Best TWAS P=5.06e-13 · Best GWAS P=3.62e-13 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Nhlrc2 | alternative polyA | ENSRNOT00000022788 | 0.03 | 1 | 0 | 1.8e-01 | 7 | 2.54e-12 | 0.03 | FALSE |
| Adipose | Nhlrc2 | alternative polyA | ENSRNOT00000105890 | 0.03 | 1 | 0.01 | 3.7e-02 | -7 | 2.52e-12 | 0.03 | FALSE |
| Adipose | Atrnl1 | alternative polyA | ENSRNOT00000105444 | 0.08 | 1 | 0.07 | 4.0e-08 | 6.15 | 7.64e-10 | 0.97 | FALSE |
| Adipose | Atrnl1 | alternative polyA | ENSRNOT00000115590 | 0.02 | 1 | 0.02 | 6.5e-03 | 6.49 | 8.83e-11 | 0.4 | FALSE |
| Adipose | Atrnl1 | alternative polyA | ENSRNOT00000118477 | 0.63 | 1 | 0.22 | 1.4e-23 | -6.49 | 8.83e-11 | 1 | FALSE |
| Adipose | Atrnl1 | alternative polyA | ENSRNOT00000105444 | 0.08 | 1 | 0.07 | 7.2e-08 | 6.15 | 7.64e-10 | 0.97 | FALSE |
| Adipose | Atrnl1 | alternative polyA | ENSRNOT00000115590 | 0.02 | 1 | 0.02 | 6.5e-03 | 6.49 | 8.83e-11 | 0.4 | FALSE |
| Adipose | Atrnl1 | alternative polyA | ENSRNOT00000118477 | 0.24 | 4 | 0.19 | 5.0e-21 | -6.49 | 8.80e-11 | 0.98 | FALSE |
| Adipose | Zdhhc6 | alternative polyA | ENSRNOT00000054681 | 0.07 | 1 | 0.05 | 1.6e-06 | 5.19 | 2.10e-07 | 0 | FALSE |
| Adipose | Zdhhc6 | alternative polyA | ENSRNOT00000087680 | 0.04 | 1 | 0.03 | 7.0e-04 | -5.19 | 2.10e-07 | 0.02 | FALSE |
| Adipose | Zdhhc6 | alternative polyA | ENSRNOT00000103424 | 0.05 | 2039 | 0.03 | 2.3e-04 | -5.64 | 1.71e-08 | 0.48 | TRUE |
| Adipose | Zdhhc6 | alternative polyA | ENSRNOT00000054681 | 0.08 | 1 | 0.06 | 1.1e-07 | 6.83 | 8.74e-12 | 0.59 | FALSE |
| Adipose | Zdhhc6 | alternative polyA | ENSRNOT00000103424 | 0.08 | 1 | 0.07 | 1.7e-08 | -6.83 | 8.74e-12 | 0.6 | FALSE |
| Adipose | Nrap | gene expression | ENSRNOG00000016714 | 0.05 | 2070 | 0.05 | 2.5e-06 | 5.63 | 1.80e-08 | 0.3 | TRUE |
| Adipose | AABR07007032.1 | gene expression | ENSRNOG00000046333 | 0.54 | 19 | 0.31 | 3.7e-35 | -5.7 | 1.18e-08 | 0.48 | FALSE |
| Adipose | Acsl5 | isoform ratio | ENSRNOT00000103067 | 0.03 | 1 | 0.02 | 9.2e-04 | -6.75 | 1.43e-11 | 0.04 | FALSE |
| Adipose | Nhlrc2 | isoform ratio | ENSRNOT00000022788 | 0.04 | 1 | 0.02 | 2.9e-03 | 7.13 | 1.04e-12 | 0.11 | FALSE |
| Adipose | Nhlrc2 | isoform ratio | ENSRNOT00000105890 | 0.04 | 1 | 0.02 | 4.0e-03 | -7.13 | 1.04e-12 | 0.09 | FALSE |
| Adipose | Atrnl1 | isoform ratio | ENSRNOT00000105444 | 0.08 | 1 | 0.07 | 4.2e-08 | 6.15 | 7.64e-10 | 0.97 | FALSE |
| Adipose | Atrnl1 | isoform ratio | ENSRNOT00000115590 | 0.02 | 1 | 0.02 | 4.6e-03 | 6.49 | 8.83e-11 | 0.56 | FALSE |
