Hub : Traits

tautz: manual_spc10

Project: tautz

5 significantly associated models · 3 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 201865024 202832586 1 1 1.6e-09 0.02357 0.536 93 Ccs
2 5 137682119 139250049 2 1 3.1e-24 0.00081 0.027 57 Stk40

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
dissection: UMAP 1 of all traits 2.7 1 0 0 0.00 1.0000 Stk40
body_g 4.0 1 0 0 0.00 1.0000 Stk40
dissection: PC 3 of all traits 4.1 1 0 0 0.00 1.0000 Stk40
glucose_mg_dl 15.3 2 1 50 0.00 1.0000 Map7d1 Stk40
EDL weight in grams 4.3 2 0 0 -0.97 0.0254 Map7d1 Stk40
sol weight in grams 5.4 2 1 50 -0.99 0.0137 Map7d1 Stk40
Number of licking bursts 8.1 1 0 0 0.00 1.0000 Ccs
Food consumed during 24 hour testing period 18.6 1 0 0 0.00 1.0000 Ccs
Water consumed over 24 hour session 11.5 1 0 0 0.00 1.0000 Ccs
delay_discounting_pc1800 7.6 2 0 0 0.00 1.0000 Map7d1 Stk40
reaction_time_falsealarm 5.6 1 0 0 0.00 1.0000 Stk40
crf_mi_active_responses 8.2 1 0 0 0.00 1.0000 Stk40
pavca_mi_d3_magazine_ncs 13.9 2 0 0 0.98 0.0183 Map7d1 Stk40
pavca_mi_d1_prob_lev 11.8 1 0 0 0.00 1.0000 Stk40
pavca_mi_d1_avg_lev_lat 12.3 1 0 0 0.00 1.0000 Stk40
Total cortical area 5.8 1 0 0 0.00 1.0000 Stk40
tb_th_sd 7.4 2 0 0 -0.97 0.0343 Map7d1 Stk40
ctth_sd 8.3 1 0 0 0.00 1.0000 Stk40
tautz: manual_mpc15 7.4 1 0 0 0.00 1.0000 Stk40
tautz: manual_spc21 17.1 1 0 0 0.00 1.0000 Stk40
tautz: manual_spc9 12.9 1 0 0 0.00 1.0000 Ccs
tautz: manual_spc12 7.2 1 0 0 0.00 1.0000 Stk40
tautz: manual_spc14 16.5 1 0 0 0.00 1.0000 Stk40
tautz: manual_spc8 27.8 2 1 50 0.00 1.0000 Stk40 Ccs
tautz: manual_mpc4 29.0 2 1 50 0.00 1.0000 Stk40 Ccs
tautz: manual_mpc10 24.5 1 1 50 0.00 1.0000 Stk40
tautz: manual_mpc5 23.1 1 1 50 0.00 1.0000 Stk40
tautz: manual_spc22 6.9 1 0 0 0.00 1.0000 Ccs
tautz: manual_mpc14 7.9 1 0 0 0.00 1.0000 Stk40
tautz: manual_mpc12 9.6 1 0 0 0.00 1.0000 Stk40
tautz: manual_mcs 17.3 1 0 0 0.00 1.0000 Stk40
tautz: manual_spc4 11.8 1 0 0 0.00 1.0000 Stk40
tautz: manual_mpc9 7.1 1 0 0 0.00 1.0000 Stk40
tautz: manual_spc2 6.1 1 0 0 0.00 1.0000 Stk40
tautz: manual_spc11 32.4 2 1 50 -0.99 0.0148 Map7d1 Stk40
tautz: manual_spc6 22.5 2 1 50 0.00 1.0000 Map7d1 Stk40
tautz: manual_mpc17 8.9 2 0 0 0.98 0.0161 Map7d1 Stk40
tautz: manual_mpc2 9.0 3 0 0 -0.39 0.5135 Map7d1 Stk40 Ccs
tautz: manual_spc1 18.8 2 2 100 -0.99 0.0084 Stk40 Ccs
tautz: manual_spc16 19.8 1 0 0 0.00 1.0000 Ccs
tautz: manual_spc5 7.4 2 0 0 0.98 0.0151 Stk40 Ccs
tautz: manual_mpc6 7.6 2 0 0 0.00 1.0000 Stk40 Ccs
tautz: manual_spc18 17.9 3 1 50 0.75 0.1417 Map7d1 Stk40 Ccs
tautz: manual_mpc11 21.0 2 1 50 0.00 1.0000 Stk40 Ccs
tautz: manual_spc19 6.6 2 0 0 0.00 1.0000 Stk40 Ccs
tautz: manual_mpc1 37.0 1 1 50 0.00 1.0000 Ccs
Liver selenium concentration 23.9 2 1 50 0.00 1.0000 Stk40 Ccs
Liver iron concentration 23.9 1 1 50 0.00 1.0000 Ccs
Liver cobalt concentration 35.3 1 1 50 0.00 1.0000 Ccs
Liver cadmium concentration 8.3 1 0 0 0.00 1.0000 Stk40
Liver zinc concentration 38.0 1 1 50 0.00 1.0000 Ccs
Liver sodium concentration 11.5 1 0 0 0.00 1.0000 Ccs

