Delay discounting using a sequential patch depletion procedure,total patch (feeder) changes in the last two sessions with an experimenter-imposed delay of 18 sec [n]
Project: p50_david_dietz
45 significantly associated models · 2 unique genes
| # | chr | p0 | p1 | # assoc genes | # joint models | best TWAS P | best SNP P | cond SNP P | % var exp | joint genes |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 5 | 152510403 | 153963656 | 2 | 2 | 9.5e-08 | 7.9e-08 | 1 | 100 | Padi2 Sdhb |
p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.
| Trait | chisq ratio | # genes+ | # genes++ | % genes++ | corr | corr P | genes |
|---|---|---|---|---|---|---|---|
| heart_g | 9.3 | 1 | 0 | 0 | 0 | 1.0e+00 | Sdhb |
| ccp_trial_3_saline_dist_mm | 8.8 | 1 | 0 | 0 | 0 | 1.0e+00 | Sdhb |
| Total cortical area | 7.0 | 2 | 0 | 0 | 1 | 1.3e-50 | Padi2 Sdhb |
| ctth_sd | 13.1 | 2 | 0 | 0 | 1 | 9.3e-57 | Padi2 Sdhb |
chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.
| tissue | modality | # hits | % hits/tests | avg chisq |
|---|---|---|---|---|
| Adipose | alternative polyA | 0 | 0.000 | 1.3 |
| Adipose | alternative TSS | 0 | 0.000 | 1.3 |
| Adipose | gene expression | 0 | 0.000 | 1.3 |
| Adipose | isoform ratio | 1 | 0.035 | 1.4 |
| Adipose | intron excision ratio | 0 | 0.000 | 1.6 |
| Adipose | mRNA stability | 0 | 0.000 | 1.3 |
| BLA | alternative polyA | 1 | 0.083 | 1.5 |
| BLA | alternative TSS | 0 | 0.000 | 1.3 |
| BLA | gene expression | 0 | 0.000 | 1.3 |
| BLA | isoform ratio | 0 | 0.000 | 1.5 |
| BLA | intron excision ratio | 0 | 0.000 | 1.3 |
| BLA | mRNA stability | 0 | 0.000 | 1.3 |
| Brain | alternative polyA | 4 | 0.199 | 1.4 |
| Brain | alternative TSS | 0 | 0.000 | 1.3 |
| Brain | gene expression | 0 | 0.000 | 1.3 |
| Brain | isoform ratio | 1 | 0.032 | 1.3 |
| Brain | intron excision ratio | 0 | 0.000 | 1.3 |
| Brain | mRNA stability | 0 | 0.000 | 1.2 |
| Eye | alternative polyA | 0 | 0.000 | 2.0 |
| Eye | alternative TSS | 0 | 0.000 | 1.6 |
| Eye | gene expression | 0 | 0.000 | 1.3 |
| Eye | isoform ratio | 0 | 0.000 | 1.4 |
| Eye | intron excision ratio | 0 | 0.000 | 1.3 |
| Eye | mRNA stability | 0 | 0.000 | 1.4 |
| IL | alternative polyA | 4 | 0.657 | 1.4 |
| IL | alternative TSS | 0 | 0.000 | 1.4 |
| IL | gene expression | 0 | 0.000 | 1.3 |
| IL | isoform ratio | 1 | 0.127 | 1.4 |
| IL | intron excision ratio | 0 | 0.000 | 1.2 |
| IL | mRNA stability | 0 | 0.000 | 1.3 |
| LHb | alternative polyA | 1 | 0.174 | 1.4 |
| LHb | alternative TSS | 0 | 0.000 | 1.6 |
| LHb | gene expression | 0 | 0.000 | 1.3 |
| LHb | isoform ratio | 0 | 0.000 | 1.4 |
| LHb | intron excision ratio | 0 | 0.000 | 1.2 |
| LHb | mRNA stability | 0 | 0.000 | 1.2 |
| Liver | alternative polyA | 1 | 0.067 | 1.5 |
| Liver | alternative TSS | 0 | 0.000 | 1.3 |
| Liver | gene expression | 1 | 0.014 | 1.3 |
| Liver | isoform ratio | 1 | 0.042 | 1.4 |
| Liver | intron excision ratio | 0 | 0.000 | 1.4 |
| Liver | mRNA stability | 1 | 0.041 | 1.2 |
| NAcc | alternative polyA | 4 | 0.768 | 1.4 |
| NAcc | alternative TSS | 0 | 0.000 | 1.2 |
| NAcc | gene expression | 0 | 0.000 | 1.3 |
| NAcc | isoform ratio | 2 | 0.269 | 1.5 |
| NAcc | intron excision ratio | 0 | 0.000 | 1.4 |
| NAcc | mRNA stability | 0 | 0.000 | 1.3 |
| NAcc2 | alternative polyA | 1 | 0.090 | 1.5 |
| NAcc2 | alternative TSS | 0 | 0.000 | 1.4 |
| NAcc2 | gene expression | 1 | 0.019 | 1.3 |
| NAcc2 | isoform ratio | 1 | 0.065 | 1.4 |
| NAcc2 | intron excision ratio | 0 | 0.000 | 1.3 |
| NAcc2 | mRNA stability | 0 | 0.000 | 1.3 |
| OFC | alternative polyA | 4 | 0.685 | 1.5 |
| OFC | alternative TSS | 0 | 0.000 | 1.5 |
| OFC | gene expression | 1 | 0.027 | 1.2 |
| OFC | isoform ratio | 2 | 0.245 | 1.3 |
| OFC | intron excision ratio | 0 | 0.000 | 1.3 |
| OFC | mRNA stability | 0 | 0.000 | 1.3 |
| PL | alternative polyA | 4 | 0.668 | 1.4 |
| PL | alternative TSS | 0 | 0.000 | 1.2 |
| PL | gene expression | 1 | 0.027 | 1.2 |
| PL | isoform ratio | 1 | 0.115 | 1.3 |
| PL | intron excision ratio | 0 | 0.000 | 1.3 |
| PL | mRNA stability | 0 | 0.000 | 1.3 |
| PL2 | alternative polyA | 2 | 0.159 | 1.5 |
| PL2 | alternative TSS | 0 | 0.000 | 1.4 |
| PL2 | gene expression | 1 | 0.016 | 1.3 |
| PL2 | isoform ratio | 2 | 0.108 | 1.4 |
| PL2 | intron excision ratio | 0 | 0.000 | 1.4 |
| PL2 | mRNA stability | 1 | 0.041 | 1.2 |
avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.