Best TWAS P = 1.91e-09 · Best GWAS P= 1.42e-07 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Tmlhe | gene expression | Tmlhe | 0.33 | 23 | 0.21 | 1.1e-22 | 5.55 | 2.85e-08 | 0.68 | FALSE |
| BLA | Tmlhe | intron excision ratio | chr20_107697_113298 | 0.37 | 18 | 0.09 | 1.3e-05 | 5.23 | 1.69e-07 | 0.66 | FALSE |
| Brain | Tmlhe | alternative TSS | NM_133387.2 | 0.08 | 35 | 0.08 | 1.2e-07 | -5.7 | 1.21e-08 | 0.22 | FALSE |
| Brain | Tmlhe | alternative TSS | XM_006255855.3 | 0.03 | 21 | 0.03 | 5.4e-04 | 5.35 | 8.99e-08 | 0.27 | FALSE |
| Brain | Tmlhe | alternative TSS | NM_133387.2 | 0.03 | 1 | 0.04 | 2.7e-04 | -5.63 | 1.77e-08 | 0.63 | FALSE |
| Brain | Tmlhe | alternative TSS | XM_006255855.3 | 0.03 | 6 | 0.04 | 2.4e-04 | 5.6 | 2.15e-08 | 0.35 | TRUE |
| Brain | LOC120098879 | gene expression | LOC120098879 | 0.65 | 37 | 0.62 | 6.5e-74 | -5.65 | 1.60e-08 | 0.16 | TRUE |
| Brain | Tmlhe | isoform ratio | XM_006255855.3 | 0.43 | 2589 | 0.29 | 1.4e-27 | 5.44 | 5.37e-08 | 0.67 | FALSE |
| Brain | Tmlhe | intron excision ratio | chr20_107697_113298 | 0.17 | 2589 | 0.13 | 3.5e-12 | 5.36 | 8.19e-08 | 0.67 | FALSE |
| IC | Tmlhe | intron excision ratio | chr20_107697_113298 | 0.18 | 2589 | 0.06 | 1.8e-03 | 5.81 | 6.35e-09 | 0.61 | FALSE |
| IC | Tmlhe | intron excision ratio | chr20_111063_113298 | 0.09 | 2589 | 0.01 | 8.5e-02 | -5.42 | 5.96e-08 | 0.21 | FALSE |
| IL | LOC120098879 | isoform ratio | XM_063279601.1 | 0.2 | 1 | 0.07 | 1.1e-02 | -5.53 | 3.15e-08 | 0.14 | FALSE |
| IL | LOC120098879 | isoform ratio | XM_063279602.1 | 0.2 | 1 | 0.06 | 1.2e-02 | 5.53 | 3.15e-08 | 0.14 | TRUE |
| NAcc | Tmlhe | isoform ratio | XM_006255855.3 | 0.41 | 2589 | 0.18 | 2.7e-26 | 6 | 1.91e-09 | 0.67 | TRUE |
| NAcc | Tmlhe | intron excision ratio | chr20_107697_113298 | 0.16 | 30 | 0.11 | 7.2e-17 | 5.74 | 9.60e-09 | 0.67 | FALSE |
| NAcc | Tmlhe | intron excision ratio | chr20_111063_113298 | 0.07 | 2589 | 0.06 | 3.0e-09 | -5.98 | 2.29e-09 | 0.22 | FALSE |
| PL | Tmlhe | isoform ratio | XM_006255855.3 | 0.2 | 2589 | 0.15 | 9.9e-16 | 5.31 | 1.08e-07 | 0.67 | FALSE |
| PL | Tmlhe | intron excision ratio | chr20_107697_113298 | 0.09 | 2589 | 0.07 | 6.3e-08 | 5.9 | 3.70e-09 | 0.66 | FALSE |
| pVTA | Tmlhe | gene expression | Tmlhe | 0.16 | 2589 | 0.03 | 9.6e-04 | 5.69 | 1.30e-08 | 0.23 | FALSE |
| pVTA | Tmlhe | isoform ratio | XM_006255855.3 | 0.17 | 33 | 0.12 | 6.9e-10 | 5.25 | 1.51e-07 | 0.67 | FALSE |
| pVTA | Tmlhe | intron excision ratio | chr20_107697_113298 | 0.18 | 2589 | 0.16 | 7.8e-13 | 5.56 | 2.74e-08 | 0.67 | FALSE |
| pVTA | LOC120098879 | mRNA stability | LOC120098879 | 0.04 | 2560 | 0.04 | 6.5e-04 | -5.3 | 1.18e-07 | 0.24 | FALSE |