Best TWAS P=4.98e-09 · Best GWAS P=9.32e-09 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Kif16b | isoform ratio | XM_006235108.4 | 0.07 | 2158 | 0.03 | 1.7e-04 | 5.68 | 1.33e-08 | 0.2 | FALSE |
| BLA | Otor | gene expression | Otor | 0.06 | 1963 | 0.01 | 1.2e-01 | -5.71 | 1.15e-08 | 0.22 | FALSE |
| BLA | Snrpb2 | gene expression | Snrpb2 | 0.06 | 1954 | 0.01 | 5.2e-02 | 5.21 | 1.85e-07 | 0.4 | FALSE |
| BLA | Pcsk2 | mRNA stability | Pcsk2 | 0.27 | 1 | 0.09 | 1.5e-05 | 5.41 | 6.21e-08 | 0.36 | FALSE |
| Brain | Rrbp1 | alternative TSS | XM_039106605.1 | 0.03 | 1 | 0.02 | 3.5e-03 | -5.4 | 6.56e-08 | 0.09 | FALSE |
| Brain | Rrbp1 | alternative TSS | XM_230637.10 | 0.03 | 1 | 0.03 | 1.7e-03 | 5.4 | 6.56e-08 | 0.13 | FALSE |
| Brain | Otor | gene expression | Otor | 0.1 | 1990 | 0.11 | 4.9e-10 | -5.76 | 8.20e-09 | 0.48 | FALSE |
| Brain | LOC120101719 | intron excision ratio | chr3_130525654_130567132 | 0.13 | 39 | 0.2 | 2.1e-18 | 5.43 | 5.56e-08 | 0.44 | FALSE |
| Brain | Snrpb2 | intron excision ratio | chr3_130399307_130400989 | 0.04 | 1981 | 0.04 | 2.9e-04 | 5.85 | 4.98e-09 | 0.49 | TRUE |
| IL | LOC120101719 | alternative polyA | XR_005502515.1 | 0.24 | 1 | 0.29 | 1.1e-07 | -5.38 | 7.50e-08 | 0.16 | FALSE |
| IL | Pcsk2 | gene expression | Pcsk2 | 0.5 | 1455 | 0.15 | 2.4e-04 | 5.25 | 1.52e-07 | 0.52 | FALSE |
| IL | LOC120101719 | isoform ratio | XR_005502514.1 | 0.26 | 1 | 0.34 | 5.5e-09 | 5.38 | 7.50e-08 | 0.19 | FALSE |
| IL | LOC120101719 | isoform ratio | XR_005502515.1 | 0.26 | 1 | 0.34 | 5.4e-09 | -5.38 | 7.50e-08 | 0.19 | FALSE |
| IL | LOC120101719 | intron excision ratio | chr3_130525654_130567132 | 0.32 | 1 | 0.13 | 5.8e-04 | 5.52 | 3.40e-08 | 0.06 | FALSE |
| IL | Dstn | mRNA stability | Dstn | 0.58 | 237 | 0.36 | 1.8e-09 | -5.19 | 2.14e-07 | 0.5 | FALSE |
| LHb | Otor | gene expression | Otor | 0.24 | 1990 | 0.01 | 1.8e-01 | -5.77 | 7.83e-09 | 0.32 | FALSE |
| LHb | Snrpb2 | gene expression | Snrpb2 | 0.3 | 1981 | 0.14 | 3.6e-04 | 5.78 | 7.54e-09 | 0.42 | FALSE |
| Liver | Kif16b | alternative polyA | XM_039105041.1 | 0.16 | 2158 | 0.13 | 6.2e-14 | 5.27 | 1.36e-07 | 0.54 | FALSE |
| Liver | LOC120101717 | gene expression | LOC120101717 | 0.05 | 2365 | 0.01 | 1.9e-02 | -5.38 | 7.41e-08 | 0.2 | FALSE |
| NAcc | Kif16b | alternative polyA | XM_039105041.1 | 0.06 | 2158 | 0.04 | 5.5e-06 | 5.8 | 6.69e-09 | 0.48 | FALSE |
| NAcc | LOC120101719 | alternative polyA | XR_005502514.1 | 0.11 | 1 | 0.15 | 1.4e-16 | 5.69 | 1.31e-08 | 0.73 | FALSE |
| NAcc | Otor | gene expression | Otor | 0.03 | 1 | 0.04 | 9.3e-06 | 5.42 | 5.86e-08 | 0.23 | FALSE |
| NAcc | Pcsk2 | gene expression | Pcsk2 | 0.09 | 1455 | 0.12 | 1.6e-13 | 5.43 | 5.50e-08 | 0.41 | FALSE |
