Best TWAS P = 1.14e-08 · Best GWAS P= 9.99e-07 conditioned to 5.55e-01
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Eye | Smtnl2 | mRNA stability | Smtnl2 | 0.29 | 513 | 0.17 | 1.3e-03 | -5.61 | 2.02e-08 | 0.28 | FALSE |
| IL | 4933427D14Rikl | alternative polyA | XM_063269343.1 | 0.26 | 93 | 0.06 | 1.6e-02 | -5.31 | 1.07e-07 | 0.24 | FALSE |
| IL | 4933427D14Rikl | alternative polyA | XM_063269343.1 | 0.27 | 27 | 0.06 | 1.7e-02 | -5.29 | 1.19e-07 | 0.26 | FALSE |
| LHb | 4933427D14Rikl | gene expression | 4933427D14Rikl | 0.31 | 203 | 0.14 | 4.1e-04 | 5.6 | 2.16e-08 | 0.31 | FALSE |
| Liver | 4933427D14Rikl | isoform ratio | XR_010055205.1 | 0.06 | 22 | 0.01 | 1.4e-02 | 5.38 | 7.51e-08 | 0.54 | FALSE |
| Liver | 4933427D14Rikl | intron excision ratio | chr10_57282557_57282672 | 0.05 | 118 | 0.02 | 3.4e-03 | 5.28 | 1.30e-07 | 0.38 | FALSE |
| NAcc | Itgae | intron excision ratio | chr10_58249594_58251233 | 0.05 | 11 | 0.02 | 4.0e-04 | 5.49 | 4.13e-08 | 0.49 | FALSE |
| NAcc | Itgae | intron excision ratio | chr10_58251328_58261109 | 0.04 | 2 | 0.01 | 2.7e-03 | -5.71 | 1.14e-08 | 0.36 | TRUE |
| NAcc | Wscd1 | intron excision ratio | chr10_56884693_56894557 | 0.03 | 10 | 0.01 | 2.1e-02 | -5.49 | 4.03e-08 | 0.33 | FALSE |
| PL | Tekt1 | gene expression | Tekt1 | 0.08 | 84 | 0.07 | 3.1e-08 | -5.42 | 5.98e-08 | 0.6 | FALSE |