | 4.54e-08 | 0.78 | FALSE |
| Brain | N4bp2l1 | gene expression | ENSRNOG00000059322 | 0.06 | 2 | 0.05 | 3.5e-05 | -5.81 | 6.18e-09 | 0.97 | FALSE |
| Brain | ENSRNOG00000065898 | gene expression | ENSRNOG00000065898 | 0.05 | 1 | 0.06 | 4.8e-06 | -5.97 | 2.40e-09 | 0.03 | FALSE |
| Brain | Rxfp2 | intron excision ratio | chr12:4945988:4950591 | 0.07 | 6 | 0.02 | 7.0e-03 | -6.64 | 3.11e-11 | 0.68 | FALSE |
| Brain | Rxfp2 | intron excision ratio | chr12:4945988:4950702 | 0.05 | 5 | 0.02 | 7.8e-03 | 6.68 | 2.38e-11 | 0.66 | FALSE |
| Brain | Trappc5 | intron excision ratio | chr12:1737769:1740114 | 0.05 | 18 | 0.03 | 5.1e-04 | -5.78 | 7.26e-09 | 0.42 | FALSE |
| Brain | Insr | intron excision ratio | chr12:1257822:1307450 | 0.63 | 224 | 0.46 | 1.8e-47 | 5.61 | 2.00e-08 | 0.9 | FALSE |
| Brain | Insr | mRNA stability | ENSRNOG00000029986 | 0.72 | 150 | 0.6 | 8.8e-69 | 5.64 | 1.73e-08 | 0.9 | FALSE |
| Brain | Katnal1 | mRNA stability | ENSRNOG00000047618 | 0.33 | 2320 | 0.32 | 2.0e-30 | -5.32 | 1.01e-07 | 0.09 | FALSE |
| Brain | B3glct | mRNA stability | ENSRNOG00000061346 | 0.18 | 3 | 0.24 | 1.6e-22 | 5.43 | 5.68e-08 | 0 | FALSE |
| Eye | Fry | gene expression | ENSRNOG00000000894 | 0.41 | 2972 | 0.18 | 9.6e-04 | -6.27 | 3.56e-10 | 0.27 | FALSE |
| Eye | Elavl1 | intron excision ratio | chr12:2667464:2684652 | 0.69 | 30 | 0.31 | 1.3e-05 | 5.68 | 1.33e-08 | 0.57 | FALSE |
| IL | AABR07035218.1 | alternative polyA | ENSRNOT00000098255 | 0.15 | 2409 | 0.04 | 3.7e-02 | -5.34 | 9.29e-08 | 0.62 | FALSE |
| IL | Snapc2 | gene expression | ENSRNOG00000001056 | 0.35 | 5 | 0.03 | 8.2e-02 | -5.32 | 1.06e-07 | 0.3 | FALSE |
| IL | Insr | intron excision ratio | chr12:1257822:1307450 | 0.73 | 1 | 0.5 | 6.5e-14 | 5.4 | 6.79e-08 | 0.66 | FALSE |
| IL | Fry | mRNA stability | ENSRNOG00000000894 | 0.16 | 2960 | 0.11 | 1.7e-03 | -6.35 | 2.19e-10 | 0.18 | FALSE |
| IL | Pds5b | mRNA stability | ENSRNOG00000001098 | 0.19 | 795 | 0.11 | 1.5e-03 | 5.57 | 2.50e-08 | 0.66 | FALSE |
| IL | Katnal1 | mRNA stability | ENSRNOG00000047618 | 0.13 | 1 | 0.09 | 4.4e-03 | -5.17 | 2.39e-07 | 0.05 | FALSE |
| LHb | Rxfp2 | gene expression | ENSRNOG00000000897 | 0.27 | 9 | 0.22 | 4.8e-06 | -6.7 | 2.06e-11 | 0.6 | FALSE |
| LHb | Zfp958l1 | mRNA stability | ENSRNOG00000000891 | 0.41 | 1952 | 0.17 | 8.6e-05 | 5.11 | 3.15e-07 | 0.46 | FALSE |
