Hub : Traits : dissection: PC 2 of all traits : ← →

chr10:79,556,094-83,007,156

Best TWAS P=2.960204e-09 · Best GWAS P=4.531016e-09 conditioned to 0.05298382

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Phospho1	alternative polyA	ENSRNOT00000007352	0.28	0.07	enet	71	0.08	8.8e-09	-5.0	5.9	4.3e-09	-0.80	0.95	0.05	FALSE
2	Adipose	Phospho1	alternative polyA	ENSRNOT00000104900	0.27	0.07	enet	72	0.07	1.3e-08	-5.0	-5.9	3.0e-09	0.79	0.95	0.05	TRUE
3	Adipose	Cbx1	alternative polyA	ENSRNOT00000011665	0.02	0.00	blup	1022	0.01	9.3e-03	-5.0	-5.2	2.0e-07	0.93	0.47	0.35	FALSE
4	Adipose	Cbx1	alternative polyA	ENSRNOT00000094691	0.02	0.01	blup	1022	0.01	1.1e-02	-5.0	5.2	2.3e-07	-0.93	0.45	0.34	FALSE
5	Adipose	Npepps	alternative polyA	ENSRNOT00000031045	0.02	0.01	enet	76	0.01	7.0e-03	-5.1	5.4	7.4e-08	-0.79	0.21	0.53	FALSE
6	Adipose	Npepps	alternative polyA	ENSRNOT00000115585	0.02	0.01	enet	42	0.01	7.6e-03	-5.1	-5.4	6.8e-08	0.82	0.21	0.52	FALSE
7	Adipose	Hoxb3	gene expression	ENSRNOG00000008313	0.09	0.08	top1	1	0.08	4.8e-09	-5.4	5.4	7.1e-08	-0.98	0.55	0.45	FALSE
8	Adipose	NA	gene expression	ENSRNOG00000008365	0.11	0.13	enet	30	0.13	2.8e-14	-5.4	5.2	1.5e-07	-0.96	0.44	0.56	FALSE
9	Adipose	Mrpl45	gene expression	ENSRNOG00000010540	0.59	0.42	enet	54	0.43	1.4e-51	-5.1	-5.2	2.5e-07	0.65	0.18	0.82	FALSE
10	Adipose	Pnpo	isoform ratio	ENSRNOT00000073746	0.02	0.00	blup	950	0.01	5.2e-02	-5.1	5.1	3.1e-07	-0.89	0.40	0.39	FALSE
11	Adipose	Pnpo	isoform ratio	ENSRNOT00000111538	0.02	0.00	blup	950	0.01	6.3e-02	-5.1	-5.1	2.8e-07	0.89	0.38	0.38	FALSE
12	Adipose	Snf8	intron excision ratio	chr10:80984820:80990408	0.02	0.01	enet	35	0.02	5.7e-03	-5.6	-5.1	2.8e-07	0.95	0.50	0.47	FALSE
13	Adipose	Osbpl7	intron excision ratio	chr10:82036178:82037412	0.04	0.03	blup	888	0.04	2.5e-05	-5.0	-5.1	2.6e-07	0.84	0.50	0.49	FALSE
14	Adipose	Npepps	mRNA stability	ENSRNOG00000023095	0.24	0.07	top1	1	0.07	2.8e-08	-5.1	-5.1	3.1e-07	0.55	0.17	0.83	FALSE
15	BLA	Cbx1	gene expression	ENSRNOG00000008689	0.09	0.07	blup	1022	0.10	8.0e-06	-4.9	5.2	1.6e-07	-0.93	0.60	0.40	FALSE
16	BLA	Scrn2	gene expression	ENSRNOG00000010214	0.24	0.14	top1	1	0.14	6.3e-08	-5.2	5.2	1.9e-07	-0.89	0.16	0.82	FALSE
17	BLA	Mrpl45	gene expression	ENSRNOG00000010540	0.78	0.59	enet	155	0.63	6.0e-43	-5.0	-5.2	1.9e-07	0.66	0.19	0.81	FALSE
18	BLA	Skap1	gene expression	ENSRNOG00000023881	0.20	0.22	lasso	10	0.22	3.0e-12	-5.3	-5.4	7.7e-08	0.96	0.75	0.25	FALSE
