Hub : Traits

tautz: manual_mpc5

Project: tautz

4 significantly associated models · 4 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 68581504 69974370 1 1 8.2e-08 1.0e-01 1.4e-01 18 Syt5
2 2 144900859 146298381 1 1 3.2e-07 2.9e-04 7.3e-03 45 Rap2b
3 5 137682119 138752373 1 1 1.2e-07 1.6e-01 6.6e-05 -706 Stk40
4 10 14522235 15920705 1 1 4.9e-08 6.2e-06 1.3e-01 89 Arhgdig

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
dissection: UMAP 1 of all traits 2.7 1 0 0 0.00 1.0000 Stk40
body_g 3.3 2 0 0 0.00 1.0000 Syt5 Stk40
dissection: UMAP 3 of all traits 3.0 1 0 0 0.00 1.0000 Syt5
kidney_right_g 2.6 1 0 0 0.00 1.0000 Syt5
dissection: PC 3 of all traits 4.1 1 0 0 0.00 1.0000 Stk40
glucose_mg_dl 18.2 2 1 25 0.00 1.0000 Syt5 Stk40
EDL weight in grams 4.1 2 0 0 0.00 1.0000 Stk40 Rap2b
Tibia length in mm 7.5 1 0 0 0.00 1.0000 Syt5
sol weight in grams 14.0 1 1 25 0.00 1.0000 Stk40
TA weight in grams 2.4 1 0 0 0.00 1.0000 Syt5
Average time between licks in bursts 11.1 1 0 0 0.00 1.0000 Rap2b
Std. dev. time between licks in bursts 16.8 2 1 25 0.00 1.0000 Syt5 Rap2b
Number of licking bursts 7.6 1 0 0 0.00 1.0000 Rap2b
Water consumed over 24 hour session 7.5 1 0 0 0.00 1.0000 Rap2b
Times rat made contact with spout 8.1 1 0 0 0.00 1.0000 Rap2b
Average drop size 12.2 1 0 0 0.00 1.0000 Syt5
light_reinforcement_lr_relactive 21.5 1 1 25 0.00 1.0000 Syt5
light_reinforcement_lr_active 21.5 1 1 25 0.00 1.0000 Syt5
Delay discounting water rate 0 sec 10.3 1 0 0 0.00 1.0000 Syt5
Median of all reaction times 7.0 1 0 0 0.00 1.0000 Syt5
reaction_time_corr 4.4 1 0 0 0.00 1.0000 Stk40
reaction_time_leftcorr 4.4 1 0 0 0.00 1.0000 Stk40
delay_discounting_pc1800 6.9 1 0 0 0.00 1.0000 Stk40
reaction_time_falsealarm 5.6 1 0 0 0.00 1.0000 Stk40
social_reinforcement_socialrfq 8.0 1 0 0 0.00 1.0000 Syt5
reaction_time_pinit_slope 9.7 1 0 0 0.00 1.0000 Syt5
reaction_time_peropfalsealarm_slope 11.6 1 0 0 0.00 1.0000 Syt5
reaction_time_meanrt_slope 15.7 1 0 0 0.00 1.0000 Syt5
reaction_time_devmedrt_slope 42.2 1 1 25 0.00 1.0000 Syt5
ccp_trial_3_saline_dist_mm 23.3 1 1 25 0.00 1.0000 Syt5
ccp_change_in_locomotor_activity 5.6 2 0 0 0.00 1.0000 Syt5 Stk40
Conditioned locomotion 15.1 1 0 0 0.00 1.0000 Syt5
crf_mi_active_responses 11.0 2 0 0 0.00 1.0000 Stk40 Rap2b
pavca_mi_d1_avg_mag_lat 5.4 1 0 0 0.00 1.0000 Syt5
pavca_mi_d3_magazine_ncs 20.8 1 0 0 0.00 1.0000 Stk40
pavca_mi_d1_prob_lev 11.8 1 0 0 0.00 1.0000 Stk40
pavca_mi_d1_avg_lev_lat 12.3 1 0 0 0.00 1.0000 Stk40
pavca_mi_d3_prob_mag 4.9 1 0 0 0.00 1.0000 Stk40
Total cortical area 5.8 1 0 0 0.00 1.0000 Stk40
tb_th_sd 15.3 3 1 25 0.00 1.0000 Syt5 Stk40 Rap2b
Cortical porosity 8.7 1 0 0 0.00 1.0000 Rap2b
Trabecular tissue density 8.2 1 0 0 0.00 1.0000 Syt5
