Best TWAS P = 5.78e-10 · Best GWAS P= 2.69e-14 conditioned to 1.73e-03
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Nr2c1 | alternative polyA | NM_145780.2 | 0.04 | 2860 | 0.03 | 2.0e-04 | -5.24 | 1.56e-07 | 0.15 | FALSE |
| Adipose | Nr2c1 | alternative polyA | XM_039078458.1 | 0.04 | 2860 | 0.03 | 2.5e-04 | 5.21 | 1.92e-07 | 0.14 | FALSE |
| Adipose | Vezt | gene expression | Vezt | 0.1 | 1 | 0.08 | 3.4e-09 | 5.45 | 5.13e-08 | 0.44 | FALSE |
| Adipose | Nr2c1 | isoform ratio | XM_039078459.2 | 0.02 | 2860 | 0.01 | 1.6e-02 | 5.38 | 7.38e-08 | 0.12 | FALSE |
| BLA | Plxnc1 | alternative polyA | NM_001426988.1 | 0.09 | 6 | 0.06 | 6.8e-04 | 5.23 | 1.67e-07 | 0.18 | FALSE |
| BLA | Fgd6 | gene expression | Fgd6 | 0.08 | 1 | 0.09 | 1.9e-05 | 5.89 | 3.79e-09 | 0.79 | FALSE |
| BLA | Metap2 | gene expression | Metap2 | 0.1 | 9 | 0.09 | 2.5e-05 | 5.63 | 1.83e-08 | 0.47 | FALSE |
| BLA | Mir331 | gene expression | Mir331 | 0.06 | 14 | 0.07 | 1.2e-04 | 5.36 | 8.27e-08 | 0.33 | FALSE |
| BLA | Ndufa12 | gene expression | Ndufa12 | 0.12 | 1 | 0.01 | 5.5e-02 | 5.43 | 5.49e-08 | 0.04 | FALSE |
| BLA | Vezt | gene expression | Vezt | 0.32 | 64 | 0.34 | 1.0e-18 | 6.06 | 1.35e-09 | 0.54 | FALSE |
| BLA | Nr2c1 | isoform ratio | NM_145780.2 | 0.04 | 2860 | 0.03 | 1.1e-02 | -6.12 | 9.08e-10 | 0.43 | FALSE |
| BLA | Plxnc1 | mRNA stability | Plxnc1 | 0.08 | 1 | 0.07 | 2.2e-04 | -6.03 | 1.60e-09 | 0.04 | FALSE |
| BLA | Vezt | mRNA stability | Vezt | 0.25 | 51 | 0.33 | 3.7e-18 | -5.65 | 1.59e-08 | 0.53 | FALSE |
| Brain | Fgd6 | alternative TSS | XM_039079738.2 | 0.05 | 1 | 0.05 | 1.8e-05 | -5.61 | 2.03e-08 | 0.48 | FALSE |
| Brain | Fgd6 | alternative TSS | XM_063264098.1 | 0.05 | 1 | 0.03 | 4.2e-04 | 5.53 | 3.21e-08 | 0.13 | FALSE |
| Brain | Fgd6 | gene expression | Fgd6 | 0.16 | 23 | 0.19 | 1.4e-17 | -5.81 | 6.17e-09 | 0.69 | FALSE |
| Brain | Vezt | gene expression | Vezt | 0.23 | 45 | 0.23 | 1.1e-21 | 5.56 | 2.64e-08 | 0.67 | FALSE |
| Brain | Vezt | intron excision ratio | chr7_30423170_30425300 | 0.04 | 2707 | 0.03 | 2.1e-03 | 5.88 | 4.16e-09 | 0.49 | FALSE |
| Brain | Lta4h | mRNA stability | Lta4h | 0.12 | 2416 | 0.08 | 3.2e-08 | 5.28 | 1.29e-07 | 0.63 | FALSE |
| Brain | Vezt | mRNA stability | Vezt | 0.07 | 18 | 0.06 | 1.9e-06 | -5.76 | 8.37e-09 | 0.58 | FALSE |