| NAcc | Snrpb2 | gene expression | Snrpb2 | 0.04 | 1981 | 0.03 | 1.2e-04 | 5.8 | 6.68e-09 | 0.45 | FALSE |
| NAcc | Kif16b | isoform ratio | XM_006235108.4 | 0.02 | 2158 | 0.02 | 1.9e-03 | 5.77 | 7.71e-09 | 0.36 | FALSE |
| NAcc | LOC120101719 | isoform ratio | XR_005502514.1 | 0.12 | 1 | 0.13 | 3.4e-15 | 5.69 | 1.31e-08 | 0.73 | FALSE |
| NAcc | Snrpb2 | intron excision ratio | chr3_130399307_130400989 | 0.08 | 1981 | 0.07 | 2.0e-08 | 5.72 | 1.10e-08 | 0.34 | FALSE |
| NAcc | Snrpb2 | intron excision ratio | chr3_130399832_130400989 | 0.08 | 1981 | 0.09 | 1.6e-10 | -5.7 | 1.19e-08 | 0.4 | FALSE |
| OFC | LOC120101719 | alternative polyA | XR_005502514.1 | 0.35 | 43 | 0.3 | 7.6e-08 | 5.44 | 5.32e-08 | 0.47 | FALSE |
| OFC | LOC120101719 | alternative polyA | XR_005502515.1 | 0.35 | 86 | 0.29 | 1.6e-07 | -5.5 | 3.83e-08 | 0.47 | FALSE |
| OFC | LOC120101719 | gene expression | LOC120101719 | 0.18 | 1 | 0.22 | 7.2e-06 | -5.31 | 1.07e-07 | 0.06 | FALSE |
| OFC | Pcsk2 | gene expression | Pcsk2 | 0.56 | 1 | 0.36 | 1.7e-09 | -5.38 | 7.50e-08 | 0.38 | FALSE |
| OFC | LOC120101719 | isoform ratio | XR_005502514.1 | 0.38 | 1 | 0.26 | 5.6e-07 | 5.25 | 1.53e-07 | 0.1 | FALSE |
| PL | Kif16b | alternative polyA | XM_039105041.1 | 0.03 | 2158 | 0.03 | 3.3e-04 | 5.84 | 5.20e-09 | 0.46 | FALSE |
| PL | LOC120101719 | alternative polyA | XR_005502514.1 | 0.3 | 1 | 0.35 | 2.0e-39 | 5.3 | 1.16e-07 | 0.25 | FALSE |
| PL | LOC120101719 | alternative polyA | XR_005502515.1 | 0.34 | 1 | 0.37 | 4.9e-42 | -5.44 | 5.18e-08 | 0.42 | FALSE |
| PL | Otor | gene expression | Otor | 0.04 | 1 | 0.06 | 5.0e-07 | 5.23 | 1.66e-07 | 0.18 | FALSE |
| PL | Pcsk2 | gene expression | Pcsk2 | 0.09 | 1455 | 0.15 | 2.6e-16 | 5.2 | 1.97e-07 | 0.36 | FALSE |
| PL | LOC120101719 | isoform ratio | XR_005502514.1 | 0.43 | 25 | 0.41 | 5.9e-48 | 5.29 | 1.22e-07 | 0.46 | FALSE |
| PL | LOC120101719 | intron excision ratio | chr3_130525654_130567132 | 0.26 | 1 | 0.4 | 3.9e-47 | 5.53 | 3.22e-08 | 0.53 | FALSE |
| PL | LOC120101719 | intron excision ratio | chr3_130529471_130567132 | 0.13 | 1 | 0.22 | 1.2e-23 | -5.44 | 5.18e-08 | 0.42 | FALSE |
| PL | Snrpb2 | intron excision ratio | chr3_130399832_130400989 | 0.06 | 1981 | 0.06 | 2.7e-07 | -5.79 | 7.13e-09 | 0.5 | FALSE |
| PL | Pcsk2 | mRNA stability | Pcsk2 | 0.04 | 1 | 0.03 | 1.1e-04 | 5.4 | 6.56e-08 | 0.27 | FALSE |
| pVTA | Otor | gene expression | Otor | 0.11 | 1 | 0.13 | 3.8e-06 | 5.3 | 1.15e-07 | 0.12 | FALSE |
| pVTA | Pcsk2 | gene expression | Pcsk2 | 0.46 | 29 | 0.38 | 2.6e-17 | 5.34 | 9.21e-08 | 0.5 | FALSE |
| pVTA | Snrpb2 | gene expression | Snrpb2 | 0.07 | 1954 | 0.06 | 1.9e-03 | 5.84 | 5.19e-09 | 0.39 | FALSE |
| pVTA | Pcsk2 | mRNA stability | Pcsk2 | 0.11 | 1 | 0.15 | 5.3e-07 | 5.21 | 1.84e-07 | 0.17 | FALSE |