Hub : Traits : Epididymis fat weight : →

chr1:252,259,928-257,369,670

Trait: Epididymis fat weight

Best TWAS P=5.057311e-13 · Best GWAS P=3.615959e-13 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Nhlrc2	alternative polyA	ENSRNOT00000022788	0.03	0.00	top1	1	0.00	1.8e-01	7.0	7.0	2.5e-12	0.95	0.06	0.03	FALSE
2	Adipose	Nhlrc2	alternative polyA	ENSRNOT00000105890	0.03	0.01	top1	1	0.01	3.7e-02	7.0	-7.0	2.5e-12	-0.96	0.06	0.03	FALSE
3	Adipose	Atrnl1	alternative polyA	ENSRNOT00000105444	0.08	0.07	top1	1	0.07	4.0e-08	6.2	6.2	7.6e-10	0.67	0.03	0.97	FALSE
4	Adipose	Atrnl1	alternative polyA	ENSRNOT00000115590	0.02	0.02	lasso	1	0.02	6.5e-03	6.5	6.5	8.8e-11	0.84	0.48	0.40	FALSE
5	Adipose	Atrnl1	alternative polyA	ENSRNOT00000118477	0.63	0.22	top1	1	0.22	1.4e-23	6.5	-6.5	8.8e-11	-0.66	0.00	1.00	FALSE
6	Adipose	Atrnl1	alternative polyA	ENSRNOT00000105444	0.08	0.07	top1	1	0.07	7.2e-08	6.2	6.2	7.6e-10	0.67	0.03	0.97	FALSE
7	Adipose	Atrnl1	alternative polyA	ENSRNOT00000115590	0.02	0.02	lasso	1	0.02	6.5e-03	6.5	6.5	8.8e-11	0.84	0.48	0.40	FALSE
8	Adipose	Atrnl1	alternative polyA	ENSRNOT00000118477	0.24	0.19	lasso	4	0.19	5.0e-21	6.5	-6.5	8.8e-11	-0.84	0.02	0.98	FALSE
9	Adipose	Zdhhc6	alternative polyA	ENSRNOT00000054681	0.07	0.05	top1	1	0.05	1.6e-06	5.2	5.2	2.1e-07	0.90	0.94	0.00	FALSE
10	Adipose	Zdhhc6	alternative polyA	ENSRNOT00000087680	0.04	0.03	top1	1	0.03	7.0e-04	5.2	-5.2	2.1e-07	-0.88	0.25	0.02	FALSE
11	Adipose	Zdhhc6	alternative polyA	ENSRNOT00000103424	0.05	0.01	blup	2039	0.03	2.3e-04	6.7	-5.6	1.7e-08	-0.57	0.47	0.48	TRUE
12	Adipose	Zdhhc6	alternative polyA	ENSRNOT00000054681	0.08	0.06	top1	1	0.06	1.1e-07	6.8	6.8	8.7e-12	0.91	0.40	0.59	FALSE
13	Adipose	Zdhhc6	alternative polyA	ENSRNOT00000103424	0.08	0.07	top1	1	0.07	1.7e-08	6.8	-6.8	8.7e-12	-0.90	0.40	0.60	FALSE
14	Adipose	Nrap	gene expression	ENSRNOG00000016714	0.05	0.03	blup	2070	0.05	2.5e-06	7.2	5.6	1.8e-08	0.88	0.70	0.30	TRUE
15	Adipose	AABR07007032.1	gene expression	ENSRNOG00000046333	0.54	0.29	enet	19	0.31	3.7e-35	6.1	-5.7	1.2e-08	-0.76	0.52	0.48	FALSE
16	Adipose	Acsl5	isoform ratio	ENSRNOT00000103067	0.03	0.02	top1	1	0.02	9.2e-04	6.8	-6.8	1.4e-11	-0.90	0.07	0.04	FALSE
17	Adipose	Nhlrc2	isoform ratio	ENSRNOT00000022788	0.04	0.02	top1	1	0.02	2.9e-03	7.1	7.1	1.0e-12	0.95	0.09	0.11	FALSE
18	Adipose	Nhlrc2	isoform ratio	ENSRNOT00000105890	0.04	0.02	top1	1	0.02	4.0e-03	7.1	-7.1	1.0e-12	-0.95	0.08	0.09	FALSE
19	Adipose	Atrnl1	isoform ratio	ENSRNOT00000105444	0.08	0.07	top1	1	0.07	4.2e-08	6.2	6.2	7.6e-10	0.67	0.03	0.97	FALSE
20	Adipose	Atrnl1	isoform ratio	ENSRNOT00000115590	0.02	0.02	top1	1	0.02	4.6e-03	6.5	6.5	8.8e-11	0.65	0.03	0.56	FALSE
