Hub : Traits : Bone: cortical thickness : ← →

chr10:102,999,385-104,353,671

Trait: Bone: cortical thickness

Best TWAS P=7.293764e-08 · Best GWAS P=7.178702e-08 conditioned to 8.9411e-16

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Usp36	gene expression	ENSRNOG00000028255	0.09	0.04	top1	1	0.04	3.7e-05	-5.36	5.4	8.4e-08	-0.41	0.09	0.43	FALSE
2	Adipose	Cep295nl	gene expression	ENSRNOG00000033143	0.25	0.12	enet	194	0.22	6.9e-24	-0.43	-5.2	2.4e-07	0.50	0.96	0.04	TRUE
3	Adipose	Cep295nl	isoform ratio	ENSRNOT00000004290	0.08	0.03	top1	1	0.03	4.5e-04	-5.31	-5.3	1.1e-07	0.49	0.07	0.16	FALSE
4	Adipose	C1qtnf1	intron excision ratio	chr10:103675735:103678361	0.06	0.02	top1	1	0.02	9.5e-04	-5.36	-5.4	8.2e-08	0.50	0.06	0.11	FALSE
5	BLA	Cep295nl	gene expression	ENSRNOG00000033143	0.23	0.10	top1	1	0.10	5.6e-06	-5.31	5.3	1.1e-07	-0.92	0.14	0.72	FALSE
6	Brain	Cep295nl	gene expression	ENSRNOG00000033143	0.33	0.24	lasso	28	0.28	5.4e-26	-5.29	5.2	1.5e-07	-0.96	0.15	0.85	FALSE
7	Brain	Cep295nl	intron excision ratio	chr10:103543287:103543754	0.10	0.03	blup	1803	0.03	4.2e-04	-4.53	-5.3	1.4e-07	0.78	0.72	0.25	FALSE
8	Brain	Usp36	mRNA stability	ENSRNOG00000028255	0.08	0.03	top1	1	0.03	4.1e-04	-5.31	-5.3	1.1e-07	0.92	0.09	0.30	FALSE
9	IL	Cep295nl	gene expression	ENSRNOG00000033143	0.42	0.14	top1	1	0.14	3.4e-04	-5.31	5.3	1.1e-07	-0.47	0.10	0.16	FALSE
10	NAcc	Lgals3bp	gene expression	ENSRNOG00000003217	0.09	0.04	enet	1	0.06	4.9e-05	-0.47	5.4	7.3e-08	-0.26	0.98	0.02	TRUE
11	NAcc	Afmid	intron excision ratio	chr10:103056570:103056650	0.36	0.05	top1	1	0.06	6.4e-05	-5.38	5.4	7.3e-08	-0.30	0.03	0.61	TRUE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.