chr1:149,923,636-152,140,050

Trait: Total locomotion distance, hab. session 2

Best TWAS P = 1.80e-15 · Best GWAS P= 8.45e-16 conditioned to 1.00e+00

Associated models

Tissue	Gene	RNA modality	RNA phenotype	h²	# weights	Model R²	Model R² P	TWAS Z	TWAS P	Coloc P	Joint
Adipose	Ctsc	alternative polyA	NM_017097.2	0.18	2571	0.19	1.5e-20	5.6	2.11e-08	0	FALSE
Adipose	Ctsc	alternative polyA	XM_008759637.4	0.19	2571	0.2	1.0e-21	-5.53	3.22e-08	0	FALSE
Adipose	Ctsc	isoform ratio	NM_017097.2	0.17	2571	0.16	1.9e-17	5.84	5.07e-09	0	FALSE
Adipose	Ctsc	isoform ratio	XM_008759637.4	0.17	2571	0.17	3.0e-18	-5.82	6.04e-09	0	FALSE
Adipose	Ctsc	intron excision ratio	chr1_151443766_151448822	0.05	2571	0.03	7.1e-04	-6.6	4.11e-11	0.63	FALSE
Adipose	Ctsc	intron excision ratio	chr1_151443766_151458158	0.04	2571	0.03	4.0e-04	6.28	3.36e-10	0.58	FALSE
BLA	Ctsc	gene expression	Ctsc	0.15	281	0.12	7.5e-07	5.78	7.40e-09	0.68	FALSE
BLA	Ctsc	isoform ratio	NM_017097.2	0.06	1	0.03	1.8e-02	-6.59	4.34e-11	0.04	FALSE
BLA	Ctsc	isoform ratio	XM_008759637.4	0.06	1	0.02	1.8e-02	6.59	4.34e-11	0.04	FALSE
Brain	Ctsc	alternative polyA	NM_017097.2	0.06	24	0.07	6.8e-07	-7.17	7.49e-13	0.63	FALSE
Brain	Ctsc	alternative polyA	XM_008759637.4	0.06	24	0.07	7.0e-07	7.18	7.09e-13	0.62	FALSE
Brain	Ctsc	gene expression	Ctsc	0.28	2571	0.37	1.3e-36	-5.53	3.15e-08	0	FALSE
Brain	Grm5	gene expression	Grm5	0.46	13	0.3	2.7e-28	7.39	1.42e-13	0.74	FALSE
Brain	Ctsc	isoform ratio	NM_017097.2	0.06	1	0.05	2.1e-05	-7.07	1.54e-12	0.03	FALSE
Brain	Ctsc	isoform ratio	XM_008759637.4	0.06	1	0.05	2.6e-05	7.07	1.54e-12	0.03	FALSE
Brain	Grm5	mRNA stability	Grm5	0.1	1	0.09	4.9e-09	-7.07	1.50e-12	0.02	FALSE
Eye	Ctsc	gene expression	Ctsc	0.34	13	0.16	1.8e-03	-6.24	4.47e-10	0.12	FALSE
IC	Ctsc	alternative polyA	NM_017097.2	0.09	1	0.06	1.6e-03	-6.28	3.42e-10	0.04	FALSE
IC	Ctsc	alternative polyA	XM_008759637.4	0.08	1	0.05	2.6e-03	6.28	3.42e-10	0.04	FALSE
IC	Ctsc	gene expression	Ctsc	0.16	2571	0.13	4.2e-06	-5.52	3.34e-08	0.05	FALSE
IC	Grm5	gene expression	Grm5	0.3	44	0.24	1.4e-10	6.65	2.98e-11	0.22	FALSE
IC	Grm5	isoform ratio	XM_006229659.5	0.06	52	0.03	2.4e-02	6.81	9.96e-12	0.26	FALSE
IL	Ctsc	gene expression	Ctsc	0.44	18	0.11	1.6e-03	-7.95	1.80e-15	0.65	TRUE
LHb	Ctsc	gene expression	Ctsc	0.2	15	0.14	3.9e-04	-6.23	4.56e-10	0.14	TRUE
Liver	LOC102554680	gene expression	LOC102554680	0.05	13	0.04	7.2e-05	7.09	1.35e-12	0.64	FALSE
NAcc	Ctsc	alternative polyA	NM_017097.2	0.04	1	0.04	2.0e-06	-6.1	1.05e-09	0	FALSE
NAcc	Ctsc	alternative polyA	XM_008759637.4	0.04	27	0.04	1.0e-06	6.86	7.11e-12	0.21	TRUE
NAcc	Ctsc	gene expression	Ctsc	0.13	2571	0.19	2.3e-28	-6.49	8.50e-11	0.44	FALSE
NAcc	Grm5	gene expression	Grm5	0.08	1	0.08	7.3e-12	-7.37	1.69e-13	0.13	FALSE
NAcc	Tyr	gene expression	Tyr	0.02	2904	0.01	1.3e-02	6.57	5.00e-11	0.44	FALSE
NAcc	Ctsc	isoform ratio	NM_017097.2	0.05	1	0.05	2.9e-08	-6.1	1.05e-09	0	FALSE
NAcc	Ctsc	isoform ratio	XM_008759637.4	0.05	1	0.05	1.5e-07	6.1	1.05e-09	0	FALSE
NAcc	Ctsc	intron excision ratio	chr1_151443766_151448822	0.02	1	0.01	1.7e-03	6.1	1.05e-09	0.02	FALSE
NAcc	Ctsc	intron excision ratio	chr1_151443766_151458158	0.02	4	0.01	8.6e-03	-6.66	2.71e-11	0.51	TRUE
NAcc	Grm5	mRNA stability	Grm5	0.03	1	0.03	3.3e-05	-7.37	1.69e-13	0.06	FALSE
OFC	Grm5	gene expression	Grm5	0.23	11	0.16	1.0e-04	-7.05	1.84e-12	0.44	FALSE
PL	Ctsc	alternative polyA	NM_017097.2	0.03	2571	0.02	1.7e-03	5.63	1.76e-08	0.23	FALSE
PL	Ctsc	gene expression	Ctsc	0.21	2571	0.21	1.0e-22	-6.12	9.31e-10	0.06	FALSE
PL	Grm5	gene expression	Grm5	0.03	2746	0.02	2.8e-03	6.35	2.22e-10	0.41	FALSE
PL	Ctsc	isoform ratio	NM_017097.2	0.02	2571	0.02	2.0e-03	5.65	1.64e-08	0.2	FALSE
PL	Ctsc	isoform ratio	XM_008759637.4	0.02	2571	0.02	2.0e-03	-5.65	1.63e-08	0.19	TRUE
PL	Grm5	intron excision ratio	chr1_150723078_150733678	0.03	2746	0.02	1.7e-03	5.75	9.09e-09	0.14	FALSE
pVTA	Grm5	mRNA stability	Grm5	0.06	2746	0.03	3.6e-03	5.45	4.94e-08	0.48	TRUE