Best TWAS P=2.432139e-08 · Best GWAS P=2.751775e-07 conditioned to 3.974562e-55
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Eye | Eno1 | isoform ratio | ENSRNOT00000081579 | 0.83 | 0.31 | enet | 251 | 0.43 | 9.1e-08 | -5.0 | 5.3 | 1.3e-07 | -0.80 | 0.44 | 0.53 | FALSE |
| 2 | PL2 | Rere | mRNA stability | ENSRNOG00000017940 | 0.15 | 0.06 | enet | 147 | 0.06 | 3.5e-04 | -4.7 | 5.6 | 2.4e-08 | -0.79 | 0.41 | 0.57 | TRUE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.