Hub : Traits : dissection: PC 2 of all traits : ← →

chr6:131,006,926-132,888,501

Best TWAS P=2.280039e-08 · Best GWAS P=8.590251e-08 conditioned to 0.08808712

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Brf1	gene expression	ENSRNOG00000014595	0.14	0.12	blup	1493	0.13	2.8e-14	5.2	5.1	2.6e-07	0.99	0.47	0.54	FALSE
2	Adipose	Pacs2	gene expression	ENSRNOG00000014744	0.08	0.05	blup	1472	0.07	5.7e-08	5.0	5.2	2.2e-07	0.98	0.53	0.47	FALSE
3	Adipose	Siva1	gene expression	ENSRNOG00000028640	0.05	0.03	blup	1788	0.04	4.1e-05	5.2	5.1	3.0e-07	0.95	0.51	0.49	FALSE
4	Adipose	Cep170b	gene expression	ENSRNOG00000033688	0.09	0.05	top1	1	0.05	3.5e-06	5.1	-5.1	3.1e-07	-0.94	0.44	0.42	FALSE
5	Adipose	NA	gene expression	ENSRNOG00000065195	0.19	0.13	lasso	6	0.14	5.9e-15	5.1	5.1	3.1e-07	0.99	0.45	0.55	FALSE
6	Adipose	Tedc1	gene expression	ENSRNOG00000070355	0.41	0.31	top1	1	0.31	1.4e-35	5.1	5.1	3.3e-07	0.98	0.56	0.44	FALSE
7	Adipose	Jag2	intron excision ratio	chr6:131985002:131986156	0.33	0.12	blup	1469	0.13	3.7e-14	5.2	5.2	1.7e-07	0.98	0.48	0.52	FALSE
8	Adipose	Brf1	intron excision ratio	chr6:132061560:132064872	0.09	0.04	blup	1493	0.05	3.0e-06	5.0	-5.1	2.9e-07	-0.97	0.58	0.42	FALSE
9	Adipose	Jag2	mRNA stability	ENSRNOG00000013927	0.18	0.24	lasso	11	0.24	2.0e-26	5.2	5.2	2.2e-07	1.00	0.49	0.51	FALSE
10	Adipose	Pld4	mRNA stability	ENSRNOG00000028566	0.11	0.05	lasso	10	0.05	4.1e-06	5.1	5.1	2.9e-07	0.99	0.44	0.55	FALSE
11	Adipose	Cep170b	mRNA stability	ENSRNOG00000033688	0.04	0.03	enet	8	0.03	4.3e-04	5.1	5.1	3.1e-07	0.99	0.45	0.50	FALSE
12	BLA	Brf1	gene expression	ENSRNOG00000014595	0.19	0.20	blup	1494	0.22	6.5e-12	5.0	-5.1	3.1e-07	-0.98	0.53	0.47	FALSE
13	BLA	Pacs2	gene expression	ENSRNOG00000014744	0.11	0.11	top1	1	0.11	2.6e-06	5.2	5.2	2.3e-07	0.99	0.32	0.35	FALSE
14	BLA	Cep170b	gene expression	ENSRNOG00000033688	0.19	0.09	lasso	15	0.11	1.6e-06	4.7	5.4	7.6e-08	0.98	0.44	0.56	FALSE
15	BLA	Jag2	intron excision ratio	chr6:131985002:131985899	0.32	0.18	blup	1470	0.20	5.4e-11	4.9	-5.2	2.4e-07	-0.99	0.50	0.50	FALSE
16	BLA	Jag2	intron excision ratio	chr6:131985002:131986156	0.49	0.22	blup	1470	0.24	3.8e-13	-4.7	5.2	2.5e-07	0.99	0.50	0.50	FALSE
17	BLA	Cep170b	intron excision ratio	chr6:131799072:131800354	0.15	0.09	blup	1784	0.10	5.0e-06	5.0	5.2	2.1e-07	0.98	0.46	0.54	FALSE