19	BLA	Prr15l	gene expression	ENSRNOG00000049162	0.13	0.14	top1	1	0.14	5.3e-08	-5.2	-5.2	1.8e-07	0.89	0.18	0.79	FALSE
20	BLA	Phospho1	isoform ratio	ENSRNOT00000094757	0.05	0.04	top1	1	0.04	3.7e-03	-5.7	-5.7	1.2e-08	0.94	0.06	0.06	FALSE
21	BLA	Osbpl7	intron excision ratio	chr10:82036178:82036809	0.16	0.19	blup	888	0.22	9.0e-12	-4.7	5.2	2.4e-07	-0.87	0.53	0.47	FALSE
22	BLA	Snf8	mRNA stability	ENSRNOG00000006500	0.10	0.02	blup	1457	0.04	3.2e-03	-4.8	5.6	2.7e-08	-0.99	0.45	0.50	FALSE
23	BLA	Osbpl7	mRNA stability	ENSRNOG00000009473	0.05	0.06	top1	1	0.06	3.0e-04	-5.1	-5.1	2.6e-07	0.88	0.06	0.15	FALSE
24	BLA	Lrrc46	mRNA stability	ENSRNOG00000009902	0.06	0.03	blup	888	0.05	1.4e-03	-4.9	-5.2	1.8e-07	0.86	0.41	0.45	FALSE
25	Brain	Kpnb1	gene expression	ENSRNOG00000009275	0.11	0.04	top1	1	0.04	8.3e-05	-5.1	-5.1	2.9e-07	0.76	0.08	0.32	FALSE
26	Brain	Npepps	gene expression	ENSRNOG00000023095	0.38	0.21	lasso	14	0.23	6.8e-21	-5.2	-5.2	2.5e-07	0.62	0.18	0.82	FALSE
27	Brain	Skap1	gene expression	ENSRNOG00000023881	0.07	0.06	blup	1165	0.07	3.9e-07	-5.7	-5.4	5.2e-08	0.99	0.34	0.66	FALSE
28	Brain	Osbpl7	intron excision ratio	chr10:82036178:82036809	0.29	0.18	top1	1	0.18	3.6e-16	-5.1	5.1	3.0e-07	-0.89	0.22	0.78	FALSE
29	Brain	Mrpl45	intron excision ratio	chr10:82310718:82313694	0.23	0.08	top1	1	0.08	5.4e-08	-5.1	-5.1	3.1e-07	0.54	0.17	0.83	FALSE
30	Brain	Tbkbp1	mRNA stability	ENSRNOG00000009370	0.14	0.05	top1	1	0.05	2.0e-05	-5.1	5.1	3.1e-07	-0.83	0.13	0.51	FALSE
31	Eye	Gip	gene expression	ENSRNOG00000006306	0.78	0.11	enet	498	0.15	2.9e-03	-5.0	-5.7	9.5e-09	0.69	0.31	0.09	FALSE
32	Eye	Nfe2l1	gene expression	ENSRNOG00000008830	0.75	0.10	lasso	21	0.11	9.6e-03	-5.0	5.4	5.9e-08	-0.98	0.31	0.32	FALSE
33	IL	Nfe2l1	gene expression	ENSRNOG00000008830	0.73	0.42	enet	8	0.45	4.0e-12	-4.9	5.4	6.9e-08	-0.98	0.41	0.59	FALSE
34	IL	Mrpl10	gene expression	ENSRNOG00000009567	0.45	0.14	lasso	5	0.21	7.1e-06	-4.7	-5.2	1.7e-07	0.82	0.41	0.56	FALSE
35	IL	Skap1	gene expression	ENSRNOG00000023881	0.24	0.09	enet	4	0.13	5.4e-04	-4.9	-5.3	1.3e-07	0.96	0.37	0.39	FALSE
36	IL	NA	gene expression	ENSRNOG00000069592	0.46	0.26	blup	1422	0.31	3.5e-08	-4.7	5.4	6.0e-08	-0.92	0.45	0.55	FALSE
37	IL	Mrpl45	intron excision ratio	chr10:82310718:82313694	0.31	0.13	top1	1	0.13	5.0e-04	-5.2	-5.2	2.5e-07	0.38	0.05	0.08	FALSE
38	IL	Mrpl45	intron excision ratio	chr10:82310797:82313694	0.32	0.13	top1	1	0.13	4.4e-04	-5.2	5.2	2.6e-07	-0.37	0.05	0.08	FALSE