| LHb | Fry | mRNA stability | ENSRNOG00000000894 | 0.34 | 2959 | 0.27 | 3.7e-07 | -5.41 | 6.47e-08 | 0.1 | FALSE |
| LHb | Brca2 | mRNA stability | ENSRNOG00000001111 | 0.19 | 1 | 0.12 | 9.6e-04 | 5.51 | 3.63e-08 | 0.1 | FALSE |
| LHb | Insr | mRNA stability | ENSRNOG00000029986 | 0.59 | 12 | 0.38 | 7.2e-10 | 5.2 | 2.04e-07 | 0.89 | FALSE |
| Liver | N4bp2l2 | alternative polyA | ENSRNOT00000118063 | 0.1 | 681 | 0.07 | 1.5e-08 | -5.09 | 3.54e-07 | 0.26 | FALSE |
| Liver | Mcoln1 | gene expression | ENSRNOG00000000975 | 0.09 | 39 | 0.04 | 1.7e-05 | 5.7 | 1.22e-08 | 0.89 | FALSE |
| Liver | Timm44 | gene expression | ENSRNOG00000001058 | 0.11 | 10 | 0.04 | 7.4e-05 | 5.13 | 2.97e-07 | 0.34 | FALSE |
| Liver | Brca2 | gene expression | ENSRNOG00000001111 | 0.04 | 1 | 0.02 | 1.7e-03 | 5.2 | 1.94e-07 | 0.06 | TRUE |
| Liver | N4bp2l1 | gene expression | ENSRNOG00000059322 | 0.21 | 107 | 0.16 | 2.5e-17 | -5.39 | 6.92e-08 | 0.97 | FALSE |
| Liver | Zfp958 | gene expression | ENSRNOG00000065430 | 0.24 | 1 | 0.05 | 7.2e-06 | 5.13 | 2.87e-07 | 0.69 | FALSE |
| Liver | Stxbp2 | isoform ratio | ENSRNOT00000107607 | 0.15 | 10 | 0.09 | 5.9e-10 | -5.36 | 8.17e-08 | 0.65 | FALSE |
| Liver | Zfp958l1 | intron excision ratio | chr12:4420448:4438512 | 0.04 | 55 | 0.03 | 2.6e-04 | 6.14 | 8.26e-10 | 0.02 | FALSE |
| Liver | AABR07035218.1 | intron excision ratio | chr12:5974685:5975080 | 0.13 | 1 | 0.11 | 4.1e-12 | 5.23 | 1.71e-07 | 0.11 | FALSE |
| Liver | Insr | intron excision ratio | chr12:1257822:1307450 | 0.44 | 94 | 0.21 | 3.2e-23 | 5.63 | 1.75e-08 | 0.91 | FALSE |
| Liver | Zfp958 | intron excision ratio | chr12:3953566:3958666 | 0.03 | 1113 | 0.01 | 1.1e-02 | -5.63 | 1.79e-08 | 0.39 | FALSE |
| Liver | Zfp958l1 | mRNA stability | ENSRNOG00000000891 | 0.23 | 1965 | 0.17 | 1.8e-18 | 5.61 | 1.98e-08 | 0.7 | FALSE |
| Liver | Hsph1 | mRNA stability | ENSRNOG00000000902 | 0.02 | 1 | 0.02 | 2.5e-03 | -6.1 | 1.04e-09 | 0.03 | FALSE |
| Liver | N4bp2l2 | mRNA stability | ENSRNOG00000001108 | 0.03 | 1 | 0.02 | 2.0e-03 | 5.81 | 6.21e-09 | 0.41 | FALSE |
| Liver | AABR07035218.1 | mRNA stability | ENSRNOG00000029813 | 0.53 | 2412 | 0.38 | 6.3e-45 | 5.47 | 4.47e-08 | 0.13 | FALSE |
| Liver | Insr | mRNA stability | ENSRNOG00000029986 | 0.69 | 78 | 0.41 | 3.0e-48 | 5.29 | 1.25e-07 | 0.91 | FALSE |