21	Adipose	Atrnl1	isoform ratio	ENSRNOT00000118477	0.73	0.22	top1	1	0.22	1.2e-23	6.5	-6.5	8.8e-11	-0.66	0.00	1.00	FALSE
22	Adipose	Zdhhc6	isoform ratio	ENSRNOT00000054681	0.05	0.04	top1	1	0.04	1.6e-05	5.2	5.2	2.1e-07	0.90	0.61	0.01	FALSE
23	Adipose	Zdhhc6	isoform ratio	ENSRNOT00000103424	0.05	0.00	blup	2039	0.02	9.0e-04	6.7	-5.3	1.3e-07	-0.51	0.50	0.32	FALSE
24	Adipose	AABR07007032.1	isoform ratio	ENSRNOT00000108182	0.32	0.12	top1	1	0.12	4.9e-13	5.5	-5.5	3.4e-08	-0.74	0.83	0.17	FALSE
25	Adipose	AABR07007032.1	intron excision ratio	chr1:256098051:256100373	0.23	0.08	enet	260	0.10	6.0e-11	6.2	-6.6	5.3e-11	-0.78	0.06	0.94	TRUE
26	Adipose	AABR07007032.1	intron excision ratio	chr1:256100420:256102022	0.10	0.04	lasso	22	0.05	1.4e-06	5.5	5.9	2.7e-09	0.82	0.40	0.60	FALSE
27	Adipose	AABR07007032.1	intron excision ratio	chr1:256230416:256255914	0.03	0.02	top1	1	0.02	1.1e-03	6.2	6.2	5.9e-10	0.73	0.08	0.13	FALSE
28	Adipose	AABR07007032.1	intron excision ratio	chr1:256230416:256298551	0.03	0.02	top1	1	0.02	8.8e-04	6.2	-6.2	5.9e-10	-0.72	0.08	0.14	FALSE
29	Adipose	Afap1l2	mRNA stability	ENSRNOG00000017164	0.03	0.01	enet	3	0.03	6.3e-04	5.4	5.5	3.9e-08	0.78	0.58	0.36	FALSE
30	Adipose	Atrnl1	mRNA stability	ENSRNOG00000017406	0.11	0.02	enet	83	0.06	1.0e-06	6.2	5.9	2.7e-09	0.76	0.42	0.58	FALSE
31	BLA	Dclre1a	mRNA stability	ENSRNOG00000026204	0.15	0.05	lasso	13	0.05	8.1e-04	5.4	5.3	1.0e-07	0.87	0.89	0.08	FALSE
32	Brain	Afap1l2	gene expression	ENSRNOG00000017164	0.21	0.14	lasso	21	0.22	2.2e-20	6.5	-6.3	3.5e-10	-0.79	0.08	0.92	TRUE
33	Brain	Casp7	gene expression	ENSRNOG00000056216	0.13	0.12	blup	2102	0.17	1.9e-15	5.3	5.7	9.6e-09	0.91	0.85	0.15	FALSE
34	Brain	Gpam	intron excision ratio	chr1:254140727:254142324	0.03	0.01	blup	2121	0.02	2.8e-03	3.2	5.1	3.2e-07	0.81	0.63	0.27	FALSE
35	Brain	Nrap	mRNA stability	ENSRNOG00000016714	0.04	0.04	top1	1	0.04	1.5e-04	6.7	-6.7	1.5e-11	-0.97	0.14	0.04	FALSE
36	Brain	Afap1l2	mRNA stability	ENSRNOG00000017164	0.56	0.41	blup	2422	0.44	2.6e-44	5.7	-5.8	5.1e-09	-0.83	0.66	0.34	FALSE
37	Brain	Casp7	mRNA stability	ENSRNOG00000056216	0.12	0.04	blup	2102	0.04	5.0e-05	7.2	5.6	2.7e-08	0.82	0.40	0.59	FALSE
38	Eye	Tectb	gene expression	ENSRNOG00000015671	0.33	0.19	lasso	24	0.20	5.8e-04	5.1	6.5	8.1e-11	-0.79	0.37	0.34	TRUE
39	Eye	Casp7	gene expression	ENSRNOG00000056216	0.51	0.05	blup	2102	0.12	7.2e-03	6.5	6.7	1.7e-11	0.83	0.28	0.30	TRUE
40	IL	Afap1l2	mRNA stability	ENSRNOG00000017164	0.39	0.23	top1	1	0.23	3.5e-06	5.7	-5.7	1.4e-08	-0.84	0.19	0.09	FALSE
