Best TWAS P = 6.44e-17 · Best GWAS P= 2.15e-17 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Ctsc | alternative polyA | NM_017097.2 | 0.18 | 2571 | 0.19 | 1.5e-20 | 6.53 | 6.68e-11 | 0 | FALSE |
| Adipose | Ctsc | alternative polyA | XM_008759637.4 | 0.19 | 2571 | 0.2 | 1.0e-21 | -6.46 | 1.05e-10 | 0 | FALSE |
| Adipose | LOC102554680 | gene expression | LOC102554680 | 0.11 | 1 | 0.1 | 9.1e-11 | -5.55 | 2.78e-08 | 0 | FALSE |
| Adipose | Ctsc | isoform ratio | NM_017097.2 | 0.17 | 2571 | 0.16 | 1.9e-17 | 6.77 | 1.25e-11 | 0 | FALSE |
| Adipose | Ctsc | isoform ratio | XM_008759637.4 | 0.17 | 2571 | 0.17 | 3.0e-18 | -6.75 | 1.48e-11 | 0 | FALSE |
| Adipose | Ctsc | intron excision ratio | chr1_151443766_151448822 | 0.05 | 2571 | 0.03 | 7.1e-04 | -7.42 | 1.16e-13 | 0.63 | FALSE |
| Adipose | Ctsc | intron excision ratio | chr1_151443766_151458158 | 0.04 | 2571 | 0.03 | 4.0e-04 | 7.18 | 7.20e-13 | 0.58 | TRUE |
| BLA | Ctsc | gene expression | Ctsc | 0.15 | 260 | 0.12 | 7.4e-07 | -5.73 | 9.98e-09 | 0.68 | TRUE |
| BLA | Tyr | gene expression | Tyr | 0.1 | 1 | 0.06 | 3.3e-04 | 5.87 | 4.46e-09 | 0.04 | FALSE |
| BLA | Ctsc | isoform ratio | NM_017097.2 | 0.06 | 1 | 0.03 | 1.8e-02 | 7.2 | 5.95e-13 | 0.04 | FALSE |
| BLA | Ctsc | isoform ratio | XM_008759637.4 | 0.06 | 1 | 0.02 | 1.8e-02 | -7.2 | 5.95e-13 | 0.04 | FALSE |
| Brain | Ctsc | alternative polyA | NM_017097.2 | 0.06 | 24 | 0.07 | 6.4e-07 | 7.74 | 1.01e-14 | 0.63 | FALSE |
| Brain | Ctsc | alternative polyA | XM_008759637.4 | 0.06 | 24 | 0.07 | 6.5e-07 | -7.75 | 9.49e-15 | 0.62 | FALSE |
| Brain | Ctsc | gene expression | Ctsc | 0.28 | 2571 | 0.37 | 1.3e-36 | -6.43 | 1.24e-10 | 0 | FALSE |
| Brain | Grm5 | gene expression | Grm5 | 0.46 | 13 | 0.3 | 2.5e-28 | 7.49 | 7.08e-14 | 0.64 | FALSE |
| Brain | Ctsc | isoform ratio | NM_017097.2 | 0.06 | 1 | 0.05 | 2.1e-05 | 7.71 | 1.26e-14 | 0.1 | FALSE |
| Brain | Ctsc | isoform ratio | XM_008759637.4 | 0.06 | 1 | 0.05 | 2.6e-05 | -7.71 | 1.26e-14 | 0.09 | FALSE |
| Brain | Grm5 | mRNA stability | Grm5 | 0.1 | 1 | 0.09 | 4.9e-09 | 7.76 | 8.37e-15 | 0.05 | FALSE |
| Eye | Ctsc | gene expression | Ctsc | 0.34 | 20 | 0.16 | 1.8e-03 | -6.39 | 1.66e-10 | 0.15 | FALSE |
| IC | Ctsc | alternative polyA | NM_017097.2 | 0.09 | 1 | 0.06 | 1.6e-03 | 6.7 | 2.04e-11 | 0.04 | FALSE |
| IC | Ctsc | alternative polyA | XM_008759637.4 | 0.08 | 1 | 0.05 | 2.6e-03 | -6.7 | 2.04e-11 | 0.04 | FALSE |
| IC | Ctsc | gene expression | Ctsc | 0.16 | 2571 | 0.13 | 4.2e-06 | -6.42 | 1.35e-10 | 0.05 | FALSE |
| IC | Grm5 | gene expression | Grm5 | 0.3 | 33 | 0.24 | 1.2e-10 | 6.62 | 3.62e-11 | 0.23 | FALSE |
| IC | Tyr | gene expression | Tyr | 0.14 | 1 | 0.03 | 1.5e-02 | 5.9 | 3.64e-09 | 0.04 | FALSE |
| IC | Grm5 | isoform ratio | XM_006229659.5 | 0.06 | 52 | 0.03 | 2.4e-02 | -6.78 | 1.17e-11 | 0.27 | FALSE |