ctth_sd 8.7 2 0 0 0.00 1.0000 Syt5 Stk40
tautz: manual_mpc15 11.2 1 0 0 0.00 1.0000 Stk40
tautz: manual_mpc18 7.6 1 0 0 0.00 1.0000 Syt5
tautz: manual_spc15 11.6 1 0 0 0.00 1.0000 Syt5
tautz: manual_spc21 11.3 2 0 0 0.00 1.0000 Syt5 Stk40
tautz: manual_spc9 24.1 1 1 25 0.00 1.0000 Syt5
tautz: manual_mpc3 8.8 1 0 0 0.00 1.0000 Syt5
tautz: manual_spc12 14.2 2 1 25 0.00 1.0000 Syt5 Stk40
tautz: manual_spc14 12.7 2 0 0 0.00 1.0000 Syt5 Stk40
tautz: manual_spc8 7.0 1 0 0 0.00 1.0000 Stk40
tautz: manual_mpc7 6.5 1 0 0 0.00 1.0000 Syt5
tautz: manual_mpc16 7.1 1 0 0 0.00 1.0000 Rap2b
tautz: manual_mpc4 19.3 2 1 25 0.00 1.0000 Syt5 Stk40
tautz: manual_mpc10 13.4 3 1 25 0.00 1.0000 Syt5 Stk40 Arhgdig
tautz: manual_spc22 41.8 2 1 25 0.00 1.0000 Syt5 Rap2b
tautz: manual_mpc14 7.4 2 0 0 0.00 1.0000 Stk40 Arhgdig
tautz: manual_mpc12 19.6 2 1 25 0.00 1.0000 Syt5 Stk40
tautz: manual_mcs 17.3 1 0 0 0.00 1.0000 Stk40
tautz: manual_spc17 6.5 1 0 0 0.00 1.0000 Rap2b
tautz: manual_spc24 8.0 1 0 0 0.00 1.0000 Syt5
tautz: manual_spc4 18.0 1 0 0 0.00 1.0000 Stk40
tautz: manual_mpc9 9.4 2 0 0 0.00 1.0000 Stk40 Rap2b
tautz: manual_spc2 6.1 1 0 0 0.00 1.0000 Stk40
tautz: manual_spc13 5.7 1 0 0 0.00 1.0000 Arhgdig
tautz: manual_mpc19 32.6 1 1 25 0.00 1.0000 Syt5
tautz: manual_spc10 28.3 4 1 25 0.99 0.0087 Syt5 Stk40 Rap2b Arhgdig
tautz: manual_spc11 85.1 1 1 25 0.00 1.0000 Stk40
tautz: manual_spc23 10.7 1 0 0 0.00 1.0000 Syt5
tautz: manual_spc6 44.8 2 2 50 0.00 1.0000 Syt5 Stk40
tautz: manual_mpc17 13.2 1 0 0 0.00 1.0000 Stk40
tautz: manual_mpc2 8.2 1 0 0 0.00 1.0000 Stk40
tautz: manual_spc1 21.1 2 1 25 0.00 1.0000 Syt5 Stk40
tautz: manual_spc16 5.2 1 0 0 0.00 1.0000 Syt5
tautz: manual_mpc13 6.5 1 0 0 0.00 1.0000 Rap2b
tautz: manual_spc5 13.3 2 0 0 0.00 1.0000 Syt5 Stk40
tautz: manual_spc3 8.5 2 0 0 0.00 1.0000 Syt5 Rap2b
tautz: manual_mpc6 9.2 1 0 0 0.00 1.0000 Stk40
tautz: manual_spc18 27.6 2 1 25 0.00 1.0000 Stk40 Rap2b
tautz: manual_mpc11 17.2 1 0 0 0.00 1.0000 Stk40
tautz: manual_spc19 9.6 2 0 0 0.00 1.0000 Syt5 Stk40
Sum of all infusions from LGA sessions 5.8 1 0 0 0.00 1.0000 Syt5
Ambulatory time at time1 of open field 36.6 1 1 25 0.00 1.0000 Syt5
The total number of resting periods in time1 37.4 1 1 25 0.00 1.0000 Syt5
punishment 133.8 1 1 25 0.00 1.0000 Syt5
Weight adjusted by age 8.2 1 0 0 0.00 1.0000 Syt5
Liver selenium concentration 9.7 2 0 0 0.00 1.0000 Stk40 Rap2b
Liver rubidium concentration 6.5 1 0 0 0.00 1.0000 Syt5
Liver iron concentration 6.0 1 0 0 0.00 1.0000 Rap2b
Liver cobalt concentration 13.2 2 0 0 0.00 1.0000 Syt5 Rap2b
Liver cadmium concentration 8.0 2 0 0 0.00 1.0000 Syt5 Stk40
Liver zinc concentration 12.4 1 0 0 0.00 1.0000 Syt5

