Best TWAS P=2.48e-09 · Best GWAS P=8.97e-09 conditioned to 3.98e-01
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLA | Mrc2 | gene expression | Mrc2 | 0.09 | 1 | 0.03 | 9.7e-03 | -5.74 | 9.45e-09 | 0.12 | FALSE |
| BLA | Marchf10 | isoform ratio | XR_005489857.1 | 0.28 | 20 | 0.23 | 1.2e-12 | -5.75 | 8.87e-09 | 0.96 | FALSE |
| BLA | Cyb561 | intron excision ratio | chr10_90884535_90888604 | 0.13 | 1 | 0.04 | 5.0e-03 | -5.74 | 9.45e-09 | 0.65 | FALSE |
| BLA | Marchf10 | intron excision ratio | chr10_90333190_90335149 | 0.15 | 86 | 0.07 | 1.3e-04 | 5.94 | 2.85e-09 | 0.92 | FALSE |
| BLA | Marchf10 | intron excision ratio | chr10_90333190_90336385 | 0.21 | 2477 | 0.1 | 6.7e-06 | 5.96 | 2.48e-09 | 0.94 | TRUE |
| Brain | Marchf10 | alternative polyA | XM_017597337.2 | 0.05 | 1 | 0.05 | 1.2e-05 | 5.7 | 1.21e-08 | 0.76 | FALSE |
| Brain | Marchf10 | alternative polyA | XM_017597340.2 | 0.05 | 1 | 0.05 | 1.5e-05 | -5.7 | 1.21e-08 | 0.73 | FALSE |
| Brain | Marchf10 | isoform ratio | XR_005489857.1 | 0.25 | 174 | 0.29 | 9.8e-27 | 5.4 | 6.53e-08 | 0.96 | FALSE |
| Brain | LOC120095188 | intron excision ratio | chr10_90474854_90527932 | 0.04 | 2540 | 0.04 | 2.8e-04 | 5.76 | 8.45e-09 | 0.84 | FALSE |
| Brain | Marchf10 | intron excision ratio | chr10_90333190_90335149 | 0.09 | 12 | 0.06 | 6.0e-06 | -5.51 | 3.65e-08 | 0.9 | FALSE |
| Brain | Marchf10 | intron excision ratio | chr10_90333190_90336385 | 0.15 | 14 | 0.13 | 8.8e-12 | 5.59 | 2.22e-08 | 0.92 | FALSE |
| IL | Marchf10 | isoform ratio | XR_005489857.1 | 0.21 | 20 | 0.07 | 1.1e-02 | -5.74 | 9.60e-09 | 0.64 | FALSE |
| Liver | Cyb561 | intron excision ratio | chr10_90882199_90884326 | 0.15 | 1 | 0.08 | 1.7e-09 | -5.7 | 1.21e-08 | 0.99 | FALSE |
| Liver | Cyb561 | intron excision ratio | chr10_90882199_90888604 | 0.16 | 1 | 0.09 | 4.6e-10 | 5.7 | 1.21e-08 | 0.99 | FALSE |
| NAcc | Marchf10 | alternative polyA | XM_017597337.2 | 0.03 | 1 | 0.02 | 2.1e-03 | 5.74 | 9.45e-09 | 0.44 | FALSE |
| NAcc | Marchf10 | alternative polyA | XM_017597340.2 | 0.03 | 1 | 0.02 | 2.3e-03 | -5.74 | 9.45e-09 | 0.4 | FALSE |
| NAcc | Mrc2 | gene expression | Mrc2 | 0.25 | 85 | 0.09 | 1.4e-10 | -5.63 | 1.81e-08 | 0.89 | FALSE |
| NAcc | Marchf10 | isoform ratio | XR_005489857.1 | 0.15 | 1 | 0.12 | 1.8e-13 | 5.74 | 9.45e-09 | 0.96 | FALSE |
| NAcc | Marchf10 | intron excision ratio | chr10_90333190_90335149 | 0.07 | 1 | 0.06 | 1.3e-07 | 5.74 | 9.45e-09 | 0.96 | FALSE |
| NAcc | Marchf10 | intron excision ratio | chr10_90333190_90336385 | 0.07 | 1 | 0.06 | 7.4e-08 | -5.74 | 9.45e-09 | 0.96 | FALSE |
| OFC | Marchf10 | isoform ratio | XR_005489857.1 | 0.36 | 308 | 0.14 | 3.4e-04 | 5.28 | 1.28e-07 | 0.61 | FALSE |
| PL | Marchf10 | alternative TSS | XM_017597337.2 | 0.03 | 2477 | 0.02 | 1.9e-03 | 5.69 | 1.26e-08 | 0.65 | FALSE |
| PL | Marchf10 | gene expression | Marchf10 | 0.24 | 1 | 0.22 | 2.4e-23 | 5.74 | 9.45e-09 | 0.96 | FALSE |
| PL | Marchf10 | isoform ratio | XR_005489857.1 | 0.29 | 80 | 0.3 | 1.8e-33 | 5.52 | 3.32e-08 | 0.96 | FALSE |
| PL | Marchf10 | intron excision ratio | chr10_90333190_90335149 | 0.07 | 1 | 0.07 | 5.9e-08 | 5.75 | 8.97e-09 | 0.96 | FALSE |
| PL | Marchf10 | intron excision ratio | chr10_90333190_90336385 | 0.1 | 1 | 0.12 | 1.0e-12 | -5.75 | 8.97e-09 | 0.96 | FALSE |
| pVTA | Marchf10 | isoform ratio | XR_005489857.1 | 0.32 | 1 | 0.23 | 2.8e-10 | 5.74 | 9.45e-09 | 0.96 | FALSE |
| pVTA | Marchf10 | intron excision ratio | chr10_90333190_90336385 | 0.1 | 28 | 0.02 | 3.8e-02 | -5.29 | 1.25e-07 | 0.6 | FALSE |
| RMTg | Cyb561 | alternative TSS | XM_039086163.1 | 0.24 | 11 | 0.05 | 1.6e-02 | -5.63 | 1.82e-08 | 0.7 | FALSE |
| RMTg | Mettl2 | mRNA stability | Mettl2 | 0.17 | 4 | 0.11 | 7.3e-04 | -5.31 | 1.09e-07 | 0.51 | FALSE |