Hub : Traits : Trabecular tissue density :

chr5:113,826,986-115,224,581

Best TWAS P=8.518921e-08 · Best GWAS P=2.853115e-07 conditioned to 0.6348487

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Brain	Itgb3bp	isoform ratio	ENSRNOT00000012947	0.32	0.38	lasso	41	0.39	2.8e-38	-4.8	-5.1	2.9e-07	0.84	0.54	0.46	FALSE
2	NAcc	Itgb3bp	gene expression	ENSRNOG00000009116	0.28	0.10	blup	1849	0.10	2.9e-03	-4.8	-5.3	1.3e-07	0.82	0.45	0.32	TRUE
3	NAcc	Itgb3bp	intron excision ratio	chr5:114460416:114473633	0.73	0.46	blup	1849	0.46	8.1e-12	-4.8	-5.2	2.3e-07	0.92	0.58	0.42	FALSE
4	NAcc2	Itgb3bp	intron excision ratio	chr5:114460416:114473633	0.45	0.38	lasso	39	0.43	4.4e-25	-5.0	-5.2	1.8e-07	0.79	0.52	0.48	FALSE
5	OFC	Itgb3bp	intron excision ratio	chr5:114460416:114473633	0.42	0.41	lasso	4	0.48	3.9e-13	-4.8	-5.4	8.5e-08	0.20	0.60	0.40	TRUE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.