41	IL	Dclre1a	mRNA stability	ENSRNOG00000026204	0.31	0.26	lasso	3	0.29	1.2e-07	7.1	6.6	3.4e-11	0.97	0.39	0.60	FALSE
42	LHb	Gpam	gene expression	ENSRNOG00000015124	0.18	0.03	blup	2117	0.12	1.1e-03	5.0	-6.0	2.4e-09	-0.87	0.46	0.44	FALSE
43	LHb	Gucy2g	gene expression	ENSRNOG00000015724	0.29	0.15	enet	9	0.21	9.6e-06	6.7	-6.2	6.4e-10	-0.89	0.49	0.49	FALSE
44	LHb	Tcf7l2	gene expression	ENSRNOG00000049232	0.14	0.04	lasso	6	0.06	1.2e-02	6.8	6.8	1.0e-11	0.90	0.41	0.28	FALSE
45	LHb	Casp7	gene expression	ENSRNOG00000056216	0.12	0.12	top1	1	0.12	1.1e-03	5.3	5.3	1.0e-07	0.97	0.11	0.05	FALSE
46	LHb	Afap1l2	mRNA stability	ENSRNOG00000017164	0.46	0.29	top1	1	0.29	1.2e-07	5.2	-5.2	2.5e-07	-0.83	0.50	0.04	FALSE
47	LHb	Atrnl1	mRNA stability	ENSRNOG00000017406	0.21	0.14	top1	1	0.14	3.1e-04	6.2	-6.2	4.2e-10	-0.69	0.07	0.53	FALSE
48	LHb	Dclre1a	mRNA stability	ENSRNOG00000026204	0.45	0.22	lasso	4	0.26	7.1e-07	5.3	5.1	3.5e-07	0.85	0.87	0.10	FALSE
49	LHb	Tcf7l2	mRNA stability	ENSRNOG00000049232	0.15	0.07	enet	7	0.08	6.4e-03	3.4	5.1	3.1e-07	0.83	0.44	0.23	FALSE
50	Liver	Casp7	alternative TSS	ENSRNOT00000080511	0.02	0.01	blup	2101	0.01	8.5e-03	5.9	-6.7	2.6e-11	-0.95	0.46	0.33	FALSE
51	Liver	Casp7	alternative TSS	ENSRNOT00000103804	0.02	0.01	top1	1	0.01	1.3e-02	5.9	5.9	3.6e-09	0.96	0.06	0.03	FALSE
52	Liver	Gpam	gene expression	ENSRNOG00000015124	0.14	0.05	lasso	16	0.09	1.3e-10	5.2	5.3	1.4e-07	0.73	0.56	0.44	FALSE
53	Liver	Acsl5	gene expression	ENSRNOG00000016265	0.05	0.03	top1	1	0.03	1.4e-04	6.8	6.8	1.4e-11	0.90	0.10	0.07	FALSE
54	Liver	Habp2	gene expression	ENSRNOG00000016659	0.92	0.57	top1	1	0.57	1.3e-76	7.2	-7.2	6.0e-13	-0.92	0.27	0.73	FALSE
55	Liver	Nhlrc2	gene expression	ENSRNOG00000016948	0.11	0.11	top1	1	0.11	1.4e-12	5.4	-5.4	6.4e-08	-0.91	1.00	0.00	FALSE
56	Liver	Fhip2a	gene expression	ENSRNOG00000017225	0.02	0.02	top1	1	0.03	8.2e-04	6.5	-6.5	8.8e-11	-0.72	0.05	0.48	FALSE
57	Liver	Trub1	gene expression	ENSRNOG00000017321	0.42	0.43	lasso	23	0.44	3.5e-54	4.1	-5.6	1.7e-08	-0.68	0.98	0.02	FALSE
58	Liver	Dclre1a	gene expression	ENSRNOG00000026204	0.23	0.16	enet	429	0.17	1.8e-18	5.4	-5.4	6.5e-08	-0.93	1.00	0.00	FALSE
59	Liver	Gpam	intron excision ratio	chr1:254140727:254170436	0.02	0.01	blup	2121	0.01	1.0e-02	6.8	-6.3	2.5e-10	-0.89	0.46	0.43	FALSE
60	Liver	Habp2	intron excision ratio	chr1:255327227:255336618	0.70	0.39	enet	28	0.40	5.1e-47	7.2	7.2	5.1e-13	1.00	0.27	0.73	FALSE
61	Liver	Habp2	intron excision ratio	chr1:255336728:255338715	0.61	0.37	enet	26	0.38	7.9e-44	7.2	-7.2	5.1e-13	-1.00	0.28	0.72	TRUE
62	Liver	Nhlrc2	intron excision ratio	chr1:255640509:255642738	0.23	0.26	enet	376	0.27	1.7e-29	5.4	5.5	3.1e-08	0.93	1.00	0.00	FALSE