| NAcc | Zfp958l1 | alternative TSS | ENSRNOT00000035992 | 0.05 | 1 | 0.05 | 1.4e-04 | -5.13 | 2.87e-07 | 0.03 | FALSE |
| NAcc | Zfp958l1 | alternative TSS | ENSRNOT00000119165 | 0.05 | 1 | 0.05 | 1.8e-04 | 5.13 | 2.87e-07 | 0.03 | FALSE |
| NAcc | Pet100 | alternative TSS | ENSRNOT00000071928 | 0.08 | 1 | 0.03 | 1.4e-03 | 5.65 | 1.58e-08 | 0.26 | FALSE |
| NAcc | Rxfp2 | gene expression | ENSRNOG00000000897 | 0.08 | 3309 | 0.06 | 1.4e-05 | -6.25 | 4.12e-10 | 0.08 | FALSE |
| NAcc | Alox5ap | gene expression | ENSRNOG00000000907 | 0.06 | 1 | 0.06 | 1.3e-05 | -6.41 | 1.46e-10 | 0.84 | FALSE |
| NAcc | Stxbp2 | gene expression | ENSRNOG00000000994 | 0.1 | 1 | 0.07 | 9.6e-06 | -5.65 | 1.58e-08 | 0.52 | FALSE |
| NAcc | Cers4 | gene expression | ENSRNOG00000001072 | 0.27 | 26 | 0.27 | 5.9e-20 | 5.59 | 2.26e-08 | 0.59 | FALSE |
| NAcc | Lrrc8e | gene expression | ENSRNOG00000028460 | 0.31 | 12 | 0.07 | 1.2e-05 | -5.73 | 1.03e-08 | 0.96 | FALSE |
| NAcc | Zfp958l1 | isoform ratio | ENSRNOT00000035992 | 0.08 | 1 | 0.07 | 9.5e-06 | -5.13 | 2.87e-07 | 0.03 | FALSE |
| NAcc | Zfp958l1 | isoform ratio | ENSRNOT00000119165 | 0.08 | 1 | 0.06 | 1.4e-05 | 5.13 | 2.87e-07 | 0.03 | TRUE |
| NAcc | Trappc5 | isoform ratio | ENSRNOT00000001327 | 0.11 | 38 | 0.04 | 2.9e-04 | -5.66 | 1.48e-08 | 0.86 | FALSE |
| NAcc | Trappc5 | isoform ratio | ENSRNOT00000111016 | 0.09 | 29 | 0.03 | 5.1e-03 | 5.76 | 8.59e-09 | 0.84 | FALSE |
| NAcc | Insr | intron excision ratio | chr12:1257822:1307450 | 0.43 | 192 | 0.25 | 2.2e-18 | 5.55 | 2.87e-08 | 0.9 | FALSE |
| NAcc | Fry | mRNA stability | ENSRNOG00000000894 | 0.11 | 1 | 0.12 | 4.3e-09 | -6.14 | 8.07e-10 | 0.09 | FALSE |
| NAcc | Snapc2 | mRNA stability | ENSRNOG00000001056 | 0.13 | 1 | 0.06 | 1.3e-05 | -5.31 | 1.11e-07 | 0.9 | FALSE |
| NAcc | Brca2 | mRNA stability | ENSRNOG00000001111 | 0.14 | 42 | 0.09 | 4.2e-07 | 5.68 | 1.36e-08 | 0.96 | FALSE |
| NAcc | Insr | mRNA stability | ENSRNOG00000029986 | 0.37 | 29 | 0.23 | 1.8e-17 | 5.73 | 1.02e-08 | 0.9 | FALSE |
| OFC | AABR07035218.1 | alternative polyA | ENSRNOT00000098255 | 0.19 | 2409 | 0.06 | 1.7e-02 | -5.79 | 7.14e-09 | 0.58 | FALSE |
| OFC | AABR07035218.1 | alternative polyA | ENSRNOT00000089476 | 0.17 | 2409 | 0.06 | 1.3e-02 | 5.33 | 1.01e-07 | 0.5 | FALSE |
