Best TWAS P=3.808106e-08 · Best GWAS P=1.065656e-06 conditioned to 0.2229532
# | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | BLA | G2e3 | gene expression | ENSRNOG00000004232 | 0.12 | 0.03 | blup | 1570 | 0.06 | 6.3e-04 | 4.6 | -5.3 | 9.8e-08 | 0.68 | 0.35 | 0.63 | FALSE |
2 | BLA | Hectd1 | gene expression | ENSRNOG00000006905 | 0.06 | 0.00 | blup | 1835 | 0.04 | 3.9e-03 | 4.7 | -5.3 | 1.0e-07 | 0.76 | 0.43 | 0.39 | FALSE |
3 | BLA | Scfd1 | mRNA stability | ENSRNOG00000031203 | 0.33 | 0.23 | lasso | 6 | 0.23 | 8.6e-13 | -4.4 | 5.2 | 2.4e-07 | -0.83 | 0.67 | 0.33 | FALSE |
4 | Brain | Hectd1 | mRNA stability | ENSRNOG00000006905 | 0.05 | 0.00 | blup | 1835 | 0.02 | 4.8e-03 | -3.8 | -5.3 | 1.4e-07 | 0.78 | 0.44 | 0.38 | FALSE |
5 | LHb | Heatr5a | gene expression | ENSRNOG00000006483 | 0.18 | 0.14 | blup | 1750 | 0.14 | 3.7e-04 | 4.6 | -5.2 | 2.0e-07 | 0.63 | 0.38 | 0.50 | FALSE |
6 | Liver | Scfd1 | mRNA stability | ENSRNOG00000031203 | 0.10 | 0.06 | blup | 1615 | 0.06 | 5.3e-07 | -4.4 | -5.1 | 2.9e-07 | 0.95 | 0.55 | 0.45 | FALSE |
7 | NAcc | G2e3 | gene expression | ENSRNOG00000004232 | 0.12 | 0.09 | lasso | 13 | 0.10 | 8.0e-08 | 4.8 | -5.5 | 3.8e-08 | 0.74 | 0.35 | 0.65 | TRUE |
8 | NAcc | Hectd1 | intron excision ratio | chr6:69206174:69209504 | 0.04 | 0.03 | blup | 1833 | 0.03 | 1.6e-03 | 4.6 | -5.1 | 3.1e-07 | 0.62 | 0.42 | 0.47 | FALSE |
9 | OFC | G2e3 | gene expression | ENSRNOG00000004232 | 0.55 | 0.13 | lasso | 5 | 0.17 | 8.2e-05 | -4.8 | -5.4 | 6.1e-08 | 0.88 | 0.31 | 0.52 | FALSE |
10 | PL | G2e3 | gene expression | ENSRNOG00000004232 | 0.23 | 0.13 | blup | 1569 | 0.21 | 1.2e-15 | 4.7 | -5.4 | 6.7e-08 | 0.75 | 0.35 | 0.65 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.