Hub : Traits

tautz: manual_spc11

Project: tautz

2 significantly associated models · 1 unique gene

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 5 137682119 138752373 1 1 8.2e-26 0.24 8.1e-62 -19845 Stk40

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
dissection: UMAP 1 of all traits 2.7 1 0 0 0 1 Stk40
retroperitoneal_fat_g 1.6 1 0 0 0 1 Stk40
body_g 4.0 1 0 0 0 1 Stk40
dissection: PC 3 of all traits 3.5 1 0 0 0 1 Stk40
glucose_mg_dl 13.9 1 1 100 0 1 Stk40
EDL weight in grams 5.7 1 0 0 0 1 Stk40
sol weight in grams 14.0 1 1 100 0 1 Stk40
TA weight in grams 1.8 1 0 0 0 1 Stk40
light_reinforcement_lr_active 5.5 1 0 0 0 1 Stk40
reaction_time_corr 4.4 1 0 0 0 1 Stk40
reaction_time_leftcorr 4.4 1 0 0 0 1 Stk40
delay_discounting_pc1800 6.9 1 0 0 0 1 Stk40
reaction_time_falsealarm 4.9 1 0 0 0 1 Stk40
reaction_time_pinit 4.2 1 0 0 0 1 Stk40
ccp_change_in_locomotor_activity 5.3 1 0 0 0 1 Stk40
crf_mi_active_responses 6.8 1 0 0 0 1 Stk40
pavca_mi_d1_avg_mag_lat 4.5 1 0 0 0 1 Stk40
pavca_mi_d3_magazine_ncs 20.8 1 0 0 0 1 Stk40
pavca_mi_d1_prob_lev 11.8 1 0 0 0 1 Stk40
pavca_mi_d1_avg_lev_lat 12.3 1 0 0 0 1 Stk40
pavca_mi_d3_prob_mag 4.9 1 0 0 0 1 Stk40
Total cortical area 5.4 1 0 0 0 1 Stk40
tb_th_sd 9.1 1 0 0 0 1 Stk40
length 2.8 1 0 0 0 1 Stk40
Trabecular tissue density 4.1 1 0 0 0 1 Stk40
ctth_sd 9.5 1 0 0 0 1 Stk40
tautz: manual_spc7 3.8 1 0 0 0 1 Stk40
tautz: manual_mpc15 11.2 1 0 0 0 1 Stk40
tautz: manual_mpc18 7.5 1 0 0 0 1 Stk40
tautz: manual_spc21 17.1 1 0 0 0 1 Stk40
tautz: manual_spc12 8.2 1 0 0 0 1 Stk40
tautz: manual_spc14 16.5 1 0 0 0 1 Stk40
tautz: manual_spc8 7.0 1 0 0 0 1 Stk40
tautz: manual_mpc4 14.8 1 0 0 0 1 Stk40
tautz: manual_mpc10 14.2 1 1 100 0 1 Stk40
tautz: manual_mpc5 15.8 1 1 100 0 1 Stk40
tautz: manual_mpc14 11.2 1 0 0 0 1 Stk40
tautz: manual_mpc12 13.8 1 0 0 0 1 Stk40
tautz: manual_mcs 17.3 1 0 0 0 1 Stk40
tautz: manual_spc4 18.0 1 0 0 0 1 Stk40
tautz: manual_mpc9 7.7 1 0 0 0 1 Stk40
tautz: manual_spc2 6.1 1 0 0 0 1 Stk40
tautz: manual_spc10 49.3 1 1 100 0 1 Stk40
tautz: manual_spc6 24.9 1 1 100 0 1 Stk40
tautz: manual_spc20 6.8 1 0 0 0 1 Stk40
tautz: manual_mpc17 13.2 1 0 0 0 1 Stk40
tautz: manual_mpc2 8.2 1 0 0 0 1 Stk40
tautz: manual_spc1 19.4 1 1 100 0 1 Stk40
tautz: manual_spc5 8.8 1 0 0 0 1 Stk40
tautz: manual_mpc6 9.2 1 0 0 0 1 Stk40
tautz: manual_spc18 28.7 1 1 100 0 1 Stk40
tautz: manual_mpc11 17.2 1 0 0 0 1 Stk40
tautz: manual_spc19 7.3 1 0 0 0 1 Stk40
tautz: manual_mpc8 5.5 1 0 0 0 1 Stk40
Liver selenium concentration 12.7 1 0 0 0 1 Stk40
Liver cadmium concentration 8.3 1 0 0 0 1 Stk40

