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chr3:129,554,891-132,075,398

Trait: Epididymis fat weight

Best TWAS P=1.360161e-08 · Best GWAS P=9.316771e-09 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Snrpb2	mRNA stability	ENSRNOG00000004967	0.04	0.01	enet	20	0.01	1.5e-02	5.1	-5.1	2.7e-07	-0.80	0.47	0.47	FALSE
2	BLA	Kif16b	gene expression	ENSRNOG00000004951	0.04	0.04	top1	1	0.04	4.1e-03	5.2	5.2	2.6e-07	0.99	0.09	0.04	FALSE
3	BLA	Snrpb2	gene expression	ENSRNOG00000004967	0.05	0.02	top1	1	0.02	4.4e-02	5.5	5.5	3.0e-08	0.99	0.08	0.04	FALSE
4	BLA	Pcsk2	gene expression	ENSRNOG00000005438	0.11	0.07	top1	1	0.07	1.9e-04	5.2	5.2	2.3e-07	0.98	0.11	0.05	FALSE
5	BLA	Otor	gene expression	ENSRNOG00000028721	0.07	0.04	blup	1960	0.04	2.7e-03	4.7	-5.6	1.7e-08	-0.84	0.51	0.24	FALSE
6	BLA	Pcsk2	mRNA stability	ENSRNOG00000005438	0.23	0.15	top1	1	0.15	3.1e-08	-5.4	-5.4	6.2e-08	-0.96	0.52	0.42	FALSE
7	BLA	Dstn	mRNA stability	ENSRNOG00000005924	0.45	0.38	enet	182	0.39	2.2e-22	-5.3	5.3	1.4e-07	0.94	0.38	0.62	FALSE
8	Brain	Pcsk2	gene expression	ENSRNOG00000005438	0.38	0.44	top1	1	0.44	3.9e-44	5.5	5.5	4.3e-08	0.98	0.47	0.53	FALSE
9	Brain	Otor	gene expression	ENSRNOG00000028721	0.10	0.09	enet	25	0.11	5.1e-10	-5.5	-5.6	2.5e-08	-0.66	0.51	0.49	FALSE
10	Brain	Snrpb2	intron excision ratio	chr3:130399307:130400989	0.03	0.03	top1	1	0.03	5.7e-04	5.7	5.7	1.5e-08	0.99	0.07	0.06	FALSE
11	IL	Pcsk2	gene expression	ENSRNOG00000005438	0.49	0.21	top1	1	0.21	7.5e-06	5.7	5.7	1.4e-08	0.99	0.10	0.18	TRUE
12	LHb	Snrpb2	gene expression	ENSRNOG00000004967	0.24	0.15	top1	1	0.15	2.3e-04	5.3	5.3	9.5e-08	1.00	0.10	0.05	FALSE
13	LHb	Rrbp1	gene expression	ENSRNOG00000005958	0.22	0.21	top1	1	0.21	1.0e-05	-5.5	-5.5	3.2e-08	-0.94	0.08	0.13	FALSE
14	LHb	Otor	gene expression	ENSRNOG00000028721	0.26	-0.01	lasso	5	0.01	1.7e-01	5.0	-5.6	2.5e-08	-0.86	0.39	0.28	FALSE
15	LHb	Kif16b	mRNA stability	ENSRNOG00000004951	0.11	0.01	enet	6	0.03	7.3e-02	5.1	-5.2	2.3e-07	-0.77	0.42	0.34	FALSE
16	Liver	Kif16b	alternative polyA	ENSRNOT00000036273	0.18	0.14	top1	1	0.14	6.7e-15	5.6	-5.6	2.4e-08	-1.00	0.40	0.60	FALSE
17	Liver	Kif16b	alternative polyA	ENSRNOT00000118037	0.18	0.14	top1	1	0.14	1.3e-15	5.5	5.5	3.5e-08	1.00	0.48	0.52	FALSE
18	Liver	Kif16b	gene expression	ENSRNOG00000004951	0.21	0.17	lasso	12	0.18	3.7e-19	5.5	-5.2	1.6e-07	-0.97	0.61	0.39	FALSE
19	Liver	Kif16b	isoform ratio	ENSRNOT00000083061	0.06	0.04	top1	1	0.04	4.7e-05	5.3	-5.3	1.0e-07	-1.00	0.35	0.13	FALSE
20	Liver	Kif16b	isoform ratio	ENSRNOT00000118037	0.15	0.13	blup	2140	0.13	4.0e-14	5.6	5.3	8.9e-08	0.99	0.45	0.55	FALSE
21	Liver	Kif16b	intron excision ratio	chr3:129976371:129996958	0.03	0.01	blup	2140	0.01	2.4e-02	4.9	-5.4	5.2e-08	-0.82	0.35	0.10	FALSE
22	Liver	Snrpb2	intron excision ratio	chr3:130399832:130400989	0.06	0.03	blup	1963	0.03	2.4e-04	-5.0	-5.3	1.1e-07	-0.99	0.64	0.35	FALSE
23	Liver	Kif16b	mRNA stability	ENSRNOG00000004951	0.13	0.06	enet	30	0.06	1.2e-07	5.1	-5.3	1.4e-07	-0.57	0.92	0.08	FALSE
24	NAcc	Snrpb2	gene expression	ENSRNOG00000004967	0.04	0.02	top1	1	0.02	1.4e-02	5.6	5.6	2.0e-08	0.99	0.07	0.04	FALSE
25	NAcc	Otor	gene expression	ENSRNOG00000028721	0.04	0.01	top1	1	0.01	5.2e-02	5.4	-5.4	5.9e-08	-1.00	0.07	0.04	FALSE
26	NAcc	Kif16b	mRNA stability	ENSRNOG00000004951	0.04	0.00	lasso	27	0.01	5.8e-02	-5.1	-5.2	2.3e-07	-0.45	0.46	0.46	FALSE
27	PL	Snrpb2	gene expression	ENSRNOG00000004967	0.12	0.10	enet	9	0.11	1.3e-08	5.1	5.2	1.8e-07	0.99	0.63	0.37	FALSE
28	PL	Pcsk2	gene expression	ENSRNOG00000005438	0.15	0.16	enet	80	0.18	1.0e-13	-5.3	5.5	3.0e-08	0.95	0.65	0.35	FALSE
29	PL	Snrpb2	intron excision ratio	chr3:130399307:130400989	0.05	0.03	blup	1963	0.03	2.9e-03	-5.3	5.6	1.8e-08	0.99	0.48	0.49	FALSE
30	PL	Pcsk2	mRNA stability	ENSRNOG00000005438	0.04	0.02	top1	1	0.02	5.4e-03	-5.4	-5.4	7.5e-08	-0.97	0.05	0.04	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.