| Adipose | Atrnl1 | isoform ratio | ENSRNOT00000118477 | 0.73 | 1 | 0.22 | 1.2e-23 | -6.49 | 8.83e-11 | 1 | FALSE |
| Adipose | Zdhhc6 | isoform ratio | ENSRNOT00000054681 | 0.05 | 1 | 0.04 | 1.6e-05 | 5.19 | 2.10e-07 | 0.01 | FALSE |
| Adipose | Zdhhc6 | isoform ratio | ENSRNOT00000103424 | 0.05 | 2039 | 0.02 | 9.0e-04 | -5.28 | 1.29e-07 | 0.32 | FALSE |
| Adipose | AABR07007032.1 | isoform ratio | ENSRNOT00000108182 | 0.32 | 1 | 0.12 | 4.9e-13 | -5.52 | 3.39e-08 | 0.17 | FALSE |
| Adipose | AABR07007032.1 | intron excision ratio | chr1:256098051:256100373 | 0.23 | 260 | 0.1 | 6.0e-11 | -6.56 | 5.35e-11 | 0.94 | TRUE |
| Adipose | AABR07007032.1 | intron excision ratio | chr1:256100420:256102022 | 0.1 | 22 | 0.05 | 1.4e-06 | 5.95 | 2.72e-09 | 0.6 | FALSE |
| Adipose | AABR07007032.1 | intron excision ratio | chr1:256230416:256255914 | 0.03 | 1 | 0.02 | 1.1e-03 | 6.19 | 5.89e-10 | 0.13 | FALSE |
| Adipose | AABR07007032.1 | intron excision ratio | chr1:256230416:256298551 | 0.03 | 1 | 0.02 | 8.8e-04 | -6.19 | 5.89e-10 | 0.14 | FALSE |
| Adipose | Afap1l2 | mRNA stability | ENSRNOG00000017164 | 0.03 | 3 | 0.03 | 6.3e-04 | 5.5 | 3.85e-08 | 0.36 | FALSE |
| Adipose | Atrnl1 | mRNA stability | ENSRNOG00000017406 | 0.11 | 83 | 0.06 | 1.0e-06 | 5.95 | 2.70e-09 | 0.58 | FALSE |
| BLA | Dclre1a | mRNA stability | ENSRNOG00000026204 | 0.15 | 13 | 0.05 | 8.1e-04 | 5.32 | 1.02e-07 | 0.08 | FALSE |
| Brain | Afap1l2 | gene expression | ENSRNOG00000017164 | 0.21 | 21 | 0.22 | 2.2e-20 | -6.27 | 3.52e-10 | 0.92 | TRUE |
| Brain | Casp7 | gene expression | ENSRNOG00000056216 | 0.13 | 2102 | 0.17 | 1.9e-15 | 5.74 | 9.62e-09 | 0.15 | FALSE |
| Brain | Gpam | intron excision ratio | chr1:254140727:254142324 | 0.03 | 2121 | 0.02 | 2.8e-03 | 5.11 | 3.24e-07 | 0.27 | FALSE |
| Brain | Nrap | mRNA stability | ENSRNOG00000016714 | 0.04 | 1 | 0.04 | 1.5e-04 | -6.75 | 1.48e-11 | 0.04 | FALSE |
| Brain | Afap1l2 | mRNA stability | ENSRNOG00000017164 | 0.56 | 2422 | 0.44 | 2.6e-44 | -5.84 | 5.14e-09 | 0.34 | FALSE |
| Brain | Casp7 | mRNA stability | ENSRNOG00000056216 | 0.12 | 2102 | 0.04 | 5.0e-05 | 5.56 | 2.74e-08 | 0.59 | FALSE |
| Eye | Tectb | gene expression | ENSRNOG00000015671 | 0.33 | 24 | 0.2 | 5.8e-04 | 6.5 | 8.14e-11 | 0.34 | TRUE |
| Eye | Casp7 | gene expression | ENSRNOG00000056216 | 0.51 | 2102 | 0.12 | 7.2e-03 | 6.73 | 1.73e-11 | 0.3 | TRUE |
| IL | Afap1l2 | mRNA stability | ENSRNOG00000017164 | 0.39 | 1 | 0.23 | 3.5e-06 | -5.67 | 1.42e-08 | 0.09 | FALSE |
| IL | Dclre1a | mRNA stability | ENSRNOG00000026204 | 0.31 | 3 | 0.29 | 1.2e-07 | 6.63 | 3.40e-11 | 0.6 | FALSE |
