Hub : Traits : Bone: cortical thickness : →

chr3:126,323,673-128,419,948

Trait: Bone: cortical thickness

Best TWAS P=5.128521e-09 · Best GWAS P=5.488523e-09 conditioned to 0.1676888

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Ndufaf5	gene expression	ENSRNOG00000004784	0.04	0.02	top1	1	0.02	4.1e-03	-5.5	5.5	4.8e-08	-0.80	0.06	0.04	FALSE
2	Adipose	Ndufaf5	intron excision ratio	chr3:127508215:127509498	0.12	0.07	top1	1	0.07	5.6e-08	-5.7	5.7	9.4e-09	-0.88	0.16	0.84	FALSE
3	Adipose	Esf1	mRNA stability	ENSRNOG00000004777	0.17	0.06	blup	1671	0.07	2.9e-08	-5.7	5.8	8.4e-09	-0.95	0.18	0.82	FALSE
4	Adipose	Ndufaf5	mRNA stability	ENSRNOG00000004784	0.04	0.00	enet	54	0.01	1.5e-02	3.4	5.1	3.3e-07	-0.83	0.55	0.36	FALSE
5	BLA	Esf1	gene expression	ENSRNOG00000004777	0.66	0.36	lasso	33	0.37	6.9e-21	-5.8	-5.8	6.0e-09	1.00	0.17	0.83	FALSE
6	BLA	Ndufaf5	intron excision ratio	chr3:127508215:127509498	0.80	0.43	enet	162	0.44	6.0e-26	-5.7	5.8	5.1e-09	-0.89	0.17	0.83	TRUE
7	BLA	Ndufaf5	intron excision ratio	chr3:127508256:127509498	0.79	0.43	enet	169	0.44	7.1e-26	-5.7	-5.8	6.2e-09	0.90	0.17	0.83	FALSE
8	BLA	Ndufaf5	mRNA stability	ENSRNOG00000004784	0.60	0.20	lasso	17	0.22	8.0e-12	-5.7	5.7	8.9e-09	-0.99	0.18	0.82	FALSE
9	Brain	Esf1	gene expression	ENSRNOG00000004777	0.69	0.52	enet	101	0.53	7.6e-58	-5.7	-5.7	1.1e-08	0.99	0.18	0.82	FALSE
10	Brain	Esf1	intron excision ratio	chr3:127505805:127507637	0.10	0.06	top1	1	0.06	2.9e-06	-5.7	-5.7	9.1e-09	0.81	0.16	0.81	FALSE
11	Brain	Esf1	intron excision ratio	chr3:127505805:127507789	0.17	0.09	top1	1	0.09	6.1e-09	-5.7	5.7	9.1e-09	-0.91	0.16	0.84	FALSE
12	Brain	Ndufaf5	intron excision ratio	chr3:127508215:127509498	0.71	0.49	lasso	28	0.49	3.6e-51	-5.7	5.7	1.3e-08	-1.00	0.18	0.82	FALSE
13	Brain	Ndufaf5	intron excision ratio	chr3:127508256:127509498	0.71	0.48	lasso	45	0.49	8.0e-51	-5.7	-5.7	1.3e-08	1.00	0.18	0.82	FALSE
14	Brain	Ndufaf5	intron excision ratio	chr3:127526933:127536740	0.07	0.03	top1	1	0.03	1.2e-03	-5.7	5.7	9.1e-09	-0.82	0.07	0.19	FALSE
15	Brain	Ndufaf5	mRNA stability	ENSRNOG00000004784	0.09	0.04	top1	1	0.04	5.0e-05	-5.7	5.7	1.2e-08	-0.78	0.16	0.65	FALSE
16	IL	Esf1	gene expression	ENSRNOG00000004777	0.66	0.28	top1	1	0.28	2.2e-07	-5.4	-5.4	6.7e-08	0.89	0.21	0.16	FALSE
17	IL	Tasp1	intron excision ratio	chr3:127355890:127385049	0.25	0.01	enet	9	0.06	1.6e-02	-5.8	-5.8	5.4e-09	0.97	0.20	0.56	FALSE
18	IL	Ndufaf5	intron excision ratio	chr3:127508215:127509498	0.41	0.06	enet	4	0.09	3.4e-03	-5.7	5.3	1.1e-07	-0.84	0.18	0.69	FALSE
19	IL	Ndufaf5	intron excision ratio	chr3:127508256:127509498	0.42	0.15	top1	1	0.15	2.2e-04	-5.7	-5.7	1.1e-08	0.95	0.09	0.10	FALSE
20	LHb	Esf1	gene expression	ENSRNOG00000004777	0.70	0.50	top1	1	0.50	9.3e-14	-5.7	-5.7	1.2e-08	0.91	0.19	0.81	FALSE