| IL | Ctsc | gene expression | Ctsc | 0.44 | 19 | 0.11 | 1.4e-03 | -8.36 | 6.44e-17 | 0.65 | TRUE |
| LHb | Ctsc | gene expression | Ctsc | 0.2 | 11 | 0.14 | 3.8e-04 | -6.49 | 8.51e-11 | 0.14 | TRUE |
| Liver | Ctsc | alternative TSS | NM_017097.2 | 0.04 | 1 | 0.04 | 8.4e-05 | -5.58 | 2.46e-08 | 0.03 | FALSE |
| Liver | Ctsc | alternative TSS | XM_008759637.4 | 0.05 | 1 | 0.04 | 9.7e-06 | 5.58 | 2.46e-08 | 0.02 | FALSE |
| Liver | LOC102554680 | gene expression | LOC102554680 | 0.05 | 13 | 0.04 | 7.2e-05 | -7.72 | 1.17e-14 | 0.64 | FALSE |
| NAcc | Ctsc | alternative polyA | NM_017097.2 | 0.04 | 1 | 0.04 | 2.0e-06 | 6.19 | 5.93e-10 | 0 | FALSE |
| NAcc | Ctsc | alternative polyA | XM_008759637.4 | 0.04 | 103 | 0.04 | 1.0e-06 | -6.51 | 7.63e-11 | 0.23 | FALSE |
| NAcc | Ctsc | gene expression | Ctsc | 0.13 | 2571 | 0.19 | 2.3e-28 | -7.34 | 2.12e-13 | 0.46 | FALSE |
| NAcc | Grm5 | gene expression | Grm5 | 0.08 | 1 | 0.08 | 7.3e-12 | 7.99 | 1.32e-15 | 0.23 | FALSE |
| NAcc | Tyr | gene expression | Tyr | 0.02 | 2904 | 0.01 | 1.3e-02 | 7.37 | 1.73e-13 | 0.43 | FALSE |
| NAcc | Ctsc | isoform ratio | NM_017097.2 | 0.05 | 1 | 0.05 | 2.9e-08 | 6.19 | 5.93e-10 | 0 | FALSE |
| NAcc | Ctsc | isoform ratio | XM_008759637.4 | 0.05 | 1 | 0.05 | 1.5e-07 | -6.19 | 5.93e-10 | 0 | FALSE |
| NAcc | Ctsc | intron excision ratio | chr1_151443766_151448822 | 0.02 | 1 | 0.01 | 1.7e-03 | -6.19 | 5.93e-10 | 0.02 | FALSE |
| NAcc | Ctsc | intron excision ratio | chr1_151443766_151458158 | 0.02 | 4 | 0.01 | 8.6e-03 | 6.94 | 3.96e-12 | 0.52 | FALSE |
| NAcc | Grm5 | mRNA stability | Grm5 | 0.03 | 1 | 0.03 | 3.3e-05 | 7.99 | 1.32e-15 | 0.1 | FALSE |
| OFC | Grm5 | gene expression | Grm5 | 0.23 | 11 | 0.16 | 1.0e-04 | 7.15 | 8.68e-13 | 0.44 | FALSE |
| PL | Ctsc | alternative polyA | NM_017097.2 | 0.03 | 2571 | 0.02 | 1.7e-03 | 6.6 | 4.02e-11 | 0.23 | FALSE |
| PL | Ctsc | alternative polyA | XM_008759637.4 | 0.03 | 1 | 0.02 | 1.3e-03 | -6 | 2.01e-09 | 0.03 | FALSE |
| PL | Ctsc | gene expression | Ctsc | 0.21 | 2571 | 0.21 | 1.0e-22 | -6.93 | 4.31e-12 | 0.08 | FALSE |
| PL | Grm5 | gene expression | Grm5 | 0.03 | 2746 | 0.02 | 2.8e-03 | 6.35 | 2.09e-10 | 0.35 | FALSE |
| PL | Ctsc | isoform ratio | NM_017097.2 | 0.02 | 2571 | 0.02 | 2.0e-03 | 6.6 | 4.04e-11 | 0.2 | FALSE |
| PL | Ctsc | isoform ratio | XM_008759637.4 | 0.02 | 2571 | 0.02 | 2.0e-03 | -6.6 | 4.13e-11 | 0.19 | FALSE |
| PL | Grm5 | intron excision ratio | chr1_150723078_150733678 | 0.03 | 2746 | 0.02 | 1.7e-03 | 5.65 | 1.56e-08 | 0.14 | FALSE |
| pVTA | Ctsc | gene expression | Ctsc | 0.25 | 1 | 0.25 | 2.0e-20 | -5.72 | 1.06e-08 | 0 | FALSE |
| pVTA | Grm5 | mRNA stability | Grm5 | 0.06 | 2746 | 0.03 | 3.6e-03 | 5.53 | 3.14e-08 | 0.49 | TRUE |