chr1:269,012,498-270,504,995

Trait: Heart weight

Best TWAS P = 6.31e-09 · Best GWAS P= 3.43e-09 conditioned to 2.32e-09

Associated models

Tissue Gene RNA modality RNA phenotype h2 # weights Model R2 Model R2 P TWAS Z TWAS P Coloc P Joint
BLA Sfxn4 gene expression Sfxn4 0.07 1 0.02 3.4e-02 -5.7 1.20e-08 0.08 FALSE
Brain Cacul1 isoform ratio NM_001416001.1 0.1 1 0.08 3.5e-08 5.81 6.31e-09 0.95 TRUE
Brain Cacul1 intron excision ratio chr1_269663603_269672274 0.11 1 0.08 4.3e-08 -5.81 6.31e-09 0.95 FALSE
IC Grk5 gene expression Grk5 0.12 1 0.07 7.4e-04 -5.61 2.03e-08 0.16 FALSE
IC Cacul1 isoform ratio NM_001014248.2 0.1 5 0.04 8.5e-03 5.58 2.43e-08 0.64 FALSE
Liver Grk5 mRNA stability Grk5 0.03 1480 0.01 3.6e-02 -5.21 1.87e-07 0.24 FALSE
NAcc Sfxn4 gene expression Sfxn4 0.05 16 0.06 1.5e-09 5.63 1.80e-08 0.38 TRUE
NAcc Cacul1 isoform ratio NM_001014248.2 0.16 1 0.05 9.7e-08 -5.73 9.97e-09 0.92 FALSE
PL Sfxn4 gene expression Sfxn4 0.1 1433 0.1 4.4e-11 5.41 6.40e-08 0.31 TRUE
PL Cacul1 isoform ratio NM_001014248.2 0.02 1822 0.01 1.3e-02 5.59 2.34e-08 0.66 FALSE
pVTA Sfxn4 gene expression Sfxn4 0.06 1433 0.04 3.2e-04 5.5 3.70e-08 0.45 FALSE