chr1:140,510,980-142,727,457

Trait: Total locomotion distance, NPP test

Best TWAS P=4.67e-17 · Best GWAS P=1.73e-17 conditioned to 8.05e-01

Associated models

Tissue	Gene	RNA modality	RNA phenotype	h²	# weights	Model R²	Model R² P	TWAS Z	TWAS P	Coloc P	Joint
Adipose	Ctsc	alternative polyA	ENSRNOT00000022342	0.16	2515	0.17	2.8e-18	6.83	8.32e-12	0	FALSE
Adipose	Ctsc	alternative polyA	ENSRNOT00000097085	0.17	2515	0.19	1.5e-20	-7.01	2.39e-12	0.02	FALSE
Adipose	Ctsc	isoform ratio	ENSRNOT00000022342	0.16	2515	0.16	4.3e-17	7.06	1.63e-12	0.18	FALSE
Adipose	Ctsc	isoform ratio	ENSRNOT00000097085	0.18	2515	0.18	1.3e-19	-7.19	6.30e-13	0.38	FALSE
Adipose	Ctsc	intron excision ratio	chr1:142031177:142036233	0.05	2515	0.04	6.5e-05	-7.39	1.47e-13	0.6	FALSE
Adipose	Ctsc	intron excision ratio	chr1:142031177:142045569	0.04	2515	0.02	4.7e-03	7.12	1.11e-12	0.5	FALSE
BLA	Ctsc	alternative polyA	ENSRNOT00000022342	0.07	2518	0.01	5.1e-02	6.01	1.90e-09	0.19	FALSE
BLA	Ctsc	alternative polyA	ENSRNOT00000097085	0.07	2518	0.02	3.2e-02	-5.7	1.18e-08	0.17	FALSE
BLA	Tyr	gene expression	ENSRNOG00000016421	0.15	1	0.09	2.4e-05	5.91	3.34e-09	0.02	FALSE
BLA	Ctsc	gene expression	ENSRNOG00000016496	0.12	1	0.1	5.0e-06	-7	2.60e-12	0.03	FALSE
BLA	Ctsc	mRNA stability	ENSRNOG00000016496	0.05	1	0.03	1.5e-02	8.29	1.13e-16	0.09	FALSE
Brain	Grm5	gene expression	ENSRNOG00000016429	0.16	6	0.15	5.3e-14	6.84	8.19e-12	0.63	FALSE
Brain	Ctsc	gene expression	ENSRNOG00000016496	0.23	2518	0.31	4.5e-29	-6.77	1.30e-11	0	FALSE
Brain	Ctsc	isoform ratio	ENSRNOT00000022342	0.03	1	0.04	1.7e-04	8.39	4.67e-17	0.69	TRUE
Eye	Ctsc	gene expression	ENSRNOG00000016496	0.29	1	0.15	2.9e-03	-7.5	6.50e-14	0.06	FALSE
IL	Ctsc	gene expression	ENSRNOG00000016496	0.3	1	0.16	1.0e-04	-7.78	7.04e-15	0.05	FALSE
LHb	Ctsc	gene expression	ENSRNOG00000016496	0.17	1	0.08	6.2e-03	-5.34	9.49e-08	0.05	FALSE
LHb	Ctsc	mRNA stability	ENSRNOG00000016496	0.17	1	0.09	3.4e-03	5.3	1.18e-07	0.05	TRUE
Liver	Ctsc	mRNA stability	ENSRNOG00000016496	0.05	2515	0.04	1.8e-05	6.53	6.74e-11	0.01	FALSE
NAcc	Ctsc	gene expression	ENSRNOG00000016496	0.12	2516	0.12	3.3e-09	-7.5	6.37e-14	0.43	FALSE
NAcc	Grm5	mRNA stability	ENSRNOG00000016429	0.07	2630	0.04	1.0e-03	-5.88	4.09e-09	0.13	FALSE
OFC	Ctsc	gene expression	ENSRNOG00000016496	0.14	1	0.05	2.4e-02	-5.31	1.09e-07	0.05	FALSE
OFC	Grm5	mRNA stability	ENSRNOG00000016429	0.17	2628	0.08	6.5e-03	-6.01	1.90e-09	0.21	FALSE
PL	Ctsc	gene expression	ENSRNOG00000016496	0.14	87	0.13	8.2e-10	-6.72	1.77e-11	0.66	FALSE
PL	Grm5	mRNA stability	ENSRNOG00000016429	0.04	1	0.03	1.3e-03	-8.35	6.72e-17	0.06	FALSE