Best TWAS P=5.148189e-09 · Best GWAS P=6.461603e-11 conditioned to 0.001013851
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | BLA | Plxnc1 | mRNA stability | ENSRNOG00000007970 | 0.11 | 0.11 | top1 | 1 | 0.11 | 3.0e-06 | -5.3 | 5.3 | 1.3e-07 | -0.70 | 0.36 | 0.04 | FALSE |
| 2 | PL | Socs2 | gene expression | ENSRNOG00000008965 | 0.05 | 0.04 | top1 | 1 | 0.04 | 9.1e-04 | -5.6 | 5.6 | 2.5e-08 | -0.76 | 0.11 | 0.03 | FALSE |
| 3 | PL | Plxnc1 | mRNA stability | ENSRNOG00000007970 | 0.05 | 0.05 | top1 | 1 | 0.05 | 1.2e-04 | -5.1 | 5.1 | 3.5e-07 | -0.71 | 0.21 | 0.03 | FALSE |
| 4 | PL | Cradd | mRNA stability | ENSRNOG00000008507 | 0.09 | 0.08 | top1 | 1 | 0.07 | 2.3e-06 | -5.8 | 5.8 | 5.1e-09 | -0.74 | 0.47 | 0.29 | TRUE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.