Hub : Traits : Bone: cortical thickness : →

chr3:126,160,536-128,206,530

Trait: Bone: cortical thickness

Best TWAS P=3.96e-09 · Best GWAS P=5.49e-09 conditioned to 1.00e+00

Associated models

Tissue	Gene	RNA modality	RNA phenotype	h2	# weights	Model R2	Model R2 P	TWAS Z	TWAS P	Coloc P	Joint
Adipose	Tasp1	alternative TSS	XM_039105024.1	0.03	4	0.02	1.6e-03	5.39	7.23e-08	0.08	TRUE
Adipose	Tasp1	alternative TSS	XM_039105025.1	0.06	1686	0.05	1.8e-06	5.22	1.83e-07	0.18	FALSE
Adipose	Tasp1	alternative TSS	XM_039105024.1	0.03	39	0.01	7.6e-03	5.54	2.96e-08	0.11	TRUE
Adipose	Tasp1	alternative TSS	XM_039105025.1	0.07	1686	0.06	5.2e-07	5.21	1.90e-07	0.13	FALSE
Adipose	Ism1	gene expression	Ism1	0.06	6	0.04	7.3e-05	-5.39	7.21e-08	0.62	FALSE
Adipose	Ndufaf5	gene expression	Ndufaf5	0.03	1	0.01	6.9e-03	-5.4	6.73e-08	0.03	TRUE
Adipose	Esf1	isoform ratio	XM_006235105.4	0.05	1	0.02	1.1e-03	5.75	9.13e-09	0.09	FALSE
Adipose	Ndufaf5	intron excision ratio	chr3_127508256_127509498	0.14	31	0.11	7.4e-12	5.78	7.56e-09	0.83	FALSE
Adipose	Esf1	mRNA stability	Esf1	0.18	102	0.08	3.3e-09	-5.62	1.93e-08	0.83	FALSE
BLA	Ndufaf5	alternative TSS	NM_001126371.1	0.13	1	0.04	3.8e-03	-5.64	1.72e-08	0.05	FALSE
BLA	Ndufaf5	alternative TSS	XM_039104593.1	0.57	34	0.28	2.4e-15	-5.73	1.03e-08	0.83	FALSE
BLA	Ndufaf5	alternative TSS	NM_001126371.1	0.6	46	0.29	9.0e-16	5.7	1.21e-08	0.83	FALSE
BLA	Ndufaf5	alternative TSS	XM_039104593.1	0.59	29	0.29	1.3e-15	-5.68	1.35e-08	0.83	FALSE
BLA	Esf1	gene expression	Esf1	0.67	1	0.38	2.6e-21	5.81	6.10e-09	0.89	FALSE
BLA	Esf1	isoform ratio	XM_006235106.3	0.11	1	0.04	2.2e-03	-5.4	6.65e-08	0.04	FALSE
BLA	Ndufaf5	isoform ratio	NM_001126371.1	0.59	40	0.29	4.0e-16	5.61	2.01e-08	0.83	FALSE
BLA	Ndufaf5	isoform ratio	XM_039104593.1	0.58	1	0.32	7.2e-18	5.81	6.10e-09	0.89	FALSE
BLA	Ndufaf5	intron excision ratio	chr3_127508215_127509498	0.77	1669	0.47	1.3e-27	5.77	8.05e-09	0.83	FALSE
BLA	Ndufaf5	intron excision ratio	chr3_127508256_127509498	0.76	1669	0.47	1.1e-27	-5.77	8.15e-09	0.83	FALSE
BLA	Ndufaf5	mRNA stability	Ndufaf5	0.4	1	0.21	2.9e-11	-5.46	4.81e-08	0.52	FALSE
Brain	Ndufaf5	alternative TSS	XM_039104593.1	0.44	20	0.27	3.4e-25	-5.74	9.67e-09	0.83	FALSE
Brain	Ndufaf5	alternative TSS	NM_001126371.1	0.46	9	0.29	2.1e-27	5.75	9.09e-09	0.83	FALSE
Brain	Ndufaf5	alternative TSS	XM_039104593.1	0.46	7	0.3	1.0e-27	-5.75	9.18e-09	0.83	FALSE
Brain	Esf1	gene expression	Esf1	0.72	70	0.51	1.1e-54	5.78	7.47e-09	0.84	FALSE
Brain	Sptlc3	gene expression	Sptlc3	0.06	1712	0.03	4.9e-04	-5.35	8.56e-08	0.53	FALSE
Brain	Esf1	isoform ratio	XM_006235105.4	0.14	1	0.09	1.1e-08	5.71	1.15e-08	0.81	FALSE
Brain	Ndufaf5	isoform ratio	NM_001126371.1	0.43	14	0.22	2.7e-20	5.72	1.05e-08	0.81	FALSE
