Best TWAS P=8.518921e-08 · Best GWAS P=2.853115e-07 conditioned to 0.6659118
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | BLA | Itgb3bp | isoform ratio | ENSRNOT00000103428 | 0.24 | 0.14 | blup | 1852 | 0.15 | 1.8e-08 | -4.9 | 5.1 | 3.5e-07 | -0.81 | 0.56 | 0.44 | FALSE |
| 2 | Brain | Itgb3bp | isoform ratio | ENSRNOT00000012947 | 0.32 | 0.38 | lasso | 41 | 0.39 | 2.8e-38 | -4.8 | -5.1 | 2.9e-07 | 0.84 | 0.54 | 0.46 | TRUE |
| 3 | OFC | Itgb3bp | intron excision ratio | chr5:114460416:114473633 | 0.42 | 0.41 | lasso | 4 | 0.48 | 3.9e-13 | -4.8 | -5.4 | 8.5e-08 | 0.20 | 0.60 | 0.40 | TRUE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.