Best TWAS P=1.11e-15 · Best GWAS P=5.32e-16 conditioned to 2.15e-273
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Ctsc | alternative polyA | ENSRNOT00000022342 | 0.16 | 2515 | 0.17 | 2.8e-18 | 5.89 | 3.75e-09 | 0 | FALSE |
| Adipose | Ctsc | alternative polyA | ENSRNOT00000097085 | 0.17 | 2515 | 0.19 | 1.5e-20 | -6.11 | 9.92e-10 | 0.02 | FALSE |
| Adipose | Ctsc | isoform ratio | ENSRNOT00000022342 | 0.16 | 2515 | 0.16 | 4.3e-17 | 6.14 | 8.45e-10 | 0.17 | FALSE |
| Adipose | Ctsc | isoform ratio | ENSRNOT00000097085 | 0.18 | 2515 | 0.18 | 1.3e-19 | -6.3 | 3.05e-10 | 0.36 | FALSE |
| Adipose | Ctsc | intron excision ratio | chr1:142031177:142036233 | 0.05 | 2515 | 0.04 | 6.5e-05 | -6.55 | 5.70e-11 | 0.6 | FALSE |
| Adipose | Ctsc | intron excision ratio | chr1:142031177:142045569 | 0.04 | 2515 | 0.02 | 4.7e-03 | 6.21 | 5.28e-10 | 0.51 | FALSE |
| BLA | Ctsc | alternative polyA | ENSRNOT00000022342 | 0.07 | 2518 | 0.01 | 5.1e-02 | 6.07 | 1.32e-09 | 0.19 | FALSE |
| BLA | Ctsc | alternative polyA | ENSRNOT00000097085 | 0.07 | 2518 | 0.02 | 3.2e-02 | -5.82 | 5.76e-09 | 0.16 | FALSE |
| BLA | Ctsc | gene expression | ENSRNOG00000016496 | 0.12 | 1 | 0.1 | 5.0e-06 | -6.53 | 6.55e-11 | 0.03 | FALSE |
| BLA | Ctsc | mRNA stability | ENSRNOG00000016496 | 0.05 | 1 | 0.03 | 1.5e-02 | 8.01 | 1.12e-15 | 0.15 | FALSE |
| Brain | Grm5 | gene expression | ENSRNOG00000016429 | 0.16 | 6 | 0.15 | 5.3e-14 | 6.54 | 6.13e-11 | 0.71 | FALSE |
| Brain | Ctsc | gene expression | ENSRNOG00000016496 | 0.23 | 2518 | 0.31 | 4.5e-29 | -5.89 | 3.79e-09 | 0 | FALSE |
| Brain | Ctsc | isoform ratio | ENSRNOT00000022342 | 0.03 | 1 | 0.04 | 1.7e-04 | 8.01 | 1.11e-15 | 0.66 | TRUE |
| Eye | Ctsc | gene expression | ENSRNOG00000016496 | 0.29 | 1 | 0.15 | 2.9e-03 | -6.84 | 7.87e-12 | 0.06 | FALSE |
| IL | Ctsc | gene expression | ENSRNOG00000016496 | 0.3 | 1 | 0.16 | 1.0e-04 | -7.11 | 1.17e-12 | 0.05 | FALSE |
| Liver | Ctsc | mRNA stability | ENSRNOG00000016496 | 0.05 | 2515 | 0.04 | 1.8e-05 | 5.63 | 1.84e-08 | 0.01 | FALSE |
| NAcc | Ctsc | gene expression | ENSRNOG00000016496 | 0.12 | 2516 | 0.12 | 3.3e-09 | -6.74 | 1.62e-11 | 0.35 | FALSE |
| NAcc | Grm5 | mRNA stability | ENSRNOG00000016429 | 0.07 | 2630 | 0.04 | 1.0e-03 | -5.1 | 3.36e-07 | 0.17 | FALSE |
| OFC | Grm5 | mRNA stability | ENSRNOG00000016429 | 0.17 | 2628 | 0.08 | 6.5e-03 | -5.23 | 1.69e-07 | 0.21 | FALSE |
| PL | Ctsc | gene expression | ENSRNOG00000016496 | 0.14 | 87 | 0.13 | 8.2e-10 | -6.03 | 1.59e-09 | 0.64 | FALSE |
| PL | Grm5 | mRNA stability | ENSRNOG00000016429 | 0.04 | 1 | 0.03 | 1.3e-03 | -7.85 | 4.04e-15 | 0.07 | FALSE |