Hub : Traits : Bone: cortical thickness : →

chr3:146,614,418-148,660,154

Trait: Bone: cortical thickness

Best TWAS P = 1.77e-08 · Best GWAS P= 1.75e-08 conditioned to 1.00e+00

Associated models

Tissue	Gene	RNA modality	RNA phenotype	h2	# weights	Model R2	Model R2 P	TWAS Z	TWAS P	Coloc P	Joint
Adipose	Esf1	isoform ratio	XM_006235105.5	0.06	1	0.04	7.3e-05	5.48	4.19e-08	0.22	FALSE
Adipose	Ndufaf5	intron excision ratio	chr3_147961868_147963151	0.14	18	0.1	2.3e-11	5.58	2.46e-08	0.83	FALSE
Adipose	Ndufaf5	intron excision ratio	chr3_147961909_147963151	0.15	33	0.1	1.2e-11	-5.58	2.47e-08	0.83	FALSE
Adipose	Esf1	mRNA stability	Esf1	0.18	1680	0.08	6.4e-09	5.51	3.64e-08	0.82	FALSE
BLA	Ndufaf5	alternative TSS	NM_001126371.1	0.36	18	0.18	9.8e-10	5.63	1.77e-08	0.82	TRUE
BLA	Ndufaf5	alternative TSS	XM_039104593.2	0.23	1	0.08	3.7e-05	5.48	4.28e-08	0.56	FALSE
BLA	Esf1	gene expression	Esf1	0.68	1	0.37	1.2e-20	5.58	2.47e-08	0.85	FALSE
BLA	Ndufaf5	isoform ratio	NM_001126371.1	0.63	31	0.35	3.9e-19	5.42	6.05e-08	0.82	FALSE
BLA	Ndufaf5	isoform ratio	XM_039104593.2	0.51	1680	0.26	5.5e-14	-5.5	3.70e-08	0.82	FALSE
BLA	Ndufaf5	intron excision ratio	chr3_147961868_147963151	0.78	1680	0.45	3.7e-26	5.54	3.07e-08	0.82	FALSE
BLA	Ndufaf5	intron excision ratio	chr3_147961909_147963151	0.78	1680	0.45	5.1e-26	-5.53	3.22e-08	0.82	FALSE
Brain	Ndufaf5	alternative TSS	NM_001126371.1	0.18	137	0.1	1.1e-09	-5.53	3.17e-08	0.83	FALSE
Brain	Ndufaf5	alternative TSS	XM_039104593.2	0.26	1	0.16	1.1e-14	5.56	2.63e-08	0.84	FALSE
Brain	Esf1	gene expression	Esf1	0.65	183	0.5	2.0e-53	5.56	2.64e-08	0.83	FALSE
Brain	Sptlc3	gene expression	Sptlc3	0.08	1744	0.06	4.1e-06	-5.24	1.60e-07	0.57	FALSE
Brain	Esf1	isoform ratio	XM_006235105.5	0.17	1	0.11	5.0e-10	5.55	2.90e-08	0.83	FALSE
Brain	Esf1	isoform ratio	XM_006235106.4	0.21	1	0.12	5.4e-11	-5.48	4.19e-08	0.77	FALSE
Brain	Ndufaf5	isoform ratio	NM_001126371.1	0.56	1	0.3	6.0e-28	-5.56	2.63e-08	0.84	FALSE
Brain	Ndufaf5	isoform ratio	XM_039104593.2	0.56	1680	0.39	3.7e-38	-5.34	9.17e-08	0.83	FALSE
Brain	Ndufaf5	isoform ratio	XR_005501826.2	0.11	8	0.04	4.9e-05	-5.56	2.75e-08	0.81	FALSE
Brain	Esf1	intron excision ratio	chr3_147959458_147961290	0.1	1	0.06	1.2e-06	5.5	3.87e-08	0.74	FALSE
Brain	Esf1	intron excision ratio	chr3_147959458_147961442	0.18	1	0.11	3.2e-10	-5.48	4.19e-08	0.77	FALSE
Brain	Ndufaf5	intron excision ratio	chr3_147961868_147963151	0.7	69	0.5	2.6e-53	5.53	3.22e-08	0.83	FALSE
Brain	Ndufaf5	intron excision ratio	chr3_147961909_147963151	0.7	59	0.5	2.9e-53	-5.54	3.00e-08	0.83	FALSE
Brain	Ndufaf5	intron excision ratio	chr3_147980587_147990391	0.07	1	0.03	4.2e-04	-5.48	4.19e-08	0.22	FALSE
Eye	Esf1	gene expression	Esf1	0.49	7	0.1	1.1e-02	5.5	3.88e-08	0.26	FALSE
IC	Ndufaf5	alternative TSS	XM_039104593.2	0.39	1	0.2	9.3e-09	5.5	3.76e-08	0.78	FALSE
