Best TWAS P=4.01e-15 · Best GWAS P=3.07e-15 conditioned to 8.09e-261
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Ctsc | alternative polyA | ENSRNOT00000022342 | 0.16 | 2515 | 0.17 | 2.8e-18 | 5.72 | 1.06e-08 | 0 | FALSE |
| Adipose | Ctsc | alternative polyA | ENSRNOT00000097085 | 0.17 | 2515 | 0.19 | 1.5e-20 | -5.92 | 3.29e-09 | 0.02 | FALSE |
| Adipose | Ctsc | isoform ratio | ENSRNOT00000022342 | 0.16 | 2515 | 0.16 | 4.3e-17 | 5.96 | 2.54e-09 | 0.17 | FALSE |
| Adipose | Ctsc | isoform ratio | ENSRNOT00000097085 | 0.18 | 2515 | 0.18 | 1.3e-19 | -6.11 | 1.03e-09 | 0.36 | FALSE |
| Adipose | Ctsc | intron excision ratio | chr1:142031177:142036233 | 0.05 | 2515 | 0.04 | 6.5e-05 | -6.34 | 2.37e-10 | 0.6 | FALSE |
| Adipose | Ctsc | intron excision ratio | chr1:142031177:142045569 | 0.04 | 2515 | 0.02 | 4.7e-03 | 6.02 | 1.73e-09 | 0.51 | FALSE |
| BLA | Ctsc | alternative polyA | ENSRNOT00000022342 | 0.07 | 2518 | 0.01 | 5.1e-02 | 5.79 | 6.89e-09 | 0.19 | FALSE |
| BLA | Ctsc | alternative polyA | ENSRNOT00000097085 | 0.07 | 2518 | 0.02 | 3.2e-02 | -5.56 | 2.71e-08 | 0.16 | FALSE |
| BLA | Ctsc | gene expression | ENSRNOG00000016496 | 0.12 | 1 | 0.1 | 5.0e-06 | -6.23 | 4.66e-10 | 0.03 | FALSE |
| BLA | Ctsc | mRNA stability | ENSRNOG00000016496 | 0.05 | 1 | 0.03 | 1.5e-02 | 7.79 | 6.83e-15 | 0.12 | FALSE |
| Brain | Grm5 | gene expression | ENSRNOG00000016429 | 0.16 | 6 | 0.15 | 5.3e-14 | 6.32 | 2.69e-10 | 0.67 | FALSE |
| Brain | Ctsc | gene expression | ENSRNOG00000016496 | 0.23 | 2518 | 0.31 | 4.5e-29 | -5.69 | 1.24e-08 | 0 | FALSE |
| Brain | Ctsc | isoform ratio | ENSRNOT00000022342 | 0.03 | 1 | 0.04 | 1.7e-04 | 7.85 | 4.01e-15 | 0.72 | TRUE |
| Eye | Ctsc | gene expression | ENSRNOG00000016496 | 0.29 | 1 | 0.15 | 2.9e-03 | -6.61 | 3.92e-11 | 0.06 | FALSE |
| IL | Ctsc | gene expression | ENSRNOG00000016496 | 0.3 | 1 | 0.16 | 1.0e-04 | -6.88 | 6.14e-12 | 0.05 | FALSE |
| Liver | Ctsc | mRNA stability | ENSRNOG00000016496 | 0.05 | 2515 | 0.04 | 1.8e-05 | 5.43 | 5.52e-08 | 0.01 | FALSE |
| NAcc | Ctsc | gene expression | ENSRNOG00000016496 | 0.12 | 2516 | 0.12 | 3.3e-09 | -6.5 | 8.06e-11 | 0.34 | FALSE |
| NAcc | Grm5 | mRNA stability | ENSRNOG00000016429 | 0.07 | 2630 | 0.04 | 1.0e-03 | -5.2 | 1.96e-07 | 0.15 | FALSE |
| OFC | Grm5 | mRNA stability | ENSRNOG00000016429 | 0.17 | 2628 | 0.08 | 6.5e-03 | -5.33 | 9.66e-08 | 0.21 | FALSE |
| PL | Ctsc | gene expression | ENSRNOG00000016496 | 0.14 | 87 | 0.13 | 8.2e-10 | -5.86 | 4.73e-09 | 0.65 | FALSE |
| PL | Grm5 | mRNA stability | ENSRNOG00000016429 | 0.04 | 1 | 0.03 | 1.3e-03 | -7.72 | 1.20e-14 | 0.06 | FALSE |