Brain	Ndufaf5	isoform ratio	XM_039104593.1	0.45	20	0.28	1.5e-26	-5.75	9.08e-09	0.82	FALSE
Brain	Ndufaf5	isoform ratio	XR_005501826.1	0.08	1	0.04	4.6e-05	5.46	4.81e-08	0.19	FALSE
Brain	Tasp1	isoform ratio	XM_039105026.1	0.04	1	0.03	1.1e-03	5.43	5.64e-08	0.04	FALSE
Brain	Esf1	intron excision ratio	chr3_127505805_127507637	0.1	1	0.07	7.4e-07	5.73	1.02e-08	0.79	FALSE
Brain	Esf1	intron excision ratio	chr3_127505805_127507789	0.19	1	0.11	1.7e-10	-5.73	1.02e-08	0.83	FALSE
Brain	Ndufaf5	intron excision ratio	chr3_127508215_127509498	0.72	86	0.49	4.8e-51	-5.71	1.13e-08	0.83	FALSE
Brain	Ndufaf5	intron excision ratio	chr3_127508256_127509498	0.72	85	0.48	8.0e-51	5.71	1.11e-08	0.83	FALSE
Brain	Ndufaf5	intron excision ratio	chr3_127526933_127536740	0.09	3	0.03	4.1e-04	5.77	7.77e-09	0.81	FALSE
Brain	Ndufaf5	mRNA stability	Ndufaf5	0.07	3	0.04	3.3e-04	5.77	8.04e-09	0.77	FALSE
Eye	Esf1	gene expression	Esf1	0.46	1	0.09	1.8e-02	5.72	1.05e-08	0.06	FALSE
IL	Esf1	gene expression	Esf1	0.67	1	0.33	1.2e-08	5.46	4.81e-08	0.29	FALSE
LHb	Esf1	gene expression	Esf1	0.66	152	0.5	7.1e-14	5.53	3.26e-08	0.82	FALSE
LHb	Ism1	gene expression	Ism1	0.51	1710	0.45	4.1e-12	-5.84	5.21e-09	0.67	FALSE
LHb	Ndufaf5	intron excision ratio	chr3_127508215_127509498	0.41	1669	0.13	4.5e-04	5.26	1.45e-07	0.76	FALSE
LHb	Ndufaf5	intron excision ratio	chr3_127508256_127509498	0.42	1	0.22	5.2e-06	5.4	6.73e-08	0.07	FALSE
Liver	Esf1	gene expression	Esf1	0.1	1	0.04	1.1e-05	-5.77	8.15e-09	0.67	FALSE
Liver	Ndufaf5	gene expression	Ndufaf5	0.15	1	0.07	7.6e-08	-5.77	8.15e-09	0.86	FALSE
Liver	Esf1	isoform ratio	XM_006235105.4	0.15	1668	0.07	1.3e-08	-5.66	1.54e-08	0.82	FALSE
Liver	Esf1	intron excision ratio	chr3_127505805_127507789	0.04	1	0.02	6.3e-03	-5.77	8.06e-09	0.06	FALSE
NAcc	Ndufaf5	alternative TSS	NM_001126371.1	0.03	1	0.02	1.3e-03	-5.43	5.55e-08	0.04	FALSE
NAcc	Ndufaf5	alternative TSS	XM_039104593.1	0.16	1	0.12	2.0e-13	5.72	1.05e-08	0.82	FALSE
NAcc	Ndufaf5	alternative TSS	NM_001126371.1	0.24	1	0.15	7.8e-17	-5.72	1.05e-08	0.82	FALSE
NAcc	Ndufaf5	alternative TSS	XM_039104593.1	0.21	1	0.13	3.1e-15	5.72	1.05e-08	0.82	FALSE
NAcc	Esf1	gene expression	Esf1	0.46	1669	0.33	3.6e-39	-5.89	3.96e-09	0.83	TRUE
NAcc	Esf1	isoform ratio	XM_006235105.4	0.07	1	0.04	6.0e-05	5.81	6.10e-09	0.78	FALSE
NAcc	Ndufaf5	isoform ratio	NM_001126371.1	0.21	1	0.15	1.7e-16	-5.71	1.14e-08	0.81	FALSE
NAcc	Ndufaf5	isoform ratio	XM_039104593.1	0.25	1	0.11	3.7e-13	5.72	1.05e-08	0.82	FALSE
NAcc	Esf1	intron excision ratio	chr3_127505805_127507789	0.03	1	0.03	7.7e-05	-5.51	3.67e-08	0.14	FALSE
NAcc	Ndufaf5	intron excision ratio	chr3_127508215_127509498	0.57	75	0.51	2.9e-69	5.77	7.82e-09	0.84	FALSE
