Best TWAS P=3.866442e-09 · Best GWAS P=0.0001846949 conditioned to 1
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | Rbks | intron excision ratio | chr6:24773350:24777704 | 0.07 | 0.05 | enet | 84 | 0.05 | 1.5e-06 | -3.3 | 5.1 | 2.7e-07 | 0.52 | 0.46 | 0.42 | TRUE |
| 2 | Brain | Rbks | intron excision ratio | chr6:24777767:24778791 | 0.05 | 0.02 | enet | 56 | 0.02 | 4.8e-03 | -2.3 | 5.9 | 3.9e-09 | -0.99 | 0.50 | 0.20 | TRUE |
| 3 | Brain | Supt7l | mRNA stability | ENSRNOG00000004927 | 0.47 | 0.00 | enet | 75 | 0.03 | 4.9e-04 | -3.5 | -5.3 | 1.1e-07 | -0.50 | 0.09 | 0.14 | TRUE |
| 4 | NAcc | AABR07063281.1 | intron excision ratio | chr6:25089154:25090053 | 0.41 | 0.01 | blup | 926 | 0.01 | 4.0e-02 | -3.1 | -5.3 | 9.9e-08 | 0.83 | 0.12 | 0.18 | TRUE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.