| LHb | Gpam | gene expression | ENSRNOG00000015124 | 0.18 | 2117 | 0.12 | 1.1e-03 | -5.97 | 2.39e-09 | 0.44 | FALSE |
| LHb | Gucy2g | gene expression | ENSRNOG00000015724 | 0.29 | 9 | 0.21 | 9.6e-06 | -6.18 | 6.43e-10 | 0.49 | FALSE |
| LHb | Tcf7l2 | gene expression | ENSRNOG00000049232 | 0.14 | 6 | 0.06 | 1.2e-02 | 6.81 | 1.01e-11 | 0.28 | FALSE |
| LHb | Casp7 | gene expression | ENSRNOG00000056216 | 0.12 | 1 | 0.12 | 1.1e-03 | 5.32 | 1.05e-07 | 0.05 | FALSE |
| LHb | Afap1l2 | mRNA stability | ENSRNOG00000017164 | 0.46 | 1 | 0.29 | 1.2e-07 | -5.16 | 2.51e-07 | 0.04 | FALSE |
| LHb | Atrnl1 | mRNA stability | ENSRNOG00000017406 | 0.21 | 1 | 0.14 | 3.1e-04 | -6.25 | 4.22e-10 | 0.53 | FALSE |
| LHb | Dclre1a | mRNA stability | ENSRNOG00000026204 | 0.45 | 4 | 0.26 | 7.1e-07 | 5.09 | 3.50e-07 | 0.1 | FALSE |
| LHb | Tcf7l2 | mRNA stability | ENSRNOG00000049232 | 0.15 | 7 | 0.08 | 6.4e-03 | 5.12 | 3.12e-07 | 0.23 | FALSE |
| Liver | Casp7 | alternative TSS | ENSRNOT00000080511 | 0.02 | 2101 | 0.01 | 8.5e-03 | -6.67 | 2.64e-11 | 0.33 | FALSE |
| Liver | Casp7 | alternative TSS | ENSRNOT00000103804 | 0.02 | 1 | 0.01 | 1.3e-02 | 5.9 | 3.61e-09 | 0.03 | FALSE |
| Liver | Gpam | gene expression | ENSRNOG00000015124 | 0.14 | 16 | 0.09 | 1.3e-10 | 5.27 | 1.37e-07 | 0.44 | FALSE |
| Liver | Acsl5 | gene expression | ENSRNOG00000016265 | 0.05 | 1 | 0.03 | 1.4e-04 | 6.75 | 1.43e-11 | 0.07 | FALSE |
| Liver | Habp2 | gene expression | ENSRNOG00000016659 | 0.92 | 1 | 0.57 | 1.3e-76 | -7.2 | 5.99e-13 | 0.73 | FALSE |
| Liver | Nhlrc2 | gene expression | ENSRNOG00000016948 | 0.11 | 1 | 0.11 | 1.4e-12 | -5.41 | 6.37e-08 | 0 | FALSE |
| Liver | Fhip2a | gene expression | ENSRNOG00000017225 | 0.02 | 1 | 0.03 | 8.2e-04 | -6.49 | 8.83e-11 | 0.48 | FALSE |
| Liver | Trub1 | gene expression | ENSRNOG00000017321 | 0.42 | 23 | 0.44 | 3.5e-54 | -5.64 | 1.74e-08 | 0.02 | FALSE |
| Liver | Dclre1a | gene expression | ENSRNOG00000026204 | 0.23 | 429 | 0.17 | 1.8e-18 | -5.41 | 6.48e-08 | 0 | FALSE |
| Liver | Gpam | intron excision ratio | chr1:254140727:254170436 | 0.02 | 2121 | 0.01 | 1.0e-02 | -6.33 | 2.49e-10 | 0.43 | FALSE |
| Liver | Habp2 | intron excision ratio | chr1:255327227:255336618 | 0.7 | 28 | 0.4 | 5.1e-47 | 7.22 | 5.08e-13 | 0.73 | FALSE |
| Liver | Habp2 | intron excision ratio | chr1:255336728:255338715 | 0.61 | 26 | 0.38 | 7.9e-44 | -7.22 | 5.06e-13 | 0.72 | TRUE |
| Liver | Nhlrc2 | intron excision ratio | chr1:255640509:255642738 | 0.23 | 376 | 0.27 | 1.7e-29 | 5.53 | 3.11e-08 | 0 | FALSE |