18	BLA	Cep170b	intron excision ratio	chr6:131799072:131800459	0.14	0.08	blup	1784	0.09	1.9e-05	5.0	-5.2	2.1e-07	-0.98	0.46	0.53	FALSE
19	BLA	Brf1	mRNA stability	ENSRNOG00000014595	0.19	0.20	blup	1494	0.21	1.6e-11	5.2	-5.2	2.5e-07	-0.99	0.52	0.48	FALSE
20	BLA	Cep170b	mRNA stability	ENSRNOG00000033688	0.15	0.09	top1	1	0.09	1.2e-05	5.3	5.3	1.1e-07	0.95	0.15	0.32	FALSE
21	Brain	Crip2	gene expression	ENSRNOG00000005041	0.05	0.06	enet	9	0.07	1.1e-06	5.2	-5.1	2.9e-07	-0.86	0.54	0.46	FALSE
22	Brain	Cdca4	gene expression	ENSRNOG00000013898	0.02	0.02	enet	5	0.02	2.7e-03	5.3	-5.5	3.0e-08	-0.94	0.44	0.40	FALSE
23	Brain	Gpr132	gene expression	ENSRNOG00000013914	0.04	0.03	enet	70	0.04	2.7e-04	5.2	5.2	2.2e-07	0.98	0.51	0.48	FALSE
24	Brain	Jag2	gene expression	ENSRNOG00000013927	0.18	0.26	top1	1	0.26	1.0e-23	-5.2	5.2	1.7e-07	0.99	0.40	0.60	FALSE
25	Brain	Nudt14	gene expression	ENSRNOG00000014362	0.26	0.21	enet	24	0.22	1.0e-19	5.0	5.6	2.3e-08	0.76	0.44	0.56	TRUE
26	Brain	Brf1	gene expression	ENSRNOG00000014595	0.28	0.19	enet	16	0.20	3.6e-18	5.2	-5.4	8.3e-08	-0.98	0.45	0.55	FALSE
27	Brain	Cep170b	gene expression	ENSRNOG00000033688	0.38	0.32	top1	1	0.32	7.5e-30	5.1	5.1	2.9e-07	0.94	0.49	0.51	FALSE
28	Brain	Jag2	intron excision ratio	chr6:131985002:131986156	0.37	0.49	top1	1	0.49	2.6e-51	5.2	5.2	2.3e-07	0.99	0.47	0.53	FALSE
29	Brain	Brf1	intron excision ratio	chr6:132044831:132046119	0.03	0.00	enet	14	0.00	1.0e-01	5.0	5.3	1.2e-07	0.92	0.47	0.29	FALSE
30	Brain	Pacs2	intron excision ratio	chr6:132134514:132135106	0.02	0.02	top1	1	0.02	1.0e-02	5.2	-5.2	2.0e-07	-0.99	0.05	0.04	FALSE
31	Brain	Pacs2	intron excision ratio	chr6:132134538:132135106	0.03	0.02	top1	1	0.02	8.8e-03	5.2	5.2	2.0e-07	0.99	0.05	0.04	FALSE
32	Brain	Pld4	intron excision ratio	chr6:131818984:131820582	0.04	0.03	top1	1	0.03	1.0e-03	5.2	5.2	2.1e-07	0.94	0.10	0.10	FALSE
33	Brain	Brf1	mRNA stability	ENSRNOG00000014595	0.31	0.25	enet	193	0.26	2.3e-24	5.2	-5.3	9.6e-08	-0.96	0.44	0.56	FALSE
34	Brain	Pld4	mRNA stability	ENSRNOG00000028566	0.16	0.07	top1	1	0.07	8.5e-07	-5.2	5.2	1.6e-07	0.96	0.34	0.60	FALSE
35	Brain	Cep170b	mRNA stability	ENSRNOG00000033688	0.24	0.25	enet	25	0.26	7.5e-24	5.2	5.4	6.5e-08	0.96	0.42	0.58	FALSE
36	Eye	Jag2	intron excision ratio	chr6:131985002:131986156	0.31	0.17	top1	1	0.17	1.2e-03	5.2	5.2	2.5e-07	0.99	0.09	0.06	FALSE
37	IL	Brf1	gene expression	ENSRNOG00000014595	0.20	0.20	top1	1	0.20	1.6e-05	-5.2	-5.2	2.1e-07	-0.99	0.10	0.08	FALSE
