Project: dissection
207 significantly associated models · 68 unique genes
# | chr | p0 | p1 | # assoc genes | # joint models | best TWAS P | best SNP P | cond SNP P | % var exp | joint genes |
---|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 258394596 | 260518987 | 10 | 3 | 5.6e-11 | 1.9e-11 | 1.0000 | 100 | Cacul1 Dennd10 Sfxn4 |
2 | 2 | 34603761 | 36646696 | 2 | 1 | 3.1e-07 | 2.4e-07 | 1.0000 | 100 | Srek1ip1 |
3 | 6 | 100633498 | 102031735 | 1 | 1 | 6.3e-08 | 2.5e-07 | 0.6132 | 99 | Ttc9 |
4 | 6 | 131006926 | 132888501 | 14 | 1 | 2.3e-08 | 8.6e-08 | 0.0881 | 90 | Nudt14 |
5 | 9 | 14884566 | 16148774 | 2 | 1 | 1.2e-07 | 5.5e-07 | 0.4122 | 97 | Nfkbie |
6 | 9 | 58867167 | 60264237 | 1 | 1 | 2.7e-07 | 9.1e-07 | 0.2245 | 94 | Kctd18 |
7 | 9 | 65337960 | 67403242 | 7 | 3 | 1.1e-08 | 3.5e-08 | 1.0000 | 100 | Mettl21a Pth2r Plekhm3 |
8 | 10 | 79556094 | 83007156 | 26 | 1 | 3.0e-09 | 4.5e-09 | 0.0530 | 89 | Phospho1 |
9 | 17 | 83014757 | 85459876 | 5 | 1 | 6.1e-08 | 1.9e-07 | 0.0043 | 70 | Enkur |
p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.
chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.
tissue | modality | # hits | % hits/tests | avg chisq |
---|---|---|---|---|
Adipose | alternative polyA | 6 | 0.283 | 2.4 |
Adipose | alternative TSS | 0 | 0.000 | 2.4 |
Adipose | gene expression | 12 | 0.145 | 2.5 |
Adipose | isoform ratio | 2 | 0.071 | 2.4 |
Adipose | intron excision ratio | 4 | 0.137 | 2.5 |
Adipose | mRNA stability | 4 | 0.116 | 2.5 |
BLA | alternative polyA | 0 | 0.000 | 2.4 |
BLA | alternative TSS | 0 | 0.000 | 2.6 |
BLA | gene expression | 11 | 0.182 | 2.6 |
BLA | isoform ratio | 2 | 0.114 | 2.7 |
BLA | intron excision ratio | 5 | 0.168 | 2.6 |
BLA | mRNA stability | 5 | 0.247 | 2.7 |
Brain | alternative polyA | 0 | 0.000 | 2.5 |
Brain | alternative TSS | 3 | 0.175 | 2.5 |
Brain | gene expression | 17 | 0.188 | 2.6 |
Brain | isoform ratio | 2 | 0.063 | 2.7 |
Brain | intron excision ratio | 9 | 0.166 | 2.7 |
Brain | mRNA stability | 4 | 0.092 | 2.5 |
Eye | alternative polyA | 0 | 0.000 | 2.7 |
Eye | alternative TSS | 0 | 0.000 | 2.4 |
Eye | gene expression | 3 | 0.267 | 2.6 |
Eye | isoform ratio | 0 | 0.000 | 2.6 |
Eye | intron excision ratio | 1 | 0.163 | 2.3 |
Eye | mRNA stability | 0 | 0.000 | 2.7 |
IL | alternative polyA | 0 | 0.000 | 2.6 |
IL | alternative TSS | 0 | 0.000 | 2.6 |
IL | gene expression | 10 | 0.274 | 2.5 |
IL | isoform ratio | 0 | 0.000 | 2.7 |
IL | intron excision ratio | 2 | 0.207 | 2.4 |
IL | mRNA stability | 5 | 0.450 | 2.6 |
LHb | alternative polyA | 0 | 0.000 | 2.3 |
LHb | alternative TSS | 0 | 0.000 | 2.6 |
LHb | gene expression | 6 | 0.187 | 2.6 |
LHb | isoform ratio | 0 | 0.000 | 2.6 |
LHb | intron excision ratio | 1 | 0.097 | 2.5 |
LHb | mRNA stability | 1 | 0.097 | 2.5 |
Liver | alternative polyA | 0 | 0.000 | 2.5 |
Liver | alternative TSS | 0 | 0.000 | 2.4 |
Liver | gene expression | 14 | 0.195 | 2.5 |
Liver | isoform ratio | 5 | 0.209 | 2.6 |
Liver | intron excision ratio | 2 | 0.046 | 2.5 |
Liver | mRNA stability | 4 | 0.163 | 2.6 |
NAcc | alternative polyA | 0 | 0.000 | 2.3 |
NAcc | alternative TSS | 0 | 0.000 | 2.3 |
NAcc | gene expression | 6 | 0.183 | 2.6 |
NAcc | isoform ratio | 0 | 0.000 | 2.8 |
NAcc | intron excision ratio | 1 | 0.105 | 2.5 |
NAcc | mRNA stability | 1 | 0.092 | 2.9 |
NAcc2 | alternative polyA | 1 | 0.090 | 2.5 |
NAcc2 | alternative TSS | 0 | 0.000 | 2.6 |
NAcc2 | gene expression | 9 | 0.169 | 2.6 |
NAcc2 | isoform ratio | 1 | 0.065 | 2.6 |
NAcc2 | intron excision ratio | 4 | 0.151 | 2.5 |
NAcc2 | mRNA stability | 1 | 0.056 | 2.6 |
OFC | alternative polyA | 0 | 0.000 | 2.2 |
OFC | alternative TSS | 1 | 0.313 | 2.6 |
OFC | gene expression | 6 | 0.162 | 2.7 |
OFC | isoform ratio | 2 | 0.245 | 2.8 |
OFC | intron excision ratio | 1 | 0.100 | 2.6 |
OFC | mRNA stability | 3 | 0.278 | 2.6 |
PL | alternative polyA | 0 | 0.000 | 2.3 |
PL | alternative TSS | 1 | 0.324 | 2.1 |
PL | gene expression | 7 | 0.188 | 2.6 |
PL | isoform ratio | 0 | 0.000 | 2.6 |
PL | intron excision ratio | 3 | 0.288 | 2.6 |
PL | mRNA stability | 0 | 0.000 | 2.7 |
PL2 | alternative polyA | 0 | 0.000 | 2.5 |
PL2 | alternative TSS | 0 | 0.000 | 2.7 |
PL2 | gene expression | 16 | 0.250 | 2.6 |
PL2 | isoform ratio | 0 | 0.000 | 2.6 |
PL2 | intron excision ratio | 1 | 0.032 | 2.6 |
PL2 | mRNA stability | 2 | 0.082 | 2.5 |
avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.