21	LHb	Ism1	gene expression	ENSRNOG00000063262	0.48	0.45	lasso	23	0.47	9.7e-13	-5.4	-5.8	7.2e-09	0.97	0.33	0.67	FALSE
22	LHb	Ndufaf5	intron excision ratio	chr3:127508215:127509498	0.43	0.18	enet	14	0.24	1.9e-06	-5.7	5.5	2.9e-08	-0.94	0.19	0.76	FALSE
23	LHb	Ndufaf5	intron excision ratio	chr3:127508256:127509498	0.42	0.22	lasso	4	0.24	2.5e-06	-5.7	-5.5	3.9e-08	0.98	0.19	0.77	FALSE
24	Liver	Esf1	gene expression	ENSRNOG00000004777	0.09	0.04	lasso	16	0.04	1.2e-05	-5.8	5.8	6.8e-09	-0.99	0.17	0.82	FALSE
25	Liver	Ndufaf5	gene expression	ENSRNOG00000004784	0.17	0.09	lasso	21	0.10	1.1e-10	-5.7	5.8	7.2e-09	-1.00	0.19	0.81	FALSE
26	NAcc	Esf1	gene expression	ENSRNOG00000004777	0.47	0.28	enet	504	0.32	3.7e-24	-5.7	-5.6	1.7e-08	0.97	0.17	0.83	FALSE
27	NAcc	Ndufaf5	intron excision ratio	chr3:127508215:127509498	0.59	0.43	lasso	19	0.45	1.4e-36	-5.7	5.7	1.0e-08	-1.00	0.17	0.83	FALSE
28	NAcc	Ndufaf5	intron excision ratio	chr3:127508256:127509498	0.59	0.43	lasso	33	0.44	5.3e-36	-5.7	-5.7	9.8e-09	1.00	0.17	0.83	FALSE
29	NAcc	AABR07054000.1	intron excision ratio	chr3:127747955:127748961	0.07	0.03	top1	1	0.03	2.0e-03	-5.7	-5.7	1.5e-08	0.69	0.07	0.10	FALSE
30	NAcc	AABR07054000.1	intron excision ratio	chr3:127747955:127749007	0.07	0.03	top1	1	0.03	1.7e-03	-5.7	5.7	1.5e-08	-0.70	0.07	0.11	FALSE
31	NAcc	Ndufaf5	mRNA stability	ENSRNOG00000004784	0.10	0.05	lasso	36	0.07	6.6e-06	-5.8	5.5	4.8e-08	-0.87	0.36	0.64	FALSE
32	OFC	Esf1	gene expression	ENSRNOG00000004777	0.65	0.39	top1	1	0.39	3.8e-10	-5.7	-5.7	1.5e-08	0.90	0.22	0.71	FALSE
33	OFC	Ndufaf5	intron excision ratio	chr3:127508215:127509498	0.58	0.21	blup	1669	0.23	4.6e-06	-5.7	5.8	7.6e-09	-0.98	0.19	0.81	FALSE
34	OFC	Ndufaf5	intron excision ratio	chr3:127508256:127509498	0.61	0.21	blup	1669	0.24	1.6e-06	-5.7	-5.8	6.3e-09	0.98	0.19	0.81	FALSE
35	PL	Tasp1	gene expression	ENSRNOG00000004493	0.04	0.01	enet	8	0.02	1.0e-02	-5.4	-5.4	6.6e-08	0.94	0.43	0.35	FALSE
36	PL	Esf1	gene expression	ENSRNOG00000004777	0.47	0.31	lasso	31	0.33	5.5e-26	-5.7	-5.7	1.1e-08	1.00	0.17	0.83	FALSE
37	PL	Ndufaf5	gene expression	ENSRNOG00000004784	0.16	0.07	lasso	24	0.08	5.9e-07	-5.6	5.6	1.7e-08	-0.95	0.18	0.81	FALSE
38	PL	Tasp1	isoform ratio	ENSRNOT00000055630	0.05	0.04	top1	1	0.04	3.5e-04	-5.4	-5.4	6.7e-08	0.88	0.06	0.04	FALSE
39	PL	Esf1	intron excision ratio	chr3:127505805:127507789	0.07	0.05	top1	1	0.05	2.1e-04	-5.7	5.7	9.1e-09	-0.86	0.08	0.19	FALSE
40	PL	Ndufaf5	intron excision ratio	chr3:127508215:127509498	0.84	0.45	top1	1	0.45	5.3e-37	-5.7	5.7	1.0e-08	-0.89	0.18	0.82	FALSE
41	PL	Ndufaf5	intron excision ratio	chr3:127508256:127509498	0.86	0.44	top1	1	0.44	2.0e-36	-5.7	-5.7	1.0e-08	0.89	0.18	0.82	FALSE
42	PL	Ndufaf5	mRNA stability	ENSRNOG00000004784	0.18	0.09	lasso	50	0.13	4.7e-10	-5.7	5.6	1.9e-08	-0.91	0.18	0.82	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.