Hub : Traits : Bone: cortical porosity : ←

chr10:88,340,994-91,822,036

Trait: Bone: cortical porosity

Best TWAS P=8.969852e-09 · Best GWAS P=8.327585e-09 conditioned to 0.02408705

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	BLA	Mrc2	gene expression	ENSRNOG00000006548	0.07	0.03	top1	1	0.03	1.3e-02	-5.7	5.7	9.4e-09	-0.61	0.11	0.11	FALSE
2	BLA	Marchf10	intron excision ratio	chr10:90333190:90335149	0.13	0.08	top1	1	0.08	5.1e-05	-5.7	-5.7	9.4e-09	0.72	0.06	0.57	FALSE
3	BLA	Marchf10	intron excision ratio	chr10:90333190:90336385	0.22	0.10	top1	1	0.10	4.6e-06	-5.7	5.7	9.4e-09	-0.71	0.05	0.86	FALSE
4	Brain	Marchf10	alternative polyA	ENSRNOT00000009316	0.06	0.03	blup	2472	0.04	1.0e-04	-5.7	-5.1	3.2e-07	0.73	0.10	0.90	FALSE
5	Brain	Crhr1	gene expression	ENSRNOG00000004900	0.14	0.01	blup	2613	0.03	1.2e-03	-3.8	-5.1	3.4e-07	0.62	0.29	0.24	FALSE
6	Brain	Kcnh6	gene expression	ENSRNOG00000008078	0.05	0.00	blup	1981	0.03	2.2e-03	-4.5	-5.2	1.7e-07	0.71	0.46	0.49	FALSE
7	Brain	Marchf10	intron excision ratio	chr10:90333190:90335149	0.10	0.08	lasso	9	0.08	4.2e-08	-5.7	-5.4	7.2e-08	0.71	0.11	0.89	FALSE
8	Brain	Marchf10	intron excision ratio	chr10:90333190:90336385	0.17	0.11	lasso	11	0.12	1.5e-11	-5.7	5.7	1.5e-08	-0.75	0.06	0.94	FALSE
9	Brain	Strada	intron excision ratio	chr10:91104254:91111276	0.05	0.02	top1	1	0.02	2.3e-03	-5.7	5.7	1.2e-08	-0.51	0.01	0.84	FALSE
10	Liver	Cyb561	intron excision ratio	chr10:90882199:90888604	0.16	0.08	lasso	15	0.08	6.2e-09	-5.7	-5.7	1.0e-08	0.92	0.01	0.99	FALSE
11	NAcc	Mrc2	gene expression	ENSRNOG00000006548	0.15	0.05	enet	126	0.09	6.3e-07	-4.9	5.4	7.9e-08	-0.50	0.57	0.43	FALSE
12	PL	Marchf10	gene expression	ENSRNOG00000007084	0.14	0.11	top1	1	0.11	6.1e-09	-5.7	-5.7	9.0e-09	0.74	0.04	0.96	TRUE
13	PL	Marchf10	intron excision ratio	chr10:90333190:90335149	0.06	0.03	lasso	13	0.04	8.1e-04	-5.7	-5.6	2.4e-08	0.78	0.17	0.81	FALSE
14	PL	Marchf10	intron excision ratio	chr10:90333190:90336385	0.12	0.13	top1	1	0.13	4.5e-10	-5.7	5.7	9.0e-09	-0.69	0.04	0.96	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.