39	IL	Cdk5rap3	mRNA stability	ENSRNOG00000048747	0.26	0.07	blup	938	0.10	2.3e-03	-4.8	-5.2	1.7e-07	0.86	0.37	0.36	FALSE
40	LHb	Nfe2l1	gene expression	ENSRNOG00000008830	0.56	0.27	blup	1028	0.37	1.2e-09	-5.3	5.2	2.6e-07	-0.93	0.55	0.45	FALSE
41	LHb	NA	gene expression	ENSRNOG00000069592	0.31	0.18	blup	1421	0.21	1.1e-05	-4.8	5.1	2.7e-07	-0.94	0.56	0.42	FALSE
42	LHb	Cdk5rap3	mRNA stability	ENSRNOG00000048747	0.40	0.22	blup	936	0.27	4.4e-07	-4.9	-5.1	3.0e-07	0.89	0.52	0.47	FALSE
43	Liver	Ube2z	gene expression	ENSRNOG00000006868	0.04	0.03	top1	1	0.03	2.6e-04	-5.6	-5.6	1.7e-08	0.97	0.11	0.31	FALSE
44	Liver	Atp5mc1	gene expression	ENSRNOG00000007235	0.08	0.07	top1	1	0.07	2.0e-08	-5.7	-5.7	9.2e-09	0.97	0.14	0.85	FALSE
45	Liver	NA	gene expression	ENSRNOG00000008365	0.13	0.02	enet	30	0.03	2.4e-04	-5.7	-5.5	3.2e-08	0.96	0.34	0.54	FALSE
46	Liver	Cbx1	gene expression	ENSRNOG00000008689	0.08	0.12	top1	1	0.12	8.9e-13	-5.2	5.2	1.9e-07	-0.93	0.44	0.56	FALSE
47	Liver	Kpnb1	gene expression	ENSRNOG00000009275	0.06	0.05	blup	867	0.06	8.0e-07	-5.1	-5.4	8.6e-08	0.81	0.26	0.74	FALSE
48	Liver	Sp2	gene expression	ENSRNOG00000010492	0.05	0.07	blup	881	0.07	5.7e-08	-4.9	-5.2	2.2e-07	0.88	0.52	0.48	FALSE
49	Liver	Mrpl45	gene expression	ENSRNOG00000010540	0.66	0.54	lasso	25	0.56	2.6e-74	-5.2	-5.3	9.3e-08	0.75	0.19	0.81	FALSE
50	Liver	Prr15l	gene expression	ENSRNOG00000049162	0.05	0.04	blup	943	0.06	5.2e-07	-5.0	-5.3	1.2e-07	0.87	0.50	0.50	FALSE
51	Liver	Phospho1	isoform ratio	ENSRNOT00000115688	0.02	0.01	blup	1424	0.02	2.2e-03	-4.8	5.4	8.2e-08	-0.94	0.53	0.18	FALSE
52	Liver	Ube2z	mRNA stability	ENSRNOG00000006868	0.03	0.03	enet	65	0.03	1.4e-04	-4.9	-5.2	1.7e-07	0.94	0.62	0.37	FALSE
53	Liver	Cbx1	mRNA stability	ENSRNOG00000008689	0.02	0.02	top1	1	0.02	2.1e-03	-5.1	5.1	3.2e-07	-0.92	0.04	0.04	FALSE
54	Liver	Sp2	mRNA stability	ENSRNOG00000010492	0.02	0.02	blup	881	0.02	9.0e-04	-5.0	-5.3	9.9e-08	0.86	0.34	0.53	FALSE
55	NAcc	Tbkbp1	gene expression	ENSRNOG00000009370	0.88	0.27	top1	1	0.27	1.2e-06	-5.2	5.2	1.7e-07	-0.70	0.08	0.44	FALSE
56	NAcc	Mrpl45	gene expression	ENSRNOG00000010540	0.87	0.25	blup	858	0.29	2.6e-07	-4.9	-5.2	1.9e-07	0.67	0.18	0.81	FALSE
57	NAcc	Kat7	mRNA stability	ENSRNOG00000022664	0.23	0.01	blup	1502	0.08	6.7e-03	-3.8	-5.2	1.8e-07	0.46	0.22	0.18	FALSE
58	NAcc2	Cbx1	gene expression	ENSRNOG00000008689	0.29	0.11	top1	1	0.11	1.5e-06	-5.3	5.3	9.0e-08	-0.93	0.26	0.68	FALSE