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.3
Adipose alternative TSS 0 0.000 1.3
Adipose gene expression 0 0.000 1.3
Adipose isoform ratio 0 0.000 1.3
Adipose intron excision ratio 2 0.069 1.3
Adipose mRNA stability 0 0.000 1.3
BLA alternative polyA 0 0.000 1.3
BLA alternative TSS 0 0.000 1.2
BLA gene expression 0 0.000 1.2
BLA isoform ratio 0 0.000 1.2
BLA intron excision ratio 0 0.000 1.3
BLA mRNA stability 0 0.000 1.3
Brain alternative polyA 0 0.000 1.2
Brain alternative TSS 0 0.000 1.3
Brain gene expression 0 0.000 1.3
Brain isoform ratio 0 0.000 1.2
Brain intron excision ratio 0 0.000 1.3
Brain mRNA stability 0 0.000 1.3
Eye alternative polyA 0 0.000 1.2
Eye alternative TSS 0 0.000 1.1
Eye gene expression 0 0.000 1.2
Eye isoform ratio 0 0.000 1.1
Eye intron excision ratio 0 0.000 1.2
Eye mRNA stability 0 0.000 1.2
IL alternative polyA 0 0.000 1.3
IL alternative TSS 0 0.000 1.3
IL gene expression 0 0.000 1.2
IL isoform ratio 0 0.000 1.2
IL intron excision ratio 0 0.000 1.3
IL mRNA stability 0 0.000 1.3
LHb alternative polyA 0 0.000 1.3
LHb alternative TSS 0 0.000 1.1
LHb gene expression 0 0.000 1.3
LHb isoform ratio 0 0.000 1.2
LHb intron excision ratio 0 0.000 1.3
LHb mRNA stability 0 0.000 1.4
Liver alternative polyA 0 0.000 1.3
Liver alternative TSS 0 0.000 1.2
Liver gene expression 2 0.028 1.3
Liver isoform ratio 0 0.000 1.2
Liver intron excision ratio 0 0.000 1.3
Liver mRNA stability 1 0.041 1.4
NAcc alternative polyA 0 0.000 1.4
NAcc alternative TSS 0 0.000 1.1
NAcc gene expression 0 0.000 1.3
NAcc isoform ratio 0 0.000 1.2
NAcc intron excision ratio 0 0.000 1.3
NAcc mRNA stability 0 0.000 1.4
NAcc2 alternative polyA 0 0.000 1.3
NAcc2 alternative TSS 0 0.000 1.3
NAcc2 gene expression 0 0.000 1.3
NAcc2 isoform ratio 0 0.000 1.2
NAcc2 intron excision ratio 0 0.000 1.3
NAcc2 mRNA stability 0 0.000 1.3
OFC alternative polyA 0 0.000 1.3
OFC alternative TSS 0 0.000 1.2
OFC gene expression 0 0.000 1.3
OFC isoform ratio 0 0.000 1.3
OFC intron excision ratio 0 0.000 1.3
OFC mRNA stability 0 0.000 1.4
PL alternative polyA 0 0.000 1.4
PL alternative TSS 0 0.000 1.1
PL gene expression 0 0.000 1.3
PL isoform ratio 0 0.000 1.1
PL intron excision ratio 0 0.000 1.4
PL mRNA stability 0 0.000 1.3
PL2 alternative polyA 0 0.000 1.2
PL2 alternative TSS 0 0.000 1.1
PL2 gene expression 0 0.000 1.3
PL2 isoform ratio 0 0.000 1.2
PL2 intron excision ratio 0 0.000 1.3
PL2 mRNA stability 0 0.000 1.3

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.