Hub : Traits : Bone: cortical thickness : ←

chr10:105,499,327-107,195,627

Trait: Bone: cortical thickness

Best TWAS P=7.742722e-17 · Best GWAS P=2.681078e-10 conditioned to 1.962204e-05

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Tbcd	mRNA stability	ENSRNOG00000036658	0.10	0.04	blup	1813	0.06	6.6e-07	-3.2	-5.3	1.5e-07	-0.17	0.99	0.00	FALSE
2	Brain	Fn3k	gene expression	ENSRNOG00000036659	0.11	0.07	top1	1	0.07	8.7e-07	5.5	5.5	4.0e-08	0.83	0.62	0.23	FALSE
3	Brain	Sectm1a	gene expression	ENSRNOG00000036672	0.07	0.00	enet	49	0.02	7.4e-03	5.1	-5.2	1.7e-07	-0.92	0.15	0.67	FALSE
4	Brain	Znf750	gene expression	ENSRNOG00000046482	0.07	0.02	blup	1653	0.04	3.1e-04	-2.7	5.5	3.6e-08	0.66	0.85	0.12	TRUE
5	Eye	Narf	mRNA stability	ENSRNOG00000036664	0.34	0.16	top1	1	0.16	1.9e-03	5.4	-5.4	8.2e-08	-0.60	0.10	0.06	FALSE
6	LHb	NA	mRNA stability	ENSRNOG00000068691	0.35	0.05	enet	47	0.13	4.8e-04	3.0	5.3	1.0e-07	0.66	0.26	0.17	FALSE
7	Liver	Wdr45b	gene expression	ENSRNOG00000036662	0.13	0.06	top1	1	0.06	5.8e-07	5.1	-5.1	3.4e-07	-0.88	0.86	0.04	FALSE
8	NAcc	Ccdc57	alternative TSS	ENSRNOT00000095877	0.27	0.02	blup	1793	0.02	5.9e-03	-3.1	8.3	7.7e-17	0.25	0.33	0.03	TRUE
9	NAcc	Ccdc57	alternative TSS	ENSRNOT00000098223	0.24	0.02	blup	1793	0.02	7.7e-03	-3.1	-8.2	1.9e-16	-0.24	0.33	0.03	FALSE
10	PL	Wdr45b	gene expression	ENSRNOG00000036662	0.06	0.03	top1	1	0.03	2.4e-03	6.2	-6.2	4.4e-10	-0.86	0.04	0.63	TRUE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.