IC	Esf1	gene expression	Esf1	0.64	1680	0.43	9.9e-20	-5.49	4.01e-08	0.84	FALSE
IC	Ndufaf5	isoform ratio	NM_001126371.1	0.65	88	0.41	1.1e-18	-5.44	5.36e-08	0.84	FALSE
IC	Ndufaf5	isoform ratio	XM_039104593.2	0.54	21	0.32	5.6e-14	-5.47	4.53e-08	0.84	FALSE
IC	Ndufaf5	intron excision ratio	chr3_147961868_147963151	0.83	17	0.57	6.5e-29	5.31	1.08e-07	0.84	FALSE
IC	Ndufaf5	intron excision ratio	chr3_147961909_147963151	0.82	26	0.57	8.4e-29	-5.29	1.22e-07	0.84	FALSE
IC	Ndufaf5	intron excision ratio	chr3_147975359_147976052	0.16	1	0.05	3.3e-03	-5.56	2.63e-08	0.1	FALSE
IC	Ndufaf5	intron excision ratio	chr3_147975359_147976074	0.16	1	0.06	2.0e-03	5.56	2.63e-08	0.1	FALSE
IL	Esf1	gene expression	Esf1	0.68	16	0.3	5.4e-08	-5.46	4.71e-08	0.81	FALSE
LHb	Esf1	gene expression	Esf1	0.64	45	0.45	3.8e-12	-5.5	3.72e-08	0.82	FALSE
LHb	Ism1	gene expression	Ism1	0.49	1	0.44	9.5e-12	5.55	2.83e-08	0.67	FALSE
Liver	Esf1	gene expression	Esf1	0.09	1	0.04	5.7e-05	-5.48	4.19e-08	0.39	FALSE
Liver	Ndufaf5	gene expression	Ndufaf5	0.12	1	0.07	3.9e-08	-5.48	4.19e-08	0.77	FALSE
Liver	Esf1	isoform ratio	XM_006235105.5	0.15	1680	0.07	1.6e-08	-5.41	6.45e-08	0.82	FALSE
Liver	Esf1	intron excision ratio	chr3_147959458_147961442	0.03	30	0.01	1.3e-02	-5.47	4.53e-08	0.7	FALSE
NAcc	Ndufaf5	alternative TSS	NM_001126371.1	0.07	1	0.05	1.0e-07	-5.45	4.98e-08	0.73	FALSE
NAcc	Ndufaf5	alternative TSS	XM_039104593.2	0.16	1	0.13	3.5e-19	5.61	1.97e-08	0.87	FALSE
NAcc	Esf1	gene expression	Esf1	0.41	25	0.31	1.2e-47	-5.58	2.46e-08	0.84	FALSE
NAcc	Esf1	isoform ratio	XM_006235105.5	0.07	1680	0.05	1.4e-07	-5.57	2.61e-08	0.81	FALSE
NAcc	Esf1	isoform ratio	XM_006235106.4	0.04	1	0.04	6.1e-07	-5.47	4.39e-08	0.73	TRUE
NAcc	Ndufaf5	isoform ratio	NM_001126371.1	0.35	1	0.22	2.4e-33	-5.42	5.87e-08	0.71	FALSE
NAcc	Ndufaf5	isoform ratio	XM_039104593.2	0.37	45	0.27	5.2e-41	-5.57	2.58e-08	0.85	FALSE
NAcc	Esf1	intron excision ratio	chr3_147959458_147961290	0.03	1	0.03	9.0e-05	5.48	4.28e-08	0.18	FALSE
NAcc	Esf1	intron excision ratio	chr3_147959458_147961442	0.04	1	0.04	1.1e-06	-5.48	4.28e-08	0.69	FALSE
NAcc	Ndufaf5	intron excision ratio	chr3_147961868_147963151	0.58	66	0.52	1.8e-93	-5.55	2.81e-08	0.84	FALSE
NAcc	Ndufaf5	intron excision ratio	chr3_147961909_147963151	0.57	64	0.53	8.4e-95	5.55	2.86e-08	0.84	FALSE
NAcc	Ndufaf5	intron excision ratio	chr3_147975359_147976074	0.04	1	0.02	2.1e-04	5.5	3.87e-08	0.25	FALSE
OFC	Esf1	gene expression	Esf1	0.65	27	0.34	6.7e-09	-5.54	3.07e-08	0.82	FALSE
OFC	Ndufaf5	intron excision ratio	chr3_147961868_147963151	0.57	1	0.26	6.6e-07	-5.48	4.16e-08	0.27	FALSE
OFC	Ndufaf5	intron excision ratio	chr3_147961909_147963151	0.61	1	0.28	2.0e-07	5.48	4.16e-08	0.35	FALSE
PL	Ndufaf5	alternative TSS	NM_001126371.1	0.09	1	0.06	4.9e-07	-5.48	4.19e-08	0.72	FALSE