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.19
Adipose alternative TSS 0 0.000 1.16
Adipose gene expression 0 0.000 1.27
Adipose isoform ratio 0 0.000 1.27
Adipose intron excision ratio 0 0.000 1.12
Adipose mRNA stability 0 0.000 1.25
BLA alternative polyA 0 0.000 1.11
BLA alternative TSS 0 0.000 1.28
BLA gene expression 1 0.016 1.30
BLA isoform ratio 0 0.000 1.31
BLA intron excision ratio 0 0.000 1.13
BLA mRNA stability 1 0.049 1.25
Brain alternative polyA 0 0.000 1.19
Brain alternative TSS 0 0.000 1.29
Brain gene expression 0 0.000 1.24
Brain isoform ratio 0 0.000 1.21
Brain intron excision ratio 0 0.000 1.19
Brain mRNA stability 0 0.000 1.22
Eye alternative polyA 0 0.000 1.14
Eye alternative TSS 0 0.000 0.97
Eye gene expression 0 0.000 1.30
Eye isoform ratio 0 0.000 1.24
Eye intron excision ratio 0 0.000 1.12
Eye mRNA stability 0 0.000 1.36
IL alternative polyA 0 0.000 1.07
IL alternative TSS 0 0.000 0.98
IL gene expression 0 0.000 1.20
IL isoform ratio 0 0.000 1.11
IL intron excision ratio 0 0.000 1.19
IL mRNA stability 0 0.000 1.20
LHb alternative polyA 0 0.000 1.03
LHb alternative TSS 0 0.000 1.21
LHb gene expression 0 0.000 1.26
LHb isoform ratio 0 0.000 1.23
LHb intron excision ratio 0 0.000 1.17
LHb mRNA stability 0 0.000 1.20
Liver alternative polyA 0 0.000 1.08
Liver alternative TSS 0 0.000 1.25
Liver gene expression 1 0.014 1.28
Liver isoform ratio 0 0.000 1.24
Liver intron excision ratio 0 0.000 1.27
Liver mRNA stability 1 0.041 1.28
NAcc alternative polyA 0 0.000 1.07
NAcc alternative TSS 0 0.000 1.27
NAcc gene expression 0 0.000 1.21
NAcc isoform ratio 0 0.000 1.16
NAcc intron excision ratio 0 0.000 1.03
NAcc mRNA stability 0 0.000 1.23
NAcc2 alternative polyA 0 0.000 1.07
NAcc2 alternative TSS 0 0.000 1.19
NAcc2 gene expression 0 0.000 1.25
NAcc2 isoform ratio 0 0.000 1.16
NAcc2 intron excision ratio 0 0.000 1.08
NAcc2 mRNA stability 0 0.000 1.20
OFC alternative polyA 0 0.000 1.16
OFC alternative TSS 0 0.000 1.18
OFC gene expression 0 0.000 1.26
OFC isoform ratio 0 0.000 1.29
OFC intron excision ratio 0 0.000 1.12
OFC mRNA stability 0 0.000 1.11
PL alternative polyA 0 0.000 1.20
PL alternative TSS 0 0.000 1.11
PL gene expression 0 0.000 1.25
PL isoform ratio 0 0.000 1.30
PL intron excision ratio 0 0.000 1.19
PL mRNA stability 0 0.000 1.20
PL2 alternative polyA 0 0.000 1.12
PL2 alternative TSS 0 0.000 1.24
PL2 gene expression 0 0.000 1.25
PL2 isoform ratio 0 0.000 1.25
PL2 intron excision ratio 0 0.000 1.13
PL2 mRNA stability 0 0.000 1.22

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.