63	Liver	Dclre1a	intron excision ratio	chr1:255572081:255578402	0.25	0.25	lasso	34	0.26	2.0e-28	5.2	5.4	7.5e-08	0.88	1.00	0.00	FALSE
64	Liver	Tcf7l2	intron excision ratio	chr1:254787414:254860496	0.03	0.00	lasso	14	0.00	2.1e-01	6.8	-6.8	8.1e-12	0.80	0.35	0.48	TRUE
65	Liver	Acsl5	mRNA stability	ENSRNOG00000016265	0.06	0.05	enet	97	0.06	8.6e-07	6.7	6.4	1.4e-10	0.87	0.51	0.49	FALSE
66	Liver	Habp2	mRNA stability	ENSRNOG00000016659	0.47	0.38	top1	1	0.38	4.8e-44	7.2	-7.2	8.4e-13	-0.93	0.34	0.66	FALSE
67	Liver	Afap1l2	mRNA stability	ENSRNOG00000017164	0.02	0.01	top1	1	0.01	1.2e-02	5.8	-5.8	7.3e-09	-0.78	0.07	0.03	FALSE
68	Liver	Ccdc186	mRNA stability	ENSRNOG00000051680	0.04	0.02	top1	1	0.02	4.3e-03	5.2	-5.2	2.3e-07	-0.80	0.06	0.03	FALSE
69	NAcc	Acsl5	gene expression	ENSRNOG00000016265	0.09	0.07	top1	1	0.07	4.0e-06	6.7	6.7	1.6e-11	0.90	0.44	0.40	FALSE
70	NAcc	Casp7	gene expression	ENSRNOG00000056216	0.21	0.10	enet	179	0.12	3.5e-09	7.2	7.1	1.7e-12	0.93	0.33	0.67	FALSE
71	NAcc	Acsl5	isoform ratio	ENSRNOT00000110033	0.03	0.02	top1	1	0.02	2.2e-02	6.7	6.7	2.2e-11	0.89	0.07	0.04	TRUE
72	NAcc	Afap1l2	mRNA stability	ENSRNOG00000017164	0.09	0.03	blup	2417	0.06	3.4e-05	6.0	-5.5	4.1e-08	-0.77	0.48	0.50	FALSE
73	NAcc	Dclre1a	mRNA stability	ENSRNOG00000026204	0.26	0.17	lasso	14	0.17	6.8e-13	5.5	5.5	3.6e-08	0.87	1.00	0.00	FALSE
74	OFC	Acsl5	gene expression	ENSRNOG00000016265	0.32	0.16	blup	2066	0.19	2.8e-05	6.8	-6.4	2.0e-10	-0.89	0.52	0.47	FALSE
75	OFC	Fhip2a	gene expression	ENSRNOG00000017225	0.16	0.09	top1	1	0.09	4.6e-03	5.3	-5.3	1.4e-07	-0.73	0.14	0.05	FALSE
76	OFC	Afap1l2	mRNA stability	ENSRNOG00000017164	0.55	0.16	enet	14	0.33	1.3e-08	5.8	-5.9	3.3e-09	-0.79	0.64	0.35	FALSE
77	OFC	Dclre1a	mRNA stability	ENSRNOG00000026204	0.34	0.22	enet	11	0.29	1.1e-07	7.2	6.8	1.3e-11	0.97	0.42	0.57	FALSE
78	PL	Tcf7l2	gene expression	ENSRNOG00000049232	0.04	0.02	enet	26	0.03	4.8e-03	6.8	-6.4	1.5e-10	-0.91	0.43	0.45	FALSE
79	PL	Ccdc186	gene expression	ENSRNOG00000051680	0.19	0.01	enet	9	0.04	9.2e-04	-2.8	5.1	2.9e-07	0.71	0.48	0.43	FALSE
80	PL	Casp7	gene expression	ENSRNOG00000056216	0.12	0.10	enet	37	0.10	2.6e-08	7.2	7.1	1.4e-12	0.96	0.34	0.66	FALSE
81	PL	Gpam	intron excision ratio	chr1:254140727:254170436	0.04	0.01	lasso	2	0.02	1.8e-02	6.8	-6.8	1.1e-11	-0.88	0.39	0.51	FALSE
82	PL	Bbip1	intron excision ratio	chr1:252958487:252959032	0.09	0.05	top1	1	0.05	2.0e-04	5.2	5.2	1.8e-07	0.58	0.01	0.86	TRUE
83	PL	Afap1l2	mRNA stability	ENSRNOG00000017164	0.20	0.09	lasso	16	0.10	3.1e-08	5.8	-5.8	7.2e-09	-0.67	0.54	0.46	TRUE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.