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chr5:152,510,403-154,082,317

Trait: Delay discounting total patch changes 18 sec

Best TWAS P=9.540249e-08 · Best GWAS P=7.861013e-08 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Sdhb	isoform ratio	ENSRNOT00000105563	0.60	0.34	lasso	32	0.34	1.1e-38	-5.1	5.2	2.0e-07	-1.00	0.13	0.87	FALSE
2	BLA	Sdhb	alternative polyA	ENSRNOT00000098351	0.80	0.58	enet	70	0.59	1.7e-38	-5.3	-5.1	3.4e-07	1.00	0.11	0.89	FALSE
3	BLA	Sdhb	alternative polyA	ENSRNOT00000098351	0.78	0.57	lasso	28	0.58	2.5e-37	-5.3	-5.2	2.6e-07	1.00	0.11	0.89	FALSE
4	BLA	Sdhb	alternative polyA	ENSRNOT00000105563	0.82	0.58	enet	61	0.60	3.2e-39	-5.3	5.1	3.4e-07	-1.00	0.11	0.89	FALSE
5	Brain	Sdhb	alternative polyA	ENSRNOT00000098351	0.79	0.66	lasso	9	0.66	3.3e-81	-5.2	-5.1	3.0e-07	1.00	0.11	0.89	FALSE
6	Brain	Sdhb	alternative polyA	ENSRNOT00000105563	0.77	0.64	top1	1	0.64	1.6e-77	-5.2	5.2	2.3e-07	-0.90	0.16	0.84	FALSE
7	Brain	Sdhb	alternative polyA	ENSRNOT00000098351	0.77	0.64	lasso	21	0.65	2.8e-78	-5.2	-5.1	3.3e-07	1.00	0.11	0.89	FALSE
8	Brain	Sdhb	alternative polyA	ENSRNOT00000105563	0.75	0.63	lasso	10	0.63	3.5e-75	-5.2	5.1	3.2e-07	-1.00	0.11	0.89	FALSE
9	Brain	Sdhb	isoform ratio	ENSRNOT00000105563	0.66	0.53	lasso	19	0.53	3.2e-57	-5.1	5.2	2.4e-07	-0.99	0.11	0.89	FALSE
10	IL	Sdhb	alternative polyA	ENSRNOT00000098351	0.59	0.27	lasso	4	0.30	4.6e-08	-5.3	-5.2	2.3e-07	0.97	0.22	0.77	TRUE
11	IL	Sdhb	alternative polyA	ENSRNOT00000105563	0.58	0.30	lasso	2	0.30	4.5e-08	-5.3	5.2	1.9e-07	-0.27	0.24	0.76	TRUE
12	IL	Sdhb	alternative polyA	ENSRNOT00000098351	0.53	0.32	top1	1	0.32	2.0e-08	-5.3	-5.3	1.5e-07	0.88	0.12	0.64	FALSE
13	IL	Sdhb	alternative polyA	ENSRNOT00000105563	0.50	0.30	top1	1	0.30	7.3e-08	-5.3	5.3	1.5e-07	-0.87	0.13	0.54	FALSE
14	IL	Sdhb	isoform ratio	ENSRNOT00000105563	0.59	0.24	top1	1	0.24	1.6e-06	-5.1	5.1	3.1e-07	-0.88	0.16	0.22	FALSE
15	LHb	Sdhb	alternative polyA	ENSRNOT00000105563	0.55	0.36	top1	1	0.36	2.3e-09	-5.1	5.1	2.6e-07	-0.86	0.17	0.67	FALSE
16	Liver	Sdhb	alternative polyA	ENSRNOT00000105563	0.36	0.33	lasso	17	0.34	4.8e-39	-5.3	5.1	2.8e-07	-0.99	0.15	0.85	FALSE
17	Liver	Sdhb	gene expression	ENSRNOG00000007967	0.16	0.07	top1	1	0.07	4.3e-08	-5.3	-5.3	9.5e-08	0.91	0.08	0.92	TRUE
18	Liver	Sdhb	isoform ratio	ENSRNOT00000105563	0.14	0.12	top1	1	0.12	4.4e-13	-5.3	5.3	1.2e-07	-0.81	0.10	0.90	FALSE