| Liver | Dclre1a | intron excision ratio | chr1:255572081:255578402 | 0.25 | 34 | 0.26 | 2.0e-28 | 5.38 | 7.50e-08 | 0 | FALSE |
| Liver | Tcf7l2 | intron excision ratio | chr1:254787414:254860496 | 0.03 | 14 | 0 | 2.1e-01 | -6.84 | 8.09e-12 | 0.48 | TRUE |
| Liver | Acsl5 | mRNA stability | ENSRNOG00000016265 | 0.06 | 97 | 0.06 | 8.6e-07 | 6.42 | 1.39e-10 | 0.49 | FALSE |
| Liver | Habp2 | mRNA stability | ENSRNOG00000016659 | 0.47 | 1 | 0.38 | 4.8e-44 | -7.15 | 8.37e-13 | 0.66 | FALSE |
| Liver | Afap1l2 | mRNA stability | ENSRNOG00000017164 | 0.02 | 1 | 0.01 | 1.2e-02 | -5.78 | 7.27e-09 | 0.03 | FALSE |
| Liver | Ccdc186 | mRNA stability | ENSRNOG00000051680 | 0.04 | 1 | 0.02 | 4.3e-03 | -5.17 | 2.32e-07 | 0.03 | FALSE |
| NAcc | Acsl5 | gene expression | ENSRNOG00000016265 | 0.09 | 1 | 0.07 | 4.0e-06 | 6.74 | 1.58e-11 | 0.4 | FALSE |
| NAcc | Casp7 | gene expression | ENSRNOG00000056216 | 0.21 | 179 | 0.12 | 3.5e-09 | 7.06 | 1.69e-12 | 0.67 | FALSE |
| NAcc | Acsl5 | isoform ratio | ENSRNOT00000110033 | 0.03 | 1 | 0.02 | 2.2e-02 | 6.69 | 2.20e-11 | 0.04 | TRUE |
| NAcc | Afap1l2 | mRNA stability | ENSRNOG00000017164 | 0.09 | 2417 | 0.06 | 3.4e-05 | -5.49 | 4.08e-08 | 0.5 | FALSE |
| NAcc | Dclre1a | mRNA stability | ENSRNOG00000026204 | 0.26 | 14 | 0.17 | 6.8e-13 | 5.51 | 3.60e-08 | 0 | FALSE |
| OFC | Acsl5 | gene expression | ENSRNOG00000016265 | 0.32 | 2066 | 0.19 | 2.8e-05 | -6.36 | 2.04e-10 | 0.47 | FALSE |
| OFC | Fhip2a | gene expression | ENSRNOG00000017225 | 0.16 | 1 | 0.09 | 4.6e-03 | -5.27 | 1.37e-07 | 0.05 | FALSE |
| OFC | Afap1l2 | mRNA stability | ENSRNOG00000017164 | 0.55 | 14 | 0.33 | 1.3e-08 | -5.91 | 3.34e-09 | 0.35 | FALSE |
| OFC | Dclre1a | mRNA stability | ENSRNOG00000026204 | 0.34 | 11 | 0.29 | 1.1e-07 | 6.77 | 1.31e-11 | 0.57 | FALSE |
| PL | Tcf7l2 | gene expression | ENSRNOG00000049232 | 0.04 | 26 | 0.03 | 4.8e-03 | -6.4 | 1.50e-10 | 0.45 | FALSE |
| PL | Ccdc186 | gene expression | ENSRNOG00000051680 | 0.19 | 9 | 0.04 | 9.2e-04 | 5.13 | 2.92e-07 | 0.43 | FALSE |
| PL | Casp7 | gene expression | ENSRNOG00000056216 | 0.12 | 37 | 0.1 | 2.6e-08 | 7.08 | 1.43e-12 | 0.66 | FALSE |
| PL | Gpam | intron excision ratio | chr1:254140727:254170436 | 0.04 | 2 | 0.02 | 1.8e-02 | -6.8 | 1.05e-11 | 0.51 | FALSE |
| PL | Bbip1 | intron excision ratio | chr1:252958487:252959032 | 0.09 | 1 | 0.05 | 2.0e-04 | 5.21 | 1.84e-07 | 0.86 | TRUE |
| PL | Afap1l2 | mRNA stability | ENSRNOG00000017164 | 0.2 | 16 | 0.1 | 3.1e-08 | -5.79 | 7.16e-09 | 0.46 | TRUE |