59	NAcc2	Mrpl45	gene expression	ENSRNOG00000010540	0.75	0.59	lasso	21	0.61	8.1e-41	-5.0	-5.2	2.2e-07	0.68	0.18	0.82	FALSE
60	NAcc2	Npepps	gene expression	ENSRNOG00000023095	0.10	0.04	blup	860	0.05	7.3e-04	-4.8	-5.2	2.6e-07	0.78	0.34	0.57	FALSE
61	NAcc2	Prr15l	gene expression	ENSRNOG00000049162	0.15	0.14	top1	1	0.14	6.3e-08	-5.3	-5.3	1.4e-07	0.89	0.15	0.83	FALSE
62	NAcc2	Cdk5rap3	mRNA stability	ENSRNOG00000048747	0.05	0.03	lasso	1	0.05	1.5e-03	-5.2	-5.2	1.9e-07	0.87	0.43	0.39	FALSE
63	OFC	Nfe2l1	alternative TSS	ENSRNOT00000067542	0.24	0.07	enet	8	0.10	2.0e-03	-4.9	-5.4	5.8e-08	0.90	0.32	0.29	FALSE
64	OFC	Cbx1	gene expression	ENSRNOG00000008689	0.21	0.09	blup	1020	0.11	1.7e-03	-4.9	5.1	2.9e-07	-0.90	0.47	0.28	FALSE
65	OFC	Mrpl45	gene expression	ENSRNOG00000010540	0.88	0.48	top1	1	0.48	3.6e-13	-5.2	-5.2	2.5e-07	0.58	0.14	0.86	FALSE
66	OFC	Skap1	gene expression	ENSRNOG00000023881	0.21	0.14	top1	1	0.14	3.6e-04	-5.4	-5.4	7.2e-08	0.97	0.07	0.06	FALSE
67	OFC	Snx11	isoform ratio	ENSRNOT00000011474	0.25	0.07	top1	1	0.07	8.1e-03	-5.1	-5.1	3.1e-07	0.92	0.06	0.06	FALSE
68	OFC	Snx11	isoform ratio	ENSRNOT00000089146	0.15	0.04	blup	1021	0.05	3.0e-02	-5.2	5.4	5.2e-08	-0.92	0.29	0.30	FALSE
69	PL	Nfe2l1	gene expression	ENSRNOG00000008830	0.72	0.44	blup	1031	0.46	2.8e-12	-4.8	5.3	1.5e-07	-0.91	0.68	0.32	FALSE
70	PL	Mrpl10	gene expression	ENSRNOG00000009567	0.35	0.12	blup	883	0.18	4.2e-05	-4.9	-5.3	1.3e-07	0.81	0.44	0.55	FALSE
71	PL	Skap1	gene expression	ENSRNOG00000023881	0.19	0.12	lasso	2	0.13	7.0e-04	-4.8	-5.6	2.8e-08	0.60	0.46	0.36	FALSE
72	PL	Mrpl45	intron excision ratio	chr10:82310718:82313694	0.50	0.15	top1	1	0.15	2.1e-04	-5.2	-5.2	1.7e-07	0.70	0.05	0.13	FALSE
73	PL	Mrpl45	intron excision ratio	chr10:82310797:82313694	0.52	0.16	top1	1	0.16	1.0e-04	-5.2	5.2	1.7e-07	-0.67	0.05	0.16	FALSE
74	PL2	Ttll6	gene expression	ENSRNOG00000004939	0.10	0.06	blup	1486	0.06	2.4e-04	-4.6	5.2	1.7e-07	-0.97	0.60	0.39	FALSE
75	PL2	Cbx1	gene expression	ENSRNOG00000008689	0.15	0.18	top1	1	0.18	4.9e-10	-5.2	5.2	2.2e-07	-0.92	0.47	0.52	FALSE
76	PL2	Npepps	gene expression	ENSRNOG00000023095	0.29	0.12	top1	1	0.12	2.9e-07	-5.2	-5.2	1.6e-07	0.67	0.09	0.82	FALSE
77	PL2	Skap1	gene expression	ENSRNOG00000023881	0.27	0.17	lasso	3	0.18	2.6e-10	-5.4	-5.5	5.0e-08	0.97	0.41	0.59	FALSE
78	PL2	Prr15l	gene expression	ENSRNOG00000049162	0.06	0.03	top1	1	0.03	1.4e-02	-5.2	-5.2	1.6e-07	0.89	0.04	0.06	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.