19	Liver	Sdhb	mRNA stability	ENSRNOG00000007967	0.10	0.10	top1	1	0.10	7.7e-11	-5.1	-5.1	3.1e-07	0.80	0.20	0.80	FALSE
20	NAcc	Sdhb	alternative polyA	ENSRNOT00000098351	0.73	0.59	top1	1	0.59	2.5e-53	-5.3	-5.3	1.2e-07	0.90	0.10	0.90	FALSE
21	NAcc	Sdhb	alternative polyA	ENSRNOT00000105563	0.78	0.63	lasso	19	0.63	2.9e-60	-5.3	5.1	2.8e-07	-1.00	0.10	0.90	FALSE
22	NAcc	Sdhb	alternative polyA	ENSRNOT00000098351	0.75	0.58	top1	1	0.58	8.9e-53	-5.3	-5.3	1.2e-07	0.90	0.10	0.90	FALSE
23	NAcc	Sdhb	alternative polyA	ENSRNOT00000105563	0.79	0.62	lasso	14	0.62	2.9e-58	-5.3	5.1	2.8e-07	-1.00	0.10	0.90	FALSE
24	NAcc	Sdhb	gene expression	ENSRNOG00000007967	0.19	0.14	lasso	9	0.14	2.1e-10	-5.3	-5.1	3.2e-07	0.99	0.14	0.86	FALSE
25	NAcc	Sdhb	isoform ratio	ENSRNOT00000105563	0.64	0.53	top1	1	0.53	6.0e-46	-5.3	5.3	1.2e-07	-0.91	0.10	0.90	FALSE
26	OFC	Sdhb	alternative polyA	ENSRNOT00000098351	0.65	0.33	top1	1	0.33	9.7e-09	-5.1	-5.1	2.6e-07	0.95	0.18	0.74	FALSE
27	OFC	Sdhb	alternative polyA	ENSRNOT00000105563	0.63	0.33	top1	1	0.33	1.5e-08	-5.1	5.1	2.6e-07	-0.95	0.18	0.73	FALSE
28	OFC	Sdhb	alternative polyA	ENSRNOT00000098351	0.59	0.31	top1	1	0.31	4.1e-08	-5.1	-5.1	2.6e-07	0.95	0.17	0.70	FALSE
29	OFC	Sdhb	alternative polyA	ENSRNOT00000105563	0.58	0.31	top1	1	0.31	3.1e-08	-5.1	5.1	2.6e-07	-0.95	0.17	0.69	FALSE
30	OFC	Padi2	gene expression	ENSRNOG00000007574	0.26	0.16	top1	1	0.16	1.4e-04	-5.3	5.3	1.5e-07	-0.95	0.14	0.14	TRUE
31	OFC	Sdhb	isoform ratio	ENSRNOT00000010593	0.28	0.07	top1	1	0.06	1.2e-02	-5.1	-5.1	2.6e-07	0.94	0.15	0.06	FALSE
32	OFC	Sdhb	isoform ratio	ENSRNOT00000105563	0.50	0.21	lasso	8	0.23	4.4e-06	-5.3	5.1	3.3e-07	-0.93	0.39	0.60	FALSE
33	PL	Sdhb	alternative polyA	ENSRNOT00000098351	0.80	0.63	lasso	31	0.65	1.2e-63	-5.3	-5.1	3.4e-07	0.99	0.10	0.90	FALSE
34	PL	Padi2	gene expression	ENSRNOG00000007574	0.58	0.39	lasso	34	0.47	3.9e-40	-5.1	5.1	2.8e-07	-0.96	0.13	0.87	FALSE
35	PL	Sdhb	isoform ratio	ENSRNOT00000010593	0.34	0.27	top1	1	0.27	2.7e-20	-5.2	-5.2	2.3e-07	0.92	0.16	0.84	FALSE
36	PL	Sdhb	isoform ratio	ENSRNOT00000105563	0.65	0.52	top1	1	0.52	1.5e-45	-5.3	5.3	1.0e-07	-0.92	0.08	0.92	FALSE
37	PL	Crocc	mRNA stability	ENSRNOG00000008334	0.06	0.04	enet	20	0.07	2.6e-06	-5.3	-5.2	2.0e-07	0.99	0.23	0.74	FALSE
38	PL	Necap2	mRNA stability	ENSRNOG00000008427	0.08	0.05	top1	1	0.05	1.1e-04	-5.1	-5.1	2.9e-07	0.95	0.12	0.25	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.