38	IL	Cep170b	gene expression	ENSRNOG00000033688	0.35	0.27	top1	1	0.27	3.0e-07	5.2	5.2	1.9e-07	0.93	0.20	0.25	FALSE
39	IL	Tmem121	mRNA stability	ENSRNOG00000005174	0.24	0.22	top1	1	0.22	4.9e-06	5.3	5.3	1.5e-07	0.98	0.11	0.12	FALSE
40	IL	Brf1	mRNA stability	ENSRNOG00000014595	0.16	0.12	top1	1	0.12	1.0e-03	5.2	-5.2	2.2e-07	-0.99	0.09	0.06	FALSE
41	IL	Pacs2	mRNA stability	ENSRNOG00000014744	0.13	0.14	top1	1	0.14	3.0e-04	5.2	-5.2	2.2e-07	-0.99	0.08	0.06	FALSE
42	IL	Cep170b	mRNA stability	ENSRNOG00000033688	0.28	0.12	top1	1	0.12	7.9e-04	-5.2	5.2	1.5e-07	0.95	0.10	0.06	FALSE
43	LHb	Nudt14	gene expression	ENSRNOG00000014362	0.39	0.21	enet	8	0.26	7.7e-07	5.1	5.2	2.1e-07	1.00	0.54	0.46	FALSE
44	LHb	Siva1	gene expression	ENSRNOG00000028640	0.13	0.04	enet	35	0.11	1.4e-03	5.2	-5.1	2.8e-07	-1.00	0.41	0.35	FALSE
45	LHb	NA	gene expression	ENSRNOG00000065195	0.33	0.21	top1	1	0.21	1.2e-05	5.2	5.2	2.3e-07	0.97	0.12	0.09	FALSE
46	LHb	Jag2	intron excision ratio	chr6:131985002:131986156	0.35	0.25	lasso	2	0.26	6.8e-07	5.1	5.2	2.2e-07	1.00	0.53	0.46	FALSE
47	Liver	Crip2	gene expression	ENSRNOG00000005041	0.09	0.05	blup	1471	0.06	3.8e-07	-4.8	-5.2	1.9e-07	-0.98	0.50	0.50	FALSE
48	Liver	Brf1	gene expression	ENSRNOG00000014595	0.16	0.16	blup	1493	0.17	4.2e-18	5.0	5.1	2.8e-07	0.98	0.55	0.45	FALSE
49	Liver	Btbd6	gene expression	ENSRNOG00000014693	0.05	0.03	blup	1457	0.03	2.5e-04	5.0	5.1	3.1e-07	0.99	0.57	0.43	FALSE
50	Liver	Cep170b	gene expression	ENSRNOG00000033688	0.33	0.25	lasso	4	0.26	8.3e-29	5.0	-5.1	3.1e-07	-0.99	0.40	0.60	FALSE
51	Liver	NA	gene expression	ENSRNOG00000065195	0.13	0.12	lasso	13	0.12	3.2e-13	5.1	5.1	2.9e-07	0.99	0.49	0.51	FALSE
52	Liver	Brf1	intron excision ratio	chr6:132061560:132064872	0.05	0.04	blup	1493	0.05	4.9e-06	5.1	-5.2	2.6e-07	-0.99	0.52	0.48	FALSE
53	Liver	Brf1	intron excision ratio	chr6:132061560:132068713	0.09	0.08	blup	1493	0.09	1.0e-09	5.0	5.2	2.2e-07	0.97	0.52	0.47	FALSE
54	NAcc	Tedc1	gene expression	ENSRNOG00000070355	0.37	0.34	blup	1452	0.38	1.6e-09	4.9	5.2	2.2e-07	0.99	0.53	0.47	FALSE
55	NAcc	Jag2	intron excision ratio	chr6:131985002:131986156	0.41	0.49	top1	1	0.49	1.5e-12	-5.2	5.2	1.7e-07	0.99	0.40	0.59	FALSE
56	NAcc2	Nudt14	alternative polyA	ENSRNOT00000109846	0.05	0.01	top1	1	0.01	5.3e-02	5.3	-5.3	1.1e-07	-0.99	0.06	0.04	FALSE
