Hub : Traits : Bone: cortical thickness : ← →

chr10:94,609,547-96,660,473

Trait: Bone: cortical thickness

Best TWAS P=6.523066e-09 · Best GWAS P=7.781234e-11 conditioned to 0.000327399

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Brain	Kcnj16	alternative TSS	ENSRNOT00000099422	0.03	0.02	blup	2831	0.03	7.9e-04	-5.2	-5.6	1.8e-08	0.73	0.60	0.36	FALSE
2	Brain	Kcnj16	alternative TSS	ENSRNOT00000102350	0.13	0.17	blup	2831	0.20	6.2e-18	-4.8	5.5	2.9e-08	-0.80	0.69	0.31	FALSE
3	Brain	Kcnj16	alternative TSS	ENSRNOT00000095753	0.05	0.04	blup	2831	0.06	6.8e-06	-5.6	-5.3	1.4e-07	0.82	0.35	0.65	FALSE
4	Brain	Kcnj16	alternative TSS	ENSRNOT00000102350	0.05	0.04	blup	2831	0.06	4.4e-06	-5.5	5.2	1.6e-07	-0.82	0.34	0.66	FALSE
5	OFC	Map2k6	gene expression	ENSRNOG00000004437	0.44	0.22	blup	2809	0.31	4.1e-08	-4.1	5.2	2.1e-07	-0.36	0.92	0.07	FALSE
6	OFC	NA	gene expression	ENSRNOG00000065020	0.19	0.01	enet	17	0.05	2.8e-02	-5.2	5.8	6.5e-09	-0.65	0.41	0.42	TRUE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.