| IC | Nr2c1 | alternative polyA | NM_145780.2 | 0.21 | 2832 | 0.15 | 8.5e-07 | -5.97 | 2.34e-09 | 0.23 | FALSE |
| IC | Nr2c1 | alternative polyA | XM_039078458.1 | 0.21 | 2832 | 0.16 | 4.0e-07 | 6.02 | 1.72e-09 | 0.25 | FALSE |
| IC | Fgd6 | gene expression | Fgd6 | 0.07 | 2699 | 0.04 | 7.5e-03 | -5.52 | 3.45e-08 | 0.28 | FALSE |
| IC | Vezt | gene expression | Vezt | 0.25 | 2699 | 0.2 | 5.8e-09 | -5.56 | 2.68e-08 | 0.4 | FALSE |
| IC | Nr2c1 | isoform ratio | NM_145780.2 | 0.11 | 2832 | 0.11 | 1.7e-05 | -6.07 | 1.25e-09 | 0.46 | FALSE |
| IC | Lta4h | mRNA stability | Lta4h | 0.22 | 2416 | 0.14 | 1.3e-06 | 5.45 | 4.97e-08 | 0.75 | FALSE |
| IC | Vezt | mRNA stability | Vezt | 0.17 | 1 | 0.11 | 2.3e-05 | 5.5 | 3.82e-08 | 0.33 | FALSE |
| IL | Elk3 | isoform ratio | XM_006241265.5 | 0.13 | 2677 | 0.11 | 1.3e-03 | 5.46 | 4.82e-08 | 0.31 | FALSE |
| LHb | LOC108351432 | alternative polyA | XR_010053675.1 | 0.31 | 2996 | 0.11 | 1.8e-03 | -5.96 | 2.60e-09 | 0.13 | FALSE |
| LHb | LOC108351432 | alternative polyA | XR_010053674.1 | 0.32 | 2996 | 0.11 | 1.8e-03 | -5.9 | 3.55e-09 | 0.12 | FALSE |
| Liver | Amdhd1 | gene expression | Amdhd1 | 0.41 | 44 | 0.37 | 8.4e-43 | -5.52 | 3.35e-08 | 0.11 | FALSE |
| Liver | LOC102553539 | gene expression | LOC102553539 | 0.13 | 2529 | 0.08 | 3.9e-09 | -5.43 | 5.66e-08 | 0.62 | FALSE |
| Liver | Ntn4 | gene expression | Ntn4 | 0.1 | 2576 | 0.07 | 2.9e-08 | -5.53 | 3.14e-08 | 0.55 | FALSE |
| Liver | Lta4h | mRNA stability | Lta4h | 0.12 | 2416 | 0.09 | 9.8e-10 | 5.28 | 1.26e-07 | 0.65 | FALSE |
| Liver | Nr2c1 | mRNA stability | Nr2c1 | 0.02 | 2860 | 0.01 | 2.8e-02 | 5.51 | 3.61e-08 | 0.16 | FALSE |
| NAcc | Nr2c1 | alternative polyA | NM_145780.2 | 0.05 | 11 | 0.05 | 3.2e-08 | -5.52 | 3.36e-08 | 0.22 | FALSE |
| NAcc | Nr2c1 | alternative polyA | XM_039078458.1 | 0.05 | 17 | 0.05 | 5.0e-08 | 5.46 | 4.86e-08 | 0.2 | FALSE |
| NAcc | Fgd6 | gene expression | Fgd6 | 0.03 | 2699 | 0.02 | 1.6e-04 | -6.02 | 1.78e-09 | 0.54 | FALSE |
| NAcc | Lta4h | gene expression | Lta4h | 0.03 | 2416 | 0.04 | 2.8e-06 | 5.72 | 1.04e-08 | 0.63 | FALSE |
| NAcc | Mir331 | gene expression | Mir331 | 0.03 | 1 | 0.03 | 6.9e-06 | -5.4 | 6.52e-08 | 0.34 | FALSE |
| NAcc | Vezt | gene expression | Vezt | 0.06 | 2699 | 0.11 | 5.7e-16 | -5.62 | 1.88e-08 | 0.11 | FALSE |
