Hub : Traits : dissection: PC 2 of all traits : →

chr1:258,394,596-260,518,987

Best TWAS P=5.578374e-11 · Best GWAS P=1.904541e-11 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Dennd10	gene expression	ENSRNOG00000010230	0.03	0.03	top1	1	0.03	2.5e-04	5.2	5.2	2.4e-07	0.69	0.24	0.02	TRUE
2	Adipose	Grk5	gene expression	ENSRNOG00000011439	0.17	0.20	lasso	24	0.22	8.6e-24	5.7	-5.7	9.9e-09	-0.73	0.62	0.38	FALSE
3	BLA	Ces2c	gene expression	ENSRNOG00000036571	0.26	0.19	lasso	16	0.20	1.1e-10	5.5	-5.4	6.7e-08	-0.71	0.23	0.77	FALSE
4	BLA	Sfxn4	gene expression	ENSRNOG00000036572	0.07	0.02	top1	1	0.02	2.1e-02	6.2	-6.2	6.3e-10	-0.83	0.06	0.04	FALSE
5	BLA	Cacul1	isoform ratio	ENSRNOT00000084760	0.07	0.00	top1	1	0.00	2.4e-01	5.6	5.6	1.9e-08	0.69	0.07	0.04	FALSE
6	Brain	Nanos1	gene expression	ENSRNOG00000025060	0.03	0.01	enet	58	0.01	2.2e-02	5.1	5.7	9.0e-09	0.86	0.53	0.32	FALSE
7	Brain	Ces2c	gene expression	ENSRNOG00000036571	0.20	0.28	blup	597	0.29	3.4e-27	5.1	-5.2	1.9e-07	-0.70	0.25	0.75	FALSE
8	Brain	Cacul1	isoform ratio	ENSRNOT00000050617	0.14	0.11	top1	1	0.11	3.3e-10	6.5	-6.5	1.0e-10	-0.95	0.30	0.70	FALSE
9	Brain	Cacul1	isoform ratio	ENSRNOT00000084760	0.12	0.10	enet	5	0.11	5.6e-10	6.5	5.9	3.1e-09	-0.47	0.20	0.80	TRUE
10	Brain	Cacul1	intron excision ratio	chr1:259677583:259686255	0.12	0.08	enet	36	0.10	1.6e-09	6.2	-6.5	6.6e-11	-0.25	0.22	0.78	TRUE
11	Eye	NA	gene expression	ENSRNOG00000065260	0.45	0.18	top1	1	0.18	9.5e-04	6.0	6.0	1.9e-09	0.91	0.10	0.06	FALSE
12	IL	Ces2c	gene expression	ENSRNOG00000036571	0.35	0.35	top1	1	0.35	2.3e-09	5.5	-5.5	3.8e-08	-0.72	0.11	0.79	FALSE
13	IL	Sfxn4	gene expression	ENSRNOG00000036572	0.19	0.13	top1	1	0.13	5.3e-04	5.4	-5.4	5.5e-08	-0.79	0.08	0.05	FALSE
14	Liver	Zfp950	gene expression	ENSRNOG00000032668	0.03	0.01	top1	1	0.01	7.7e-03	5.9	5.9	3.2e-09	0.75	0.03	0.05	FALSE
15	Liver	Cacul1	isoform ratio	ENSRNOT00000050617	0.03	0.02	top1	1	0.02	1.3e-03	6.6	-6.6	5.6e-11	-0.94	0.06	0.10	TRUE
16	Liver	Cacul1	isoform ratio	ENSRNOT00000084760	0.03	0.01	blup	1780	0.02	4.5e-03	6.5	6.0	2.2e-09	0.83	0.25	0.54	FALSE
17	Liver	Cacul1	mRNA stability	ENSRNOG00000009954	0.03	0.01	top1	1	0.01	1.4e-02	6.5	-6.5	8.1e-11	-0.94	0.05	0.04	FALSE
18	NAcc	Prlhr	gene expression	ENSRNOG00000009922	0.16	0.06	blup	1904	0.08	8.4e-03	4.9	-6.0	1.9e-09	-0.81	0.39	0.29	FALSE
19	NAcc	Ces2c	gene expression	ENSRNOG00000036571	0.14	0.00	blup	594	0.04	5.1e-02	5.4	-5.4	5.6e-08	-0.72	0.17	0.48	FALSE
20	NAcc2	Prlhr	gene expression	ENSRNOG00000009922	0.10	0.02	blup	1906	0.03	8.1e-03	6.6	-5.5	4.5e-08	-0.88	0.32	0.56	FALSE
21	NAcc2	Zfp950	isoform ratio	ENSRNOT00000096833	0.05	0.02	blup	954	0.03	1.2e-02	4.2	5.1	3.1e-07	0.72	0.25	0.43	FALSE
22	OFC	Rab11fip2	gene expression	ENSRNOG00000009523	0.30	0.23	lasso	17	0.27	5.1e-07	6.2	6.3	2.8e-10	0.98	0.36	0.63	FALSE
23	OFC	Ces2c	gene expression	ENSRNOG00000036571	0.38	0.42	top1	1	0.42	3.6e-11	5.4	-5.4	6.0e-08	-0.71	0.17	0.82	FALSE
24	OFC	Sfxn4	gene expression	ENSRNOG00000036572	0.41	0.18	enet	17	0.26	7.0e-07	5.4	-5.8	6.0e-09	-0.81	0.91	0.08	FALSE
25	OFC	Rab11fip2	mRNA stability	ENSRNOG00000009523	0.16	0.19	top1	1	0.19	2.9e-05	6.2	6.2	4.8e-10	0.89	0.12	0.05	FALSE
26	PL	Ces2c	gene expression	ENSRNOG00000036571	0.29	0.11	blup	595	0.16	1.0e-04	5.2	-5.2	1.8e-07	-0.70	0.22	0.74	FALSE
27	PL2	Rab11fip2	gene expression	ENSRNOG00000009523	0.07	0.04	top1	1	0.04	3.2e-03	6.1	6.1	8.4e-10	0.93	0.09	0.04	FALSE
28	PL2	Ces2c	gene expression	ENSRNOG00000036571	0.41	0.26	lasso	44	0.30	1.8e-16	5.2	-5.4	7.0e-08	-0.77	0.23	0.77	FALSE
29	PL2	Sfxn4	gene expression	ENSRNOG00000036572	0.08	0.01	blup	1401	0.03	8.4e-03	6.3	-5.7	9.7e-09	-0.79	0.29	0.43	TRUE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.