chr1:149,923,636-152,140,050

Trait: Locomotion velocity, hab. session 2

Best TWAS P = 6.15e-15 · Best GWAS P= 3.22e-15 conditioned to 1.00e+00

Associated models

Tissue	Gene	RNA modality	RNA phenotype	h²	# weights	Model R²	Model R² P	TWAS Z	TWAS P	Coloc P	Joint
Adipose	Ctsc	alternative polyA	NM_017097.2	0.18	2571	0.19	1.5e-20	5.43	5.51e-08	0	FALSE
Adipose	Ctsc	alternative polyA	XM_008759637.4	0.19	2571	0.2	1.0e-21	-5.36	8.13e-08	0	FALSE
Adipose	Ctsc	isoform ratio	NM_017097.2	0.17	2571	0.16	1.9e-17	5.68	1.37e-08	0	FALSE
Adipose	Ctsc	isoform ratio	XM_008759637.4	0.17	2571	0.17	3.0e-18	-5.65	1.61e-08	0	FALSE
Adipose	Ctsc	intron excision ratio	chr1_151443766_151448822	0.05	2571	0.03	7.1e-04	-6.38	1.74e-10	0.63	FALSE
Adipose	Ctsc	intron excision ratio	chr1_151443766_151458158	0.04	2571	0.03	4.0e-04	6.09	1.10e-09	0.58	TRUE
BLA	Ctsc	gene expression	Ctsc	0.15	260	0.12	7.4e-07	-5.48	4.22e-08	0.7	TRUE
BLA	Ctsc	isoform ratio	NM_017097.2	0.06	1	0.03	1.8e-02	6.33	2.45e-10	0.04	FALSE
BLA	Ctsc	isoform ratio	XM_008759637.4	0.06	1	0.02	1.8e-02	-6.33	2.45e-10	0.04	FALSE
Brain	Ctsc	alternative polyA	NM_017097.2	0.06	24	0.07	6.4e-07	6.88	5.97e-12	0.62	FALSE
Brain	Ctsc	alternative polyA	XM_008759637.4	0.06	24	0.07	6.5e-07	-6.89	5.62e-12	0.61	FALSE
Brain	Ctsc	gene expression	Ctsc	0.28	2571	0.37	1.3e-36	-5.34	9.27e-08	0	FALSE
Brain	Grm5	gene expression	Grm5	0.46	13	0.3	2.5e-28	7.19	6.28e-13	0.67	FALSE
Brain	Ctsc	isoform ratio	NM_017097.2	0.06	1	0.05	2.1e-05	6.84	7.66e-12	0.03	FALSE
Brain	Ctsc	isoform ratio	XM_008759637.4	0.06	1	0.05	2.6e-05	-6.84	7.66e-12	0.03	FALSE
Brain	Grm5	mRNA stability	Grm5	0.1	1	0.09	4.9e-09	6.84	8.10e-12	0.01	FALSE
Eye	Ctsc	gene expression	Ctsc	0.34	20	0.16	1.8e-03	-6.04	1.51e-09	0.11	FALSE
IC	Ctsc	alternative polyA	NM_017097.2	0.09	1	0.06	1.6e-03	6.02	1.71e-09	0.04	FALSE
IC	Ctsc	alternative polyA	XM_008759637.4	0.08	1	0.05	2.6e-03	-6.02	1.71e-09	0.04	FALSE
IC	Ctsc	gene expression	Ctsc	0.16	2571	0.13	4.2e-06	-5.33	1.01e-07	0.05	FALSE
IC	Grm5	gene expression	Grm5	0.3	33	0.24	1.2e-10	6.49	8.52e-11	0.21	FALSE
IC	Grm5	isoform ratio	XM_006229659.5	0.06	52	0.03	2.4e-02	-6.65	2.96e-11	0.27	FALSE
IL	Ctsc	gene expression	Ctsc	0.44	19	0.11	1.4e-03	-7.8	6.15e-15	0.65	TRUE
LHb	Ctsc	gene expression	Ctsc	0.2	11	0.14	3.8e-04	-6.02	1.76e-09	0.14	TRUE
Liver	LOC102554680	gene expression	LOC102554680	0.05	13	0.04	7.2e-05	-6.81	9.64e-12	0.64	FALSE
NAcc	Ctsc	alternative polyA	NM_017097.2	0.04	1	0.04	2.0e-06	5.9	3.65e-09	0	FALSE
NAcc	Ctsc	alternative polyA	XM_008759637.4	0.04	103	0.04	1.0e-06	-5.88	4.18e-09	0.19	TRUE
NAcc	Ctsc	gene expression	Ctsc	0.13	2571	0.19	2.3e-28	-6.28	3.31e-10	0.42	FALSE
NAcc	Grm5	gene expression	Grm5	0.08	1	0.08	7.3e-12	7.15	8.93e-13	0.08	FALSE
NAcc	Tyr	gene expression	Tyr	0.02	2904	0.01	1.3e-02	6.57	5.12e-11	0.43	FALSE
NAcc	Ctsc	isoform ratio	NM_017097.2	0.05	1	0.05	2.9e-08	5.9	3.65e-09	0	FALSE
NAcc	Ctsc	isoform ratio	XM_008759637.4	0.05	1	0.05	1.5e-07	-5.9	3.65e-09	0	FALSE
NAcc	Ctsc	intron excision ratio	chr1_151443766_151448822	0.02	1	0.01	1.7e-03	-5.9	3.65e-09	0.02	FALSE
NAcc	Ctsc	intron excision ratio	chr1_151443766_151458158	0.02	4	0.01	8.6e-03	6.38	1.74e-10	0.5	FALSE
NAcc	Grm5	mRNA stability	Grm5	0.03	1	0.03	3.3e-05	7.15	8.93e-13	0.04	FALSE
OFC	Grm5	gene expression	Grm5	0.23	11	0.16	1.0e-04	7.14	9.23e-13	0.44	TRUE
PL	Ctsc	alternative polyA	NM_017097.2	0.03	2571	0.02	1.7e-03	5.48	4.30e-08	0.23	FALSE
PL	Ctsc	gene expression	Ctsc	0.21	2571	0.21	1.0e-22	-5.88	4.03e-09	0.06	FALSE
PL	Grm5	gene expression	Grm5	0.03	2746	0.02	2.8e-03	6.3	3.02e-10	0.37	FALSE
PL	Ctsc	isoform ratio	NM_017097.2	0.02	2571	0.02	2.0e-03	5.48	4.25e-08	0.2	FALSE
PL	Ctsc	isoform ratio	XM_008759637.4	0.02	2571	0.02	2.0e-03	-5.48	4.31e-08	0.19	FALSE
PL	Grm5	intron excision ratio	chr1_150723078_150733678	0.03	2746	0.02	1.7e-03	5.78	7.29e-09	0.14	TRUE