| NAcc | Nr2c1 | intron excision ratio | chr7_30628520_30638147 | 0.02 | 2832 | 0.01 | 1.9e-03 | 5.94 | 2.80e-09 | 0.57 | FALSE |
| NAcc | Nr2c1 | intron excision ratio | chr7_30638268_30645655 | 0.01 | 2832 | 0.01 | 1.6e-02 | -6 | 2.03e-09 | 0.43 | FALSE |
| NAcc | Lta4h | mRNA stability | Lta4h | 0.05 | 1 | 0.06 | 3.4e-09 | -5.53 | 3.18e-08 | 0.74 | FALSE |
| NAcc | Vezt | mRNA stability | Vezt | 0.12 | 34 | 0.18 | 5.6e-26 | 5.37 | 7.77e-08 | 0.61 | FALSE |
| OFC | Vezt | gene expression | Vezt | 0.28 | 2707 | 0.21 | 1.1e-05 | -5.25 | 1.50e-07 | 0.52 | FALSE |
| OFC | Plxnc1 | mRNA stability | Plxnc1 | 0.19 | 3252 | 0.08 | 5.7e-03 | 6.2 | 5.78e-10 | 0.55 | TRUE |
| PL | Lta4h | gene expression | Lta4h | 0.03 | 2416 | 0.02 | 3.4e-03 | 5.69 | 1.27e-08 | 0.58 | FALSE |
| PL | Mir331 | gene expression | Mir331 | 0.03 | 13 | 0.03 | 5.4e-04 | -6.06 | 1.36e-09 | 0.42 | FALSE |
| PL | Ndufa12 | gene expression | Ndufa12 | 0.06 | 31 | 0.08 | 3.1e-09 | 5.69 | 1.28e-08 | 0.45 | FALSE |
| PL | Cep83 | isoform ratio | XM_063264041.1 | 0.02 | 2840 | 0.01 | 1.7e-02 | -5.22 | 1.75e-07 | 0.36 | FALSE |
| PL | Socs2 | intron excision ratio | chr7_31902203_31927923 | 0.03 | 12 | 0.01 | 4.0e-02 | 5.38 | 7.46e-08 | 0.16 | FALSE |
| PL | LOC134479863 | mRNA stability | LOC134479863 | 0.04 | 3521 | 0.02 | 1.3e-03 | 5.75 | 9.17e-09 | 0.09 | FALSE |
| PL | Lta4h | mRNA stability | Lta4h | 0.05 | 2416 | 0.05 | 1.4e-06 | 5.28 | 1.27e-07 | 0.64 | FALSE |
| PL | Vezt | mRNA stability | Vezt | 0.12 | 23 | 0.17 | 4.7e-18 | -5.53 | 3.25e-08 | 0.59 | FALSE |
| pVTA | Fgd6 | gene expression | Fgd6 | 0.05 | 2699 | 0.05 | 5.4e-05 | -6.04 | 1.57e-09 | 0.47 | FALSE |
| pVTA | Lta4h | gene expression | Lta4h | 0.05 | 22 | 0.03 | 3.2e-03 | 5.64 | 1.67e-08 | 0.36 | FALSE |
| pVTA | Ndufa12 | gene expression | Ndufa12 | 0.03 | 1 | 0.05 | 9.7e-05 | 5.38 | 7.36e-08 | 0.08 | FALSE |
| pVTA | Vezt | gene expression | Vezt | 0.15 | 22 | 0.17 | 2.6e-13 | -5.63 | 1.83e-08 | 0.62 | FALSE |
| pVTA | Nr2c1 | isoform ratio | NM_145780.2 | 0.05 | 2832 | 0.03 | 8.8e-04 | -5.32 | 1.04e-07 | 0.39 | FALSE |
| pVTA | Cdk17 | mRNA stability | Cdk17 | 0.04 | 24 | 0.03 | 3.6e-03 | 5.33 | 9.60e-08 | 0.15 | TRUE |
| pVTA | Lta4h | mRNA stability | Lta4h | 0.07 | 2416 | 0.06 | 6.7e-06 | 5.4 | 6.76e-08 | 0.54 | FALSE |