Best TWAS P=6.071517e-08 · Best GWAS P=1.933395e-07 conditioned to 0.004301534
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brain | Gad2 | gene expression | ENSRNOG00000018200 | 0.66 | 0.09 | top1 | 1 | 0.09 | 2.4e-08 | 5.1 | -5.1 | 3.0e-07 | -0.86 | 0.20 | 0.80 | FALSE |
| 2 | Brain | Enkur | intron excision ratio | chr17:83703535:83714117 | 0.18 | 0.11 | lasso | 47 | 0.17 | 3.4e-15 | 4.4 | 5.4 | 6.1e-08 | 0.51 | 0.86 | 0.14 | TRUE |
| 3 | LHb | Gpr158 | gene expression | ENSRNOG00000024832 | 0.51 | 0.20 | lasso | 3 | 0.32 | 2.3e-08 | 4.9 | 5.3 | 1.5e-07 | 0.51 | 0.27 | 0.73 | FALSE |
| 4 | NAcc2 | Thnsl1 | gene expression | ENSRNOG00000033076 | 0.21 | 0.10 | blup | 2089 | 0.18 | 5.2e-10 | 4.0 | -5.1 | 3.1e-07 | -0.49 | 0.86 | 0.13 | FALSE |
| 5 | PL2 | NA | gene expression | ENSRNOG00000018478 | 0.20 | 0.09 | top1 | 1 | 0.09 | 1.5e-05 | 5.1 | -5.1 | 3.2e-07 | -0.85 | 0.14 | 0.37 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.