Hub : Traits : Locomotion velocity, hab. session 2 : →

chr1:140,610,199-142,727,457

Trait: Locomotion velocity, hab. session 2

Best TWAS P=4.01e-15 · Best GWAS P=3.07e-15 conditioned to 1.00e+00

Associated models

Tissue	Gene	RNA modality	RNA phenotype	h2	# weights	Model R2	Model R2 P	TWAS Z	TWAS P	Coloc P	Joint
Adipose	Ctsc	isoform ratio	NM_017097.2	0.18	2521	0.16	5.6e-17	5.64	1.70e-08	0	FALSE
Adipose	Ctsc	isoform ratio	XM_008759637.3	0.19	2521	0.16	1.2e-17	-5.58	2.40e-08	0	FALSE
Adipose	Ctsc	intron excision ratio	chr1_142031177_142036233	0.05	2521	0.02	1.1e-03	-6.44	1.17e-10	0.64	FALSE
Adipose	Ctsc	intron excision ratio	chr1_142031177_142045569	0.04	2521	0.03	4.0e-04	6.22	5.13e-10	0.61	FALSE
BLA	Ctsc	gene expression	Ctsc	0.1	1	0.08	7.2e-05	7.85	4.01e-15	0.82	TRUE
BLA	Ctsc	isoform ratio	XM_008759637.3	0.05	1	0.03	1.2e-02	6.24	4.49e-10	0.04	FALSE
BLA	Grm5	isoform ratio	XM_017588780.2	0.06	2702	0.01	6.6e-02	7.08	1.46e-12	0.53	FALSE
Brain	Ctsc	alternative polyA	NM_017097.2	0.06	1	0.07	5.1e-07	-6.24	4.49e-10	0	FALSE
Brain	Ctsc	alternative polyA	XM_008759637.3	0.06	1	0.07	2.3e-07	6.8	1.04e-11	0.03	FALSE
Brain	Ctsc	gene expression	Ctsc	0.3	143	0.38	2.8e-37	5.2	2.03e-07	0	TRUE
Brain	Grm5	gene expression	Grm5	0.55	26	0.32	1.9e-30	-6.69	2.22e-11	0.65	TRUE
Brain	Ctsc	isoform ratio	NM_017097.2	0.06	1	0.06	4.1e-06	-6.84	7.67e-12	0.03	FALSE
Brain	Ctsc	isoform ratio	XM_008759637.3	0.06	1	0.06	1.2e-06	6.84	7.67e-12	0.03	FALSE
Brain	Grm5	isoform ratio	XM_017588780.2	0.05	93	0.04	2.2e-04	-6.83	8.48e-12	0.55	FALSE
Brain	Grm5	mRNA stability	Grm5	0.11	1	0.09	4.7e-09	-6.7	2.10e-11	0	FALSE
Eye	Ctsc	gene expression	Ctsc	0.37	2521	0.14	3.3e-03	-6.88	5.80e-12	0.11	FALSE
IL	Ctsc	gene expression	Ctsc	0.48	10	0.14	2.9e-04	-7.21	5.58e-13	0.64	FALSE
Liver	LOC102554680	gene expression	LOC102554680	0.04	2516	0.03	5.3e-04	-6.88	6.16e-12	0.64	FALSE
NAcc	Ctsc	gene expression	Ctsc	0.14	2521	0.16	1.5e-18	-6.33	2.47e-10	0.46	FALSE
NAcc	Grm5	gene expression	Grm5	0.05	1	0.05	1.4e-06	-7.08	1.45e-12	0.04	FALSE
NAcc	Ctsc	isoform ratio	NM_017097.2	0.03	1	0.04	2.3e-05	-6.52	7.27e-11	0.03	FALSE
NAcc	Ctsc	isoform ratio	XM_008759637.3	0.03	1	0.04	5.3e-05	6.52	7.27e-11	0.03	FALSE
NAcc	Grm5	isoform ratio	XM_017588779.2	0.05	2702	0.05	4.8e-06	-6.51	7.76e-11	0.61	FALSE
NAcc	Grm5	isoform ratio	XM_017588780.2	0.04	2702	0.03	1.1e-04	6.82	9.29e-12	0.68	TRUE
OFC	Grm5	gene expression	Grm5	0.29	2702	0.25	1.4e-06	5.77	8.11e-09	0.19	FALSE
PL	Ctsc	gene expression	Ctsc	0.2	2521	0.2	7.0e-22	-5.97	2.35e-09	0.04	FALSE
PL	Grm5	gene expression	Grm5	0.03	23	0.03	1.2e-04	7.02	2.15e-12	0.21	TRUE
PL	Grm5	isoform ratio	XM_006229659.4	0.02	2702	0.01	5.9e-02	-6.1	1.05e-09	0.21	FALSE
pVTA	Ctsc	gene expression	Ctsc	0.24	11	0.21	1.1e-09	5.68	1.38e-08	0.02	FALSE