| OFC | AABR07035218.1 | alternative polyA | ENSRNOT00000098255 | 0.23 | 2409 | 0.12 | 9.8e-04 | -5.53 | 3.14e-08 | 0.57 | FALSE |
| OFC | Rxfp2 | gene expression | ENSRNOG00000000897 | 0.67 | 28 | 0.29 | 1.1e-07 | -6.19 | 6.00e-10 | 0.02 | FALSE |
| OFC | Hsph1 | gene expression | ENSRNOG00000000902 | 0.12 | 1 | 0.09 | 3.1e-03 | 6.84 | 7.97e-12 | 0.11 | FALSE |
| OFC | Stxbp2 | gene expression | ENSRNOG00000000994 | 0.43 | 1 | 0.14 | 2.8e-04 | -5.63 | 1.84e-08 | 0.09 | FALSE |
| OFC | Snapc2 | gene expression | ENSRNOG00000001056 | 0.54 | 2272 | 0.12 | 1.0e-03 | -5.94 | 2.90e-09 | 0.41 | FALSE |
| OFC | B3glct | gene expression | ENSRNOG00000061346 | 0.36 | 2634 | 0.45 | 5.9e-12 | 5.71 | 1.12e-08 | 0.46 | FALSE |
| OFC | ENSRNOG00000069263 | gene expression | ENSRNOG00000069263 | 0.24 | 1 | 0.12 | 1.0e-03 | -5.14 | 2.81e-07 | 0.05 | FALSE |
| OFC | Insr | intron excision ratio | chr12:1257822:1307450 | 0.64 | 1 | 0.28 | 2.2e-07 | 5.4 | 6.79e-08 | 0.41 | FALSE |
| OFC | Zfp958l1 | mRNA stability | ENSRNOG00000000891 | 0.45 | 20 | 0.2 | 2.2e-05 | -7.62 | 2.52e-14 | 0.44 | TRUE |
| OFC | Fry | mRNA stability | ENSRNOG00000000894 | 0.3 | 1 | 0.25 | 1.6e-06 | -6.1 | 1.06e-09 | 0.05 | FALSE |
| OFC | Insr | mRNA stability | ENSRNOG00000029986 | 0.82 | 1 | 0.37 | 1.0e-09 | 5.66 | 1.55e-08 | 0.86 | FALSE |
| PL | Zfp958 | alternative TSS | ENSRNOT00000104360 | 0.1 | 1 | 0.05 | 1.1e-04 | -5.23 | 1.73e-07 | 0.43 | FALSE |
| PL | Stxbp2 | gene expression | ENSRNOG00000000994 | 0.13 | 1819 | 0.06 | 2.6e-05 | -5.35 | 8.68e-08 | 0.21 | FALSE |
| PL | ENSRNOG00000067247 | gene expression | ENSRNOG00000067247 | 0.1 | 2289 | 0.07 | 3.7e-06 | 5.76 | 8.41e-09 | 0.84 | FALSE |
| PL | Insr | intron excision ratio | chr12:1257822:1307450 | 0.58 | 216 | 0.38 | 1.3e-30 | 5.47 | 4.55e-08 | 0.9 | FALSE |
| PL | Fry | mRNA stability | ENSRNOG00000000894 | 0.17 | 5 | 0.13 | 2.6e-10 | -5.88 | 4.19e-09 | 0.08 | FALSE |
| PL | Insr | mRNA stability | ENSRNOG00000029986 | 0.65 | 32 | 0.49 | 2.3e-42 | 5.74 | 9.57e-09 | 0.9 | FALSE |
| PL | Katnal1 | mRNA stability | ENSRNOG00000047618 | 0.09 | 5 | 0.09 | 5.0e-07 | -5.56 | 2.77e-08 | 0.8 | FALSE |
| PL | B3glct | mRNA stability | ENSRNOG00000061346 | 0.18 | 207 | 0.08 | 1.8e-06 | 5.16 | 2.52e-07 | 0.2 | TRUE |