57	NAcc2	Cep170b	gene expression	ENSRNOG00000033688	0.05	0.04	top1	1	0.04	3.3e-03	5.1	5.1	3.1e-07	0.94	0.07	0.04	FALSE
58	NAcc2	Pacs2	intron excision ratio	chr6:132142847:132143116	0.06	0.02	blup	1473	0.02	2.6e-02	5.0	-5.1	2.9e-07	-0.99	0.48	0.40	FALSE
59	NAcc2	Pacs2	intron excision ratio	chr6:132143190:132143659	0.05	0.01	blup	1473	0.01	5.7e-02	5.0	5.1	2.8e-07	0.99	0.39	0.33	FALSE
60	NAcc2	Cep170b	intron excision ratio	chr6:131799072:131800354	0.14	0.07	blup	1784	0.07	1.5e-04	5.1	5.2	2.0e-07	0.98	0.44	0.55	FALSE
61	NAcc2	Cep170b	intron excision ratio	chr6:131799072:131800459	0.14	0.06	blup	1784	0.06	2.4e-04	5.1	-5.2	2.0e-07	-0.99	0.44	0.55	FALSE
62	OFC	Pacs2	intron excision ratio	chr6:132143190:132143659	0.11	0.19	top1	1	0.19	3.5e-05	5.2	5.2	2.0e-07	0.99	0.08	0.05	FALSE
63	OFC	Jag2	mRNA stability	ENSRNOG00000013927	0.15	0.09	lasso	3	0.09	3.2e-03	5.2	5.2	2.0e-07	1.00	0.43	0.34	FALSE
64	OFC	Cep170b	mRNA stability	ENSRNOG00000033688	0.30	0.13	enet	6	0.16	1.4e-04	5.2	5.2	1.8e-07	1.00	0.45	0.51	FALSE
65	PL	Jag2	gene expression	ENSRNOG00000013927	0.15	0.05	enet	6	0.06	1.9e-02	5.2	5.2	1.9e-07	1.00	0.38	0.31	FALSE
66	PL	Brf1	gene expression	ENSRNOG00000014595	0.23	0.24	top1	1	0.24	2.5e-06	5.2	-5.2	2.3e-07	-0.99	0.11	0.09	FALSE
67	PL	Tedc1	gene expression	ENSRNOG00000070355	0.28	0.19	top1	1	0.19	2.9e-05	5.3	5.3	1.1e-07	0.98	0.13	0.20	FALSE
68	PL	Jag2	intron excision ratio	chr6:131985002:131986156	0.22	0.18	top1	1	0.18	5.5e-05	-5.2	5.2	1.5e-07	0.99	0.10	0.09	FALSE
69	PL2	Gpr132	gene expression	ENSRNOG00000013914	0.14	0.06	top1	1	0.06	2.3e-04	5.3	5.3	1.2e-07	0.99	0.09	0.09	FALSE
70	PL2	Brf1	gene expression	ENSRNOG00000014595	0.31	0.30	lasso	18	0.31	4.6e-17	5.3	-5.3	1.1e-07	-0.68	0.50	0.49	FALSE
71	PL2	Pacs2	gene expression	ENSRNOG00000014744	0.06	0.03	blup	1473	0.04	2.9e-03	5.3	5.1	2.8e-07	0.98	0.43	0.36	FALSE
72	PL2	Cep170b	gene expression	ENSRNOG00000033688	0.16	0.11	lasso	19	0.13	2.2e-07	5.1	5.2	2.4e-07	0.98	0.45	0.55	FALSE
73	PL2	Tedc1	gene expression	ENSRNOG00000070355	0.09	0.06	blup	1463	0.06	4.9e-04	5.0	5.2	2.1e-07	0.98	0.51	0.43	FALSE
74	PL2	Brf1	mRNA stability	ENSRNOG00000014595	0.28	0.20	lasso	45	0.30	5.1e-17	5.0	-5.2	2.1e-07	-1.00	0.51	0.49	FALSE
75	PL2	Cep170b	mRNA stability	ENSRNOG00000033688	0.07	0.04	lasso	23	0.04	5.0e-03	5.1	5.2	1.9e-07	0.97	0.51	0.40	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.