Best TWAS P=1.24357e-07 · Best GWAS P=5.454611e-07 conditioned to 0.4121621
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | IL | Nfkbie | gene expression | ENSRNOG00000019907 | 0.26 | 0.08 | blup | 2019 | 0.11 | 1.5e-03 | 4.6 | 5.3 | 1.2e-07 | 0.87 | 0.33 | 0.60 | TRUE |
| 2 | PL2 | Hsp90ab1 | gene expression | ENSRNOG00000019834 | 0.21 | 0.16 | lasso | 14 | 0.16 | 5.6e-09 | 4.8 | 5.1 | 3.0e-07 | 0.96 | 0.22 | 0.78 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.