Hub : Traits : Total locomotion distance, hab. session 2 : →

chr1:140,614,300-142,727,457

Trait: Total locomotion distance, hab. session 2

Best TWAS P=1.112537e-15 · Best GWAS P=5.318548e-16 conditioned to 2.154471e-273

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Ctsc	alternative polyA	ENSRNOT00000022342	0.16	0.14	blup	2515	0.17	2.8e-18	4.4	5.9	3.8e-09	-0.85	1.00	0.00	FALSE
2	Adipose	Ctsc	alternative polyA	ENSRNOT00000097085	0.17	0.13	blup	2515	0.19	1.5e-20	4.3	-6.1	9.9e-10	0.88	0.98	0.02	FALSE
3	Adipose	Ctsc	isoform ratio	ENSRNOT00000022342	0.16	0.10	blup	2515	0.16	4.3e-17	4.4	6.1	8.5e-10	-0.88	0.83	0.17	FALSE
4	Adipose	Ctsc	isoform ratio	ENSRNOT00000097085	0.18	0.11	blup	2515	0.18	1.3e-19	-6.9	-6.3	3.1e-10	0.90	0.64	0.36	FALSE
5	Adipose	Ctsc	intron excision ratio	chr1:142031177:142036233	0.05	0.03	blup	2515	0.04	6.5e-05	-7.4	-6.6	5.7e-11	0.92	0.39	0.60	FALSE
6	Adipose	Ctsc	intron excision ratio	chr1:142031177:142045569	0.04	0.01	blup	2515	0.02	4.7e-03	-7.4	6.2	5.3e-10	-0.89	0.47	0.51	FALSE
7	BLA	Ctsc	alternative polyA	ENSRNOT00000022342	0.07	0.00	blup	2518	0.01	5.1e-02	-6.3	6.1	1.3e-09	-0.74	0.46	0.19	FALSE
8	BLA	Ctsc	alternative polyA	ENSRNOT00000097085	0.07	0.00	blup	2518	0.02	3.2e-02	2.8	-5.8	5.8e-09	0.70	0.46	0.16	FALSE
9	BLA	Ctsc	gene expression	ENSRNOG00000016496	0.12	0.10	top1	1	0.10	5.0e-06	-6.5	-6.5	6.5e-11	0.95	0.35	0.03	FALSE
10	BLA	Ctsc	mRNA stability	ENSRNOG00000016496	0.05	0.03	top1	1	0.03	1.5e-02	-8.0	8.0	1.1e-15	-0.90	0.09	0.15	FALSE
11	Brain	Grm5	gene expression	ENSRNOG00000016429	0.16	0.10	lasso	6	0.15	5.3e-14	-7.0	6.5	6.1e-11	-0.86	0.29	0.71	FALSE
12	Brain	Ctsc	gene expression	ENSRNOG00000016496	0.23	0.27	blup	2518	0.31	4.5e-29	4.3	-5.9	3.8e-09	0.84	1.00	0.00	FALSE
13	Brain	Ctsc	isoform ratio	ENSRNOT00000022342	0.03	0.04	top1	1	0.04	1.7e-04	-8.0	8.0	1.1e-15	-0.90	0.04	0.66	TRUE
14	Eye	Ctsc	gene expression	ENSRNOG00000016496	0.29	0.15	top1	1	0.15	2.9e-03	-6.8	-6.8	7.9e-12	0.93	0.14	0.06	FALSE
15	IL	Ctsc	gene expression	ENSRNOG00000016496	0.30	0.16	top1	1	0.16	1.0e-04	-7.1	-7.1	1.2e-12	0.93	0.14	0.05	FALSE
16	Liver	Ctsc	mRNA stability	ENSRNOG00000016496	0.05	0.04	blup	2515	0.04	1.8e-05	4.3	5.6	1.8e-08	-0.82	0.99	0.01	FALSE
17	NAcc	Ctsc	gene expression	ENSRNOG00000016496	0.12	0.09	blup	2516	0.12	3.3e-09	-6.9	-6.7	1.6e-11	0.93	0.65	0.35	FALSE
18	NAcc	Grm5	mRNA stability	ENSRNOG00000016429	0.07	0.02	blup	2630	0.04	1.0e-03	4.2	-5.1	3.4e-07	0.68	0.78	0.17	FALSE
19	OFC	Grm5	mRNA stability	ENSRNOG00000016429	0.17	0.05	blup	2628	0.08	6.5e-03	4.4	-5.2	1.7e-07	0.69	0.47	0.21	FALSE
20	PL	Ctsc	gene expression	ENSRNOG00000016496	0.14	0.11	enet	87	0.13	8.2e-10	-7.2	-6.0	1.6e-09	0.75	0.36	0.64	FALSE
21	PL	Grm5	mRNA stability	ENSRNOG00000016429	0.04	0.03	top1	1	0.03	1.3e-03	-7.9	-7.9	4.0e-15	0.92	0.09	0.07	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.