PL	Ndufaf5	alternative TSS	XM_039104593.2	0.21	1	0.12	3.1e-13	5.54	3.02e-08	0.82	FALSE
PL	Esf1	gene expression	Esf1	0.45	66	0.37	2.8e-42	5.58	2.35e-08	0.82	FALSE
PL	Tasp1	gene expression	Tasp1	0.03	1699	0.02	5.7e-03	-5.22	1.80e-07	0.65	FALSE
PL	Esf1	isoform ratio	XM_006235105.5	0.14	1680	0.07	3.5e-08	-5.51	3.67e-08	0.82	FALSE
PL	Esf1	isoform ratio	XM_006235106.4	0.08	1	0.05	6.9e-06	-5.56	2.63e-08	0.76	FALSE
PL	Esf1	isoform ratio	XM_017591950.3	0.05	43	0.02	2.4e-03	5.49	4.05e-08	0.69	TRUE
PL	Ndufaf5	isoform ratio	NM_001126371.1	0.53	1	0.26	8.4e-28	-5.56	2.63e-08	0.84	FALSE
PL	Ndufaf5	isoform ratio	XM_039104593.2	0.51	55	0.31	1.7e-34	-5.58	2.44e-08	0.85	FALSE
PL	Ndufaf5	isoform ratio	XR_005501826.2	0.04	1	0.02	1.2e-03	5.47	4.39e-08	0.16	FALSE
PL	Tasp1	isoform ratio	XM_039105027.1	0.04	1	0.03	8.8e-04	-5.5	3.81e-08	0.44	FALSE
PL	Esf1	intron excision ratio	chr3_147959458_147961442	0.09	1	0.06	5.8e-07	-5.56	2.63e-08	0.81	FALSE
PL	Ndufaf5	intron excision ratio	chr3_147961868_147963151	0.88	60	0.53	2.8e-67	5.57	2.54e-08	0.84	FALSE
PL	Ndufaf5	intron excision ratio	chr3_147961909_147963151	0.89	63	0.52	4.8e-66	-5.57	2.55e-08	0.84	FALSE
PL	Ndufaf5	intron excision ratio	chr3_147980587_147990391	0.07	1	0.03	5.9e-04	-5.49	3.95e-08	0.26	TRUE
pVTA	Ndufaf5	alternative TSS	NM_001126371.1	0.18	30	0.1	2.7e-08	5.57	2.53e-08	0.84	FALSE
pVTA	Ndufaf5	alternative TSS	XM_039104593.2	0.18	1	0.11	5.1e-09	5.56	2.63e-08	0.84	FALSE
pVTA	Esf1	gene expression	Esf1	0.49	42	0.4	6.6e-34	-5.59	2.23e-08	0.84	FALSE
pVTA	Ndufaf5	gene expression	Ndufaf5	0.1	5	0.1	3.1e-08	5.45	5.05e-08	0.12	TRUE
pVTA	Esf1	isoform ratio	XM_006235106.4	0.1	1	0.04	7.5e-04	-5.46	4.85e-08	0.09	FALSE
pVTA	Esf1	isoform ratio	XM_017591950.3	0.05	100	0.03	1.7e-03	5.54	3.02e-08	0.75	FALSE
pVTA	Ndufaf5	isoform ratio	NM_001126371.1	0.42	1680	0.3	3.4e-24	5.49	3.94e-08	0.84	FALSE
pVTA	Ndufaf5	isoform ratio	XM_039104593.2	0.42	1	0.31	3.8e-25	5.56	2.63e-08	0.84	FALSE
pVTA	Esf1	intron excision ratio	chr3_147959458_147961442	0.13	1	0.06	1.0e-05	-5.48	4.19e-08	0.56	FALSE
pVTA	Ndufaf5	intron excision ratio	chr3_147961868_147963151	0.59	31	0.53	1.4e-49	5.57	2.55e-08	0.85	FALSE
pVTA	Ndufaf5	intron excision ratio	chr3_147961909_147963151	0.58	24	0.53	1.5e-49	-5.57	2.51e-08	0.85	FALSE
pVTA	Ndufaf5	intron excision ratio	chr3_147975359_147976052	0.04	17	0.02	7.8e-03	5.56	2.73e-08	0.7	FALSE
pVTA	Ndufaf5	intron excision ratio	chr3_147975359_147976074	0.04	1	0.03	1.8e-03	5.55	2.90e-08	0.12	FALSE
RMTg	Ndufaf5	isoform ratio	NM_001126371.1	0.35	1	0.16	6.0e-05	-5.42	5.87e-08	0.08	FALSE
RMTg	Ndufaf5	isoform ratio	XM_039104593.2	0.43	1	0.12	4.9e-04	5.49	3.97e-08	0.11	FALSE
RMTg	Esf1	intron excision ratio	chr3_147960213_147961290	0.3	1	0.09	1.8e-03	5.42	5.87e-08	0.05	FALSE