NAcc	Ndufaf5	intron excision ratio	chr3_127508256_127509498	0.57	61	0.51	5.6e-69	-5.77	7.84e-09	0.84	FALSE
NAcc	Ndufaf5	mRNA stability	Ndufaf5	0.1	1669	0.1	3.5e-11	5.27	1.38e-07	0.82	FALSE
OFC	Esf1	gene expression	Esf1	0.65	20	0.36	2.0e-09	-5.69	1.29e-08	0.82	FALSE
OFC	Ndufaf5	intron excision ratio	chr3_127508215_127509498	0.59	1	0.26	7.5e-07	-5.4	6.73e-08	0.1	FALSE
OFC	Ndufaf5	intron excision ratio	chr3_127508256_127509498	0.61	1	0.27	3.3e-07	5.4	6.73e-08	0.13	FALSE
PL	Ndufaf5	alternative TSS	NM_001126371.1	0.09	38	0.06	5.0e-07	-5.75	9.09e-09	0.83	FALSE
PL	Ndufaf5	alternative TSS	XM_039104593.1	0.28	25	0.2	7.2e-22	-5.74	9.55e-09	0.83	FALSE
PL	Ndufaf5	alternative TSS	NM_001126371.1	0.31	1	0.23	4.6e-25	-5.72	1.05e-08	0.82	FALSE
PL	Ndufaf5	alternative TSS	XM_039104593.1	0.29	55	0.22	1.7e-23	5.5	3.76e-08	0.83	FALSE
PL	Esf1	gene expression	Esf1	0.46	19	0.37	5.5e-43	-5.75	8.91e-09	0.83	FALSE
PL	Tasp1	gene expression	Tasp1	0.03	1687	0.01	1.0e-02	-5.43	5.60e-08	0.66	FALSE
PL	Esf1	isoform ratio	XM_006235105.4	0.1	17	0.04	1.1e-05	-5.73	1.01e-08	0.82	FALSE
PL	Esf1	isoform ratio	XM_006235106.3	0.07	1	0.04	1.5e-05	-5.72	1.05e-08	0.59	FALSE
PL	Ndufaf5	isoform ratio	NM_001126371.1	0.38	1	0.2	7.2e-22	-5.73	1.01e-08	0.83	FALSE
PL	Ndufaf5	isoform ratio	XR_005501826.1	0.04	25	0.03	2.2e-04	5.75	9.08e-09	0.8	FALSE
PL	Tasp1	isoform ratio	XM_039105027.1	0.05	1	0.05	8.5e-06	-5.71	1.13e-08	0.59	TRUE
PL	Esf1	intron excision ratio	chr3_127505805_127507789	0.09	33	0.06	7.1e-07	-5.72	1.04e-08	0.82	FALSE
PL	Ndufaf5	intron excision ratio	chr3_127508215_127509498	0.74	57	0.52	1.5e-66	5.74	9.45e-09	0.84	FALSE
PL	Ndufaf5	intron excision ratio	chr3_127508256_127509498	0.8	54	0.51	2.3e-65	-5.74	9.51e-09	0.84	FALSE
pVTA	Ndufaf5	alternative TSS	XM_039104593.1	0.31	16	0.2	4.4e-09	-5.74	9.38e-09	0.82	FALSE
pVTA	Ndufaf5	alternative TSS	NM_001126371.1	0.37	71	0.26	1.3e-11	-5.75	8.79e-09	0.82	FALSE
pVTA	Ndufaf5	alternative TSS	XM_039104593.1	0.37	37	0.26	1.3e-11	5.74	9.47e-09	0.81	FALSE
pVTA	Esf1	gene expression	Esf1	0.51	1669	0.44	4.2e-21	-5.88	4.12e-09	0.83	FALSE
pVTA	Ndufaf5	isoform ratio	NM_001126371.1	0.28	1669	0.14	1.2e-06	5.84	5.30e-09	0.82	FALSE
pVTA	Ndufaf5	isoform ratio	XM_039104593.1	0.31	28	0.18	1.9e-08	-5.72	1.09e-08	0.82	FALSE
pVTA	Esf1	intron excision ratio	chr3_127505805_127507789	0.16	33	0.08	2.9e-04	-5.25	1.53e-07	0.76	FALSE
pVTA	Ndufaf5	intron excision ratio	chr3_127508215_127509498	0.62	45	0.5	7.0e-25	5.72	1.07e-08	0.82	FALSE
pVTA	Ndufaf5	intron excision ratio	chr3_127508256_127509498	0.63	29	0.51	1.6e-25	-5.7	1.21e-08	0.82	FALSE
pVTA	Ndufaf5	mRNA stability	Ndufaf5	0.19	1	0.09	9.6e-05	-5.62	1.94e-08	0.15	FALSE
RMTg	Esf1	mRNA stability	Esf1	0.25	1	0.12	4.8e-04	-5.66	1.52e-08	0.06	FALSE