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.3
Adipose alternative TSS 0 0.000 1.3
Adipose gene expression 0 0.000 1.3
Adipose isoform ratio 0 0.000 1.3
Adipose intron excision ratio 0 0.000 1.4
Adipose mRNA stability 0 0.000 1.3
BLA alternative polyA 0 0.000 1.4
BLA alternative TSS 0 0.000 1.4
BLA gene expression 0 0.000 1.3
BLA isoform ratio 0 0.000 1.3
BLA intron excision ratio 0 0.000 1.3
BLA mRNA stability 0 0.000 1.3
Brain alternative polyA 0 0.000 1.3
Brain alternative TSS 0 0.000 1.2
Brain gene expression 0 0.000 1.3
Brain isoform ratio 0 0.000 1.4
Brain intron excision ratio 0 0.000 1.3
Brain mRNA stability 0 0.000 1.3
Eye alternative polyA 0 0.000 1.3
Eye alternative TSS 0 0.000 1.2
Eye gene expression 0 0.000 1.2
Eye isoform ratio 0 0.000 1.5
Eye intron excision ratio 0 0.000 1.3
Eye mRNA stability 0 0.000 1.2
IL alternative polyA 0 0.000 1.3
IL alternative TSS 0 0.000 1.1
IL gene expression 0 0.000 1.3
IL isoform ratio 0 0.000 1.3
IL intron excision ratio 0 0.000 1.3
IL mRNA stability 0 0.000 1.2
LHb alternative polyA 0 0.000 1.2
LHb alternative TSS 0 0.000 1.3
LHb gene expression 0 0.000 1.3
LHb isoform ratio 0 0.000 1.3
LHb intron excision ratio 0 0.000 1.3
LHb mRNA stability 0 0.000 1.3
Liver alternative polyA 0 0.000 1.3
Liver alternative TSS 0 0.000 1.2
Liver gene expression 0 0.000 1.3
Liver isoform ratio 0 0.000 1.2
Liver intron excision ratio 1 0.023 1.4
Liver mRNA stability 1 0.041 1.4
NAcc alternative polyA 0 0.000 1.2
NAcc alternative TSS 0 0.000 1.2
NAcc gene expression 0 0.000 1.3
NAcc isoform ratio 0 0.000 1.2
NAcc intron excision ratio 0 0.000 1.3
NAcc mRNA stability 0 0.000 1.3
NAcc2 alternative polyA 0 0.000 1.2
NAcc2 alternative TSS 0 0.000 1.3
NAcc2 gene expression 0 0.000 1.3
NAcc2 isoform ratio 0 0.000 1.3
NAcc2 intron excision ratio 0 0.000 1.3
NAcc2 mRNA stability 0 0.000 1.3
OFC alternative polyA 0 0.000 1.3
OFC alternative TSS 0 0.000 1.4
OFC gene expression 0 0.000 1.3
OFC isoform ratio 0 0.000 1.4
OFC intron excision ratio 0 0.000 1.4
OFC mRNA stability 0 0.000 1.2
PL alternative polyA 0 0.000 1.3
PL alternative TSS 0 0.000 1.3
PL gene expression 0 0.000 1.3
PL isoform ratio 0 0.000 1.3
PL intron excision ratio 0 0.000 1.4
PL mRNA stability 0 0.000 1.2
PL2 alternative polyA 0 0.000 1.3
PL2 alternative TSS 0 0.000 1.4
PL2 gene expression 0 0.000 1.3
PL2 isoform ratio 0 0.000 1.3
PL2 intron excision ratio 0 0.000 1.3
PL2 mRNA stability 0 0.000 1.2

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.