Hub : Traits

tautz: manual_mpc3

Project: tautz

3 significantly associated models · 3 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 4 148138010 149534180 1 1 2.1e-08 3.6e-07 0.061 86 Cand2
2 16 75682169 77358717 2 1 8.9e-08 1.1e-03 0.433 94 AC117058.1

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
dissection: UMAP 1 of all traits 3.6 1 0 0 0 1 AC117058.1
retroperitoneal_fat_g 2.8 1 0 0 0 1 AC117058.1
body_g 2.3 1 0 0 0 1 AC117058.1
os_mean 4.6 1 0 0 0 1 Lamp1
tautz: manual_spc12 5.6 1 0 0 0 1 Cand2
tautz: manual_mpc19 7.4 2 0 0 0 1 Lamp1 AC117058.1
tautz: manual_spc20 7.8 2 0 0 0 1 Lamp1 AC117058.1
tautz: manual_spc3 5.7 1 0 0 0 1 Cand2
locomotor2 8.9 2 0 0 0 1 Cand2 AC117058.1
Liver rubidium concentration 5.2 1 0 0 0 1 Lamp1

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.5
Adipose alternative TSS 1 0.062 1.4
Adipose gene expression 0 0.000 1.5
Adipose isoform ratio 0 0.000 1.5
Adipose intron excision ratio 0 0.000 1.5
Adipose mRNA stability 0 0.000 1.5
BLA alternative polyA 0 0.000 1.5
BLA alternative TSS 0 0.000 1.6
BLA gene expression 0 0.000 1.6
BLA isoform ratio 0 0.000 1.5
BLA intron excision ratio 0 0.000 1.5
BLA mRNA stability 0 0.000 1.5
Brain alternative polyA 0 0.000 1.6
Brain alternative TSS 0 0.000 1.6
Brain gene expression 0 0.000 1.5
Brain isoform ratio 0 0.000 1.5
Brain intron excision ratio 0 0.000 1.4
Brain mRNA stability 0 0.000 1.5
Eye alternative polyA 0 0.000 1.7
Eye alternative TSS 0 0.000 1.8
Eye gene expression 0 0.000 1.5
Eye isoform ratio 0 0.000 1.5
Eye intron excision ratio 0 0.000 1.6
Eye mRNA stability 0 0.000 1.4
IL alternative polyA 0 0.000 1.6
IL alternative TSS 0 0.000 1.7
IL gene expression 0 0.000 1.6
IL isoform ratio 0 0.000 1.6
IL intron excision ratio 0 0.000 1.5
IL mRNA stability 0 0.000 1.6
LHb alternative polyA 0 0.000 1.4
LHb alternative TSS 0 0.000 1.8
LHb gene expression 0 0.000 1.5
LHb isoform ratio 0 0.000 1.5
LHb intron excision ratio 0 0.000 1.5
LHb mRNA stability 0 0.000 1.5
Liver alternative polyA 0 0.000 1.6
Liver alternative TSS 0 0.000 1.6
Liver gene expression 1 0.014 1.5
Liver isoform ratio 0 0.000 1.4
Liver intron excision ratio 0 0.000 1.5
Liver mRNA stability 0 0.000 1.5
NAcc alternative polyA 0 0.000 1.5
NAcc alternative TSS 0 0.000 1.6
NAcc gene expression 0 0.000 1.5
NAcc isoform ratio 0 0.000 1.4
NAcc intron excision ratio 0 0.000 1.7
NAcc mRNA stability 0 0.000 1.6
NAcc2 alternative polyA 0 0.000 1.7
NAcc2 alternative TSS 0 0.000 1.7
NAcc2 gene expression 0 0.000 1.6
NAcc2 isoform ratio 0 0.000 1.6
NAcc2 intron excision ratio 0 0.000 1.5
NAcc2 mRNA stability 0 0.000 1.6
OFC alternative polyA 0 0.000 1.5
OFC alternative TSS 0 0.000 1.5
OFC gene expression 0 0.000 1.5
OFC isoform ratio 0 0.000 1.8
OFC intron excision ratio 0 0.000 1.6
OFC mRNA stability 0 0.000 1.7
PL alternative polyA 0 0.000 1.7
PL alternative TSS 0 0.000 1.7
PL gene expression 0 0.000 1.5
PL isoform ratio 0 0.000 1.6
PL intron excision ratio 0 0.000 1.7
PL mRNA stability 0 0.000 1.7
PL2 alternative polyA 0 0.000 1.7
PL2 alternative TSS 0 0.000 1.4
PL2 gene expression 1 0.016 1.6
PL2 isoform ratio 0 0.000 1.5
PL2 intron excision ratio 0 0.000 1.5
PL2 mRNA stability 0 0.000 1.5

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.